Growth Failure: Causes & Reasons

Possible Causes for Growth Failure

A new syndrome of congenital hypoparathyroidism, severe growth failure, and dysmorphic features. [doi.org]

He had a history of intra-uterine growth failure, birth weight being 1.8 kg, with no fetal distress. [ijcpjournal.org]

We believe that this association of congenital hypoparathyroidism with severe growth failure and dysmorphism represents a new syndrome. [doi.org]

Cockayne Syndrome

The frame shift mutation of ERCC6 found in this patient is a novel one, which caused postnatal growth failure and early death. [ncbi.nlm.nih.gov]

failure. [ncbi.nlm.nih.gov]

Cockayne Syndrome (CS) is a rare autosomal recessive disorder, which leads to neurodegeneration, growth failure and premature aging. [ncbi.nlm.nih.gov]

Malpuech Syndrome

failure, lip/palate cleft(s), and urogenital anomalies. [link.springer.com]

Characterized by growth failure, craniofacial deformities, hydrocephalus, mental retardation, and skeletal defects. [accessanesthesiology.mhmedical.com]

G, Demeocq F, Palcoux JB, Vanilieferinghen P (1983): A previously undescribed autosomal recessive multiple congenital anomalies/mental retardation (MCA/MR) syndrome with growth [link.springer.com]

Dubowitz Syndrome

Dubowitz syndrome is a presumed autosomal recessive disorder characterized by multiple congenital abnormalities: microcephaly, learning and developmental delay, growth failure [ncbi.nlm.nih.gov]

Analysis of approximately 30 cases reveals prevalence of growth failure and delayed bone age, mild microcephaly, broad forehead with sparse frontal hair, telecanthus, blepharophimosis [ncbi.nlm.nih.gov]

Dubowitz syndrome (DS) (MIM#223370) (4) is a very rare genetic and developmental disorder involving multiple congenital anomalies including: 1) growth failure/short stature [ncbi.nlm.nih.gov]

Donohue Syndrome

Although some patients survived for several years, most die of severe failure to thrive with recurrent infections in the first year of life. [accessanesthesiology.mhmedical.com]

Both patients shared the same mutation and presented with intra-uterine growth restriction, failure to thrive, fasting hyperinsulinaemic hypoglycaemia and episodic post-prandial [ncbi.nlm.nih.gov]

Pathophysiology The primary defect in leprechaunism is located in the insulin receptor, but a secondary associated defect probably is responsible for growth failure because [accesspediatrics.mhmedical.com]

Congenital Bile Acid Synthesis Defect Type 2

failure (panhypopituitarism) (see these terms). [rarediseases.info.nih.gov]

[…] tyrosinemia type 1, biliary atresia, choledochal cyst, cystic fibrosis, Alagille syndrome, galactosemia and hereditary fructose intolerance or diseases that present with growth [rarediseases.info.nih.gov]

Mulibrey Nanism Syndrome

• The features of the syndrome of mulibrey nanism, an autosomal recessive disorder of unknown pathogenesis, include severe growth failure, yellow pigmentation of the retina [jamanetwork.com]

It causes severe growth failure along with abnormalities of the heart, muscle, liver, brain and eye. [definitions.net]

It is important that physicians look for this disorder in children with severe growth failure and hepatomegaly because of the potential seriousness of undetected pericardial [jamanetwork.com]

CAMFAK Syndrome

MalaCards integrated aliases for Cataract, Microcephaly, Failure to Thrive, Kyphoscoliosis Syndrome: Name: Cataract, Microcephaly, Failure to Thrive, Kyphoscoliosis Syndrome [malacards.org]

CAMFAK is an acronym for cataract, microcephaly, failure to thrive, and kyphoscoliosis. Extremely rare, with probably fewer than 15 cases described. Autosomal recessive. [accessanesthesiology.mhmedical.com]

Diseases related to Cataract, Microcephaly, Failure to Thrive, Kyphoscoliosis Syndrome via text searches within MalaCards or GeneCards Suite gene sharing: Human phenotypes [malacards.org]

Oculopalatoskeletal Syndrome

Abstract In 1985, Frydman et al. [1985: Clin Genet 27:414-419] described a syndrome characterized by growth failure, microcephaly, persistent hyperplastic primary vitreous [pubmed.ncbi.nlm.nih.gov]

A previously undescribed autosomal recessive multiple congenital anomalies/mental retardation (MCA/MR) syndrome with growth failure, lip/palate cleft (s), and urogenital anomalies [acarindex.com]

failure, lip/palate cleft(s), and urogenital anomalies. [cureus.com]

Bartter Syndrome

They may improve polyuria, salt wasting and growth failure. [clinicaladvisor.com]

Infants who have severe growth failure may grow normally with treatment. Over time, some people with the condition will develop kidney failure. [medlineplus.gov]

Outlook (Prognosis) Infants who have severe growth failure may grow normally with treatment. Over time, some people with the condition will develop kidney failure. [ufhealth.org]

Fanconi-Bickel Syndrome

Affected patients have rickets, aminoaciduria, phosphaturia, growth failure, hepatomegaly, and fasting hypoglycemia. [cags.org.ae]

Present in infancy (fever, vomiting, growth failure, and rickets). [accessanesthesiology.mhmedical.com]

Polyuria, polydipsia, failure to thrive and progressive lower limb deformity in the form of knock knees was observed since 1.5 years of age. [indianpediatrics.net]

Cartilage Hair Hypoplasia

Presence of anaemia significantly correlated to severity of immunodeficiency and growth failure and to presence of neutropenia. [ncbi.nlm.nih.gov]

The growth failure was progressive. [ncbi.nlm.nih.gov]

This study suggests that Hirschsprung disease is associated especially with severe cartilage-hair hypoplasia: the patients with Hirschsprung disease had severe growth failure [ncbi.nlm.nih.gov]

Drayer Syndrome

[…] retardation and postnatal growth failure. [humpath.com]

[…] abnormality Failure to thrive Fetal growth restriction Short stature Small for gestational age IMPORTANT NOTE: NIH does not independently verify information submitted to [ncbi.nlm.nih.gov]

[…] retardation and postnatal catch-up growth failure. [emedicine.medscape.com]

Shwachman Syndrome

Shwachman syndrome A condition characterized by pancreatic atrophy, neutropenia, growth failure, metaphyseal defects, hepatitis, anemia, thrombocytopenia, myocardial lesions–myofiber [medical-dictionary.thefreedictionary.com]

[…] the enzymes that digest fats, proteins and carbohydrates, leading to long-standing diarrhea) Growth failure Bone marrow failure Neutropenia (most patients present with recurrent [chop.edu]

Shwachman Diamond syndrome (SDS) is one of the inherited bone marrow failure syndromes characterized by: Abnormal pancreas function (the pancreas does not produce enough of [chop.edu]

Diencephalic Syndrome

This syndrome should be considered in the differential diagnosis of children with growth failure. [mattioli1885journals.com]

[…] to thrive in the context of normal linear growth. [symptoma.com]

Key words: Diencephalic syndrome Emaciation Growth failure Brain tumor El Texto completo está disponible en PDF Bibliografía [1.] A. Russell. [analesdepediatria.org]

Ring Chromosome 7

We report on a boy with ring chromosome 7 who had severe mental retardation, growth failure, microcephaly, cleft lip and palate, café-au-lait spots, nevus flammeus, and genital [ncbi.nlm.nih.gov]

A 13-year-old boy with a 46,XY,r(7) karyotype presented with growth failure, microcephaly, achromic spots and multiple pigmented naevi. [ncbi.nlm.nih.gov]

Search for a rare disease Disease definition Ring chromosome 7 syndrome is a rare chromosomal anomaly syndrome, with highly variable phenotype, principally characterized by growth [orpha.net]

Juvenile Cystinosis

Physical examination revealed severe growth failure and genu valgum. Venous blood gas analysis indicated metabolic acidosis. [adc.bmj.com]

Cystinosis may present with symptoms of polyuria, thirst, failure to thrive, growth retardation, vomiting, periods of dehydration, constipation and developmental delay. [jcdr.net]

Growth failure is also a common early finding. [webeye.ophth.uiowa.edu]

Valinemia

Diagnosis Among the symptoms of Valinemia are vomiting, hypotonia, growth retardation, failure to thrive, and poor feeding. [healthinformationview.com]

Symptoms & Signs Among the symptoms of Valinemia are vomiting, hypotonia, growth retardation, failure to thrive & poor feeding. [signssymptoms.org]

Symptoms and Signs Among the symptoms of Valinemia are vomiting, hypotonia, growth retardation, failure to thrive, and poor feeding. [dianamossop.com]

Coats Plus Syndrome

We describe the phenotype of a patient with severe growth failure where whole exome sequencing (WES) revealed compound heterozygosity for two mutations in the CTC1 gene. [abstracts.eurospe.org]

failure. [research.manchester.ac.uk]

Conclusion: Multiple characteristics (progeroid appearance, cerebral calcifications of the basal ganglia, osteopenia, bone anomalies, fractures, growth failure, anemia) are [abstracts.eurospe.org]

Warburg Micro Syndrome 3

micro cornea, joint contractures, and growth failure) [8], COCKAYNE syndrome (neurodegenerative disorder characterized by low birth weight, growth failure, brain demyelination [juniperpublishers.com]

Mulchandani S, Bhoj EJ, Luo M, Powell-Hamilton N, Jenny K, Gripp KW, et al: Maternal uniparental disomy of chromosome 20: a novel imprinting disorder of growth failure. [karger.com]

failure, and hypothalamic hypogonadism. [iamg.in]

Glycogen Storage Disease Type 6

Children born with GSD I typically exhibit growth failure, chronic hunger, fatigue, irritability, an enlarged liver, and a swollen abdomen. [liverfoundation.org]

Untreated or inadequately treated patients exhibit muscle weakness and failure to thrive in infancy, whereas older children show poor growth and delayed puberty. [clinicaladvisor.com]

Clinical features : Hepatomegaly, failure to thrive, cirrhosis, splenomegaly, jaundice, hypotonia, waddling gait, lumbar lordosis. [patient.info]

Renal Tubular Acidosis

Mental retardation, growth failure, complications of osteopetrosis and other features were all recorded in this syndrome. [ncbi.nlm.nih.gov]

failure and, if left untreated, complicated by osteomalacia with pathologic fractures, hypokalemic muscle weakness and periodic paralysis, nephrocalcinosis leading to renal [ncbi.nlm.nih.gov]

[…] alkalinization with sodium bicarbonate and sodium citrate suggest the plausible speculation that Tiny Tim had renal tubular acidosis (type I), a disorder that is characterized by growth [ncbi.nlm.nih.gov]

Aromatic L-Amino Acid Decarboxylase Deficiency

(failure to thrive), and are prone to many medical complications. [rarediseases.org]

(failure to thrive), and disruption of the part of the nervous system responsible for unconscious modulation of body functions such as heartbeat (autonomic nervous system [rarediseases.org]

[…] deficiency most commonly leads to decreased muscle tone (hypotonia), movement disorders including abnormal eyes movement (oculogyric crises), developmental delay, restricted growth [rarediseases.org]

Wiedemann-Rautenstrauch Syndrome

She had prenatal and postnatal growth failure, generalized lipoatrophy except for fat pads in the suprabuttock areas, triangular face, pseudo hydrocephalous, sparse scalp [search.emarefa.net]

She had prenatal and postnatal growth failure, generalized lipoatrophy except for fat pads in the suprabuttock areas, triangular face, pseudohydrocephalous, sparse scalp hair [ajol.info]

Further on the patient showed the diagnostic criteria of Wiedemann-Rautenstrauch syndrome: Beside growth failure and nearly absence of subcutaneous fat, old-looking face with [ncbi.nlm.nih.gov]

Childhood Celiac Disease

Results indicate that significant reduction in IGF-I levels in CCD patients occurs only after prolonged gluten exposure but before growth failure. [ncbi.nlm.nih.gov]

Underlying celiac disease should be considered in children with persistent pica and growth failure even if gastrointestinal disturbances are minimal. [hero.epa.gov]

failure in children. [celiac.org]

Acrocallosal Syndrome

[…] to thrive Faltering weight Weight faltering [ more ] 0001508 Finger syndactyly 0006101 Growth delay Delayed growth Growth deficiency Growth failure Growth retardation Poor [rarediseases.info.nih.gov]

[…] malformation 0001305 Downslanted palpebral fissures Downward slanting of the opening between the eyelids 0000494 Epicanthus Eye folds Prominent eye folds [ more ] 0000286 Failure [rarediseases.info.nih.gov]

Chromosome 19q13.11 Deletion Syndrome

[…] retardation and postnatal growth failure. [humpath.com]

It is characterized by sparse, kinky hair; failure to thrive; and progressive deterioration of the nervous system. [checkrare.com]

[…] to thrive Faltering weight Weight faltering [ more ] 0001508 Feeding difficulties Feeding problems Poor feeding [ more ] 0011968 Hypospadias 0000047 Intellectual disability [rarediseases.info.nih.gov]

IMAGE Syndrome

Additional manifestations include postnatal growth failure and delayed bone age, mild developmental delay, macrocephaly, mild facial dysmorphism (with frontal bossing, wide [orpha.net]

Figure 1 Photographs demonstrating hyperpigmentation, severe eczema, rhizomelic shortening, and growth failure. [degruyter.com]

Coffin-Siris Syndrome

Clin-Dysmorphol. 2000 Jan; 9(1): 15-9 Kirel,-B; Kural,-N; Yakut,-A; Adapinar,-B Triplets with growth failure, microcephaly, mental retardation, nail hypoplasia and corpus [malattierare.regione.veneto.it]

Turk-J-Pediatr. 2000 Apr-Jun; 42(2): 171-6 Ounap,-K; Justus,-I; Lipping-Sitska,-M Two sisters with growth failure, microcephaly, peculiar facies and apical dystrophy: the [malattierare.regione.veneto.it]

3-Methylglutaconic Aciduria Type 5

[…] abnormality Failure to thrive Growth delay IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information [ncbi.nlm.nih.gov]

[…] developmental delay Motor delay Abnormality of the respiratory system Recurrent bronchitis Constitutional symptom Exercise intolerance Fatigue Ear malformation Macrotia Growth [ncbi.nlm.nih.gov]