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43 Possible Causes for Glomerular Filtration Rate Decreased, Onset at Age 5-10 Years

  • Hypertension

    In general, all patients with young onset-age (  40-50 years) or resistant hypertension should be screened for secondary forms.[ncbi.nlm.nih.gov] It is hypothesized that a high potassium intake increases vasodilation and glomerular filtration rate while decreasing renin level, renal sodium reabsorption, reactive oxygen[doi.org] […] renal blood flow, and glomerular filtration rate, increased aldosterone release and increased fractional sodium reabsorption at both proximal and distal nephron segments[doi.org]

  • Renal Impairment

    Table 2: Nitrofurantoin adverse reaction onset time by age group Age 1 week 1 month Unknown Total 4 1 0 0 5 20-29 years 10 4 1 0 15 30-39 years 14 6 4 0 24 40-49 years 13[medsafe.govt.nz] RI leads to various physiologic changes, in addition to a decrease in glomerular filtration rate, that impact the pharmacokinetics (PK) and, specifically, the renal clearance[ncbi.nlm.nih.gov] INTRODUCTION: The glomerular filtration rate (GFR), a measure of renal function, decreases by approximately 10 mL/min every 10 years after the age of 40 years, which could[ncbi.nlm.nih.gov]

  • Diabetes Mellitus

    Maternal history of diabetes or GDM during the child's gestation Age of initiation: age 10 years or at onset of puberty, if puberty occurs at a younger age Frequency: every[omicsonline.org] This decreases plasma volume, thus lowering the glomerular filtration rate and enhancing the absorption of sodium and water in the proximal nephron.[en.wikipedia.org] 3 years Preferred Test: Fasting plasma glucose Table 5: Modified ADA Guidelines for screening children and youths for T2DM.[omicsonline.org]

  • Renal Artery Stenosis

    67% at 5 years 41% at 10 years Presentation History hypertension before 30 years of age consider fibromuscular dysplasia in young women with abrupt onset of hypertension[step2.medbullets.com] In these trials, poor correlation is noted between the reduction of stenosis and the improvement of renovascular hypertension and glomerular filtration rate, and decrease[ncbi.nlm.nih.gov] glomerular filtration rate (OR 0.55 per 30 mL/minute/1.73 m 2 , 95% CI 0.41-0.75; p CONCLUSION: Incidental RAS is frequent (14%) among patients with PAD undergoing lower[ncbi.nlm.nih.gov]

  • Cronkhite-Canada Syndrome

    The average patient age at the onset of symptoms is 32 years, but the first symptoms may appear at any age between 5 and 55 years.[suprepkit.com] filtration rate of 81 (between 60 – 89 indicates a mild decrease).[peertechz.com] A gap of 10 years usually occurs between the recognition of disease and the onset of symptoms. Patients with Gardner syndrome are typically aged 15-30 years.[suprepkit.com]

  • Pediatric Crohn Disease

    Indications and results of surgery in patients with Crohn’s disease with onset under 10 years of age: a series of 18 patients. Eur J Pediatr Surg 2002 ; 12 : 180 –5.[doi.org] A decrease in glomerular filtration rate (GFR) and filtration of sodium as well as stimulation of arginine vasopressin (which decreases free water excretion) by hypoxemia[emedicine.medscape.com]

  • Nephrotic Syndrome

    Age at onset of 10 months.. .. .. c. Relapse 1 year after initial course of therapy.. .. .. d. Cholesterol level greater than 400 mg/dL.. .. .. e.[hawaii.edu] There is evidence pointing to a decrease of the glomerular filtration rate (GFR) in a subgroup of nephrotic children, likely secondary to hypovolemia.[ncbi.nlm.nih.gov] Hemodynamic changes also take place, which may result in decreased rate of glomerular filtration.[newhealthadvisor.com]

  • Inflammatory Bowel Disease Type 1

    Indications and results of surgery in patients with Crohn’s disease with onset under 10 years of age: a series of 18 patients. Eur J Pediatr Surg 2002 ; 12 : 180 –5.[doi.org] A decrease in glomerular filtration rate (GFR) and filtration of sodium as well as stimulation of arginine vasopressin (which decreases free water excretion) by hypoxemia[emedicine.medscape.com]

  • Diabetes Insipidus

    Two peak ages of onset exist: in adults, the peak age of onset is approximately 50 years, whereas in children, the peak age is approximately 5-10 years.[emedicine.medscape.com] Most patients with DI have modest dehydration, decreased glomerular filtration rate, and have urine volumes in the range of 6-12 liters/day.[endocrinologyadvisor.com] Diuretics may decrease the glomerular filtration rate, allowing water reabsorption at the proximal tubule rather than at the collecting duct.[journals.lww.com]

  • Spondylitic Aortitis

    Age of onset - 30-50 years  1-3% of the population has psoriasis  510 % of people with psoriasis get psoriatic arthritis  Family studies suggest a 50-fold increase[slideshare.net] Filtration Rate Decreased, Glomerulonephritis Proliferative, Glossitis, Glossodynia, Glossopharyngeal Neuralgia, Glucose Tolerance Decreased, Glucose Tolerance Impaired,[bonkersinstitute.org] Gingival Infection, Gingival Pain, Gingival Recession, Gingival Swelling, Gingivitis, Glasgow Coma Scale Abnormal, Glaucoma, Glaucoma Surgery, Glioblastoma, Glioma, Gliosis, Glomerular[bonkersinstitute.org]

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