It has a gradual progression and most patients require a wheelchair by the third or fourth decade of life.
[cags.org.ae]
Most patients present in childhood, progress gradually, and are confined to wheelchairs 10-20 years after onset [ 4 ].
[omicsonline.org]
Ambulation is maintained for many years and the progress is gradual. A proportion of patients begins with proximal weakness and then goes on to have distal involvement.
[annalsofian.org]
A gradual and progressive increase in the interval between voiding can be achieved by consciously delaying urinating.
[njurology.com]
A complex autosomal recessive form (OMIM:248900) of spastic paraplegia, a neurodegenerative spinal cord disease characterised by a slow, gradual, progressive weakness and
[medical-dictionary.thefreedictionary.com]
progressive weakness and spasticity of the lower limbs.
[sinobiological.com]
[…] of hereditary spastic paraplegia autosomal recessive type 21 (also designated Mast syndrome), an autosomal recessive neurodegenerative disorder characterized by a slow, gradual
[biossusa.com]
Spastic paraplegia is a neurodegenerative disorder characterised by a slow, gradual, progressive weakness and spasticity of the lower limbs [ PMID: 10610178, PMID: 11809724
[ebi.ac.uk]
UniProtKB/Swiss-Prot : 76 Spastic paraplegia 42, autosomal dominant: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive
[malacards.org]
Definition A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
[uniprot.org]
UniProtKB/Swiss-Prot : 75 Spastic paraplegia 53, autosomal recessive: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive
[malacards.org]
progressive weakness and spasticity of the lower limbs.
[ghr.nlm.nih.gov]
Definition A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
[uniprot.org]
UniProtKB/Swiss-Prot : 76 Spastic paraplegia 42, autosomal dominant: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive
[malacards.org]
progressive weakness and spasticity of the lower limbs.
[genecards.org]
A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
[abcam.com]
Disease description A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
[uniprot.org]
UniProtKB/Swiss-Prot : 75 Spastic paraplegia 33, autosomal dominant: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive
[malacards.org]
UniProtKB/Swiss-Prot : 75 Spastic paraplegia 62, autosomal recessive: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive
[malacards.org]
UniProtKB/Swiss-Prot : 76 Spastic paraplegia 42, autosomal dominant: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive
[malacards.org]
Spastic paraplegia 11, autosomal recessive (SPG11) [MIM:604360]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness
[genecards.org]
Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
[abcam.com]
UniProtKB/Swiss-Prot : 75 Spastic paraplegia 56, autosomal recessive: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive
[malacards.org]
A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
[nectarmutation.org]
progressive weakness and spasticity of the lower limbs.
[genecards.org]
Definition A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
[uniprot.org]
progressive weakness and spasticity of the lower limbs; initial symptoms include difficulty with balance, weakness and stiffness in legs, muscle spasms, and dragging of
[medical-dictionary.thefreedictionary.com]
UniProtKB/Swiss-Prot : 76 Spastic paraplegia 12, autosomal dominant: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive
[malacards.org]
Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
[malacards.org]
progressive weakness and spasticity of the lower limbs.
[genecards.org]
[…] association via MalaCards Spastic paraplegia 21, autosomal recessive (SPG21) [MIM:248900]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual
[genecards.org]
Definition A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
[uniprot.org]
progressive weakness and spasticity of the lower limbs.
[ghr.nlm.nih.gov]
[…] association via MalaCards Spastic paraplegia 54, autosomal recessive (SPG54) [MIM:615033]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual
[genecards.org]
Changes may be sudden or gradual and then progress in a stepwise manner. Binswanger's disease can often coexist with Alzheimer's disease.
[alzheimers.emedtv.com]
Prognosis BD is a progressive disease; there is no cure. Changes may be sudden or gradual and then progress in a stepwise manner.
[ninds.nih.gov]
Consequently, the symptoms and signs of this disease develop in a stuttering or stepwise fashion; in contrast to the insidious, gradually progressive course of neurodegenerative
[rarediseases.org]
The age of onset is around 6 years and they may present with gait disturbance which may caused by lower limb dystonia with diurnal variation that may gradually progression
[explainmedicine.com]
Spastic paraplegia 7, autosomal recessive (SPG7) [MIM:607259]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness
[genecards.org]
The phenotype (SPG31) has occasionally been described with peripheral nervous system involvement, in additional to the gradually progressing lower limb spasticity that characterizes
[readbyqxmd.com]
UniProtKB/Swiss-Prot : 76 Spastic paraplegia 56, autosomal recessive: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive
[malacards.org]
Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
[abcam.com]
Spastic paraplegia 8, autosomal dominant (SPG8) [MIM:603563]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness
[genecards.org]
usually autosomal dominant, but also recessive and X-linked, form (OMIM:607259) of spastic paraplegia, a neurodegenerative spinal cord disease characterised by a slow, gradual
[medical-dictionary.thefreedictionary.com]
Spastic paraplegia 7, autosomal recessive (SPG7) [MIM:607259]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness
[genecards.org]
Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
[mybiosource.com]
Definition A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
[uniprot.org]
progressive weakness and spasticity of the lower limbs.
[genecards.org]
Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
[mybiosource.com]
Training frequency and intensity should be gradually progressed with adequate rest between trainings.
[coreconcepts.com.sg]
[…] and progressive stretching of the Achilles tendon Exercises to strengthen and support the ankle Rest or reduced weight bearing activities Immobilisation in a cast for 4-6
[heelandarchpainclinic.com.au]
Gradual progressive stretching of the calf muscle and Achilles tendon is also advocated. Changing the footwear.
[coreconcepts.com.sg]
Then he developed slurring of speech which was gradually progressive. After about 1/12,speech which was gradually progressive.
[slideshare.net]
progression: Stiffness, weakness and spasticity of legs Tripping, difficulty in maintaining balance Weakness and stiffness that progresses towards the trunk and subsequently
[thehumanthebody.com]
Adult-onset, 50 years of age or later No family history of PLS Gradual progression of the disease Duration: 3 years or more.
[physio-pedia.com]
She initially presented to Neurology at the age of 8 with gradually progressive lower extremity weakness.
[ncbi.nlm.nih.gov]
progressive pain and swelling around right shoulder and knee.
[ncbi.nlm.nih.gov]
[…] than 100 cases of synchronous type of MOGS have been reported in the literature till date.[6,8,9] CASE REPORT A 15-year-old male patient presented with 2-month history of gradually
[ncbi.nlm.nih.gov]
- We report the case of a 78-year-old male patient in whom systemic lymphoma associated with inflammation of the cavernous sinus was uncovered by painful, gradually progressing
[infona.pl]
progression of atherosclerosis in relation to age.
[ahajournals.org]
[…] general population.14,15,34 This age-dependent increase in chitotriosidase activity could be explained by the ongoing accumulation of lipid-laden macrophages during the gradual
[ahajournals.org]
The darkening of skin was first noticed over the feet and face at the age of 5 months and gradually progressed to involve the entire body.
[ijdvl.com]
There was a gradual progression of refractive error from the full-term group to the FEVR group.
[nature.com]
In more severe cases the paralysis gradually progresses in a descending order and may affect respiratory muscles leading to mechanical ventilation.
[researchportal.helsinki.fi]
The rate of progression between individuals is variable and the history generally reflects gradual and progressive worsening over time until death occurs.
[mda.org]
Stages of ALS ALS is a relentlessly progressive disorder.
[mda.org]
The early and extensive involvement of the CNS leads to a marked delay in neuropsychomotor development (NPMD), which gradually progresses to generalized hypotonia and seizures
[scielo.br]
The exercises in this phase should begin on a stable surface and gradually progress to unstable surfaces to challenge the neuromuscular control of the knee.
[totum.ca]
It is important that the athlete is progressed gradually during this stage as a lot of rehabilitation programs fail when there is a rapid increase in exercise load.
[totum.ca]
[…] running and agility drills introduced Proper knee alignment and landing technique during hopping activities During Phase 3, the drills become more complex and the player is gradually
[totum.ca]
Background Senile cataract is a vision-impairing disease characterized by gradual, progressive thickening of the lens.
[emedicine.medscape.com]
Practice Essentials Senile cataract is an age-related, vision-impairing disease characterized by gradual progressive clouding and thickening of the lens of the eye.
[emedicine.medscape.com]
Signs and symptoms A patient with senile cataract often presents with a history of gradual progressive visual deterioration and disturbance in night and near vision.
[emedicine.medscape.com]
