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117 Possible Causes for Global Muscle Weakness, Hyperreflexia

  • Amyotrophic Lateral Sclerosis 5

    Pyramidal signs such as hyperreflexia and spasticity are observed in advanced-stage ALS5 only.[symptoma.com] There was global muscle weakness and atrophy of the right leg, and mild muscle atrophy in the left leg.[atm.amegroups.com] Hyperreflexia is present in all limbs and pes cavus can lead to difficulty walking. Pseudobulbar symptoms are sometimes seen but cerebellar signs are absent.[wohproject.org]

  • Autosomal Recessive Spastic Paraplegia Type 18

    People with this condition can also experience exaggerated reflexes (hyperreflexia), a decreased ability to feel vibrations, muscle wasting (amyotrophy), and reduced bladder[ghr.nlm.nih.gov] […] notable at the iliopsoas , tibialis anterior, hamstring muscles  difficulty in walking, decreased vibratory sense at the ankles, and paresthesia  In lower extremities hyperreflexia[slideshare.net] […] or pain in the arms and legs (sensory neuropathy); disturbance in the nerves used for muscle movement (motor neuropathy); intellectual disability; exaggerated reflexes (hyperreflexia[ghr.nlm.nih.gov]

  • West Syndrome

    […] difficulties Swallowing difficulty [ more ] 0002015 Dyspnea Trouble breathing 0002094 Dystonia 0001332 Epileptic encephalopathy 0200134 Generalized myoclonic seizures 0002123 Hyperreflexia[rarediseases.info.nih.gov] A 5 year-old boy exhibited global hypotonia with generalized muscle weakness from birth.[ncbi.nlm.nih.gov]

  • Infantile Neuroaxonal Dystrophy

    On physical examination there was optic atrophy, hypertonia and hyperreflexia.[ingentaconnect.com] […] tone Low muscle tone [ more ] 0001290 Generalized muscle weakness 0003324 Gliosis 0002171 Global developmental delay 0001263 Hearing impairment Deafness Hearing defect [[rarediseases.info.nih.gov] […] weakness 0003324 Gliosis 0002171 Global developmental delay 0001263 Hearing impairment Deafness Hearing defect [ more ] 0000365 Hyperactivity More active than typical 0000752 Hyperreflexia[rarediseases.info.nih.gov]

  • Pontocerebellar Hypoplasia Type 1B

    […] abnormality Muscular hypotonia of the trunk Poor head control Absent speech Cognitive delay Seizures Respiratory system abnormality Skeletal system abnormality Growth symptoms Hyperreflexia[familydiagnosis.com] Objectives: Pontocerebellar hypoplasia with spinal muscular atrophy, also known as PCH1, is a group of autosomal recessive disorders characterized by generalized muscle weakness[scinapse.io] There is diffuse muscle weakness, progressive microcephaly, global developmental delay, and brainstem involvement.[mybiosource.com]

  • Cervical Spondylosis

    Eleven patients (58%) had lower limb hyperreflexia or Babinski sign.[ncbi.nlm.nih.gov] weakness).[en.wikipedia.org] In an otherwise asymptomatic patient, hyperreflexia, a positive Babinski test, and a positive Hoffman’s sign (hand contraction in response to tapping on distal finger joints[americannursetoday.com]

  • Autosomal Recessive Spastic Paraplegia Type 72

    SPG72 is a pure form of spastic paraplegia with onset of difficulty walking and stiff legs associated with hyperreflexia and extensor plantar responses in early childhood.[malacards.org] weakness Skeletal muscle atrophy Peripheral neuropathy Motor delay Peripheral axonal neuropathy Urinary incontinence Muscle weakness Pain Ataxia Postural tremor Difficulty[mendelian.co] The pure form presents isolated pyramidal signs such as spasticity, hyperreflexia, Babinski sign, and motor deficits, which can be associated with sphincter disorder and deep[neurohic.com]

  • Multicore Myopathy

    Clinical manifestations included microcephaly, mental retardation, spasticity with hyperreflexia, cerebellar dysfunction, short stature, Hirschsprung's disease, pharyngeal[ncbi.nlm.nih.gov] […] atrophy Muscle weakness Trophic changes related to pain Areflexia High palate Proximal muscle weakness Torticollis Distal muscle weakness Joint laxity Global developmental[mendelian.co] […] delay Arachnodactyly Dolichocephaly Camptodactyly Centrally nucleated skeletal muscle fibers Hypertelorism Single transverse palmar crease Retinal hemorrhage High, narrow[mendelian.co]

  • Allan-Herndon-Dudley Syndrome

    Hyperreflexia appears later in life.[orpha.net] Symptoms The children affected with allan-herndon-dudley syndrome are presented with weak muscle tone (hypotonia) and problems with the muscles.[mybiosource.com] Clinical features The disorder causes severe cognitive deficiency , infantile hypotonia that progresses to spastic quadriplegia with hyperreflexia, contractures, Babinski[bredagenetics.com]

  • Maple Syrup Urine Disease

    Cerebral edema: If neurological signs develop or worsen (vomiting, lethargy, hyperreflexia, clonus), suspect cerebral edema.[newenglandconsortium.org] General muscle tone may be poor.[wohproject.org] Symptoms in acute episodes Include: seizures, abdominal pain, muscle weakness, unsteadiness, a dull affect, and sometimes hallucinations.[wohproject.org]

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