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13 Possible Causes for Globulins Increased, Hypersplenism, Virus Associated Hemophagocytic Syndrome

  • Infectious Mononucleosis

    , gamma globulin increased less frequently, and beta globulin, which was normal in practically all the cases of infectious mononucleosis, was increased in a considerable number[link.springer.com] One year later he underwent splenectomy for hypersplenism; at surgery, mesenteric lymphadenopathy and chylous ascites were noted.[dx.doi.org] Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[emedicine.medscape.com]

  • Lymphoma

    The erythrocyte sedimentation rate is a sign of activity of the disease and is caused by the increase of the a2-globulins and of the gamma globulins.[lecturio.com] Differential diagnosis See also separate Generalised Lymphadenopathy and Splenomegaly and Hypersplenism articles. Hodgkin's lymphoma. Acute or chronic leukaemia.[patient.info] Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com]

  • Autoimmune Hepatitis

    More than 80% of affected individuals have increased gamma globulin in the blood.[hepatitiscentral.com] Associated diseases Concurrent autoimmune disorders occur in approximately 40% of patients, particularly autoimmune thyroid disorder. [ 10 ] Haematological: hypersplenism,[patient.info] Virus-, drug- and lymphoma-associated hemophagocytic syndrome (HPS) was ruled out. Therefore, the patient was diagnosed with autoimmune-associated HPS (AAHS).[ncbi.nlm.nih.gov]

  • Sickle Cell Disease

    We report a case of MSI in a 12-year-old boy with homozygous sickle cell anemia (Hb SS) whose chronic transfusion therapy resulted in hypersplenism.[ncbi.nlm.nih.gov] […] type. 30 – 32 Late persistent splenomegaly is reported in 50% to 80% of patients, resulting in a higher risk of splenic complications such as sequestration crisis, chronic hypersplenism[doi.org] The platelet count may be decreased due hypersplenism in the acute splenic sequestration crisis or from decreased production in the aplastic crisis. Reticulocyte count.[clinicaladvisor.com]

  • Hodgkin Lymphoma

    Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com]

  • Chronic Active Hepatitis

    Severe chronic active hepatitis, defined as the presence of a fivefold increase in serum aminotransferases and a twofold rise in gamma globulin for at least 10 weeks, is considered[ncbi.nlm.nih.gov] Portal hypertension : ascites , hypersplenism , lower oesophageal and rectal varices. Hypoalbuminaemia. Coagulopathy. Osteoporosis .[patient.info] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov]

  • Pancytopenia

    […] levels of serum gamma globulin or IgG4; (iii) diffusely irregular narrowing of the main pancreatic duct on ERCP; (iv) fibrotic changes with lymphocyte infiltration on histology[smjonline.org] Hypersplenism secondary to portal hypertension (cirrhosis) was the second most common diagnosis (n 19).[ayubmed.edu.pk] Virus-associated hemophagocytic syndrome and hemorrhagic jejunal ulcer caused by cytomegalovirus infection in a noncompromised host; a case report of unusual entity.[scielo.br]

  • Adult Idiopathic Neutropenia

    RESULTS: We found that serum gamma-globulin, IgG and IgG1 levels were all significantly increased in the entire group of patients studied, compared to controls (p CONCLUSION[ncbi.nlm.nih.gov] […] of neutrophils (either as a primary condition or associated with another disease such as Felty's syndrome) or from drugs stimulating the immune system to attack the cells Hypersplenism[medicinenet.com] syndrome Hemophagocytic syndrome associated with an infection Hepatic veno-occlusive disease-immunodeficiency syndrome Hereditary neutrophilia Hereditary periodic fever syndrome[se-atlas.de]

  • Lymphoproliferative Syndrome 1

    The increase in DNT cells, interleukin 10 (IL-10) and polyclonal elevation of gamma globulin (IgG) can be diagnostically relevant in patients under suspicion of this syndrome[casereports.bmj.com] Also: Splenectomy should be avoided except in cases of uncontrollable hypersplenism.[patient.info] […] characterized by autosomal recessive inheritance, early childhood onset of Epstein-Barr virus-associated immune dysregulation typically manifesting as lymphoma, lymphomatoid[rgd.mcw.edu]

  • Severe Aplastic Anemia

    […] and cyclosporine increased response rates in patients with treatment-naive severe aplastic anemia.[healio.com] Differential diagnosis Hypersplenism. Hypocellular myelodysplasia, acute myeloid leukaemia. Hypocellular acute lymphoblastic leukaemia. Hairy cell leukaemia. Lymphoma.[patient.info] In virus-associated hemophagocytic syndrome with an acute parvovirus B19 infection, raised levels of cytokines such as interferon γ would impair regulation of the phagocytic[omicsonline.org]

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