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27 Possible Causes for Globulins Increased, Malaise, Virus Associated Hemophagocytic Syndrome

  • Infectious Mononucleosis

    , gamma globulin increased less frequently, and beta globulin, which was normal in practically all the cases of infectious mononucleosis, was increased in a considerable number[link.springer.com] Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[emedicine.medscape.com] A 16-year-old, previously healthy girl presents with a several-day history of fever, sore throat, and malaise. She appears very tired and has a temperature of 39 C.[doi.org]

  • Chronic Active Hepatitis B

    In all patients AST and ALT values returned to normal and there was a fall in serum delta GT and improvement of prothrombin time. an increase of globulins was noted.[ncbi.nlm.nih.gov] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov] Transient side effects of malaise and influenza like symptoms occurred in all patients and resolved rapidly after treatment.[ncbi.nlm.nih.gov]

  • Chronic Active Hepatitis

    Severe chronic active hepatitis, defined as the presence of a fivefold increase in serum aminotransferases and a twofold rise in gamma globulin for at least 10 weeks, is considered[ncbi.nlm.nih.gov] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov] A 56-year-old Saudi male was admitted with abnormal liver chemistry values and a 5-month history of lethargy, malaise, anorexia, and jaundice.[ncbi.nlm.nih.gov]

  • Autoimmune Hepatitis

    More than 80% of affected individuals have increased gamma globulin in the blood.[hepatitiscentral.com] Virus-, drug- and lymphoma-associated hemophagocytic syndrome (HPS) was ruled out. Therefore, the patient was diagnosed with autoimmune-associated HPS (AAHS).[ncbi.nlm.nih.gov] It starts with acute symptoms in 30% of the cases with jaundice, fever, malaise, liver tenderness, like an acute viral hepatitis.[meddean.luc.edu]

  • Hepatitis A

    , which can help increase protection to HAV.[liverfoundation.org] hemophagocytic syndrome [3].[ncbi.nlm.nih.gov] A 25-year-old Japanese man was admitted with general malaise and fever, which had developed 12 days after coming back to Japan from Indonesia.[ncbi.nlm.nih.gov]

  • Erythema Infectiosum

    IV immune globulin has been used to curtail viremia and increase erythropoiesis in immunocompromised patients with pure RBC aplasia.[merckmanuals.com] Virus-associated hemophagocytic syndrome.[cmr.asm.org] It is a mild, self-limiting 'slapped-cheek' facial rash with low-grade fever and malaise in immunocompetent children.[genome.jp]

  • Sickle Cell Disease

    (which contains 2 gamma globulin chains instead of 2 beta globulin ones, the latter being genetically malformatted by the disease) and thus decreases the number of attacks[en.wikipedia.org] Pain may be accompanied by fever, malaise, and leukocytosis. Bone pain is often due to bone marrow infarction.[emedicine.medscape.com] Examples of symptoms that may stem from these complications include pain, fatigue, malaise, shortness of breath, and difficulty feeding in infants.[ssa.gov]

  • Precursor-Cell Lymphoblastic Leukemia

    Late-onset fatal Epstein-Barr virusassociated hemophagocytic syndrome following cord blood cell transplantation for adult acute lymphoblastic leukemia .[ajcp.oxfordjournals.org] They largely reflect bone marrow failure and include malaise, fatigue, bleeding or bruising, and secondary infections.[accessmedicine.mhmedical.com] […] fatigue (including ‘malaise’ and ‘malaise/fatigue’) and infections (including ‘infection’ and ‘recurrent infections’).[adc.bmj.com]

  • Lymphoma

    The erythrocyte sedimentation rate is a sign of activity of the disease and is caused by the increase of the a2-globulins and of the gamma globulins.[lecturio.com] Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com] Gastrointestinal Tract Symptoms of gastrointestinal lymphoma may include: Abdominal tenderness and pain Cramps Indigestion Constipation Diarrhea Malaise (a general feeling[verywellhealth.com]

  • Hodgkin Lymphoma

    Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com] Whilst the risk is very small indeed, it is a good thing to be aware of this and to report any symptoms of malaise, fever, weight loss or enlarged lymph glands, although of[netdoctor.co.uk]

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