Glomerular Filtration Rate Decreased: Causes & Reasons

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Possible Causes for Glomerular Filtration Rate Decreased

Glycogen Storage Disease Type 1

glomerular filtration rate, decreased muscle mass, underdeveloped muscles, delayed pubertal development, doll-like facies, elevated hepatic transaminase, high liver enzymes [xpertdox.com]

glomerular filtration rate 0012213 Decreased muscle mass Underdeveloped muscles 0003199 Delayed puberty Delayed pubertal development Delayed pubertal growth Pubertal delay [rarediseases.info.nih.gov]

RESULTS: A significant and progressive decrease of glomerular filtration rate was observed in treated patients vs. those who were not treated with ACE-inhibitors (P < 0.05 [ncbi.nlm.nih.gov]

Chronic Kidney Disease

Her estimated glomerular filtration rate decreased from an admission value of 34 mL/min/1.73 m2 to 13 mL/min/1.73 m2. CT scan showed retroperitoneal haematoma. [ncbi.nlm.nih.gov]

CKD is characterized by the development of progressive glomerulosclerosis, interstitial fibrosis and tubular atrophy along with a decreased glomerular filtration rate. [ncbi.nlm.nih.gov]

Patients with reduced glomerular filtration rates have a decreased ability to excrete fluoride in the urine. [academic.oup.com]

Renal Function Impairment

RI leads to various physiologic changes, in addition to a decrease in glomerular filtration rate, that impact the pharmacokinetics (PK) and, specifically, the renal clearance [ncbi.nlm.nih.gov]

INTRODUCTION: The glomerular filtration rate (GFR), a measure of renal function, decreases by approximately 10 mL/min every 10 years after the age of 40 years, which could [ncbi.nlm.nih.gov]

This stage is broken up into two: a decrease in glomerular filtration rate (GFR) for Stage 3A is 45-59 mL/min and a decrease in GFR for Stage 3B is 30-44 mL/min. [davita.com]

Medullary Cystic Kidney Disease Type 1

[…] in size of the outer layer of the brain due to loss of brain cells 0002120 Decreased glomerular filtration rate 0012213 Elevated serum creatinine Elevated creatinine High [rarediseases.info.nih.gov]

Adult onset Symptoms begin in adulthood 0003581 Anemia Low number of red blood cells or hemoglobin 0001903 Autosomal dominant inheritance 0000006 Cerebral cortical atrophy Decrease [rarediseases.info.nih.gov]

Primary Hyperoxaluria Type 1

Although serum oxalate levels have not been measured, they would certainly be high, since oxalate content increases as glomerular filtration rate decreases. [jped.com.br]

As glomerular filtration rate decreases due to progressive renal damage, oxalate accumulates leading to systemic oxalosis. [hindawi.com]

glomerular filtration rate 0012213 Dysuria Painful or difficult urination 0100518 Failure to thrive Faltering weight Weight faltering [ more ] 0001508 Hematuria Blood in [rarediseases.info.nih.gov]

Nodular Glomerulosclerosis

When the glomerular filtration rate fell to 30 ml/min, the syndrome of mild renal failure, decreased potassium excretion, and hyporeninemic hypoaldosteronism developed, suggesting [ncbi.nlm.nih.gov]

A moderately-to-severely decreased glomerular filtration rate with nephrotic syndrome was seen at the time of diagnosis of diabetes. [ekjm.org]

[…] lesion, and decreased glomerular filtration rates. [scielo.br]

Primary Hyperoxaluria Type 2

Although serum oxalate levels have not been measured, they would certainly be high, since oxalate content increases as glomerular filtration rate decreases. [jped.com.br]

As glomerular filtration rate decreases due to progressive renal damage, oxalate accumulates leading to systemic oxalosis. [hindawi.com]

Fabry Disease

rate (GFR) decreased in 3 cases while it increased in the other 3 without statistical differences. [ncbi.nlm.nih.gov]

The results showed urinary protein loss (45.7%) and decreased glomerular filtration rate (31.4%), mainly in adults. [ncbi.nlm.nih.gov]

The mean serum creatinine level and estimated glomerular filtration rate also remained stable after 30-36 mo of treatment. [ncbi.nlm.nih.gov]

Primary Hyperoxaluria

Although serum oxalate levels have not been measured, they would certainly be high, since oxalate content increases as glomerular filtration rate decreases. [jped.com.br]

As glomerular filtration rate decreases due to progressive renal damage, oxalate accumulates leading to systemic oxalosis. [hindawi.com]

In patients with estimated glomerular filtration rate (eGFR) 2, Pox increased by 3.25 µmol/L in the placebo group and decreased by -1.7 µmol/L in the OC3 group (p = 0.13). [ncbi.nlm.nih.gov]

Primary Hyperoxaluria Type 3

Although serum oxalate levels have not been measured, they would certainly be high, since oxalate content increases as glomerular filtration rate decreases. [jped.com.br]

As glomerular filtration rate decreases due to progressive renal damage, oxalate accumulates leading to systemic oxalosis. [hindawi.com]

Bartter Syndrome Type 4A

ID: C0853068 • Finding A laboratory test result which indicates a decreased glomerular filtration rate. [ncbi.nlm.nih.gov]

Schapel GJ, Seyberth HW, Sweetman BJ, et al: Reduced glomerular filtration rate associated with the decrease in prostaglandin synthesis produced by indomethacin in sodium-deprived [jamanetwork.com]

Glomerular filtration rate The glomerular filtration rate (GFR) is preserved during the early stages of the disease; however, it may decrease as a result of chronic hypokalemia [de.slideshare.net]

Hypertension

In approximately one quarter of patients renal denervation was followed by an increase (>20%) in glomerular filtration rate (GFR), while one patient displayed a GFR decrease [doi.org]

Glomerular filtration rate (GFR) remains normal until late in the disorder; as a result, the filtration fraction is increased. [merckmanuals.com]

Renal blood flow gradually decreases as diastolic BP increases and arteriolar sclerosis begins. [merckmanuals.com]

Diabetes Mellitus

This decreases plasma volume, thus lowering the glomerular filtration rate and enhancing the absorption of sodium and water in the proximal nephron. [en.wikipedia.org]

It seems paradoxical to treat an extreme diuresis with a diuretic, and the exact mechanism of action is unknown but the thiazide diuretics will decrease distal convoluted [en.wikipedia.org]

Postrenal Azotemia

This occurs because as the pressure inside the kidneys increases from the obstruction, the glomerular filtration rate decreases. [study.com]

In cases of renal disease, glomerular filtration rate decreases, so nothing gets filtered as well as it normally would. [ipfs.io]

The glomerular filtration rate is the speed with which your kidneys filter waste substances from the blood. [study.com]

Prerenal Azotemia

[…] reabsorption in the distal tubules, but eventually → decreased glomerular filtration rate → decreased excretory function → azotemia. [vetstream.com]

[…] reabsorption in the distal tubules, but eventually → decreased glomerular filtration rate → decreased excretory function → azotemia Azotemia. [vetstream.com]

filtration rate decreases, so nothing gets filtered as well as it normally would. [en.wikipedia.org]

Acute Renal Failure with Oliguria

Sudden and sustained deterioration of the kidney function characterized by decreased glomerular filtration rate, increased serum creatinine or oliguria. [icd9data.com]

Angiotensin II increases the glomerular filtration rate by causing constriction of the efferent arteriole; its absence decreases the glomerular filtration rate because of [aafp.org]

[…] in urine output after a major operation that may be a normal physiological response to: fluid/ blood loss – decreased glomerular filtration rate secondary to hypovolemia [en.wikipedia.org]

Non-Oliguric Renal Failure

Trimethoprim can also reversibly increase serum creatinine concentration and reduce creatinine clearance without decreasing glomerular filtration rate both in people with [bmj.com]

glomerular filtration rate both in people with normal renal function and in those with renal allografts trimethoprim alone can cause an important but reversible increase [gpnotebook.co.uk]

[…] trimethoprim in combination with sulphamethoxazole (cotrimoxazole) trimethoprim can also reversibly increase serum creatinine concentration and reduce creatinine clearance without decreasing [gpnotebook.co.uk]

Acute Kidney Injury

Sudden and sustained deterioration of the kidney function characterized by decreased glomerular filtration rate, increased serum creatinine or oliguria. [icd9data.com]

Angiotensin II increases the glomerular filtration rate by causing constriction of the efferent arteriole; its absence decreases the glomerular filtration rate because of [aafp.org]

Clinical syndrome characterized by a sudden decrease in glomerular filtration rate, usually associated with oliguria and always associated with biochemical consequences of [icd9data.com]

Hyperchloremia

Essentially, hyperchloremia causes the tubuloglomerular feedback mechanism to over-estimate the glomerular filtration rate, ultimately leading to a decrease in glomerular [emcrit.org]

Loss of glomerular function (associated with decreased glomerular filtration rate [GRF]) results in the retention of many end products of metabolism, including the anions [emedicine.medscape.com]

filtration rate back to normal. [emcrit.org]

Proximal Renal Tubular Acidosis

Increased alkalinity of proximal tubular cells would explain the low rate of bicarbonate reabsorption per liter glomerular filtration and the decreased rate of ammonium excretion [ncbi.nlm.nih.gov]

was inappropriately low, ( b ) the glomerular filtration rate remained unchanged or decreased modestly, and ( c ) urinary excretion of titratable acid increased briskly [doi.org]

glomerular filtration rate (GFR) (e.g. failure to excrete acid anions accumulation of acidic anions such as phosphate and sulfate occurs causes high anion gap metabolic acidosis [lifeinthefastlane.com]

AApoAIV Amyloidosis

glomerular filtration rate 60 33 occasional (7.5%) Occasional (29-5%) HP:0012213 7 stage 3 chronic kidney disease 60 33 occasional (7.5%) Occasional (29-5%) HP:0012625 8 [malacards.org]

glomerular filtration rate 58 31 occasional (7.5%) Occasional (29-5%) HP:0012213 7 stage 3 chronic kidney disease 58 31 occasional (7.5%) Occasional (29-5%) HP:0012625 8 [malacards.org]

Frequent (79-30%) HP:0005576 4 dysuria 60 33 occasional (7.5%) Occasional (29-5%) HP:0100518 5 glomerulosclerosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0000096 6 decreased [malacards.org]

Glycogen Storage Disease Type 1B

Rapidly Progressive Glomerulonephritis

The glomerular filtration rate decreases significantly over days, weeks, to months and may result in irreversible renal failure. [symptoma.com]

In patients with RPGN, the glomerular filtration rate decreases over a short period of time ranging in general from a few days to 3 months.[1] Light and electron microscopy [journals.lww.com]

Rapidly progressive glomerulonephritis (RPGN) is a disease of the kidney characterized clinically by a rapid decrease in the glomerular filtration rate (GFR) of at least 50% [emedicine.com]

Intestinal Fistula

glomerular filtration rate). [derangedphysiology.com]

[…] fistula or a high output ileostomy would result in a more rapid increase in the strong ion difference, as well as a diminished ability to compensate (with dehydration and decreased [derangedphysiology.com]

Sickle Cell Nephropathy

[…] hyper filtration in children 11 progressive decrease in glomerular filtration rate with advancing age. [slideplayer.com]

Glomerular ischemia leads to a compensatory increase in renal blood flow and glomerular filtration rate (GFR); such hyperfiltration, combined with glomerular hypertrophy, [emedicine.medscape.com]

[…] renal abnormalities have been observed in SCD patients. impaired urinary concentrating ability defects of urinary acidification defects of potassium excretion defects of glomerular [slideplayer.com]

Myxedema

glomerular filtration rate because there is decreased blood flow to the kidneys) Hypoglycemia (due to the reduced metabolic rate hence decreased gluconeogenesis) Very confused [registerednursern.com]

Renal Kidney function may be compromised with reduced glomerular filtration rate because of low cardiac output and peripheral vasoconstriction or because of rhabdomyolysis [emedicine.com]

Hypothermia (not just cold intolerance) Myxedema: swelling of tissues that have a waxy appearance or orange peel texture which will be located on the eyes and face Slow heart rate [registerednursern.com]

MYH9-Related Disorder

One year after the diagnosis the proteinuria increased to 3.6g/24h and the glomerular filtration rate decreased to 48ml/min/1.73m2. [revistanefrologia.com]

Additional studies for patients presenting with thrombocytopenia, decreasing glomerular filtration rate, proteinuria and haematuria are suggested. [medcraveonline.com]

Renal Injury

glomerular filtration rate leading to eventual renal failure. [ncbi.nlm.nih.gov]

filtration rate compared with control/sham mice. [ncbi.nlm.nih.gov]

GFR: Your blood test will also help find your GFR (glomerular filtration rate) to estimate the decrease in kidney function Imaging tests: Imaging tests, such as ultrasound [kidney.org]

Low Protein Diet

RESULTS: During the study period, the glomerular filtration rate decreased slightly in Group I (C(in) from 32.4 +/- 12.6 to 29.8 +/- 8.6 ml/min/1.73 m(2)) and more markedly [ncbi.nlm.nih.gov]

During the study period, the glomerular filtration rate slightly decreased (CCr from 28.2 +/- 3.4 to 26.4 +/- 4.1 ml/min and 29.6 +/- 4.8 to 23.4 +/- 4.4 ml/min in groups [ncbi.nlm.nih.gov]

To determine whether a low-protein diet slows the decrease in glomerular filtration rate (GFR) and decreases the albumin excretion rate (AER) in diabetic patients with incipient [ncbi.nlm.nih.gov]

Diabetic Nephropathy

DN provokes a decrease in glomerular filtration rate, which ends up in chronic renal failure. [doi.org]

The third stage, microalbuminuria, is characterized by elevations in blood pressure and urinary excretion of albumin and stable or decreasing glomerular filtration rate. [britannica.com]

Stage four is known as overt albuminuria and is characterized by elevated urinary excretion of albumin (greater than 300 mg/ml, or more than 10 times normal), decreased glomerular [britannica.com]