Create issue ticket

26 Possible Causes for Globulins Increased, Hepatomegaly, Virus Associated Hemophagocytic Syndrome

  • Sickle Cell Disease

    Additional autopsy findings included cardiomegaly with a heart weight of 450 gm (312 78), right atrial and right ventricular chamber dilatation, and hepatomegaly with a liver[ncbi.nlm.nih.gov] Hepatomegaly was seen in 28.6% of the subjects.[doi.org] […] sex, the genotypes of both patient and donor, the number of transfusions received, the incidence of red-cell alloimmunization, previous chelation therapy, the presence of hepatomegaly[doi.org]

  • Infectious Mononucleosis

    The patient showed severe hepatomegaly incidentally, and dual positivity of Immunoglobulin (Ig) M to Epstein-Barr virus (EBV) viral capsid antigen (VCA) and cytomegalovirus[ncbi.nlm.nih.gov] , gamma globulin increased less frequently, and beta globulin, which was normal in practically all the cases of infectious mononucleosis, was increased in a considerable number[link.springer.com] Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[emedicine.medscape.com]

  • Chronic Active Hepatitis B

    Clinical signs include liver tenderness, hepatomegaly, and splenomegaly. Acute HBV infection typically lasts two to four months.[aafp.org] In all patients AST and ALT values returned to normal and there was a fall in serum delta GT and improvement of prothrombin time. an increase of globulins was noted.[ncbi.nlm.nih.gov] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov]

  • Lymphoma

    Hepatomegaly. Intermediate- and high-grade lymphomas: Most patients present with rapidly growing and bulky lymphadenopathy.[patient.info] The erythrocyte sedimentation rate is a sign of activity of the disease and is caused by the increase of the a2-globulins and of the gamma globulins.[lecturio.com] Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com]

  • Autoimmune Hepatitis

    CT Nonspecific, ranging from normal to hepatomegaly and cirrhosis.[radiopaedia.org] More than 80% of affected individuals have increased gamma globulin in the blood.[hepatitiscentral.com] Virus-, drug- and lymphoma-associated hemophagocytic syndrome (HPS) was ruled out. Therefore, the patient was diagnosed with autoimmune-associated HPS (AAHS).[ncbi.nlm.nih.gov]

  • Hepatitis A

    The child was deeply icteric and had hepatomegaly. IgM antibodies for hepatitis A virus were positive.[ncbi.nlm.nih.gov] , which can help increase protection to HAV.[liverfoundation.org] hemophagocytic syndrome [3].[ncbi.nlm.nih.gov]

  • Hodgkin Lymphoma

    The presenting feature common in all cases was superficial lymphadenopathy followed by hepatomegaly in 17 (20%) cases and splenomegaly in 16 (19%).[ncbi.nlm.nih.gov] Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com] Abdomen: Abdominal enlargement may be noted with splenomegaly or hepatomegaly.[symptoma.com]

  • Precursor-Cell Lymphoblastic Leukemia

    We emphasize the importance of being aware of this condition when a patient with ALL in complete remission presents with unexplained hepatomegaly, cytopenia, and fever.[ncbi.nlm.nih.gov] Late-onset fatal Epstein-Barr virusassociated hemophagocytic syndrome following cord blood cell transplantation for adult acute lymphoblastic leukemia .[ajcp.oxfordjournals.org] Five features were present in 50% of children: hepatomegaly (64%), splenomegaly (61%), pallor (54%), fever (53%) and bruising (52%).[doi.org]

  • Chronic Active Hepatitis

    […] to symptomatic decompensated cirrhosis Many patients are asymptomatic or have mild nonspecific complaints such as fatigue Physical findings are typically few; may include hepatomegaly[pathologyoutlines.com] Severe chronic active hepatitis, defined as the presence of a fivefold increase in serum aminotransferases and a twofold rise in gamma globulin for at least 10 weeks, is considered[ncbi.nlm.nih.gov] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov]

  • Erythema Infectiosum

    Anemia, blueberry-muffin rash, and hepatomegaly in a newborn infant. J Pediatr. 1996;128:579–86. 28. Fairley CK, Smoleniec JS, Caul OE, Miller E.[aafp.org] IV immune globulin has been used to curtail viremia and increase erythropoiesis in immunocompromised patients with pure RBC aplasia.[merckmanuals.com] Virus-associated hemophagocytic syndrome.[cmr.asm.org]

Similar symptoms