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170 Possible Causes for Glial Inclusions

  • Shy Drager Syndrome

    Glial cytoplasmic inclusions (GCIs) were demonstrated by silver staining, immunocytochemistry and by electron microscopy in the central nervous system (CNS) of 11 patients[ncbi.nlm.nih.gov] Neuronal and glial cytoplasmic inclusions (NCIs and GCIs), which contain alpha-synuclein as a major component, are characteristic cytopathological features of multiple system[ncbi.nlm.nih.gov] A glial cytoplasmic inclusion has been found to occur intracellularly in both glial cells and neurons of involved portions of the brain.[mc.vanderbilt.edu]

  • Neuronal Intranuclear Inclusion Disease

    Optineurin immunoreactivity in neuronal and glial intranuclear inclusions in adult-onset neuronal intranuclear inclusion disease.[mayoclinic.pure.elsevier.com] inclusions in neuronal and glial cells.[ncbi.nlm.nih.gov] Glial inclusions were not seen. Neurons of the striatum and globus pallidus showed fewer neuronal intranuclear inclusions (NII).[path.upmc.edu]

  • Olivopontocerebellar Atrophy

    None of the 54 control cases had glial argyrophilic inclusions. Immunohistochemically, these inclusions were intensely labeled by anti-ubiquitin antibody.[ncbi.nlm.nih.gov] We identified three cases of CBD with olivopontocerebellar atrophy (CBD-OPCA) that did not have α-synuclein-positive glial cytoplasmic inclusions of multiple system atrophy[ncbi.nlm.nih.gov] The astrocytosis localized in the primary motor cortex and its distribution pattern were clearly different from those of so-called glial cytoplasmic inclusion.[ncbi.nlm.nih.gov]

  • Orthostatic Hypotension

    Alpha-synuclein is present in the glial inclusions and appears to play an important role in MSA.[emedicine.medscape.com] However, brain autopsy specimens in MSA show distinct glial cytoplasmic inclusions composed of 20- to 30-nm multilayered tubular filaments that are argyrophilic.[emedicine.medscape.com] The inclusions are found in the basal ganglia, the supplementary and primary motor cortex, the reticular formation, and the pontocerebellar system.[emedicine.medscape.com]

  • Alzheimer Disease

    ., et al. (1998) Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein. Ann.[doi.org]

  • X-linked Parkinsonism-Spasticity Syndrome

    inclusions or another one affecting elderly individuals; biomarker research; comparative studies of brain ageing and brain development; and pathogenesis studies on prion[books.google.com] […] achievements include first descriptions, characterization and pathogenic elucidation of several peculiar types of neurological diseases, like frontotemporal dementia with globular glial[books.google.com]

  • Motor Neuron Disease

    The nuclear staining of FUS was preserved in some neurons with FUS-positive inclusions, and a few FUS-positive glial inclusions were found.[ncbi.nlm.nih.gov] TDP-43 globular glial inclusions (GGI) were identified in one case. There were no mutations in PGRN or TARDBP genes.[ncbi.nlm.nih.gov] The globular nature of glial inclusions and the non-fibrillar properties of tau in astrocytes are characteristic features that allow them to be distinguished from PSP and[ncbi.nlm.nih.gov]

  • Orthostatic Syncope

    ''Definite'' MSA requires post-mortem demonstration of α-synuclein positive glial cytoplasmic inclusions with neurodegeneration of striatonigral and olivopontocerebellar structures[orpha.net]

  • Ondine Syndrome

    A glial cytoplasmic inclusion has been found to occur intracellularly in both glial cells and neurons of involved portions of the brain.[ww2.mc.vanderbilt.edu] The glial cytoplasmic inclusions tend to be irregular in outline in contrast to the target-shaped concentric circular Lewy bodies.[ww2.mc.vanderbilt.edu] These inclusions contain ubiquitin, but are quite distinct from Lewy bodies, which also contain ubiquitin.[ww2.mc.vanderbilt.edu]

  • Progressive Supranuclear Palsy

    In particular, glial inclusions varied dramatically between the disorders.[ncbi.nlm.nih.gov] inclusions throughout the cerebral cortex and brainstem.[doi.org] All had neuronal and glial inclusions in the basal ganglia and brainstem. However, 13 cases had low tau pathology and were categorized as atypical PSP.[ncbi.nlm.nih.gov]

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