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13 Possible Causes for Globulins Increased, Hyperglobulinemia, Virus Associated Hemophagocytic Syndrome

  • Sickle Cell Disease

    (which contains 2 gamma globulin chains instead of 2 beta globulin ones, the latter being genetically malformatted by the disease) and thus decreases the number of attacks[en.wikipedia.org] Nevertheless, it has been a barrier for its wider use in patients with sickle-cell disease.[14] Mechanism of action[edit] In sickle-cell disease it increases fetal hemoglobin[en.wikipedia.org]

  • Infectious Mononucleosis

    , gamma globulin increased less frequently, and beta globulin, which was normal in practically all the cases of infectious mononucleosis, was increased in a considerable number[link.springer.com] Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[emedicine.medscape.com] […] rate of EBV reactivation after HSCT is expected to increase.[dx.doi.org]

  • Chronic Active Hepatitis B

    […] authorities require the presence of immunologic features, particularly high titers (usually more than 1:40) of certain non organic specific autoantibodies and polyclonal hyperglobulinemia[hepatitiscentral.com] In all patients AST and ALT values returned to normal and there was a fall in serum delta GT and improvement of prothrombin time. an increase of globulins was noted.[ncbi.nlm.nih.gov] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov]

  • Lymphoma

    The erythrocyte sedimentation rate is a sign of activity of the disease and is caused by the increase of the a2-globulins and of the gamma globulins.[lecturio.com] Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com] Lymphoma via Wikipedia Typical findings on laboratory tests are a relative lymphopenia and eosinophilia in the differential blood count, elevation of CRP and LDH, and an increase[lecturio.com]

  • Hepatitis A

    , which can help increase protection to HAV.[liverfoundation.org] hemophagocytic syndrome [3].[ncbi.nlm.nih.gov] […] common Sexual partners and household members of people with HAV If you think you have come in contact with HAV, your doctor may give you a HAV vaccination or a shot of immune globulin[liverfoundation.org]

  • Hodgkin Lymphoma

    Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com]

  • Precursor-Cell Lymphoblastic Leukemia

    Late-onset fatal Epstein-Barr virusassociated hemophagocytic syndrome following cord blood cell transplantation for adult acute lymphoblastic leukemia .[ajcp.oxfordjournals.org] Epstein-Barr virus associated hemophagocytic lymphohystiocytosis during maintenance treatment of acute lymphoblastic leukemia .[ajcp.oxfordjournals.org]

  • Chronic Active Hepatitis

    […] authorities require the presence of immunologic features, particularly high titers (usually more than 1:40) of certain non organic specific autoantibodies and polyclonal hyperglobulinemia[hepatitiscentral.com] Severe chronic active hepatitis, defined as the presence of a fivefold increase in serum aminotransferases and a twofold rise in gamma globulin for at least 10 weeks, is considered[ncbi.nlm.nih.gov] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov]

  • Autoimmune Hepatitis

    More than 80% of affected individuals have increased gamma globulin in the blood.[hepatitiscentral.com] Although patients may present with or without evidence of circulating autoantibodies, hyperglobulinemia is a rather consistent laboratory feature.[ncbi.nlm.nih.gov] Virus-, drug- and lymphoma-associated hemophagocytic syndrome (HPS) was ruled out. Therefore, the patient was diagnosed with autoimmune-associated HPS (AAHS).[ncbi.nlm.nih.gov]

  • Chronic Infection

    Hepatitis C infection in patients with primary hypogammaglobulinemia after treatment with contaminated immune globulin . N Engl J Med. 1994 ; 331 (24):1607-11 46.[medsci.org] , J Infect Dis , 1988 , vol. 157 (pg. 405 - 12 ) 5 Differential cellular targets of Epstein-Barr virus (EBV) infection between acute EBV-associated hemophagocytic lymphohistiocytosis[academic.oup.com] HCV-related fibrosis progression following liver transplantation: increase in recent years . J Hepatol. 2000 ; 32 (4):673-84 47. D'Souza R, Sabin C.A, Foster G.R.[medsci.org]

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