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80 Possible Causes for Globulins Increased, Progressive Loss of Vision, Retinal Detachment

  • Toxoplasmosis

    […] neuritis [19] Scleritis [36,39] Retinal detachment [68] Punctate outer retinitis [29,31,34] Branch retinal artery occlusion [69]; Frosted branch angiitis Coats’-type response[eyewiki.aao.org] If the central structures of the retina are involved there will be a progressive loss of vision that can lead to blindness.[web.archive.org] Eye pain Sensitivity to light (photophobia) Tearing of the eyes Blurred vision The eye disease can reactivate months or years later, each time causing more damage to the retina[cdc.gov]

  • Hyperviscosity Syndrome

    The most common cause of hyperviscosity is increased concentrations of gamma globulins, either monoclonal in malignant disease or polyclonal, usually seen with rheumatic disorders[ncbi.nlm.nih.gov] (PED) beneath the serous retinal detachment.[ncbi.nlm.nih.gov] Neurologic symptoms of hyperviscosity include blurring or loss of vision, headache, vertigo, sudden deafness, diplopia, ataxia, confusion, and disturbances of consciousness[signavitae.com]

  • Diabetic Retinopathy

    The increased activity of protein kinase C and protein glycosylation lead to the formation of advanced glycation end products (AGE).[doi.org] The serous retinal detachment subsided with partial recovery of vision.[ncbi.nlm.nih.gov] With early diagnosis and treatment, progression of diabetic eye disease and its associated vision loss can at a minimum be slowed, and in many cases vision loss from diabetic[bweyecenter.com]

  • Diabetes Mellitus

    Spontaneous bleeding from the new and brittle blood vessels can lead to retinal scarring and retinal detachment, thus impairing vision.[medicinenet.com] It is caused by small blood vessel damage to the back layer of the eye, the retina, leading to progressive loss of vision, even blindness.[who.int] There are no early symptoms or signs, but focal blurring, vitreous or retinal detachment, and partial or total vision loss eventually develop; rate of progression is highly[web.archive.org]

  • Waldenstrom Macroglobulinemia

    These macroglobulins increase the thickness of blood and aggregate with one another causing a condition known as hyperviscosity syndrome.[osmosis.org] A patient with Waldenstrom macroglobulinemia presented with serous retinal detachments at the time of diagnosis with Waldenstrom.[ncbi.nlm.nih.gov] […] changes, such as blurred vision or blind spots Weight loss for no reason Diagnostic Exams Flow cytometry Immunohistochemistry Immunophenotyping Peripheral blood smear Progression[seer.cancer.gov]

  • Meningitis

    Cases without fever, with increased CSF gamma globulin and transient neurological signs and symptoms, have been reported.[emedicine.medscape.com] Headaches, vision loss Ophthalmic examination and visual field testing revealed a progressive optic neuropathy with severe vision loss and optic atrophy in the right eye.[healio.com] vision loss.[tiptiktak.com]

  • Syphilis

    Also, nonspecifically, CSF gamma globulin can be increased, and oligoclonal bands can be present.[epilepsy.com] We present a case of a 33-year-old man with recently identified syphilis and HIV, who was diagnosed with bilateral retinal detachments (RDs) with the help of point-of-care[ncbi.nlm.nih.gov] Abstract We present a case of ocular syphilis after a renal transplantation involving progressive vision loss without clinically identifiable ocular disease.[ncbi.nlm.nih.gov]

  • Eales Disease

    A distinct protein with an isoelectric point of 5.9 and a weight of 23 kDa has been associated with Eales disease, as have increased alpha globulins, increased alpha-1 acid[eyewiki.aao.org] Retinal Disorders First Online: 15 December 2011 227 Downloads 10 Citations Abstract Background To report the occurrence of secondary rhegmatogenous retinal detachment (RRD[link.springer.com] In rare cases, the retina may get detached leading to loss of vision. There can also be damage to the most sensitive part of the retina (optic disk).[modasta.com]

  • Systemic Lupus Erythematosus

    […] gamma globulins), cryoglobulins (frequently positive), and direct Comb’s test (frequently positive).[clinicaladvisor.com] Because of the choroidal effusion, retinal detachment and secondary angle-closure glaucoma may occur.[ncbi.nlm.nih.gov] Optic neuropathy is a rare ophthalmological complication of SLE that can progress to total bilateral vision loss if not identified and treated rapidly.[ncbi.nlm.nih.gov]

  • Renal Cell Carcinoma

    Here we present a grade 4 panuveitis with bilateral serous retinal detachment following treatment with nivolumab for metastatic renal cell carcinoma.[ncbi.nlm.nih.gov] As the disease progresses, symptoms may include: a lump in the abdomen blood in the urine unexplained weight loss loss of appetite fatigue vision problems persistent pain[healthline.com] detachment.[ncbi.nlm.nih.gov]

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