Growth Failure: Causes & Reasons

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Possible Causes for Growth Failure

Malpuech Syndrome

Characterized by growth failure, craniofacial deformities, hydrocephalus, mental retardation, and skeletal defects. [accessanesthesiology.mhmedical.com]

failure, lip/palate cleft(s), and urogenital anomalies. [link.springer.com]

Malpuech Syndrome : Malformative syndrome characterized by hypertelorism, facial clefting, urogenital abnormalities, severe growth failure, and mental retardation. [accessanesthesiology.mhmedical.com]

Sanjad-Sakati Syndrome

A new syndrome of congenital hypoparathyroidism, severe growth failure, and dysmorphic features. [doi.org]

Signs and symptoms SSS is a relatively severe disorder that causes seizures, growth failure, failure to thrive, and intellectual disabilities. [forgottendiseases.org]

We believe that this association of congenital hypoparathyroidism with severe growth failure and dysmorphism represents a new syndrome. [doi.org]

Cockayne Syndrome

The frame shift mutation of ERCC6 found in this patient is a novel one, which caused postnatal growth failure and early death. [ncbi.nlm.nih.gov]

The patient was diagnosed with Cockayne syndrome in the pediatrics clinic for growth failure and developmental delay. [ncbi.nlm.nih.gov]

Failure to thrive and neurological disorders are criteria for diagnosis, while photosensitivity, hearing loss, eye abnormalities, and cavities are other very common features [snpedia.com]

Donohue Syndrome

Although some patients survived for several years, most die of severe failure to thrive with recurrent infections in the first year of life. [accessanesthesiology.mhmedical.com]

Both patients shared the same mutation and presented with intra-uterine growth restriction, failure to thrive, fasting hyperinsulinaemic hypoglycaemia and episodic post-prandial [ncbi.nlm.nih.gov]

DS is characterized by pre- and postnatal growth retardation with failure to thrive, lipoatrophy, muscle wasting, acanthosis nigricans, hypertrichosis, and dysmorphic features [ncbi.nlm.nih.gov]

Dubowitz Syndrome

Failure to Thrive : growth failure, or failure to thrive (FTT), is a descriptive term and not a specific diagnosis. [ric.edu]

Analysis of approximately 30 cases reveals prevalence of growth failure and delayed bone age, mild microcephaly, broad forehead with sparse frontal hair, telecanthus, blepharophimosis [ncbi.nlm.nih.gov]

Dubowitz syndrome (DS) (MIM#223370) (4) is a very rare genetic and developmental disorder involving multiple congenital anomalies including: 1) growth failure/short stature [ncbi.nlm.nih.gov]

Glycogen Storage Disease Type 6

Children born with GSD I typically exhibit growth failure, chronic hunger, fatigue, irritability, an enlarged liver, and a swollen abdomen. [liverfoundation.org]

Untreated or inadequately treated patients exhibit muscle weakness and failure to thrive in infancy, whereas older children show poor growth and delayed puberty. [clinicaladvisor.com]

Clinical features : Hepatomegaly, failure to thrive, cirrhosis, splenomegaly, jaundice, hypotonia, waddling gait, lumbar lordosis. [patient.info]

Freeman-Sheldon Syndrome

But swallowing difficulties as well as vomiting can lead to failure to thrive during infancy and in some cases retarded growth can occur. [syndrome.org]

Dysphagia, failure to thrive, growth deficit, and life-threatening respiratory complications (caused by structural anomalies of the oropharynx and upper airways) are frequent [wiki.romse.org]

Growth retardation and failure to thrive are also some of the common features of children with Freeman-Sheldon Syndrome. [epainassist.com]

Coats Plus Syndrome

We describe the phenotype of a patient with severe growth failure where whole exome sequencing (WES) revealed compound heterozygosity for two mutations in the CTC1 gene. [abstracts.eurospe.org]

failure. [research.manchester.ac.uk]

Conclusion: Multiple characteristics (progeroid appearance, cerebral calcifications of the basal ganglia, osteopenia, bone anomalies, fractures, growth failure, anemia) are [abstracts.eurospe.org]

Warburg Micro Syndrome 3

micro cornea, joint contractures, and growth failure) [8], COCKAYNE syndrome (neurodegenerative disorder characterized by low birth weight, growth failure, brain demyelination [juniperpublishers.com]

Mulchandani S, Bhoj EJ, Luo M, Powell-Hamilton N, Jenny K, Gripp KW, et al: Maternal uniparental disomy of chromosome 20: a novel imprinting disorder of growth failure. [karger.com]

Affected infants exhibit growth failure and may have diminished muscle tone (hypotonia) so that they appear floppy. [rarediseases.org]

Chromosome 19q13.11 Deletion Syndrome

[…] retardation and postnatal growth failure. [humpath.com]

It is characterized by sparse, kinky hair; failure to thrive; and progressive deterioration of the nervous system. [checkrare.com]

[…] to thrive Faltering weight Weight faltering [ more ] 0001508 Feeding difficulties Feeding problems Poor feeding [ more ] 0011968 Hypospadias 0000047 Intellectual disability [rarediseases.info.nih.gov]

Oculopalatoskeletal Syndrome

failure, lip/palate cleft(s), and urogenital anomalies. [genome.jp]

A previously undescribed autosomal recessive multiple congenital anomalies/mental retardation (MCA/MR) syndrome with growth failure, lip/palate cleft(s), and urogenital anomalies [nature.com]

"A previously undescribed autosomal recessive multiple congenital anomalies/mental retardation (MCA/MR) syndrome with growth failure, lip/palate cleft(s), and urogenital anomalies [en.wikipedia.org]

Acrocallosal Syndrome

[…] to thrive Faltering weight Weight faltering [ more ] 0001508 Finger syndactyly 0006101 Growth delay Delayed growth Growth deficiency Growth failure Growth retardation Poor [rarediseases.info.nih.gov]

[…] malformation 0001305 Downslanted palpebral fissures Downward slanting of the opening between the eyelids 0000494 Epicanthus Eye folds Prominent eye folds [ more ] 0000286 Failure [rarediseases.info.nih.gov]

Rubinstein-Taybi Syndrome

Growth retardation and postnatal growth failure are present in the majority of patients. [symptoma.com]

[…] retardation characteristic of this syndrome, often result in a clinical picture of failure to thrive. [ispub.com]

[…] to thrive in infancy Faltering weight in infancy Weight faltering in infancy [ more ] 0001531 Feeding difficulties in infancy 0008872 Global developmental delay 0001263 High [rarediseases.info.nih.gov]

Coffin-Siris Syndrome

Clin-Dysmorphol. 2000 Jan; 9(1): 15-9 Kirel,-B; Kural,-N; Yakut,-A; Adapinar,-B Triplets with growth failure, microcephaly, mental retardation, nail hypoplasia and corpus [malattierare.regione.veneto.it]

Turk-J-Pediatr. 2000 Apr-Jun; 42(2): 171-6 Ounap,-K; Justus,-I; Lipping-Sitska,-M Two sisters with growth failure, microcephaly, peculiar facies and apical dystrophy: the [malattierare.regione.veneto.it]

Chromosome 16q22 Deletion Syndrome

Patient 1 was first evaluated at 17 months of age because of a history of intrauterine growth retardation, failure to thrive, developmental delay, and congenital heart defect [ashg.org]

OMIM : 57 The interstitial 16q22 deletion syndrome is a multiple congenital anomaly disorder associated with failure to thrive in infancy, poor growth, delayed psychomotor [malacards.org]

The interstitial 16q22 deletion syndrome is a multiple congenital anomaly disorder associated with failure to thrive in infancy, poor growth, delayed psychomotor development [ncbi.nlm.nih.gov]

Filippi Syndrome

UniProtKB/Swiss-Prot : 72 Filippi syndrome: A rare disorder characterized by microcephaly, pre- and postnatal growth failure, syndactyly, and distinctive facial features, [malacards.org]

Definition A rare disorder characterized by microcephaly, pre- and postnatal growth failure, syndactyly, and distinctive facial features, including a broad nasal bridge and [uniprot.org]

A low birth weight and short stature are common features, and most infants with the syndrome are also diagnosed with failure to thrive. [fdna.health]

Mucopolysaccharidosis Type 7

failure, cloudy corneas, mild coarsening of facial features, hepatomegaly and micrognathism in MPS I H/S. [contempclindent.org]

[…] multiorgan deterioration that includes hepatosplenomegaly, dysostosis multiplex, short stature, coarse facial features, corneal clouding, joint contractures, umbilical hernias, failure [surgicalneurologyint.com]

However, cases of attenuated MPS I show wide variation with respect to age of presentation, symptoms and disease course. [2], [6] The clinical presentation may be limited to growth [contempclindent.org]

Cerebro-Costo-Mandibular Syndrome

Proceedings of the National Academy of Sciences 105 (37), 14046-14051, 2008 123 2008 Maternal uniparental disomy of chromosome 20: a novel imprinting disorder of growth failure [scholar.google.com]

Growth failure leading to short stature is sometimes due to a growth hormone deficiency. [findzebra.com]

[…] to thrive and conductive hearing loss (seen in about 10 % of cases). [3], [9] The developmental anomalies in our case with the estimated percentage of those described in [jpgmonline.com]

Mucopolysaccharidosis

Accumulation of DS in connective tissue causes growth failure, resulting in short stature. [ncbi.nlm.nih.gov]

Manifestations of abnormal cell function include syndromic intellectual disability, growth failure, and skeletal dysplasia. [emedicine.medscape.com]

Our lab has shown that a defining feature of spine disease in across multiple types of MPS is the failure of vertebral bones to calcify normally during growth. [mpssociety.org]

CHARGE Syndrome

In this report, we describe a patient with a typical phenotype characterized by psychomotor retardation, hypertrichosis, facial asymmetry, synophria, failure to thrive, developmental [ncbi.nlm.nih.gov]

[…] restriction occurred in 38 of 51 patients or 75% of those studied. 8, 13 Growth failure may be a primary feature of CHARGE syndrome of unknown etiology, 21 or it may be caused [nursingcenter.com]

Failure to thrive is often related to the severe sucking/swallowing problems. [orpha.net]

Carnevale Krajewska Fischetto Syndrome

failure, lip/palate cleft(s), and urogenital anomalies. [genome.jp]

Malpuech G, Demeocq F, Palcoux JB, Vanlieferinghen P タイトル A previously undescribed autosomal recessive multiple congenital anomalies/mental retardation (MCA/MR) syndrome with growth [genome.jp]

A previously undescribed autosomal recessive multiple congenital anomalies/mental retardation (MCA/MR) syndrome with growth failure, lip/palate cleft(s), and urogenital anomalies [journals.sagepub.com]

IMAGE Syndrome

Other syndrome we must think foetal alcohol syndrome [FAS] [ 17, 18 ] usually have intrauterine growth retardation, microcephaly, failure to thrive, and often triangular faces [omicsonline.org]

A few individuals do not have adrenal crisis, but rather milder adrenal insufficiency, presenting with failure to thrive and recurrent vomiting. [ncbi.nlm.nih.gov]

Slow weight gain, especially during the first several years of life, is also a common problem and many children are diagnosed as "failure to thrive". [williams-syndrome.org]

Congenital Bile Acid Synthesis Defect Type 2

Affected infants show failure to thrive and secondary coagulopathy. [malacards.org]

failure (panhypopituitarism) (see these terms). [rarediseases.info.nih.gov]

failure. [malacards.org]

Component Complement 5 Deficiency

[…] to thrive, anemia and recurring local and systemic infections. [checkorphan.org]

[…] to thrive. [malacards.org]

From Wikidata Jump to navigation Jump to search disease Erythroderma desquamativum Generalized erythroderma, diarrhea, and failure to thrive Erythroderma desquamativa of Leiner [wikidata.org]

Childhood Celiac Disease

Results indicate that significant reduction in IGF-I levels in CCD patients occurs only after prolonged gluten exposure but before growth failure. [ncbi.nlm.nih.gov]

Underlying celiac disease should be considered in children with persistent pica and growth failure even if gastrointestinal disturbances are minimal. [hero.epa.gov]

Babies with failure to thrive may have a weight that is lower than the 3rd percentile of standard growth charts or 20% below the ideal weight for their height, and they may [verywellhealth.com]

Anophthalmia or Microphthalmia - Esophageal Atresia Syndrome

Several other associated anomalies have been described including developmental anomalies of the central nervous system, cardiac defects, vertebral anomalies, growth failure [orpha.net]

[…] delay Delayed growth Growth deficiency Growth failure Growth retardation Poor growth Retarded growth [ more ] 0001510 Hemivertebrae Missing part of vertebrae 0002937 Holoprosencephaly [rarediseases.info.nih.gov]

[…] to thrive / difficulties for feeding in infancy / growth delay - Holoprosencephaly / arhinencephaly / unique lateral ventricle - Hydrocephaly - Hypospadias / epispadias / [csbg.cnb.csic.es]

Genee-Wiedemann Syndrome

[…] delay Delayed growth Growth deficiency Growth failure Growth retardation Poor growth Retarded growth [ more ] 0001510 Low-set ears Low set ears Lowset ears [ more ] 0000369 [rarediseases.info.nih.gov]

[…] to thrive, vomiting, dehydration, and nephrocalcinosis. [kegg.jp]

0001374 Conical tooth Cone shaped tooth Shark tooth [ more ] 0000698 Cryptorchidism Undescended testes Undescended testis [ more ] 0000028 Ectropion Eyelid turned out 0000656 Growth [rarediseases.info.nih.gov]

Short Stature - Optic Atrophy - Pelger-Huët Anomaly Syndrome

[…] population isolate that is located in the northeastern part of Siberia, Maksimova et al. (2010) ascertained a short stature syndrome involving autosomal recessive postnatal growth [malacards.org]

The key triad of clinical findings includes postnatal growth failure, optic nerve atrophy with decreased visual acuity, and Pelger-Huët anomaly (underlobulated neutrophil [epostersonline.com]

Clinical features include anemia, renal tubulopathy, developmental delay, seizures, failure to thrive, and liver steatosis and fibrosis. {ECO:0000269 PubMed:26073778}. [genecards.org]

Fanconi-Bickel Syndrome

Untreated patients usually complain of growth failure, osteoporosis, rickets, nephrolithiasis and eventually renal insufficiency. [scinapse.io]

[…] liver = glycogen accumulates patient presents with hypoglycemia, hyperlipidemia, enlarged liver and kidney, and growth failure. what is the diagnosis and cause? [quizlet.com]

Clinical description Onset occurs during the first few months of life with failure to thrive, polyuria and rickets related to proximal tubular losses. [orpha.net]

Renal Tubular Acidosis

Mental retardation, growth failure, complications of osteopetrosis and other features were all recorded in this syndrome. [ncbi.nlm.nih.gov]

failure and, if left untreated, complicated by osteomalacia with pathologic fractures, hypokalemic muscle weakness and periodic paralysis, nephrocalcinosis leading to renal [ncbi.nlm.nih.gov]

[…] alkalinization with sodium bicarbonate and sodium citrate suggest the plausible speculation that Tiny Tim had renal tubular acidosis (type I), a disorder that is characterized by growth [ncbi.nlm.nih.gov]