Granulomatous Arthritis: Causes & Reasons

Possible Causes for Granulomatous Arthritis

Patients with sporadic early-onset granulomatous arthritis are clinically identical to Blau syndrome, but without the family history. [ncbi.nlm.nih.gov]

arthritis are clinically identical to Blau syndrome, but without the family history. [jrheum.org]

Abstract Blau syndrome (MK186580) comprises granulomatous arthritis, iritis, and skin rash, and is an autosomal-dominant trait with variable expressivity. [ncbi.nlm.nih.gov]

Sarcoidosis

Genetic linkage of familial granulomatous inflammatory arthritis, skin rash, and uveitis to chromosome 16. [ncbi.nlm.nih.gov]

Semin Arthritis Rheum 36(3):159–167 PubMed CrossRef Google Scholar 4. [doi.org]

Although data from noncomparative trials suggest that all three have comparable therapeutic effects in rheumatoid arthritis, their effects in a granulomatous disease such [ncbi.nlm.nih.gov]

Joint Tuberculosis

[…] banal germ, a fungal arthritis, other granulomatous synovitis and pigmented villo-nodular synovitis. [3,7–9]. [elynsgroup.com]

Extension of the TB osteomyelitis into joint spaces results in tuberculous arthritis. The infection crosses to the bone on the other side of the joint. [www0.sun.ac.za]

Delayed diagnosis of tuberculous arthritis. Jpn J Infect Dis. 2005;58(6):373-5. Medline 21. Albornoz MA, Mezgarzedeh M, Neumann CH, Myers AR. [ramb.elsevier.es]

Disseminated Sporotrichosis

Wojno WC. et ai: Sporotrichal arthritis presenting as granulomatous myositis. Arthritis Rheum 1985: 28:1425-1429. 14. [healio.com]

Tompkins RB: Sporotrichosis arthritis: Clinical features in seven patients. Ann Intern Med 1977; 86:294-297. 13. Halverson PB. Lahiri S. [healio.com]

Synovial Sarcoma

Abstract Development of a soft-tissue sarcoma is an infrequent but well-known long-term complication of radiotherapy. Malignant fibrous histiocytomas, extraskeletal osteosarcomas, fibrosarcomas, malignant peripheral nerve sheath tumors, and angiosarcomas are most frequently encountered. Radiation-associated[…] [nature.com]

Mycosis

Indoor mold levels typically increase after natural disasters, flooding, and water damage. Eurotium herbariorum is the sexual stage of Aspergillus glaucus. Case Presentation A 66-year-old, Japanese male, ex-smoker had been diagnosed with bronchial asthma when he was five years old; he achieved remission at the age[…] [ncbi.nlm.nih.gov]

Mycobacterial Infection

The need for isolation of nontuberculous mycobacteria (NTM) from clinical specimens has increased in recent years. Our aim was to determine the clinical usefulness of PCR for differential diagnosis of tuberculosis and nontuberculous mycobacterial infection in lung tissue that show chronic granulomatous inflammation.[…] [ncbi.nlm.nih.gov]

Atypical Mycobacteria

Abstract One hundred non-BCG vaccinated Danish school children aged 7.3-14.9 yrs (median 12.8 yrs) were studied with regard to the size of skin induration 72 hrs following intracutaneous injections of 1 unit of tuberculin PPD and 0.1 microgram of four different sensitins produced from M. chelonae subsp. abscessus.[…] [ncbi.nlm.nih.gov]

Granulomatous Iritis

[…] inflammatory arthritis, dermatitis, and uveitis Granulomatous synovitis-uveitis syndrome PGA Pediatric granulomatous arthritis Prevalence: - Inheritance: - Age of onset: [orpha.net]

Drugs (1999) [ Pubmed ] Autosomal dominant granulomatous arthritis, uveitis, skin rash, and synovial cysts. [wikigenes.org]

[…] syndrome, characterized by granulomatous uveitis, arthritis, and rash. [the-rheumatologist.org]

Sporotrichosis

Definition (MSH) The commonest and least serious of the deep mycoses, characterized by nodular lesions of the cutaneous and subcutaneous tissues. It is caused by inhalation of contaminated dust or by infection of a wound. Concepts Disease or Syndrome ( T047 ) MSH D013174 ICD9 117.1 ICD10 B42, B42.9 SnomedCT[…] [fpnotebook.com]

Mycobacterium Kansasii

V. Pintado E. Gómez-Mampaso P. Martín-Dávila J. Cobo E. Navas C. Quereda J. Fortún A. Guerrero Note 42 Downloads 13 Citations Abstract To investigate the clinical and radiographic features and the response to therapy of Mycobacterium kansasii infection in human immunodeficiency virus-infected patients, the clinical[…] [link.springer.com]

Fungal Arthritis

Black yeasts including Exophiala species are increasingly recognized as agents of human disease. In recent years, progress in molecular phylogeny and taxonomy of the genus Exophiala has led to the description of numerous novel species. The 'classical' but highly variable species Exophiala jeanselmei was split into a[…] [ncbi.nlm.nih.gov]

Early-Onset Sarcoidosis

A syndrome of granulomatous arthritis-uveitis-rash has been described in children. [ncbi.nlm.nih.gov]

Blau syndrome/early-onset sarcoidosis (Blau/EOS) is an autoinflammatory disease characterized by granulomatous arthritis, uveitis, and skin rash. [ncbi.nlm.nih.gov]

Ting SS, Ziegler J, Fischer E (1998) Familial granulomatous arthritis (Blau syndrome) with granulomatous renal lesions. [link.springer.com]

Fibroblastic Rheumatism

Palisaded neutrophilic granulomatous dermatitis in rheumatoid arthritis. J Am Acad Dermatol 2002; 47:251–257. [link.springer.com]

Interstitial granulomatous dermatitis with plaques and arthritis. Eur J Dermatol 2003; 13:308–310. PubMed Google Scholar Tomasini C, Pippione M. [link.springer.com]

Interstitial granulomatous dermatitis with cutaneous cords and arthritis: a disorder associated with autoantibodies. J Am Acad Dermatol 2001; 45:286–291. [link.springer.com]

Idiopathic Erythema Nodosum

Coincidence of granulomatous mastitis, EN and arthritis is a rare feature. [scinapse.io]

[…] with erythema nodosum (EN) and ankle arthritis. [scinapse.io]

Objective: To analyze the history of relapses in idiopathic granulomatous mastitis (IGM) and to define an appropriate therapeutic strategy. [scinapse.io]

Yao Syndrome

Familial granulomatous arthritis, iritis, and rash. J Pediatr 1985;107:689–693. Crossref, Medline, Google Scholar 15. James DG. [atsjournals.org]

arthritis PLCG2 PLC-gamma2 associated antibody deficiency and immune dysregulation (PLAID) Proteasome-associated autoinflammatory syndrome (PRASS) PSMB8 PSTPIP1 (CD2BP1) [mayocliniclabs.com]

The chronic granulomatous arthritis is almost always polyarticular, presenting as minimally symptomatic swelling involving the wrists, ankles, and knees. [musculoskeletalkey.com]

Granulomatous Mastitis

Coincidence of granulomatous mastitis, EN and arthritis is a rare feature. [ncbi.nlm.nih.gov]

Fine needle aspiration cytology led to a diagnosis of granulomatous mastitis. Oral prednisolone rapidly improved the arthritis and the erythema nodosum. [ncbi.nlm.nih.gov]

Full Text Authors +Show Affiliations, Department of General Medicine, Muslim Educational Society Medical College, Malappuram. jemshadalungal@gmail.com., Source MeSH Adult Arthritis [unboundmedicine.com]

Ocular Sarcoidosis

Autosomal, dominantly inherited Blau syndrome (familial granulomatous inflammatory arthritis, uveitis and rash, and camptodactylia) is characterised by multiorgan inflammation [bjo.bmj.com]

Pediatric granulomatous arthritis: an international registry. Arthritis Rheum. 2006;54(10):3337–3344. [PubMed] [Google Scholar] 9. [ncbi.nlm.nih.gov]

[…] involvement in children with onset of sarcoidosis at a very early age.37 Childhood sarcoidosis might be misdiagnosed because of its rarity and resemblance to juvenile chronic arthritis [bjo.bmj.com]

Granulomatous Lung Disease

OBJECTIVE: To describe cases of development of pulmonary nodulosis or aseptic granulomatous lung disease in patients with rheumatoid arthritis (RA) receiving anti-tumor necrosis [ncbi.nlm.nih.gov]

Strawberry gingivitis, mouth ulcers, purpura and arthritis may also appear due to granulomatous lung disease. [ic.steadyhealth.com]

[…] disease 2 hypersensitivity pneumonitis hot tub lung bronchocentric granulomatosis pulmonary manifestations of rheumatoid arthritis rheumatoid lung nodules granulomatosis [radiopaedia.org]

Ansell-Bywaters-Elderking Syndrome

pyoderma gangrenosum, and acne syndrome; PGA, pediatric granulomatous arthritis encompasses the familial Blau syndrome and the sporadic early-onset sarcoidosis (MIM 609464 [jacionline.org]

NOD2 gene-associated pediatric granulomatous arthritis: clinical diversity, novel and recurrent mutations, and evidence of clinical improvement with interleukin-1 blockade [jacionline.org]

[…] cryopyrin-associated periodic syndromes (CAPS), and its structurally related cousin NOD2 (C-terminal caspase recruitment domain 15), which is mutated in patients with pediatric granulomatous [jacionline.org]

Autoinflammatory Syndrome

[…] disorders Blau’s syndrome CARD15/NOD2 16q12 CARD15 AD Early onset (< 5 years) Polyarticular granulomatous arthritis, uveitis, skin rash Good response to anti-TNF monoclonal [printo.it]

Inflammatory Arthritis, Dermatitis, And Uveitis, Familial|Granulomatosis, Familial, Blau Type BLAUS ACUG 186580 Genetic Test Registry CINCA Syndrome CINCA 607115 Genetic [ukgtn.nhs.uk]

pyoderma gangrenosum and acne syndrome, deficiency of interleukin 36 receptor antagonist, pediatric granulomatous arthritis, congenital neutropenia and cyclic neutropenia [blueprintgenetics.com]

Posterior Scleritis

[…] sometimes with more rare but life-threatening conditions such as systemic lupus erythematous and granulomatous polyangiitis. [reviewofophthalmology.com]

A thorough review of systems is crucial in the evaluation of these patients, with a particular focus on systemic signs of rheumatoid arthritis such as joint pain, sinus issues [reviewofophthalmology.com]

[…] women.1 Posterior scleritis represents approximately 10 percent of all cases of scleritis, half of which can be associated with systemic disease—most commonly rheumatoid arthritis—but [reviewofophthalmology.com]

Sterile Multifocal Osteomyelitis with Periostitis and Pustulosis

[…] disorders Blau’s syndrome CARD15/NOD2 16q12 CARD15 AD Early onset (< 5 years) Polyarticular granulomatous arthritis, uveitis, skin rash Good response to anti-TNF monoclonal [printo.it]

Inflammatory Arthritis, Dermatitis, And Uveitis, Familial|Granulomatosis, Familial, Blau Type BLAUS ACUG 186580 Genetic Test Registry CINCA Syndrome CINCA 607115 Genetic [ukgtn.nhs.uk]

[…] meningitis and bone deformities Good response to IL-1 blockade NLRP12-associated Periodic Fever NALP12 / NLRP12 19p13 NLRP 12 AD Periodic fever after cold exposure, hearing loss Granulomatous [printo.it]

Carcinomatous Polyarthritis

Gaucher’s disease Giant cell arteritis Gonococcal arthritis Goodpasture’s syndrome Gout Granulomatous arteritis Haemochromatosis Hemarthrosis Hemochromatosis Henoch-Schonlein [buyprovailencheap.org]

Gaucher's disease Giant cell arteritis Gonococcal arthritis Goodpasture's syndrome Gout Granulomatous arteritis Hemarthrosis Hemochromatosis Henoch-Schonlein purpura Hepatitis [americanimagingpr.com]

Gaucher’s disease Giant cell arteritis Gonococcal arthritis Goodpasture’s syndrome Gout Granulomatous arteritis Hemarthrosis Hemochromatosis Henoch-Schonlein purpura Hepatitis [healthmattersdirect.com]

Familial Reactive Perforating Collagenosis

Familial granulomatous arthritis, iritis, and rash. J Pediatr intractable leg ulcers. [deepdyve.com]

Granulomatous Myositis

[…] graulomatosis Other idiopathic myositides include: inclusion body myositis granulomatous myositis eosinophilic myositis localized nodular myositis Links: rheumatoid arthritis [gpnotebook.co.uk]

arthritis presenting as granulomatous myositis. ( 4084333 ) Halverson PB...Sulaiman AR 1985 32 Granulomatous myositis in association with Sarcocystis sp. infection in wild [malacards.org]

[…] rheumatologic and dermatologic disorders may also warrant consideration: Raynaud phenomenon Lupus erythematosus (systemic, discoid, subacute cutaneous) Juvenile idiopathic arthritis [emedicine.medscape.com]

Nakajo Syndrome

Pyoderma Gangrenosum and Acne Syndrome (PAPA) Blau Syndrome (NOD2), also known as Pediatric Granulomatous Arthritis (PGA) Chronic Recurrent Multifocal Osteomyelitis (CRMO [saidsupport.org]

Inflammatory Arthritis, Dermatitis, And Uveitis, Familial|Granulomatosis, Familial, Blau Type BLAUS ACUG 186580 Genetic Test Registry CINCA Syndrome CINCA 607115 Genetic [ukgtn.nhs.uk]

pyoderma gangrenosum and acne [PAPA]; Majeed syndrome), diseases with granulomatous lesions (ie, Blau syndrome), diseases with psoriasis (ie, deficiency of interleukin 36 [logan.testcatalog.org]

Septic Arthritis

Chronic granulomatous monarticular arthritis may occur because of infection with either mycobacteria or fungi, which must be differentiated from other causes of chronic monarticular [ncbi.nlm.nih.gov]

The patient's history and clinical course often provide clues to distinguish between gonococcal, nongonococcal, and granulomatous arthritis. [doi.org]

However, nonbacterial inflammatory processes, such as acute crystalline joint disease or reactive arthritis, may have counts above this level while gonococcal and granulomatous [doi.org]

Transient Sarcoidosis

Six months or more after the diagnosis of sarcoid, up to 40% of patients may develop joint symptoms due to granulomatous arthritis. [en.wikibooks.org]

[…] hepatitis when sarcoidosis affects the liver only Joint 25–50% Ankle, knee, wrist, and elbow arthritis (most common) May cause chronic arthritis with Jaccoud deformities [merckmanuals.com]

The granulomatous synovitis usually follows a chronic transient or relapsing course which may eventually lead to irreversible joint damage. [en.wikibooks.org]

Granulomatous Hepatitis

We describe a patient with rheumatoid arthritis who developed granulomatous hepatitis after taking etanercept. [ncbi.nlm.nih.gov]

A Owen, Eric M Yoshida and Graham D Reid The Journal of Rheumatology February 2008, 35 (2) 349-351; Abstract Etanercept has recently been implicated in the induction of granulomatous [jrheum.org]

Etanercept has recently been implicated in the induction of granulomatous reactions. [ncbi.nlm.nih.gov]