Glycosuria: Causes & Reasons

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Possible Causes for Glycosuria

Familial Renal Glucosuria

Sodium-glucose transport proteins Media related to Renal glycosuria at Wikimedia Commons [en.wikipedia.org]

Pregnant women with familial renal glycosuria can be at risk of profound polyuria during pregnancy due to the associated increase in glycosuria. [ncbi.nlm.nih.gov]

Etiologically, renal glycosuria is of 3 types-benign renal glycosuria, glycosuria with diabetes mellitus (including gestational diabetes) and tubular defects (Fanconi syndrome [ncbi.nlm.nih.gov]

Renal Tubular Acidosis

He was also found to have hyperchloraemic metabolic acidosis with hypokalaemia, hypophosphataemia, phosphaturia and glycosuria, which favoured a diagnosis of proximal renal [ncbi.nlm.nih.gov]

The blood salicylate level was undetectable, and a urinalysis showed glycosuria, proteinuria and elevated beta-2 microglobulin and n-acetyl glucosamine levels, with a normal [ncbi.nlm.nih.gov]

Urinalysis showed inappropriate alkaline urine (urinary PH: 7), glycosuria with normal blood glucose, phosphaturia and uricosuria. [ncbi.nlm.nih.gov]

Nephropathic Cystinosis

Renal tubular disease is usually present causing aminoaciduria, glycosuria and hypokalemia. Cysteine deposition is most evident in the conjunctiva and cornea. [en.wikipedia.org]

Renal tubular disease, aminoaciduria, glycosuria, and hypokalemia are usually present. [whonamedit.com]

[…] diagnosis is based on blood and urine analysis showing features of Fanconi syndrome (metabolic acidosis, hypokalemia, hyponatremia, hypophosphatemia, hyperaminoaciduria, glycosuria [orpha.net]

Cystinosis

All had nephropathic infantile-type cystinosis with evidence of proximal tubulopathy, with glycosuria and renal phosphate wasting. [ncbi.nlm.nih.gov]

The de Toni-Fanconi syndrome* is a clinical constellation characterized by resistant rickets, acidosis, glycosuria, hyperamino-aciduria, and organic aciduria. [doi.org]

It is associated with slight increase of the plasma cystine, cystinuria, aminoaciduria, glycosuria, polyuria, hypophosphatemia, rickets, and renal tubular dysfunction Constellation [icd9data.com]

Diabetes Mellitus

Subsequently, hyperglycemia and glycosuria, but not ketonuria, occured. [pediatrics.aappublications.org]

[…] weight loss is specific for IDDM; type 2 patients rarely have either Severe fasting hypoglycemia is due to cessation of glycogen storage in fat and muscle Glycosemia causes glycosuria [pathologyoutlines.com]

Initial clinical manifestations include hyperglycemia, glycosuria, intrauterine growth retardation, osmotic polyuria, severe dehydration, and failure to gain weight. [orpha.net]

Oculocerebrorenal Syndrome

Glycosuria. Lowe noted the absence of glycosuria in his first three patients, even when blood glucose levels were increased to 150 mg/dl in two patients ( 1 ). [cjasn.asnjournals.org]

P., a 2-month-old infant, was examined because of bilateral congenital cataracts and was also found to have bilateral glaucoma, albuminuria, and minimal glycosuria. [doi.org]

In a series of patients with genetically proven LS, low-molecular-weight proteinuria, and albuminuria were the prominent findings, although none had glycosuria and only some [sjkdt.org]

Fanconi Renotubular Syndrome Type 3

Other laboratory tests showed phosphatemia at 0.57 mmol/L, metabolic acidosis, and normoglycemic glycosuria at 31 mmol/L. [journals.lww.com]

Glycosuria and aminoaciduria probably do not play a role. [abdominalkey.com]

phosphaturia, renal tubular acidosis (RTA) type 2 (proximal), hypophosphataemic rickets (children) or osteomalacia (adults), and renal glycosuria. [ 2, 3 ] Epidemiology [patient.info]

Fanconi Renotubular Syndrome Type 2

phosphaturia, renal tubular acidosis (RTA) type 2 (proximal), hypophosphataemic rickets (children) or osteomalacia (adults), and renal glycosuria. [ 2, 3 ] Epidemiology [patient.info]

Hypokalemia Hyperchloremia Other features of the generalized proximal tubular dysfunction of the Fanconi syndrome are:[citation needed] Hypophosphatemia/hyperphosphaturia Glycosuria [en.wikipedia.org]

Proximal tubular dysfunction, resembling adult Fanconi's syndrome, was suggested by an increased urinary loss of phosphate and urate and glycosuria. [jamanetwork.com]

Cadmium Poisoning

The effects of cadmium proximal renal function are characterized by increased cadmium in the urine, proteinuria (primarily Beta-2-microglobulin), aminoaciduria, glycosuria [pathopedia-india.com]

In the final stages of cadmium nephropathy, glycosuria, wasting of calcium and phosphate, and altered calcium metabolism with secondary effects on the skeleton of osteoporosis [atsdr.cdc.gov]

Renal dysfunction affects calcium, vitamin D, phosphorus and sodium levels, resulting in proteinuria, glycosuria, renal hypertension and other metabolic disorders. [arltma.com]

Wilson Disease

Dribbling 0002307 Dysphagia Poor swallowing Swallowing difficulties Swallowing difficulty [ more ] 0002015 Dystonia 0001332 Esophageal varix Enlarged vein in esophagus 0002040 Glycosuria [rarediseases.info.nih.gov]

Endocrine Dysfunction

BACKGROUND: Diamond-Blackfan anemia (DBA) is a rare inherited bone marrow failure syndrome. The mainstays of treatment involve chronic red cell transfusions, long-term glucocorticoid therapy, and stem cell transplantation. Systematic data concerning endocrine function in DBA are limited. We studied patients in the[…] [ncbi.nlm.nih.gov]

Cushing Syndrome

Cushing's syndrome results from sustained pathologic hypercortisolism caused by excessive corticotropin (ACTH) secretion by tumors in the pituitary gland (Cushing's disease, 70%) or elsewhere (15%), or by ACTH-independent cortisol secretion from adrenal tumors (15%). The clinical features are variable, and no single[…] [ncbi.nlm.nih.gov]

Renal Tubular Dysfunction

In other words, individuals who inherit one mutated copy of a gene for renal glycosuria (heterozygous carriers) may have modest glycosuria due to mild reductions in the renal [rarediseases.org]

Other laboratory tests showed phosphatemia at 0.57 mmol/L, metabolic acidosis, and normoglycemic glycosuria at 31 mmol/L. [journals.lww.com]

Our patients (5 women and 2 men) developed renal tubular dysfunction, with hypophosphatemia, normoglycemic glycosuria, proteinuria, and decrease of creatinine clearance. [ncbi.nlm.nih.gov]

Pentosuria

Positive Benedict’s test for urine signifies Glycosuria. Glycosuria is a non-specific term. [usmle.biochemistryformedics.com]

He emphasized the likelihood of their being mistakenly classified as examples of renal glycosuria unless the ty[ill] of urinary sugar is determined. [jamanetwork.com]

Lactosuria and glycosuria in pregnancy and the puerperium. Lancet. 1953 Oct 3;265(6788):698–704. [PubMed] [Google Scholar] LASKER M. [ncbi.nlm.nih.gov]

Proximal Renal Tubular Acidosis

[…] a solitary defect, but is usually associated with a more generalised dysfunction of the proximal tubular cells called Fanconi syndrome where there is also phosphaturia, glycosuria [en.wikipedia.org]

Proximal tubular dysfunction, resembling adult Fanconi's syndrome, was suggested by an increased urinary loss of phosphate and urate and glycosuria. [archinte.ama-assn.org]

Additional findings from urinalysis include glycosuria, hyperphosphaturia, and proteinuria. [symptoma.com]

Fanconi Renotubular Syndrome

Defects in proximal tubular function can be isolated (e.g. isolated renal glycosuria, aminoacidurias, or hypophosphataemic rickets) or generalized. [oxfordmedicine.com]

Low molecular weight proteinuria is the most sensitive test, and non-diabetic glycosuria is the most specific. [orpha.net]

Laboratory investigations showed generalized aminoaciduria, glycosuria, hyperphosphaturia, hypercalciuria, and low-molecular weight proteinuria including ${beta}$-microglobulin [chikd.org]

Adult Fanconi Syndrome

Defects in proximal tubular function can be isolated (e.g. isolated renal glycosuria, aminoacidurias, or hypophosphataemic rickets) or generalized. [oxfordmedicine.com]

Renal Glycosuria Synonyms of Renal Glycosuria Benign Glycosuria Familial Renal Glycosuria Nondiabetic Glycosuria Primary Renal Glycosuria Renal Glucosuria Subdivisions of [rarediseases.org]

Her 15-year-old son had renal glycosuria without metabolic acidosis. Both had mildly to moderately impaired renal function. [ncbi.nlm.nih.gov]

Acquired Fanconi Syndrome

Defects in proximal tubular function can be isolated (e.g. isolated renal glycosuria, aminoacidurias, or hypophosphataemic rickets) or generalized. [oxfordmedicine.com]

[…] tubular reabsorption of phosphate (%TRP), increased fractional excretion of potassium (FEK) and uric acid (FEUA), low-molecular-weight proteinuria, panaminoaciduria and glycosuria [ncbi.nlm.nih.gov]

This manifests as glycosuria, aminoaciduria, hyperphosphaturia and proximal tubular acidosis. [revistanefrologia.com]

Fanconi-Bickel Syndrome

1 Glycosuria and hyperglycemia in the neonatal period as the first clinical sign of Fanconi-Bickel syndrome. ( 28493372 ) 2017 2 Hepatocellular Carcinoma in Fanconi-Bickel [malacards.org]

Glycosuria[?] GM2 gangliosidosis, 0 variant[?] GM2-gangliosidosis, B, B1, AB variant[?] Gms syndrome[?] Goldberg Bull syndrome[?] Goldberg syndrome[?] [encyclopedia.kids.net.au]

Glycosuria and ketonuria occur after breakfast and therefore may be confused with diabetes mellitus. Treatment : adequate diet and avoidance of fasting hypoglycaemia. [gopatients.info]

Disorders of Amino-Acid Transport

[…] precipitate within lysosomes in proximal tubules CLINICAL ISSUES Epidemiology Incidence Rare (68 cases reported as of 2000) Presentation Fanconi syndrome (acquired) Normoglycemic glycosuria [basicmedicalkey.com]

In the case presented here, testing for Fanconi syndrome was not performed although the patient was noted to have glycosuria in the setting of normal serum glucose. [theisn.org]

Short IA, Smith JP: Myelomatosis associated with glycosuria and aminoaciduria. Scott Med J 489-93, 1959 28. [docslide.net]

Transient Neonatal Diabetes Mellitus

The firstborn sibling, aged 19 years, is reported to be free of signs and symptoms of diabetes; the third born was clinically well with no glycosuria at 9 years 3 months of [ncbi.nlm.nih.gov]

Clinical manifestations at the time of diagnosis include intrauterine growth retardation (IUGR), hyperglycemia, glycosuria, osmotic polyuria, severe dehydration, and failure [dnatesting.uchicago.edu]

Additional laboratory findings may include glycosuria and marked serum hyperosmolarity. [merckmanuals.com]

Retinohepatoendocrinologic Syndrome

Renal dysplasia limb defects Renal dysplasia megalocystis sirenomelia Renal dysplasia mesomelia radiohumeral fusion Renal failure Renal genital middle ear anomalies Renal glycosuria [fact-index.com]

[…] dysplasia limb defects * Renal dysplasia megalocystis sirenomelia * Renal dysplasia mesomelia radiohumeral fusion * Renal failure * Renal genital middle ear anomalies * Renal glycosuria [en.academic.ru]

Juvenile Cystinosis

However, there was no glycosuria, despite having nephrotic range proteinuria with stage IV CKD. [jcdr.net]

Conclusion Proteinuria and glycosuria could indicate nephropathic juvenile cystinosis. [link.springer.com]

Salient Features 2-6 Three types - Nephropathic (infantile), Juvenile, Occular (non nephropathic) Renal : Fanconi syndrome (renal tubule dysfunction - glycosuria, aminoaciduria [genetics4medics.com]

Non-Allergic Interstitial Nephritis

Galloway Mowat syndrome Giant Cell (Temporal) Arteritis with Kidney Involvement Gestational Hypertension Gitelman Syndrome Glomerular Diseases Glomerular Tubular Reflux Glycosuria [thekaiganfoundation.com]

In mild cases, the clinical presentation may consist of subtle tubular function abnormalities, such as Fanconi syndrome (ie, aminoaciduria, glycosuria, renal tubular acidosis [emedicine.medscape.com]

Arthrogryposis - Renal Dysfunction - Cholestasis Syndrome

Renal tubular dysfunction ranges from isolated renal tubular acidosis to complete Fanconi syndrome (polyuria, aminoaciduria, glycosuria, phosphaturia and bicarbonate wasting [rarediseases.info.nih.gov]

Urine analysis revealed 6 cases(85 $%$ ) with proteinuria, 3(43 $%$ ) with hematuria, 5(71 $%$ ) with glycosuria, 2(29 $%$ ) with phosphaturia and 2(29 $%$ ) with calciuria [chikd.org]

Urine analysis revealed 6 cases(85%) with proteinuria, 3(43%) with hematuria, 5(71%) with glycosuria, 2(29%) with phosphaturia and 2(29%) with calciuria. [ir.ymlib.yonsei.ac.kr]

Hyperdibasic Aminoaciduria Type 1

4 / Hereditary elliptocytosis 4 ) · SLC4A11 ( Congenital endothelial dystrophy type 2, Fuchs' dystrophy 4 ) · SLC5A1 ( Glucose-galactose malabsorption ) · SLC5A2 ( Renal glycosuria [dictionary.sensagent.com]

The syndrome comprises hepatic glycogenosis with glycosuria and aminoaciduria. [gut.bmj.com]

Three homozygous mutations in the GLUT-2 gene have been reported. 20 The different phenotypes under the general term of renal glycosuria may involve genetic alteration of [gut.bmj.com]

Disorder of Sulfur-Bearing Amino Acid Metabolism

Includes: Essential pentosuria, Oxalosis, Oxaluria, Renal glycosuria E74.9 Disorder of carbohydrate metabolism, unspecified E75 Disorders of sphingolipid metabolism and other [emprocell.com]

[…] of pyruvate carboxylase Deficiency of pyruvate dehydrogenase ( E74.8 ) Other specified disorders of carbohydrate metabolism Essential pentosuria Oxalosis Oxaluria Renal glycosuria [wikidoc.org]

[…] of pyruvate carboxylase Deficiency of pyruvate dehydrogenase ( E 74.8) Other specified disorders of carbohydrate metabolism Essential pentosuria Oxalosis Oxaluria Renal glycosuria [bionity.com]

Alcoholic Ketoacidosis

On admission, blood glucose level was normal or moderately elevated, glycosuria was absent or trivial, and alcohol had disappeared from blood, but ketoacidosis was sometimes [dx.doi.org]

The dissociation of severe ketosis from glycosuria and hyperglycemia in these patients raises important questions concerning coupling of ketogenesis to gluconeogenesis. [diabetes.diabetesjournals.org]

Disorder of Carbohydrate Metabolism

probably as a result of intracellular accumulation of fructose-l-phosphate. 13 Case Histories Case 1 A 26-year-old patient expecting her second child was found to have glycosuria [slideplayer.com]

Deficiency of pyruvate carboxylase Deficiency of pyruvate dehydrogenase E74.8 Other specified disorders of carbohydrate metabolism Inclusion term(s): Essential pentosuria Renal glycosuria [icd10coded.com]

This is Alimentary Glycosuria. ¨ Observed in some normal people and patients of hepatic disease and hyperthyroidism 17. ¨ For GTT in children -> oral glucose is given on the [slideshare.net]

Orthostatic Proteinuria

[…] varicocele, dyspareunia, dysmenorrhoea and fatigue. [ 3 ] Investigations Urinalysis: initial check for possible urinary tract infection (urinary nitrite, leukocytes), diabetes (glycosuria [patient.info]

R80.1 Persistent proteinuria, unspecified R80.2 Orthostatic proteinuria, unspecified R80.3 Bence Jones proteinuria R80.8 Other proteinuria R80.9 Proteinuria, unspecified R81 Glycosuria [icd10data.com]