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18 Possible Causes for Globulins Increased, Lactate Dehydrogenase Increased, Virus Associated Hemophagocytic Syndrome

  • Sickle Cell Disease

    (which contains 2 gamma globulin chains instead of 2 beta globulin ones, the latter being genetically malformatted by the disease) and thus decreases the number of attacks[en.wikipedia.org] Nevertheless, it has been a barrier for its wider use in patients with sickle-cell disease.[14] Mechanism of action[edit] In sickle-cell disease it increases fetal hemoglobin[en.wikipedia.org]

  • Infectious Mononucleosis

    , gamma globulin increased less frequently, and beta globulin, which was normal in practically all the cases of infectious mononucleosis, was increased in a considerable number[link.springer.com] Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[emedicine.medscape.com] […] rate of EBV reactivation after HSCT is expected to increase.[dx.doi.org]

  • Chronic Active Hepatitis

    Severe chronic active hepatitis, defined as the presence of a fivefold increase in serum aminotransferases and a twofold rise in gamma globulin for at least 10 weeks, is considered[ncbi.nlm.nih.gov] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov] The positive anti-HCV antibody common in patients with IACAH is caused by disease related hypergammaglobulinemia and steroid therapy usually leads to decrease in gamma globulin[hepatitiscentral.com]

  • Lymphoma

    The erythrocyte sedimentation rate is a sign of activity of the disease and is caused by the increase of the a2-globulins and of the gamma globulins.[lecturio.com] Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com] Lymphoma via Wikipedia Typical findings on laboratory tests are a relative lymphopenia and eosinophilia in the differential blood count, elevation of CRP and LDH, and an increase[lecturio.com]

  • Precursor-Cell Lymphoblastic Leukemia

    Serum level of lactate dehydrogenase (LDH) predicts increased anaerobic glycolysis and is associated with metabolic modulation in cancer cells.[ncbi.nlm.nih.gov] Late-onset fatal Epstein-Barr virusassociated hemophagocytic syndrome following cord blood cell transplantation for adult acute lymphoblastic leukemia .[ajcp.oxfordjournals.org] Epstein-Barr virus associated hemophagocytic lymphohystiocytosis during maintenance treatment of acute lymphoblastic leukemia .[ajcp.oxfordjournals.org]

  • Hodgkin Lymphoma

    Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com]

  • Erythema Infectiosum

    IV immune globulin has been used to curtail viremia and increase erythropoiesis in immunocompromised patients with pure RBC aplasia.[merckmanuals.com] Virus-associated hemophagocytic syndrome.[cmr.asm.org] Virus-associated hemophagocytic syndrome: a benign histiocytic proliferation distinct from malignant histiocytosis. Cancer 44 : 993 -1002. Rodis, J. F., A. F.[cmr.asm.org]

  • Autoimmune Hepatitis

    Lactate dehydrogenase (LD) – an enzyme released with cell damage; found in cells throughout the body.[labtestsonline.org] More than 80% of affected individuals have increased gamma globulin in the blood.[hepatitiscentral.com] Virus-, drug- and lymphoma-associated hemophagocytic syndrome (HPS) was ruled out. Therefore, the patient was diagnosed with autoimmune-associated HPS (AAHS).[ncbi.nlm.nih.gov]

  • Hepatitis A

    Liver enzymes like aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transferase and lactate dehydrogenase were severely elevated.[ncbi.nlm.nih.gov] , which can help increase protection to HAV.[liverfoundation.org] hemophagocytic syndrome [3].[ncbi.nlm.nih.gov]

  • Lymphadenitis

    Lactate dehydrogenase level in serum was normal.[jmedicalcasereports.biomedcentral.com] Serum albumin falls and gamma globulins increase. • An X-ray chest is mandatory for coexisting pulmonary lesion. • Positive FNAC and biopsy are essential for confirming diagnosis[de.slideshare.net] We describe a fatal case of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome with human herpesvirus-6B (HHV-6B)-associated lymphadenitis and virus-associated[ncbi.nlm.nih.gov]

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