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592 Possible Causes for Glossalgia, Macrocytosis, Pernicious Anemia not due to Intrinsic Factor Deficiency

  • Vitamin B12 Deficiency

    In pernicious anemia, the intrinsic factor necessary for vitamin B12 absorption is lacking, often due to an autoimmune factor.[livestrong.com] We report a case of a 46-year-old Moroccan man presenting with severe hemolytic anemia, thrombocytopenia, and renal failure in absence of macrocytosis, thus mimicking a genuine[ncbi.nlm.nih.gov] There were no clinical or biological signs of maternal anaemia or macrocytosis. Treatment with oral vitamin B12 rapidly improved the biological findings of the child.[ncbi.nlm.nih.gov]

  • Pernicious Anemia

    BACKGROUND/PURPOSE: Macrocytosis is defined as having the mean corpuscular volume (MCV) 100 fL.[ncbi.nlm.nih.gov] Technically, the term "pernicious anemia" refers to vitamin B12 deficiency due to a lack of intrinsic factor.[web.archive.org] Abstract Pernicious anemia is a macrocytic anemia due to cobalamin deficiency, which is the result of intrinsic factor deficiency.[ncbi.nlm.nih.gov]

  • Malabsorption Syndrome

    Vitamin B12 (cobalamin) deficiency due to pernicious anemia is caused by a lack of intrinsic factor and by pancreatic enzyme deficiency.[emedicine.medscape.com] In this setting, microcytic anaemia usually implies iron deficiency and macrocytosis can be caused by impaired folic acid or B12 absorption or both.[en.wikipedia.org]

  • Folate-Deficiency Anemia

    Nonalcoholic liver disease and hypothyroidism account for a substantial portion of macrocytosis.[aafp.org] Megaloblastic anemia due to vitamin B12 deficiency caused by a lack of intrinsic factor is specifically referred to as pernicious anemia.[med-ed.virginia.edu] Etiology and diagnostic evaluation of macrocytosis. Am J Med Sci. 2000;319(6):343–352. 4. Mahmoud MY, Lugon M, Anderson CC. Unexplained macrocytosis in elderly patients.[aafp.org]

  • Vitamin B Deficiency

    […] term pernicious anemia is sometimes used colloquially to refer to any anemia caused by vitamin B12 deficiency.[uofmhealth.org] […] causes distinctive dyserythropoietic abnormalities in the bone marrow - megaloblastic erythropoiesis - associated with abnormally large red cells in the peripheral blood i.e. macrocytosis[gpnotebook.co.uk] Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med. 1988;318(26):1720-1728. 4.[todaysgeriatricmedicine.com]

  • Iron Deficiency Anemia

    A vitamin B12 deficiency due to pernicious anemia (positive intrinsic factor antibodies) was also highlighted, but this was not enough to explain the anemia without macrocytosis[ncbi.nlm.nih.gov] […] presenting with IDA had a high proportion of atrophic gastritis, active chronic inflammation was nearly 4 times more common in IDA patients than in patients presenting with macrocytosis[bloodjournal.org] A vitamin B12 deficiency due to pernicious anemia (positive intrinsic factor antibodies) was also highlighted, but this was not enough to explain the anemia without macrocytosis[ncbi.nlm.nih.gov]

  • Celiac Disease

    […] as can be seen in CD can result in atypical findings on the blood smear, and patients with deficiencies of folate and vitamin B 12 may not present with the characteristic macrocytosis[bloodjournal.org]

    Missing: Pernicious Anemia not due to Intrinsic Factor Deficiency
  • Subacute Combined Degeneration of Spinal Cord

    anemia 2016 2017 2018 2019 Billable/Specific Code Applicable To Vegan anemia D51.3 ) pernicious ( ICD-10-CM Diagnosis Code D51.0 Vitamin B12 deficiency anemia due to intrinsic[icd10data.com] Moreover, no haematological alterations like macrocytosis were determined.[bmcresnotes.biomedcentral.com] , [3] and copper deficiency. [4] It is usually associated with pernicious anemia.[ipfs.io]

  • Tropical Sprue

    Neither patient was anemic, although one had hypersegmented polymorphonuclear leukocytes and both had macrocytosis and megaloblastic bone marrows.[ncbi.nlm.nih.gov] Macrocytosis occurs early. Serum and erythrocyte levels of folate are low. Anaemia may also be hypochromic from defective absorption of iron.[histopathology-india.net] Macrocytosis may be demonstrated in the gastric mucosa. Small bowel biopsy will disclose the morphologic changes previously discussed.[history.amedd.army.mil]

    Missing: Pernicious Anemia not due to Intrinsic Factor Deficiency
  • Diphyllobothrium Latum Infection

    Laboratory evaluation was remarkable for a hemoglobin of 14.7, with macrocytosis (MCV 100), and no eosinophilia.[healio.com]

    Missing: Pernicious Anemia not due to Intrinsic Factor Deficiency

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