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6 Possible Causes for Globular Basal Ganglia

  • Cortical Dysplasia Complex with Other Brain Malformations 5

    basal ganglia, thin and dysmorphic corpus callosum, mild brainstem hypoplasia with a flat pons, mild cerebellar vermis hypoplasia, and mildly enlarged posterior fossa.[] Clinical features include seizures, global developmental delay, and various brain malformations such as a diffuse simplified gyral pattern with reduced volume of white matter, globular[]

  • Frontotemporal Dementia

    Although less severe, such changes were also observed in other brain regions, including the basal ganglia and substantia nigra.[] AT8 immunostaining revealed that predominant occurrence of astrocytic tau lesions termed globular astrocytic inclusions (GAIs) was a feature of the affected regions.[]

  • Prion Disease

    Neuronal loss was restricted mainly to the occipital cortex and the basal ganglia.[] Surprisingly, numerous eosinophilic globular structures were noted in the molecular layer and the parahippocampal gyrus.[]

  • Neuroferritinopathy

    Iron deposition was detected in perivascular areas, localizing to terminal astrocytic processes, especially in the basal ganglia, which show neuronal loss and accumulation[] […] of large iron-rich globular structures that appear to be the remains of dead astrocytes ( Gonzalez-Cuyar et al., 2008 ).[]

  • Deficiency of Ceruloplasmin

    A number of globular structures also were identified in the superficial layers of frontal cortex and in the basal ganglia.[] The globular structures (inclusions) were identified in the cerebral cortices as well as the basal ganglia.[] Massive iron accumulation and extensive loss of neurons are observed in the basal ganglia.[]

  • Tauopathy

    Pathology affected the pons, medulla, spinal cord, cerebellum and basal ganglia but the cortex was relatively spared.[] The tau-positive neuronal cytoplasmic inclusions, seen in affected cerebral cortices, basal ganglia, and brain stem nuclei, were represented either by diffuse cytoplasmic[] […] revealed widespread tau pathology including astrocytic plaque reminiscent of corticobasal degeneration, tufted–like astrocytes reminiscent of progressive supranuclear palsy and globular[]

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