Gowers Sign: Causes & Reasons

Possible Causes for Gowers Sign

She exhibited Gowers' sign, calf muscle hypertrophy, and a high serum creatine kinase level at 2 years. [ncbi.nlm.nih.gov]

A physical examination revealed proximal muscle weakness, calf hypertrophy, deep tendon hyporflexia and a positive Gower's sign. [ncbi.nlm.nih.gov]

Common questions our doctors are asked What is Gower's sign? [rch.org.au]

Muscular Dystrophy

The condition progresses rapidly and the child develops a waddling gait and a positive Gower's sign. [orpha.net]

’ sign, abnormal gait, muscle pains, calf hypertrophy, unexplained elevated liver enzymes, learning difficulties, behavioural problems, or speech and language delay Test for [bmj.com]

In Duchenne muscular dystrophy, young boys start walking very late and have difficulties arising from the floor (Gowers sign, using their hands to push on their legs to get [jamanetwork.com]

Limb-Girdle Muscular Dystrophy Type 2C

Mild to moderate elevated serum creatine kinase levels and positive Gowers sign are reported. [orpha.net]

Image : “Gower’s sign.” by William Richard Gowers (1845–1915) – Gowers WR. Clinical lecture on pseudohypertrophic muscular paralysis. Lancet 1879;ii,73-5. [lecturio.com]

They are usually unable to stand without using their own body to steady themselves and, as such, present with Gower’s sign (where patients use their own hands to push off [lecturio.com]

Limb-Girdle Muscular Dystrophy Type 1E

Image : “Gower’s sign.” by William Richard Gowers (1845–1915) – Gowers WR. Clinical lecture on pseudohypertrophic muscular paralysis. Lancet 1879;ii,73-5. [lecturio.com]

Gower’s sign was positive. Winging of scapula was present. [jcdr.net]

In his adolescence, he developed proximal leg weakness with Gowers’ sign (i.e., with hip girdle weakness, the patient arises from a stooped or a squatting position by using [bmcresnotes.biomedcentral.com]

Muscular Dystrophy-Dystroglycanopathy Type C3

Mild to moderate elevated serum creatine kinase levels and positive Gowers sign are reported. [orpha.net]

Image : “Gower’s sign.” by William Richard Gowers (1845–1915) – Gowers WR. Clinical lecture on pseudohypertrophic muscular paralysis. Lancet 1879;ii,73-5. [lecturio.com]

Is there a finding (or history) of Gower's sign? [patient.info]

Becker Muscular Dystrophy

From age 27 years, he developed proximal muscle weakness predominantly of the lower limbs, a positive Gower sign, and a waddling gait. [ncbi.nlm.nih.gov]

The doctor will check for the Gower sign. [aapmr.org]

sign Contractures Especially ankles; Also hips & knees Treatment Non-surgical Night splints on ankles: More effective than passive stretch 3 Surgical Contracture release [neuromuscular.wustl.edu]

Muscular Dystrophy-Dystroglycanopathy Type C9

Image : “Gower’s sign.” by William Richard Gowers (1845–1915) – Gowers WR. Clinical lecture on pseudohypertrophic muscular paralysis. Lancet 1879;ii,73-5. [lecturio.com]

sign 0003391 Left ventricular systolic dysfunction 0025169 Long face Elongation of face Increased height of face Increased length of face Vertical elongation of face Vertical [rarediseases.info.nih.gov]

Is there a finding (or history) of Gower's sign? [patient.info]

Limb-Girdle Muscular Dystrophy Type 2Q

Image : “Gower’s sign.” by William Richard Gowers (1845–1915) – Gowers WR. Clinical lecture on pseudohypertrophic muscular paralysis. Lancet 1879;ii,73-5. [lecturio.com]

Is there a finding (or history) of Gower's sign? [patient.info]

Muscular Dystrophy-Dystroglycanopathy Type C4

sign 0003391 Increased variability in muscle fiber diameter 0003557 Myopathic facies 0002058 Myopathy Muscle tissue disease 0003198 Pelvic girdle muscle weakness 0003749 [rarediseases.info.nih.gov]

Is there a finding (or history) of Gower's sign? [patient.info]

CPK Increased creatine kinase Increased creatine phosphokinase Increased serum CK Increased serum creatine kinase Increased serum creatine phosphokinase [ more ] 0003236 Gowers [rarediseases.info.nih.gov]

Autosomal Recessive Centronuclear Myopathy

He had symmetric scapular winging, Gowers' sign, hyperlordosis, and waddling gait. [neurology.org]

[…] muscle wasting Generalized muscle degeneration Muscle atrophy, generalized [ more ] 0003700 Generalized hypotonia Decreased muscle tone Low muscle tone [ more ] 0001290 Gowers [rarediseases.info.nih.gov]

sign 0003391 High palate Elevated palate Increased palatal height [ more ] 0000218 Motor delay 0001270 Progressive muscle weakness 0003323 Respiratory insufficiency Respiratory [rarediseases.info.nih.gov]

Jankovic Rivera Syndrome

ID: 3391 Name: Gowers sign Synonym: Gower sign; Positive Gower sign; Positive Gowers sign Definition: A phenomenon whereby patients are not able to stand up without the use [mseqdr.org]

sign Muscular atrophy Progressive distal muscular atrophy Proximal muscle weakness Scoliosis Spinal muscular atrophy Abnormality of the nervous system Areflexia Degeneration [ncbi.nlm.nih.gov]

HP:0003391 Gowers sign 0 BIN1 CL E G H 274 1052 OMIM:255200 Myopathy, centronuclear, 2. 99 HP:0003391 HP:0003391 Gowers sign 0 CFL2 CL E G H 1073 1875 OMIM:610687 Nemaline [mseqdr.org]

Autosomal Dominant Progressive External Ophthalmoplegia Type 6

Gowers sign MedGen UID: 108389 • Concept ID: C0575071 • Finding A phenomenon whereby patients are not able to stand up without the use of the hands owing to weakness of the [ncbi.nlm.nih.gov]

sign Muscle cramps Cerebellar atrophy Dysphagia Intellectual disability Global developmental delay Infantile onset Gait disturbance Obesity Depressed nasal bridge Areflexia [mendelian.co]

Autosomal dominant inheritance Hyporeflexia Ptosis Hearing impairment Elevated serum creatine phosphokinase Overgrowth Hyperostosis Slow progression Pes cavus Areflexia Gowers [mendelian.co]

Nemaline Myopathy Type 4

Gowers sign MedGen UID: 65865 •Concept ID: C0234182 • Finding A phenomenon whereby patients are not able to stand up without the use of the hands owing to weakness of the [ncbi.nlm.nih.gov]

sign Easy fatigability Toe walking Neurological speech impairment Dilatation Waddling gait Type 1 muscle fiber predominance Generalized muscle weakness Abnormality of the [mendelian.co]

Fifty percent of individuals in the study were unable to rise from the floor; 16% could rise with assistance; 16% had a classic Gowers sign; 14% had a modified Gowers sign [n.neurology.org]

Pompe Disease

The patient presented unmistakable signs of muscular atrophy in the upper and lower limbs, as well as positive Gowers' sign. Levels of creatinkinase in serum were high. [ncbi.nlm.nih.gov]

sign Joint contractures Cardiac hypertrophy (childhood onset) The current worldwide prevalence of Pompe disease is estimated at 1 in 5,000 to 10,000 people 4, 5. [centogene.com]

[…] first year of life and is predominantly characterized by the following 1 : Progressive muscular weakness and motor delays Pseudohypertrophy of the calf muscles and positive Gower [centogene.com]

Muscular Dystrophy-Dystroglycanopathy Type C12

The older sister, aged 25 years, had proximal weakness, calf pseudohypertrophy, hyporeflexia, mild facial weakness, and Gowers sign. [findzebra.com]

sign Skeletal muscle atrophy Difficulty walking Sprengel anomaly Intellectual disability Back pain Myotonia Atrioventricular block Arrhythmia Lipodystrophy Myalgia Dyspnea [mendelian.co]

Symptoms INHERITANCE: Autosomal recessive MUSCLE, SOFT TISSUE: Muscular dystrophy; Neonatal hypotonia; Muscle weakness, proximal; Gower sign; Difficulty climbing stairs; Calf [findzebra.com]

Thymidine Kinase 2 Deficiency

Typically, progressive proximal limb myopathy with Gowers signs, dropped head, and myopathic histological changes are seen. [ncbi.nlm.nih.gov]

Neurologic examination revealed weakness of the neck flexors and proximal 4 limbs, positive Gower sign, generalized hyporeflexia, and symmetrical wasting of the bilateral [ncbi.nlm.nih.gov]

All patients fulfilled criteria for childhood limb myopathy with proximal weakness, Gower signs and myopathic histological changes, but some also manifested facial diplegia [ncbi.nlm.nih.gov]

Erb Muscular Dystrophy

Contractures Tachypnea and shortness of breath Assessment-Duchenne and Becker's types Wide stance and waddling gait Gowers' sign when rising from a sitting or supine position [quizlet.com]

Physical examination shows a positive Gower sign and scoliosis. Laboratory tests show elevated serum creatine phosphokinase. [orthobullets.com]

sign Contractures Especially ankles; Also hips & knees Treatment Non-surgical Night splints on ankles: More effective than passive stretch 3 Surgical Contracture release [neuromuscular.wustl.edu]

Scapuloperoneal Spinal Muscular Atrophy

Abstract German English Ionenkanalerkrankungen des peripheren Nervensystems können sich primär als Syndrome mit veränderter Schmerzwahrnehmung oder als periphere Neuropathien manifestieren. Von besonderem Interesse sind die Erkrankungen, die durch Mutationen im SCN9A -Gen verursacht werden, das für den[…] [infona.pl]

Muscular Dystrophy-Dystroglycanopathy Type C14

Image : “Gower’s sign.” by William Richard Gowers (1845–1915) – Gowers WR. Clinical lecture on pseudohypertrophic muscular paralysis. Lancet 1879;ii,73-5. [lecturio.com]

sign 0003391 Hyperlordosis Prominent swayback 0003307 Limited shoulder movement 0006467 Muscular dystrophy 0003560 Scapular winging Winged shoulder blade 0003691 Toe walking [rarediseases.info.nih.gov]

Limb-Girdle Muscular Dystrophy Type 2A

At presentation, waddling gait, positive Gowers' sign, and marked muscle atrophy in pelvic and leg muscles were noted. [ncbi.nlm.nih.gov]

Is there a finding (or history) of Gower's sign? [patient.info]

Limb-Girdle Muscular Dystrophy Type 1G

Mild to moderate elevated serum creatine kinase levels and positive Gowers sign are reported. [orpha.net]

Frequent falls Fatty replacement of skeletal muscle Increased endomysial connective tissue Hyporeflexia Milia Progressive Waddling gait Myofibrillar myopathy Facial palsy Gowers [mendelian.co]

sign Centrally nucleated skeletal muscle fibers Pain Foot dorsiflexor weakness Flexion contracture of finger Inability to walk Respiratory failure Internally nucleated skeletal [mendelian.co]

Limb-Girdle Muscular Dystrophy Type 2J

Image : “Gower’s sign.” by William Richard Gowers (1845–1915) – Gowers WR. Clinical lecture on pseudohypertrophic muscular paralysis. Lancet 1879;ii,73-5. [lecturio.com]

Limb-Girdle Muscular Dystrophy Type 2E

Image : “Gower’s sign.” by William Richard Gowers (1845–1915) – Gowers WR. Clinical lecture on pseudohypertrophic muscular paralysis. Lancet 1879;ii,73-5. [lecturio.com]

sign 0003391 Increased variability in muscle fiber diameter 0003557 Myopathic facies 0002058 Myopathy Muscle tissue disease 0003198 Pelvic girdle muscle weakness 0003749 [rarediseases.info.nih.gov]

Is there a finding (or history) of Gower's sign? [patient.info]

Rigid Spine Syndrome

Gowers’ sign was negative in all 10 of these children. MRI scans of the spine were diagnostic in cases of primary RSS. [ncbi.nlm.nih.gov]

sign 0003391 Waddling gait 'Waddling' gait Waddling walk [ more ] 0002515 Percent of people who have these symptoms is not available through HPO Abnormality of the rib cage [rarediseases.info.nih.gov]

The Gower sign was negative in all cases. They could not bend the neck (Figures 1 and 2). [brieflands.com]

Emery-Dreifuss Muscular Dystrophy Type 2

sign. [elsevier.es]

On physical examination, he had waddling gait, Gowers sign, and proximal dominant muscle weakness and atrophy. [mafiadoc.com]

[…] year of life he experienced difficulty maintaining the position of his head due to cervical hyperextension; he displayed toe walking, frequent falls, and showed a positive Gowers [elsevier.es]

Zebra Body Myopathy

sign 60 33 hallmark (90%) Very frequent (99-80%) HP:0003391 15 difficulty climbing stairs 60 33 hallmark (90%) Very frequent (99-80%) HP:0003551 16 distal muscle weakness [malacards.org]

sign 58 30 Hallmark (90%) Very frequent (99-80%) HP:0003391 15 myofibrillar myopathy 58 30 Hallmark (90%) Very frequent (99-80%) HP:0003715 16 torticollis 58 30 Hallmark [malacards.org]

Mild to moderate elevated serum creatine kinase levels and positive Gowers sign are reported. [mendelian.co]

Limb-Girdle Muscular Dystrophy Type 2F

Image : “Gower’s sign.” by William Richard Gowers (1845–1915) – Gowers WR. Clinical lecture on pseudohypertrophic muscular paralysis. Lancet 1879;ii,73-5. [lecturio.com]

Is there a finding (or history) of Gower's sign? [patient.info]

Dystrophinopathies

Duchenne muscular dystrophy clinically manifests in patients aged 3–7 years, with development of lordosis, a waddling gait, and the Gowers sign. [emedicine.medscape.com]

sign Possible toe-walking Can climb stairs Stage 3 – Late ambulatory More difficulty walking Around age 8 years, most patients notice difficulty with ascending stairs, and [emedicine.medscape.com]

[…] flexors, shoulders, and arms Because of proximal lower back and extremity weakness, parents often note that the boy pushes on his knees in order to stand; this is known as the Gowers [emedicine.medscape.com]

Congenital Myasthenic Syndrome 14

April 06, 2015 ; 84 (14 Supplement) April 21, 2015 Jorge Bevilacqua, Marian Lara, Jorge Díaz, Ricardo Maselli First published April 8, 2015, Abstract OBJECTIVE: To describe the clinical features, the genetic findings and the underlying pathophysiology of a congenital myasthenic syndrome (CMS) in a Chilean family.[…] [neurology.org]

3-Methylglutaconic Aciduria Type 5

sign Skeletal myopathy Abnormality of the nervous system Gait disturbance Global developmental delay Motor delay Abnormality of the respiratory system Recurrent bronchitis [ncbi.nlm.nih.gov]

[…] neutropenia Granulocytopenia Neutropenia Recurrent infections in infancy and early childhood Abnormality of the integument Fair hair Abnormality of the musculoskeletal system Gowers [ncbi.nlm.nih.gov]