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158 Possible Causes for Glucose Increased, Insulin Increased, Variable Hypoglycemia

  • Diabetes Mellitus

    Associated Complications: CNS : retinopathy, peripheral neuropathies, and autonomic neuropathy (decreased heart rate variability, orthostatic hypotension, gastroparesis,[] […] frequency of insulin-dependent diabetes in several countries is best explained today by the decline of infections.[] As the blood glucose level increases, so also does the glucose content in the aqueous humor.[]

  • Septicemia

    This conclusion is supported by the wide variability in hypoglycemia rates reported with protocols [ 205, 206, 207, 212, 213 ].[] Furthermore it was also pointed out that intensive insulin therapy increased the labor requirement of nursing staff in the ICU[ 26 ].[] This conclusion is supported by the wide variability in hypoglycemia rates reported with protocols [ 205 – 207, 212, 213 ].[]

  • Glycogen Storage Disease Type 6

    Individuals with GSD VI typically exhibit hepatomegaly, growth retardation, and variable but mild episodes of fasting hypoglycemia and hyperketosis during early childhood.[] Ingestion of glucose alone, glucose plus prtrteiu Or infusion of arginine monochlorid resulted in significantly less than normal increase in insulin.[] Oral galactose and fructose fail to increase glucose levels but plasma lactic acid levels increase.[]

  • Islet Cell Tumor

    PNETs are functional or non-functional tumors and represent a heterogeneous group of neoplasms with extremely variable clinical behavior.[] It is considered to cause hypoglycemia by increasing the insulin-like bioactivity of the circulating insulin-like growth factor (IGF) system, however, the precise mechanism[] Glucagon also plays a role in the amount of glucose in the bloodstream, and in this case, it increases the amount of glucose present.[]

  • Insulin Resistance

    Armen, Simulation and qualitative analysis of glucose variability, mean glucose, and hypoglycemia after subcutaneous insulin therapy for stress hyperglycemia, Theoretical[] (Reuters Health) - Insulin resistance may increase the risk for Alzheimer’s disease by depriving the brain of sugar needed for normal cognition, a small study suggests.[] This was associated with suppression of endogenous glucose production by 42%, increased glucose utilization by 64%, and increased glucose oxidation by 100%.[]

  • Diabetes Mellitus Type 2

    The choice of glycemic target also depends on consideration of other variables, such as risk for hypoglycemia, weight gain, and other drug-related adverse effects, as well[] However, sulfonylurea might increase the secretion of insulin, which might contribute to sympathoexcitation.[] glucose concentration and associated glycemia/HbA1c values, with the strength of the correlation increasing for higher glycemia/HbA1c values.[]

  • Hypoglycemia

    Glycemic variability portends increased risk for hypoglycemia and should be a focus of further research.[] Insulin levels were not different among sessions, whereas glucagon increased with MDG administration ( P 0.001).[] Continuous monitoring of glycemia due to the ability to show glycemia variability and unrecognized hypoglycemia as well as predictive options for long-term metabolic control[]

  • Diabetic Ketotic Coma

    Glycemic variability: A strong independent predictor of mortality in critically ill patients. Crit Care Med 2008;36:3008-3013. Moore C, Woollard M.[] If glucose levels do not decrease by 50-75 mg/dL during the first hour of insulin therapy, the insulin infusion should be increased every hour until a steady decline in glucose[] As the blood glucose levels increase in HHS, the body tries to get rid of the excess glucose by increased urinary volume.[]

  • Diabetes Mellitus Type 1

    There was no significant between-group difference in the number of severe hypoglycemia events. (p 0.1276).[] Postprandial glucose levels increased more markedly in T1DM (to 22.1 1.4 vs. 11.2 0.6mmol/L) while insulin levels increased only in T2DM (from 24.4 4.4 to 68.8 12.3μU/mL).[] […] pump If patient is on epinephrine, glucocorticoids, or growth hormone, there may be an increase in blood glucose levels, thus an increased level of insulin may be needed.[]

  • Insulinoma

    A somatostatin analog, octreotide (100 to 500 mcg sc bid to tid), is variably effective and should be considered for patients with continuing hypoglycemia refractory to diazoxide[] Insulin sensitivity was greatly reduced in patients with insulinoma (38.9% 22.3%), while beta cells function was increased (359.0 171.5%), but to a variable extent (range:[] Then, the frequency of blood glucose measurement is increased to every hour until values are 49 mg/dL (2.7 mmol/L).[]

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