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24 Possible Causes for Gynecomastia, Small Testicular Volume

  • Klinefelter Syndrome

    Gynecomastia is treated surgically because of the potential danger of malignancy or for cosmetic reasons.[ncbi.nlm.nih.gov] The treatment of men with Klinefelter syndrome has been thought to be limited by the small testicular volume, extensive tubular sclerosis, and high FSH typically found for[dx.doi.org] REIFENSTEIN, FULLER ALBRIGHT, Syndrome Characterized by Gynecomastia, Aspermatogenesis without A-Leydigism, and Increased Excretion of Follicle-Stimulating Hormone, The Journal[doi.org]

  • Primary Male Hypogonadism

    Increase oestrogen effect on breast tissue What are the causes of gynecomastia?[brainscape.com] Signs include hair loss, decreased sexual function, voice changes, eunuchoidal habitus and gynecomastia. The testes are small and osteoporosis may be present.[colombiamedica.univalle.edu.co] Signs and symptoms may include: Erectile dysfunction Infertility Decrease in beard and body hair growth Decrease in muscle mass Development of breast tissue (gynecomastia)[mayoclinic.org]

  • Klinefelter's Syndrome with XY/XXY Mosaic

    Physical examination revealed bilateral gynecomastia and small testes [Figure 3] and a female escutcheon. Considering the possibility of KFS, he was investigated.[e-ijd.org] These features would include first and foremost small firm testes (low testicular volume), tall slender body habitus, and in some cases breast enlargement (gynecomastia) and[dermatologyadvisor.com] After puberty, signs of androgen deficiency develop (infertility, decreased virilization, small penis, low muscle mass), in addition small firm testes, gynecomastia, and an[urology-textbook.com]

  • Male Hypogonadism 

    The scrotum was thin, and two small, soft testicles (testicular volume, 1 to 2 ml) were palpated.[nejm.org] Since gynecomastia is a prominent clinical manifestation in patients with 17-ketosteroid reductase deficiency after puberty, 2,9-11 we suspected that some men with gynecomastia[nejm.org] Both the gynecomastia and the decrease in testicular size developed in the 5-year period before presentation.[ncbi.nlm.nih.gov]

  • Anorchia 

    Testicles are “born” small and grow in size during puberty and later adulthood before losing some volume in later age.[drelist.com] Types of Gynecomastia: Type I: Benign adolescent hypertrophy Physiologic discoid subacute mass Resolves spontaneously Type II: Physiologic gynecomastia - Generalized enlargement[enotes.tripod.com] What is gynecomastia? Gynecomastia is the benign enlargement of glandular breast tissue in men.[qunomedical.com]

  • 46,XX Disorder of Sex Development

    The testicles were descended in the scrotum but small in size with volumes 3.5 and 4 ml (normal range 18–30 ml).[endocrine-abstracts.org] Herein, we report an adolescent who presented with low testicular volume and who was diagnosed as a 46,XX male.[ncbi.nlm.nih.gov] The SOX9 gene is very close to the locus for “tylosis”.26Hypospadias & hypogenitalism, PPKXX TD27Hypospadias & hypogenitalism, two epididymal cysts (4.5 mm), gynecomastia,[e-kjgm.org]

  • 48,XXYY Syndrome

    In puberty and adult life, the main clinical characteristic that differentiates KS syndrome from X fragile syndrome is testicular volume, which is small in the first and big[scielo.br] Abstract A 56-yr-old man with hypogonadism, gynecomastia, and mental retardation was evaluated for chromosome constitution and thrombocytopenia.[ncbi.nlm.nih.gov] Testicular volume is typically less than 10 ml in postpubertal 47,XXY individuals [ 5 ].[ojrd.biomedcentral.com]

  • XXXXY Syndrome

    Characteristics are small firm testes, long legs, gynecomastia, poor social adaptation, subnormal intelligence, chronic pulmonary disease, and varicose veins.[medical-dictionary.thefreedictionary.com] Testicular volume is typically less than 10 ml in postpubertal 47,XXY individuals [ 5 ].[doi.org] […] of chromosome defects with multiple X chromosomes and one Y chromosome Clinical Somatic defects overlap Klinefelter syndrome–small undescended testes, hypoplastic penis, gynecomastia[medical-dictionary.thefreedictionary.com]

  • 48,XXXY Syndrome

    Testicular volume is typically less than 10 ml in postpubertal 47,XXY individuals [ 5 ].[ojrd.biomedcentral.com] Carious teeth;HP:0000679 Taurodontia;HP:0000682 Abnormality of dental enamel;HP:0000684 Delayed eruption of teeth;HP:0000689 Dental malocclusion;HP:0000717 Autism;HP:0000771 Gynecomastia[pediascape.org] Starting in adolescence, affected boys and men may have sparse body hair, and some experience breast enlargement (gynecomastia).[ghr.nlm.nih.gov]

  • Hypogonadotropic Hypogonadism

    The treatment of men with Klinefelter syndrome has been thought to be limited by the small testicular volume, extensive tubular sclerosis, and high FSH typically found for[dx.doi.org] A 54 year-old man presented with a two month history of gynecomastia and reduced libido.[ncbi.nlm.nih.gov] Register Syndrome Characterized by Gynecomastia, Aspermatogenesis without A-Leydigism, and Increased Excretion of Follicle-Stimulating Hormone 1 - 24 Hours access EUR 36.00[doi.org]

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