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80 Possible Causes for Globulins Increased, Progressive Loss of Vision, Retinal Detachment

  • Toxoplasmosis

    […] neuritis [19] Scleritis [36,39] Retinal detachment [68] Punctate outer retinitis [29,31,34] Branch retinal artery occlusion [69]; Frosted branch angiitis Coats’-type response[] If the central structures of the retina are involved there will be a progressive loss of vision that can lead to blindness.[] Eye pain Sensitivity to light (photophobia) Tearing of the eyes Blurred vision The eye disease can reactivate months or years later, each time causing more damage to the retina[]

  • Hyperviscosity Syndrome

    The most common cause of hyperviscosity is increased concentrations of gamma globulins, either monoclonal in malignant disease or polyclonal, usually seen with rheumatic disorders[] (PED) beneath the serous retinal detachment.[] Neurologic symptoms of hyperviscosity include blurring or loss of vision, headache, vertigo, sudden deafness, diplopia, ataxia, confusion, and disturbances of consciousness[]

  • Diabetic Retinopathy

    The increased activity of protein kinase C and protein glycosylation lead to the formation of advanced glycation end products (AGE).[] The serous retinal detachment subsided with partial recovery of vision.[] With early diagnosis and treatment, progression of diabetic eye disease and its associated vision loss can at a minimum be slowed, and in many cases vision loss from diabetic[]

  • Diabetes Mellitus

    Spontaneous bleeding from the new and brittle blood vessels can lead to retinal scarring and retinal detachment, thus impairing vision.[] It is caused by small blood vessel damage to the back layer of the eye, the retina, leading to progressive loss of vision, even blindness.[] There are no early symptoms or signs, but focal blurring, vitreous or retinal detachment, and partial or total vision loss eventually develop; rate of progression is highly[]

  • Waldenstrom Macroglobulinemia

    These macroglobulins increase the thickness of blood and aggregate with one another causing a condition known as hyperviscosity syndrome.[] A patient with Waldenstrom macroglobulinemia presented with serous retinal detachments at the time of diagnosis with Waldenstrom.[] […] changes, such as blurred vision or blind spots Weight loss for no reason Diagnostic Exams Flow cytometry Immunohistochemistry Immunophenotyping Peripheral blood smear Progression[]

  • Meningitis

    Cases without fever, with increased CSF gamma globulin and transient neurological signs and symptoms, have been reported.[] Headaches, vision loss Ophthalmic examination and visual field testing revealed a progressive optic neuropathy with severe vision loss and optic atrophy in the right eye.[] vision loss.[]

  • Syphilis

    Also, nonspecifically, CSF gamma globulin can be increased, and oligoclonal bands can be present.[] We present a case of a 33-year-old man with recently identified syphilis and HIV, who was diagnosed with bilateral retinal detachments (RDs) with the help of point-of-care[] Abstract We present a case of ocular syphilis after a renal transplantation involving progressive vision loss without clinically identifiable ocular disease.[]

  • Eales Disease

    A distinct protein with an isoelectric point of 5.9 and a weight of 23 kDa has been associated with Eales disease, as have increased alpha globulins, increased alpha-1 acid[] Retinal Disorders First Online: 15 December 2011 227 Downloads 10 Citations Abstract Background To report the occurrence of secondary rhegmatogenous retinal detachment (RRD[] In rare cases, the retina may get detached leading to loss of vision. There can also be damage to the most sensitive part of the retina (optic disk).[]

  • Systemic Lupus Erythematosus

    […] gamma globulins), cryoglobulins (frequently positive), and direct Comb’s test (frequently positive).[] Because of the choroidal effusion, retinal detachment and secondary angle-closure glaucoma may occur.[] Optic neuropathy is a rare ophthalmological complication of SLE that can progress to total bilateral vision loss if not identified and treated rapidly.[]

  • Renal Cell Carcinoma

    Here we present a grade 4 panuveitis with bilateral serous retinal detachment following treatment with nivolumab for metastatic renal cell carcinoma.[] As the disease progresses, symptoms may include: a lump in the abdomen blood in the urine unexplained weight loss loss of appetite fatigue vision problems persistent pain[] detachment.[]

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