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170 Possible Causes for Glial Inclusions

  • Shy Drager Syndrome

    Glial cytoplasmic inclusions (GCIs) were demonstrated by silver staining, immunocytochemistry and by electron microscopy in the central nervous system (CNS) of 11 patients[] Neuronal and glial cytoplasmic inclusions (NCIs and GCIs), which contain alpha-synuclein as a major component, are characteristic cytopathological features of multiple system[] A glial cytoplasmic inclusion has been found to occur intracellularly in both glial cells and neurons of involved portions of the brain.[]

  • Neuronal Intranuclear Inclusion Disease

    Optineurin immunoreactivity in neuronal and glial intranuclear inclusions in adult-onset neuronal intranuclear inclusion disease.[] inclusions in neuronal and glial cells.[] Glial inclusions were not seen. Neurons of the striatum and globus pallidus showed fewer neuronal intranuclear inclusions (NII).[]

  • Olivopontocerebellar Atrophy

    None of the 54 control cases had glial argyrophilic inclusions. Immunohistochemically, these inclusions were intensely labeled by anti-ubiquitin antibody.[] We identified three cases of CBD with olivopontocerebellar atrophy (CBD-OPCA) that did not have α-synuclein-positive glial cytoplasmic inclusions of multiple system atrophy[] The astrocytosis localized in the primary motor cortex and its distribution pattern were clearly different from those of so-called glial cytoplasmic inclusion.[]

  • Orthostatic Hypotension

    Alpha-synuclein is present in the glial inclusions and appears to play an important role in MSA.[] However, brain autopsy specimens in MSA show distinct glial cytoplasmic inclusions composed of 20- to 30-nm multilayered tubular filaments that are argyrophilic.[] The inclusions are found in the basal ganglia, the supplementary and primary motor cortex, the reticular formation, and the pontocerebellar system.[]

  • Alzheimer Disease

    ., et al. (1998) Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein. Ann.[]

  • X-linked Parkinsonism-Spasticity Syndrome

    inclusions or another one affecting elderly individuals; biomarker research; comparative studies of brain ageing and brain development; and pathogenesis studies on prion[] […] achievements include first descriptions, characterization and pathogenic elucidation of several peculiar types of neurological diseases, like frontotemporal dementia with globular glial[]

  • Motor Neuron Disease

    The nuclear staining of FUS was preserved in some neurons with FUS-positive inclusions, and a few FUS-positive glial inclusions were found.[] TDP-43 globular glial inclusions (GGI) were identified in one case. There were no mutations in PGRN or TARDBP genes.[] The globular nature of glial inclusions and the non-fibrillar properties of tau in astrocytes are characteristic features that allow them to be distinguished from PSP and[]

  • Orthostatic Syncope

    ''Definite'' MSA requires post-mortem demonstration of α-synuclein positive glial cytoplasmic inclusions with neurodegeneration of striatonigral and olivopontocerebellar structures[]

  • Ondine Syndrome

    A glial cytoplasmic inclusion has been found to occur intracellularly in both glial cells and neurons of involved portions of the brain.[] The glial cytoplasmic inclusions tend to be irregular in outline in contrast to the target-shaped concentric circular Lewy bodies.[] These inclusions contain ubiquitin, but are quite distinct from Lewy bodies, which also contain ubiquitin.[]

  • Progressive Supranuclear Palsy

    In particular, glial inclusions varied dramatically between the disorders.[] inclusions throughout the cerebral cortex and brainstem.[] All had neuronal and glial inclusions in the basal ganglia and brainstem. However, 13 cases had low tau pathology and were categorized as atypical PSP.[]

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