Hypoglycemia: Causes & Reasons

Possible Causes for Hypoglycemia

On this page: What is hypoglycemia? What are the symptoms of hypoglycemia? What causes hypoglycemia in people with diabetes? How can hypoglycemia be prevented? [web.archive.org]

Falls Injuries Motor vehicle accidents Hypoglycemia unawareness Over time, repeated episodes of hypoglycemia can lead to hypoglycemia unawareness. [mayoclinic.com]

The most common cause of factitious hypoglycemia is surreptitious injection of insulin, and this is best diagnosed by the triad of hypoglycemia, inappropriately high insulin [ncbi.nlm.nih.gov]

Insulin Resistance

[…] defense against developing hypoglycemia, favors severe hypoglycemia ( 41 ). [doi.org]

Changes in glucose metabolism occurring during counterregulation are, in part, mediated by increased plasma free fatty acids (FFAs), as a result of hypoglycemia-activated [ncbi.nlm.nih.gov]

We aimed to identify the cause of postprandial hypoglycemia in a 10-year-old boy. [ncbi.nlm.nih.gov]

Acute Alcohol Intoxication

Previous case reports suggest hypoglycemia and faster than normal rates of alcohol elimination found in children with acute alcohol intoxication compared with adults, but [ncbi.nlm.nih.gov]

[…] intoxication stems from many complications that arise in the presence of large quantities of ethanol in the circulation (> 350mg/100ml), including lactic acidosis, hypokalemia, hypoglycemia [symptoma.com]

Madison LL (1968) Ethanol induced hypoglycemia. Adv Metab Disord 3: 85–109 Google Scholar 47. [link.springer.com]

Diabetes Mellitus Type 2

Although both blood glucose control and sepsis can strongly affect the occurrence of severe hypoglycemia, few studies have examined the seasonal variation of severe hypoglycemia [ncbi.nlm.nih.gov]

hypoglycemia, or severe hypoglycemia. [clinicaltrials.gov]

When added to metformin, drugs were associated with similar HbA1C levels, while SGLT-2 inhibitors offered the lowest odds of hypoglycemia (OR, 0.12 [95% CI, 0.08 to 0.18]; [ncbi.nlm.nih.gov]

Diabetes Mellitus Type 1

The main concern is hypoglycemia, which can cause sudden incapacitation. [ncbi.nlm.nih.gov]

[…] overall hypoglycemia rate in type 2 DM. [ncbi.nlm.nih.gov]

It is also useful for patients with recurrent asymptomatic hypoglycemia (i.e., hypoglycemia unawareness).9,11 In 14 randomized, controlled clinical trials, rt-CGM has led [uspharmacist.com]

Adrenal Insufficiency

Hypoglycemia occurred in three patients (10%) during the fasting day but not during the nonfasting day (P = 0.23). Hypoglycemia was asymptomatic in two cases. [ncbi.nlm.nih.gov]

Hypoglycemia may be a presenting symptom; therefore, laboratory investigation for hypoglycemia should include serum cortisol, drawn at the time of hypoglycemia. [hindawi.com]

Often insidious in onset, patients may present in shock due to increased stress Malaise, lassitude, fatigue, weakness, anorexia, weight loss, nausea, vomiting, hypotension, hypoglycemia [pathologyoutlines.com]

Addison Disease

ACTH stimulation tests and Insulin-induced hypoglycemia tests, imaging studies with CT scan and MRI may follow. [symptoma.com]

Addisonian (adrenal) crisis: acute complication of adrenal insufficiency (circulatory collapse, dehydration, hypotension, nausea, vomiting, hypoglycemia); usually precipitated [unboundmedicine.com]

Insulin-induced hypoglycemia test: This will test for secondary adrenal insufficiency or those caused by a pituitary dysfunction. [symptoma.com]

Neonatal Hypoglycemia

[…] of the following infants to exclude persistent causes of hypoglycemia [4]: Symptomatic hypoglycemia or severe hypoglycemia requiring treatment with intravenous dextrose Infants [statpearls.com]

• Hypoglycemia can cause long term neurologic sequelae.  The important steps in preventing and treating hypoglycemia are  to identify neonates at risk of developing hypoglycemia [slideshare.net]

hypoglycemia. © American Academy of Pediatrics, 2017. [pedsinreview.aappublications.org]

Maternal Diabetes Syndrome

Hypoglycemia that requires intervention may persist for as long as 1 week. [emedicine.medscape.com]

Applicable To Newborn (with hypoglycemia) affected by maternal gestational diabetes Type 1 Excludes Type 1 Excludes Help A type 1 excludes note is a pure excludes. [icd10data.com]

A newborn infant of a diabetic mother may develop one, or more, of the following: Hypoglycemia Hypoglycemia refers to low blood glucose in the baby immediately after delivery [stanfordchildrens.org]

Acute Fatty Liver of Pregnancy

Elevated liver transaminase levels (alanine and aspartate aminotransferases, or ALT and AST, respectively), hypoglycemia, leukocytosis, hyperbilirubinemia, hypoglycemia, increased [symptoma.com]

Raised transaminases and serum bilirubin as well as coagulopathy were found in all patients (100%), while hypoglycemia was found in 8 patients (53%). [ncbi.nlm.nih.gov]

As the disease progresses, profound hypoglycemia may develop, due to impaired hepatic gluconeogenesis. [medicaljoyworks.com]

Factitious Hypoglycemia

Two patients had sulfonylurea-induced factitious hypoglycemia. [ncbi.nlm.nih.gov]

Factitious hypoglycemia typically occurs in adolescents with type 1 diabetes who use insulin to induce hypoglycemia. [ncbi.nlm.nih.gov]

We concluded that this patient had factitious hypoglycemia, a syndrome where patients self-induce hypoglycemia to seek medical attention or assume a sick role. [medical-dictionary.thefreedictionary.com]

Cinchonism

Patients treated with quinine may also suffer from hypoglycemia (especially if administered intravenously ) and hypotension (low blood pressure ). [academickids.com]

Patients treated with quinine may also suffer from hypoglycemia (especially if administered intravenously) and hypotension (low blood pressure). [the-medical-dictionary.com]

Congenital Isolated ACTH Deficiency

hypoglycemia, may indicate ACTH deficiency. [journals.plos.org]

At the age of 7 months the patient presented with severe hypoglycemia (blood glucose 10.9 mg/dl). [abstracts.eurospe.org]

All had hypoglycemia, and 4 had had seizures. [journals.plos.org]

Hypopituitarism

A total of 78 patients who had undergone ITT were divided into adequate and inadequate hypoglycemia groups. [ncbi.nlm.nih.gov]

Hypopituitarism explains the protracted hypoglycemia and the short stature. [ncbi.nlm.nih.gov]

The standard test for growth hormone deficiency is the insulin-induced hypoglycemia test. This test does carry some risk from the induced hypoglycemia. [medical-dictionary.thefreedictionary.com]

Panhypopituitarism

Hypoglycemia and cholestasis resolved with treatment of the underlying panhypopituitarism. [ncbi.nlm.nih.gov]

Its clinical features are hypoglycemia, hyponatremia, shock, severe jaundice, micropenis at birth, and even death if not managed appropriately. [ekjm.org]

At the time of admission, laboratory tests showed hypoglycemia with a blood glucose level of 26 mg/dL. [dermsinica.org]

Islet Cell Tumor

Non-islet cell tumor hypoglycemia syndrome is caused by the tumor producing insulin-like growth factor II, causing hypoglycemia. [ncbi.nlm.nih.gov]

Spontaneous hypoglycemia. J. Mt. Sinai Hosp. 1955; 21: 321 Howard J.E. Differential diagnosis and therapy of spontaneous hypoglycemia. V. A. Tech. [amjmed.com]

In cases of hypoglycemia with apparently normal insulin levels, the measurement of somatostatin and various provocative tests are recommended. [ncbi.nlm.nih.gov]

Addisonian Crisis

Treat severe hyperglycemia with 1-2 gm/kg of D50 Consider infusion of D5NS for continued hypoglycemia Check FS glucose Q1-2 hours to ensure improving hypoglycemia Hypotension [coreem.net]

[…] deficiency in cortisol production and this results in circulatory collapse and electrolyte imbalances hypotension, tachycardia, dehydration, hypovolemic shock, profound hypoglycemia [quizlet.com]

An insulin stress test should cause hypoglycemia and a spike in both plasma cortisol and serum growth hormone within 1-2 hours. hypoglycemia hyponatremia, hyperkalemia return [sharinginhealth.ca]

Drug-Induced Hypoglycemia

Sweating How is Drug-Induced Hypoglycemia Diagnosed? [dovemed.com]

Asymptomatic hypoglycemia : An event without typical symptoms of hypoglycemia and a measured plasma glucose concentration ≤3.9 mmol/L (70 mg/dL). 3. [empendium.com]

This case report comprises three cases of antipsychotic drug-induced hypoglycemia and hypothermia. [ncbi.nlm.nih.gov]

Alcohol-Induced Hypoglycemia

Glycogen stores get depleted; hypoglycemia is not due to inhibition of glycogenolysis. Hypoglycemia is also not due to the diuretic effect of alcohol. [usmle.biochemistryformedics.com]

hypoglycemia 4) Asymptomatic hypoglycemia(or hypoglycemic Unawareness) 5) Relative hypoglycemia • Without diabetes mellitus the hypoglycemia is classified as: 1) reactive [slideshare.net]

Hypoglycemia Objectives The objectives of this module will be to Review the signs and symptoms associated with hypoglycemia. [cdemcurriculum.com]

Growth Hormone Deficiency

Glucagon injection during hypoglycemia resulted in a further decrease of blood glucose. [ncbi.nlm.nih.gov]

Two full-term infants had undetectable cortisol levels, but also low GH levels, at the time of severe hypoglycemia. [ncbi.nlm.nih.gov]

OBJECTIVE: This study aimed to understand the biochemical basis of hypoglycemia in the index case and the molecular basis of severe short stature in a large consanguineous [ncbi.nlm.nih.gov]

Disorder of Fructose Metabolism

What are the specific reasons for hypoglycemia seen in hereditary fructose intolerance? [evolvinghealthscience.blogspot.com]

Previous confirmatory testing used liver biopsy or induction of hypoglycemia by fructose infusion 200 mg/kg IV. [merckmanuals.com]

Signs and symptoms from fructose ingestion are evident in infancy and include vomiting, abdominal pain and hypoglycemia. [icd9data.com]

Hereditary Fructose Intolerance

What are the specific reasons for hypoglycemia seen in hereditary fructose intolerance? [evolvinghealthscience.blogspot.com]

The disruption of fructose metabolism results in both gastrointestinal problems and hypoglycemia upon fructose consumption. [symptoma.com]

Herein we report on a case of hereditary fructose intolerance with initial presentation of episodic unconsciousness, seizure, hypoglycemia, hepatomegaly, and abnormal liver [ncbi.nlm.nih.gov]

Salicylate Poisoning

We describe a case of severe refractory hypoglycemia secondary to topical salicylate intoxication. [jamanetwork.com]

particularly CNS hypoglycemia Abnormal hemostasis and coagulation Clinical presentations of patients with salicylate toxicity range from minor symptoms to a syndrome initially [unboundmedicine.com]

Intoxication is characterized by rapid breathing, vomiting, headache, irritability, ketosis, hypoglycemia, and, in severe cases, seizures and respiratory failure. salicylate [medical-dictionary.thefreedictionary.com]

Paraneoplastic Syndrome

[…] and inexplicable hypoglycemia. [mattioli1885journals.com]

Seen in febrosarcoma, haemangiofibropericytoma, hepatoma)  Diagnosis: fasting hypoglycemia  Plasma insulin/pro-insulin/peptide C during hypoglycemia  Treatment:  Anticancer [slideshare.net]

Some examples are given below 1,2: paraneoplastic endocrine syndromes carcinoid syndrome Cushing syndrome hypercalcemia hypoglycemia syndrome of inappropriate antidiuretic [radiopaedia.org]

Pancreatic Adenoma

Hypoglycemia occurs typically during the late post-prandial period. [enets.org]

Since the liberation of insulin, by the monumental work of Banting and Best 1 in 1922, the clinical syndrome of hypoglycemia or insulin shock has become a well recognized [jamanetwork.com]

Signs : If no insulin resistance - hypoglycemia Hypoglycemia, ie ataxia, disorientation, recumbency, seizures, coma, death. [vetstream.com]

Dumping Syndrome

[…] after the decline in circulating insulin to undetectable levels, and (4) inadequate glucagon response to hypoglycemia resulting in sustained hypoglycemia. [ncbi.nlm.nih.gov]

This case demonstrates that hypoglycemia unawareness has to be taken into account not only in patients affected by IDDM or insulinoma but also in any case of reactive hypoglycemia [ncbi.nlm.nih.gov]

At 120 min, when most of the hypoglycemias are encountered, pancreatic glucagon is no longer detectable, probably through inhibition by GLP-1. [ncbi.nlm.nih.gov]

Aromatic L-Amino Acid Decarboxylase Deficiency

The episodes of hypoglycemia and the chronic diarrhea were suppressed. Here is the first case report of long-fasting hypoglycemia due to a nontypical AADC deficiency. [ncbi.nlm.nih.gov]

The episodes of hypoglycemia and the chronic diarrhea were suppressed. [hal.archives-ouvertes.fr]

Submitted by a.bergoend on Thu, 04/30/2015 - 10:46 Titre Aromatic L-Amino Acid Decarboxylase Deficiency Is a Cause of Long-Fasting Hypoglycemia Type de publication Article [okina.univ-angers.fr]

Myxedema

High mortality (30-60%) How do patients present (clinical diagnosis) AMS Hypothermia Hypotension Respiratory Failure Hypoglycemia Hyponatremia Potential physical exam findings [emdocs.net]

Hypoglycemia – The reduction on the metabolic rate affects the conversion of carbohydrates into glucose leading to hypoglycemia. [ehealthwall.com]

[…] to the increased antidiuretic hormone which causes the body to conserve water & decreased glomerular filtration rate because there is decreased blood flow to the kidneys) Hypoglycemia [registerednursern.com]

Beta Blocker Poisoning

Monitor the glucose following glucagon therapy as rebound hypoglycemia can occur. [calsprogram.org]

Resistance and Hyperglycemia Serum Glucose >250 mg/dl (without Diabetes Mellitus ) suggests severe Overdose Contrast with Beta Blocker Overdose which is associated with Hypoglycemia [fpnotebook.com]

High-dose insulin, euglycemia can cause profound hypokalemia and hypoglycemia that can potentiate the cardiotoxicity in the setting of beta-blocker overdose. [ncbi.nlm.nih.gov]

Glycogen Storage Disease

Since the majority of children with recurrent hypoglycemia cannot be diagnosed with a known endocrine or metabolic disorder on a critical sample, ketotic hypoglycemia has [ncbi.nlm.nih.gov]

We describe a patient presenting with severe ketotic hypoglycemia found to have both GSD IX and isolated GH deficiency. [ncbi.nlm.nih.gov]

 Fasting hypoglycemia:  Hypoglycemia, decreases insulin secretion, which in turn inhibits protein synthesis causes stunted growth (dwarfism).  Lactic acidemia:  Glucose [slideshare.net]