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1,522 Possible Causes for Globulins Increased, Splenic Infarction, Virus Associated Hemophagocytic Syndrome

  • Sickle Cell Disease

    Massive splenic infarction (MSI) is a rare complication of sickle cell disease, as the spleen generally atrophies within the first few years of life.[ncbi.nlm.nih.gov] These include splenic infarction, pulmonary involvement, acute chest syndrome, and orbital compression syndrome.[ncbi.nlm.nih.gov] Splenic infarction and subsequent functional asplenia tend to occur early in the disease. The hepatobiliary and renal systems are also commonly involved.[radiopaedia.org]

  • Infectious Mononucleosis

    Splenic infarction is an uncommon complication of infectious mononucleosis, and may have a wide range of clinical presentations, from dramatic to more subtle.[ncbi.nlm.nih.gov] , gamma globulin increased less frequently, and beta globulin, which was normal in practically all the cases of infectious mononucleosis, was increased in a considerable number[link.springer.com] Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[emedicine.medscape.com]

  • Lymphoma

    The erythrocyte sedimentation rate is a sign of activity of the disease and is caused by the increase of the a2-globulins and of the gamma globulins.[lecturio.com] Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com] Lymphoma via Wikipedia Typical findings on laboratory tests are a relative lymphopenia and eosinophilia in the differential blood count, elevation of CRP and LDH, and an increase[lecturio.com]

  • Precursor-Cell Lymphoblastic Leukemia

    On the basis of blood tests, bone marrow biopsy and imaging, a diagnosis of ALL complicated by massive hepatosplenomegaly with splenic infarctions was made.[ncbi.nlm.nih.gov] Late-onset fatal Epstein-Barr virusassociated hemophagocytic syndrome following cord blood cell transplantation for adult acute lymphoblastic leukemia .[ajcp.oxfordjournals.org] Epstein-Barr virus associated hemophagocytic lymphohystiocytosis during maintenance treatment of acute lymphoblastic leukemia .[ajcp.oxfordjournals.org]

  • Hodgkin Lymphoma

    Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com]

  • Infective Endocarditis

    CASE PRESENTATION: We present the case of a 56-year-old man who developed multiple mycotic aneurysms of the right hepatic artery and massive splenic infarction as rare complications[ncbi.nlm.nih.gov] The third patient had a splenic infarction and abscess associated with infected cardiac thrombi.[ncbi.nlm.nih.gov] […] causes loin pain and hematuria Immune complex deposition may cause glomerulonephritis Splenomegaly and splenic infarction due to emboli Diagnosis Requires (a) 2 major criteria[pathologyoutlines.com]

    Missing: Virus Associated Hemophagocytic Syndrome
  • Bacterial Endocarditis

    We present a rare case of bacterial endocarditis of the aortic valve complicated by intracranial haemorrhage, splenic and renal infarcts.[ncbi.nlm.nih.gov] Complications include systemic emboli (blood vessels obstructed by fragments of tissue carried through the bloodstream), tissue death in the spleen (splenic infarction), stroke[nmihi.com] […] causes loin pain and hematuria Immune complex deposition may cause glomerulonephritis Splenomegaly and splenic infarction due to emboli Diagnosis Requires (a) 2 major criteria[pathologyoutlines.com]

    Missing: Virus Associated Hemophagocytic Syndrome
  • Subacute Bacterial Endocarditis

    -Distant emboli, e.g. splenic infarct . More common in acute IE. /-Valvular vegetations. Irregular ball of loosely adherent tissue - dull, irregular surface.[librepathology.org] Mesenteric or splenic abscess or infarction.[patient.info] […] causes loin pain and hematuria Immune complex deposition may cause glomerulonephritis Splenomegaly and splenic infarction due to emboli Diagnosis Requires (a) 2 major criteria[pathologyoutlines.com]

    Missing: Virus Associated Hemophagocytic Syndrome
  • Myeloproliferative Disease

    infarction and perisplenitis Clinical symptoms can include the following: Pallor (except in patients with polycythemia vera) Plethora secondary to polycythemia Petechiae[emedicine.com] […] secondary to gouty arthritis that is secondary to hyperuricemia Priapism, tinnitus, or stupor from leukostasis Left upper quadrant and left shoulder pain as a consequence of splenic[emedicine.com]

    Missing: Virus Associated Hemophagocytic Syndrome
  • Chronic Lymphocytic Leukemia

    […] a person's risk of infection because of low production of antibodies (gamma globulins) that help fight bacteria.[ucsfhealth.org] Hypogammaglobulinaemia is frequently seen because of CLL and therapy (specifically rituximab). 14 If the patient has low globulin levels, specifically immunoglobulin G, and[racgp.org.au] […] cause: Anemia, due to low levels of red blood cells Infections, due to low levels of white blood cells called neutrophils Bleeding, due to low levels of platelets CLL also increases[ucsfhealth.org]

    Missing: Virus Associated Hemophagocytic Syndrome

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