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13 Possible Causes for Globulins Increased, Liver Tenderness, Virus Associated Hemophagocytic Syndrome

  • Infectious Mononucleosis

    , gamma globulin increased less frequently, and beta globulin, which was normal in practically all the cases of infectious mononucleosis, was increased in a considerable number[link.springer.com] Apply a heating pad or a warm washcloth to swollen neck glands to help relieve tenderness.[uhs.umich.edu] Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[emedicine.medscape.com]

  • Chronic Active Hepatitis

    Severe chronic active hepatitis, defined as the presence of a fivefold increase in serum aminotransferases and a twofold rise in gamma globulin for at least 10 weeks, is considered[ncbi.nlm.nih.gov] It starts with acute symptoms in 30% of the cases with jaundice, fever, malaise, liver tenderness, like an acute viral hepatitis.[meddean.luc.edu] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov]

  • Lymphoma

    The erythrocyte sedimentation rate is a sign of activity of the disease and is caused by the increase of the a2-globulins and of the gamma globulins.[lecturio.com] Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com] Lymphoma via Wikipedia Typical findings on laboratory tests are a relative lymphopenia and eosinophilia in the differential blood count, elevation of CRP and LDH, and an increase[lecturio.com]

  • Hepatitis A

    , which can help increase protection to HAV.[liverfoundation.org] Hepatitis A is a viral infection of the liver. The liver becomes inflamed, tender, and swollen. How does it occur? Hepatitis A is caused by the hepatitis A virus.[web.archive.org] hemophagocytic syndrome [3].[ncbi.nlm.nih.gov]

  • Hodgkin Lymphoma

    Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com]

  • Chronic Active Hepatitis B

    In all patients AST and ALT values returned to normal and there was a fall in serum delta GT and improvement of prothrombin time. an increase of globulins was noted.[ncbi.nlm.nih.gov] Clinical signs include liver tenderness, hepatomegaly, and splenomegaly. Acute HBV infection typically lasts two to four months.[aafp.org] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov]

  • Autoimmune Hepatitis

    More than 80% of affected individuals have increased gamma globulin in the blood.[hepatitiscentral.com] It starts with acute symptoms in 30% of the cases with jaundice, fever, malaise, liver tenderness, like an acute viral hepatitis.[meddean.luc.edu] Virus-, drug- and lymphoma-associated hemophagocytic syndrome (HPS) was ruled out. Therefore, the patient was diagnosed with autoimmune-associated HPS (AAHS).[ncbi.nlm.nih.gov]

  • Precursor-Cell Lymphoblastic Leukemia

    The liver is palpable 3 cm below the right costal margin, and the spleen is palpable 2 cm below the left costal margin.[doi.org] Late-onset fatal Epstein-Barr virusassociated hemophagocytic syndrome following cord blood cell transplantation for adult acute lymphoblastic leukemia .[ajcp.oxfordjournals.org] Tenderness is elicited over the right distal femur. Radiographs of the right distal femur reveal osteopenia plus a small lytic lesion.[doi.org]

  • Chronic Infection

    Hepatitis C infection in patients with primary hypogammaglobulinemia after treatment with contaminated immune globulin . N Engl J Med. 1994 ; 331 (24):1607-11 46.[medsci.org] […] legs, feet, or ankles tenderness or swelling in your abdomen What tests do doctors use to diagnose hepatitis C?[niddk.nih.gov] , J Infect Dis , 1988 , vol. 157 (pg. 405 - 12 ) 5 Differential cellular targets of Epstein-Barr virus (EBV) infection between acute EBV-associated hemophagocytic lymphohistiocytosis[academic.oup.com]

  • Pancytopenia

    […] levels of serum gamma globulin or IgG4; (iii) diffusely irregular narrowing of the main pancreatic duct on ERCP; (iv) fibrotic changes with lymphocyte infiltration on histology[smjonline.org] A markedly tender and enlarged liver and spleen, 3 cm and 10 cm below the costal margins, respectively, were noted, with no palpable lymph nodes.[journals.plos.org] Virus-associated hemophagocytic syndrome and hemorrhagic jejunal ulcer caused by cytomegalovirus infection in a noncompromised host; a case report of unusual entity.[scielo.br]

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