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30 Possible Causes for Globulins Increased, Virus, Virus Associated Hemophagocytic Syndrome

  • Infectious Mononucleosis

    Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a member of the herpes virus family. It is one of the most common human viruses.[cdc.gov] , gamma globulin increased less frequently, and beta globulin, which was normal in practically all the cases of infectious mononucleosis, was increased in a considerable number[link.springer.com] Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[emedicine.medscape.com]

  • Chronic Active Hepatitis B

    There was serological evidence of chronic active hepatitis B and acute hepatitis C virus infection.[ncbi.nlm.nih.gov] In all patients AST and ALT values returned to normal and there was a fall in serum delta GT and improvement of prothrombin time. an increase of globulins was noted.[ncbi.nlm.nih.gov] The positive anti-HCV antibody common in patients with IACAH is caused by disease related hypergammaglobulinemia and steroid therapy usually leads to decrease in gamma globulin[hepatitiscentral.com]

  • Chronic Active Hepatitis

    There was serological evidence of chronic active hepatitis B and acute hepatitis C virus infection.[ncbi.nlm.nih.gov] Severe chronic active hepatitis, defined as the presence of a fivefold increase in serum aminotransferases and a twofold rise in gamma globulin for at least 10 weeks, is considered[ncbi.nlm.nih.gov] The positive anti-HCV antibody common in patients with IACAH is caused by disease related hypergammaglobulinemia and steroid therapy usually leads to decrease in gamma globulin[hepatitiscentral.com]

  • Sickle Cell Disease

    INTRODUCTION: Hepatitis B virus infection attacks the liver and can cause both acute and chronic disease.[ncbi.nlm.nih.gov] (which contains 2 gamma globulin chains instead of 2 beta globulin ones, the latter being genetically malformatted by the disease) and thus decreases the number of attacks[en.wikipedia.org] Human parvovirus B19 (B19V) is a small (22-24 nm) nonenveloped DNA virus belonging to the genus Erythrovirus (family Parvoviridae).[ncbi.nlm.nih.gov]

  • Hepatitis A

    Hepatitis A virus.[irmng.org] , which can help increase protection to HAV.[liverfoundation.org] hemophagocytic syndrome [3].[ncbi.nlm.nih.gov]

  • Erythema Infectiosum

    Once the virus enters the host cell and provokes an immune response, the host cell produces IgM against the virus along with the formation of immune complexes.[symptoma.com] IV immune globulin has been used to curtail viremia and increase erythropoiesis in immunocompromised patients with pure RBC aplasia.[merckmanuals.com] Virus-associated hemophagocytic syndrome.[cmr.asm.org]

  • Lymphoma

    Acquired immunodeficiencies predominantly occur in the setting of infection with the Human Immunodeficiency Virus or arise following immunosuppressive therapy administered[ncbi.nlm.nih.gov] The erythrocyte sedimentation rate is a sign of activity of the disease and is caused by the increase of the a2-globulins and of the gamma globulins.[lecturio.com] Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com]

  • Autoimmune Hepatitis

    Influenza virus vaccination could trigger the development of AIH. Clinicians should be mindful of the fact that AIH can occur after influenza virus vaccination.[ncbi.nlm.nih.gov] More than 80% of affected individuals have increased gamma globulin in the blood.[hepatitiscentral.com] Virus-, drug- and lymphoma-associated hemophagocytic syndrome (HPS) was ruled out. Therefore, the patient was diagnosed with autoimmune-associated HPS (AAHS).[ncbi.nlm.nih.gov]

  • Hodgkin Lymphoma

    Several recently reported studies are implicating Epstein-Barr virus (EBV) as one of the key players in MS pathogenesis.[ncbi.nlm.nih.gov] Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com] Abstract In almost half of patients diagnosed with Hodgkin's disease (HD), the malignant Reed-Sternberg (RS) cells express Epstein-Barr virus (EBV) antigens.[ncbi.nlm.nih.gov]

  • Precursor-Cell Lymphoblastic Leukemia

    Histologic examination revealed intestinal smooth muscle sarcomas associated with Epstein-Barr virus.[ncbi.nlm.nih.gov] Late-onset fatal Epstein-Barr virusassociated hemophagocytic syndrome following cord blood cell transplantation for adult acute lymphoblastic leukemia .[ajcp.oxfordjournals.org] Human T-cell lymphotropic virus type-1 is known to cause adult T-cell leukemia/lymphoma ( 5 ); Epstein-Barr virus has been associated with lymphoproliferative disorders, including[accessmedicine.mhmedical.com]

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