Glomerular-filtration-rate-decreased: Causes & Reasons

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Possible Causes for glomerular filtration rate decreased

Hypertension

It is hypothesized that a high potassium intake increases vasodilation and glomerular filtration rate while decreasing renin level, renal sodium reabsorption, reactive oxygen [doi.org]

[…] renal blood flow, and glomerular filtration rate, increased aldosterone release and increased fractional sodium reabsorption at both proximal and distal nephron segments [doi.org]

In approximately one quarter of patients renal denervation was followed by an increase ( 20%) in glomerular filtration rate (GFR), while one patient displayed a GFR decrease [doi.org]

Renal Function Impairment

RI leads to various physiologic changes, in addition to a decrease in glomerular filtration rate, that impact the pharmacokinetics (PK) and, specifically, the renal clearance [ncbi.nlm.nih.gov]

INTRODUCTION: The glomerular filtration rate (GFR), a measure of renal function, decreases by approximately 10 mL/min every 10 years after the age of 40 years, which could [ncbi.nlm.nih.gov]

This stage is broken up into two: a decrease in glomerular filtration rate (GFR) for Stage 3A is 45-59 mL/min and a decrease in GFR for Stage 3B is 30-44 mL/min. [davita.com]

Diabetes Mellitus

This decreases plasma volume, thus lowering the glomerular filtration rate and enhancing the absorption of sodium and water in the proximal nephron. [en.wikipedia.org]

It seems paradoxical to treat an extreme diuresis with a diuretic, and the exact mechanism of action is unknown but the thiazide diuretics will decrease distal convoluted [en.wikipedia.org]

Chronic Kidney Disease

Her estimated glomerular filtration rate decreased from an admission value of 34 mL/min/1.73 m2 to 13 mL/min/1.73 m2. CT scan showed retroperitoneal haematoma. [ncbi.nlm.nih.gov]

CKD is characterized by the development of progressive glomerulosclerosis, interstitial fibrosis and tubular atrophy along with a decreased glomerular filtration rate. [ncbi.nlm.nih.gov]

Patients with reduced glomerular filtration rates have a decreased ability to excrete fluoride in the urine. [academic.oup.com]

Fabry Disease

rate (GFR) decreased in 3 cases while it increased in the other 3 without statistical differences. [ncbi.nlm.nih.gov]

The results showed urinary protein loss (45.7%) and decreased glomerular filtration rate (31.4%), mainly in adults. [ncbi.nlm.nih.gov]

The mean serum creatinine level and estimated glomerular filtration rate also remained stable after 30-36 mo of treatment. [ncbi.nlm.nih.gov]

Glycogen Storage Disease Type 1

glomerular filtration rate, decreased muscle mass, underdeveloped muscles, delayed pubertal development, doll-like facies, elevated hepatic transaminase, high liver enzymes [xpertdox.com]

glomerular filtration rate 0012213 Decreased muscle mass Underdeveloped muscles 0003199 Delayed puberty Delayed pubertal development Delayed pubertal growth Pubertal delay [rarediseases.info.nih.gov]

RESULTS: A significant and progressive decrease of glomerular filtration rate was observed in treated patients vs. those who were not treated with ACE-inhibitors (P 0.05). [ncbi.nlm.nih.gov]

Primary Hyperoxaluria

As glomerular filtration rate decreases due to progressive renal damage, oxalate accumulates leading to systemic oxalosis. [hindawi.com]

Although serum oxalate levels have not been measured, they would certainly be high, since oxalate content increases as glomerular filtration rate decreases. [jped.com.br]

In patients with estimated glomerular filtration rate (eGFR) 2, Pox increased by 3.25 µmol/L in the placebo group and decreased by -1.7 µmol/L in the OC3 group (p 0.13). [ncbi.nlm.nih.gov]

Primary Hyperoxaluria Type 1

Although serum oxalate levels have not been measured, they would certainly be high, since oxalate content increases as glomerular filtration rate decreases. [jped.com.br]

As glomerular filtration rate decreases due to progressive renal damage, oxalate accumulates leading to systemic oxalosis. [hindawi.com]

glomerular filtration rate 0012213 Dysuria Painful or difficult urination 0100518 Failure to thrive Faltering weight Weight faltering [ more ] 0001508 Hematuria Blood in [rarediseases.info.nih.gov]

Postrenal Azotemia

In cases of renal disease, glomerular filtration rate decreases, so nothing gets filtered as well as it normally would. [ipfs.io]

This occurs because as the pressure inside the kidneys increases from the obstruction, the glomerular filtration rate decreases. [study.com]

The glomerular filtration rate is the speed with which your kidneys filter waste substances from the blood. [study.com]

Nodular Glomerulosclerosis

When the glomerular filtration rate fell to 30 ml/min, the syndrome of mild renal failure, decreased potassium excretion, and hyporeninemic hypoaldosteronism developed, suggesting [ncbi.nlm.nih.gov]

A moderately-to-severely decreased glomerular filtration rate with nephrotic syndrome was seen at the time of diagnosis of diabetes. [ekjm.org]

[…] lesion, and decreased glomerular filtration rates. [scielo.br]

Primary Hyperoxaluria Type 2

Although serum oxalate levels have not been measured, they would certainly be high, since oxalate content increases as glomerular filtration rate decreases. [jped.com.br]

As glomerular filtration rate decreases due to progressive renal damage, oxalate accumulates leading to systemic oxalosis. [hindawi.com]

Primary Hyperoxaluria Type 3

Although serum oxalate levels have not been measured, they would certainly be high, since oxalate content increases as glomerular filtration rate decreases. [jped.com.br]

As glomerular filtration rate decreases due to progressive renal damage, oxalate accumulates leading to systemic oxalosis. [hindawi.com]

Prerenal Azotemia

[…] in the distal tubules, but eventually decreased glomerular filtration rate decreased excretory function azotemia. [vetstream.com]

[…] in the distal tubules, but eventually decreased glomerular filtration rate decreased excretory function azotemia Azotemia. [vetstream.com]

filtration rate decreases, so nothing gets filtered as well as it normally would. [en.wikipedia.org]

Acute Renal Failure

Sudden and sustained deterioration of the kidney function characterized by decreased glomerular filtration rate, increased serum creatinine or oliguria. [icd9data.com]

Angiotensin II increases the glomerular filtration rate by causing constriction of the efferent arteriole; its absence decreases the glomerular filtration rate because of [aafp.org]

Clinical syndrome characterized by a sudden decrease in glomerular filtration rate, usually associated with oliguria and always associated with biochemical consequences of [icd9data.com]

Acute Renal Failure with Oliguria

Sudden and sustained deterioration of the kidney function characterized by decreased glomerular filtration rate, increased serum creatinine or oliguria. [icd9data.com]

Angiotensin II increases the glomerular filtration rate by causing constriction of the efferent arteriole; its absence decreases the glomerular filtration rate because of [aafp.org]

[…] in urine output after a major operation that may be a normal physiological response to: fluid/ blood loss – decreased glomerular filtration rate secondary to hypovolemia [en.wikipedia.org]

Non-Oliguric Renal Failure

Trimethoprim can also reversibly increase serum creatinine concentration and reduce creatinine clearance without decreasing glomerular filtration rate both in people with [bmj.com]

glomerular filtration rate both in people with normal renal function and in those with renal allografts trimethoprim alone can cause an important but reversible increase [gpnotebook.co.uk]

[…] trimethoprim in combination with sulphamethoxazole (cotrimoxazole) trimethoprim can also reversibly increase serum creatinine concentration and reduce creatinine clearance without decreasing [gpnotebook.co.uk]

Anemia

In the most severe cases, there is a decrease in renal flow and the glomerular filtration rate. [revespcardiol.org]

Essential Hypertension

A decrease in glomerular filtration rate is related to aging and this results in decreasing efficiency of sodium excretion. [en.wikipedia.org]

[…] in glomerular filtration rate (GFR) with progressive impairment in sodium excretion. 5 This may relate to the development of age-related renal microvascular disease, glomerulosclerosis [doi.org]

RENAL Vasospasm in preeclampsia leads to decreased renal perfusion and subsequent decreased “glomerular filtration rate” (GFR). [glowm.com]

Diabetic Nephropathy

DN provokes a decrease in glomerular filtration rate, which ends up in chronic renal failure. [doi.org]

filtration rate Decreased Decreased Increased risk of chronic kidney disease Present Present Despite the increased incidence of NP-DN, few clinical or experimental studies [wjgnet.com]

[…] parameter Diabetic nephropathy Non-proteinuric diabetic nephropathy Proteinuria Present Absent Regression of proteinuria Present Absent Histology Abnormal Normal or abnormal Glomerular [wjgnet.com]

Hyperuricemia

However, in a preplanned subgroup analysis, there was a significant decrease in SBP from baseline to Week 6 in subjects with normal renal function (estimated glomerular filtration [ncbi.nlm.nih.gov]

filtration rate (GFR) decreases, hyperuricemia is associated with chronic kidney disease (CKD). [journals.plos.org]

[…] renal tubular excretion of urate, declining glomerular filtration rate, and drug-induced interstitial nephropathy. [ajmc.com]

Acute Renal Injury

Sudden and sustained deterioration of the kidney function characterized by decreased glomerular filtration rate, increased serum creatinine or oliguria. [icd9data.com]

Definition (NCI) Sudden and sustained deterioration of the kidney function characterized by decreased glomerular filtration rate, increased serum creatinine or oliguria. [fpnotebook.com]

Acute kidney injury (AKI) refers to any acute decrease in glomerular filtration rate, regardless of etiology. [ncbi.nlm.nih.gov]

Periodontitis

CKD is defined as kidney damage with decreased function (glomerular filtration rate 60 mL/min per 1.73 m2) for 3 months or more. [nature.com]

Hyponatremia

Decreased glomerular filtration rate and cardiac function also contribute to hyponatremia in cirrhosis. [vaprisol.com]

A well-known elevation of BUN and serum creatinine is induced by a decrease of glomerular filtration rate. [tandfonline.com]

[…] intrarenal generation of prostaglandins Decreased glomerular filtration rate Increased water intake Extracellular volume depletion leading to ADH-mediated water retention [ncbi.nlm.nih.gov]

Hyperkalemia

Excretion) Decreased glomerular filtration rate (eg, acute or end-stage chronic renal failure) Decreased mineralocorticoid activity Defect in tubular secretion (eg, renal [lifeinthefastlane.com]

Specifically, diabetic patients or elderly patients with a decreased glomerular filtration rate need to have their potassium level monitored frequently [5]. [escardio.org]

In chronic kidney disease, renal adaptive mechanisms allow the kidneys to maintain potassium homeostasis until the glomerular filtration rate (GFR) decreases to less than [emedicine.medscape.com]

Renal Artery Stenosis

In these trials, poor correlation is noted between the reduction of stenosis and the improvement of renovascular hypertension and glomerular filtration rate, and decrease [ncbi.nlm.nih.gov]

glomerular filtration rate (OR 0.55 per 30 mL/minute/1.73 m 2, 95% CI 0.41-0.75; p CONCLUSION: Incidental RAS is frequent (14%) among patients with PAD undergoing lower extremity [ncbi.nlm.nih.gov]

glomerular filtration rate and worsens renal function sudden unexplained volume overload (heart failure or pulmonary edema) Symptoms primary symptoms hypertension Physical [step2.medbullets.com]

Chronic Kidney Insufficiency

Distinguishing Acute Kidney Injury From Chronic Kidney Disease Finding Comment Decreased kidney function (estimated glomerular filtration rate [eGFR] 60 mL/min/1.73 m2) for [msdmanuals.com]

Criteria include a decreased glomerular filtration rate (GFR) [ 60 mL/min/1.73 m2) or evidence of kidney damage such as albuminuria (albumin excretion rate 30 mg/24 h; urinary [academic.oup.com]

The glomerular filtration rate refers to the amount of blood that is filtered by the glomeruli per minute. As kidney function declines, the filtration rate decreases. [labtestsonline.org]

Peripheral Neuropathy

After 6 weeks of combined acupuncture and herbal treatments, glomerular filtration rate increased significantly from 37 mL/min to 51 mL/min and serum creatinine level decreased [ncbi.nlm.nih.gov]

Acidosis

Lowered glomerular filtration rate (GFR). Hypokalemia may decrease GFR, which in turn decreases the filtered load of bicarbonate. [acid-base.com]

glomerular filtration rate (GFR) (e.g. failure to excrete acid anions accumulation of acidic anions such as phosphate and sulfate occurs causes high anion gap metabolic acidosis [lifeinthefastlane.com]

[…] may be normal, due to renal tubular acidosis (RTA) URAEMIC ACIDOSIS Uraemic acidosis results from the loss of functional nephrons involves injury to glomeruli and tubules decreased [lifeinthefastlane.com]

Iron Deficiency Anemia

Iron deficiency anemia of chronic disease is the result of reduced glomerular filtration rate, reduced plasma flow, impaired erythropoietin production, and hemodilution. [symptoma.com]

Decreased levels of ferroportin inhibit the absorption of iron into the plasma. [symptoma.com]

Gout

It may be hereditary and also occurs in patients receiving diuretics and in those with diseases that decrease the glomerular filtration rate (GFR). [merckmanuals.com]

[…] of creatinine clearance compared with placebo, but there was a reduction in creatinine clearance with allopurinol in hypertensive patients with glomerular filtration rates [doi.org]

Decreased renal excretion is by far the most common cause of hyperuricemia. [merckmanuals.com]