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48 Possible Causes for Gynecomastia with Sertoli Cell Tumors

  • Peutz-Jeghers Syndrome

    Endocrine manifestations in PJS include gynecomastia and advanced bone age due to estrogen production by large-cell calcifying Sertoli cell tumors (LSCT).[ncbi.nlm.nih.gov] In Peutz-Jeghers syndrome, bilateral Sertoli cell testicular tumors cause endocrine manifestations including gynecomastia and feminization.[ncbi.nlm.nih.gov] More infrequently, affected males can develop calcifying Sertoli cell tumors of the testes which may cause gynecomastia.[genedx.com]

  • Sertoli Cell Tumor of the Testis

    […] on ultrasonography, 29.2% present with a palpable testicular mass, 16.6% with scrotal pain, and 12.5% with gynecomastia. 4 Sertoli cell tumors represent only about 1% of[ncbi.nlm.nih.gov] Gynecomastia has been described in 26% of benign Sertoli cell tumor and in a majority, regressed following surgery, although a few cases of Sertoli cell tumor had evidence[sjkdt.org] Patients with Sertoli cell tumors might present with excess estrogen production and gynecomastia as already explained.[lecturio.com]

  • Gynecomastia

    Sertoli cell tumors account for 2% of prepubertal testicular tumors and very few have occurred in the first decade of life.[ncbi.nlm.nih.gov] Endocrine manifestations in PJS include gynecomastia and advanced bone age due to estrogen production by large-cell calcifying Sertoli cell tumors (LSCT).[ncbi.nlm.nih.gov] In Peutz-Jeghers syndrome, bilateral Sertoli cell testicular tumors cause endocrine manifestations including gynecomastia and feminization.[ncbi.nlm.nih.gov]

  • Androblastoma

    Two with gynecomastia, one with metastases 2.8 X 1.1 cm. yellow Sertoli cell tumor ---· Scully: New Engl.[kundoc.com] Gynecomastia preceded the clinical appearace of testicular swelling by 3 months, suggesting that the 2 tumors developed contemporaneously and that, in theory, the Sertoli[ncbi.nlm.nih.gov] Yellow-orange Sertoli cell tumor 68 yrs. Yellow Lt. Feminizing tumor testicular Gynecomastia w --- Dixon and lHoore: Atlas of Tumor Path., sec. 7, fasc. 31 b and 32.[kundoc.com]

  • Klinefelter Syndrome

    Definition / general 47XXY, reduced body and pubic hair, gynecomastia in 40 - 80%, high FSH, variable LH Increased risk of breast cancer and extragonadal germ cell tumor Microscopic[pathologyoutlines.com] (histologic) description Reduced number of intratubular germ cells, some tubules are Sertoli cell only Also tubular sclerosis, Leydig cell nodules (appear hyperplastic due[pathologyoutlines.com]

  • Lipid Cell Tumor of the Ovary

    Some lesions have morphology intermediate to that of the first two subtypes of Sertoli cell tumor just listed.[nature.com] cell tumors to be misdiagnosed as seminoma, 7 as discussed below.[nature.com] There is some evidence in the literature to suggest that gynecomastia is seen more often in clinically malignant tumors.[nature.com]

  • Seminoma

    Reinke crystals (eosinophilic cytoplasmic inclusions) Sertoli cell tumors 1% - - Derived from normal Sertoli cells , which facilitate spermatogenesis Multiple Sertoli cells[amboss.com] […] like prominent external genitalia, pubic hair growth, accelerated skeletal and muscle development, and mature masculine voice Occassionally, estrogen excess features, like gynecomastia[amboss.com]

  • Testicular Teratocarcinoma

    • elevated serum & urinary 17- ketosteroids & estrogens • Sertoli Cell Tumors • rare; 1% testicular tumors • bimodal age distribution - 1 year; 20 - 45 years age • presentation[slideshare.net] Gynecomastia is present in 5% of all germ cell tumors but may be present in 30-50% of Sertoli and Leydig cell tumors.[slideplayer.com] - testicular mass; virilization in children; gynecomastia in adults • Gonadoblastomas • rare • seen in patients with gonadal dysgenesis • age group - 30 years of age • clinical[slideshare.net]

  • Testicular Embryonal Carcinoma

    Reinke crystals (eosinophilic cytoplasmic inclusions) Sertoli cell tumors 1% - - Derived from normal Sertoli cells, which facilitate spermatogenesis Multiple Sertoli cells[amboss.com] Sertoli Cell Tumor These tumors are more rare than Leydig cell tumors. They elaborate androgens or estrogens.[med-ed.virginia.edu] […] like prominent external genitalia, pubic hair growth, accelerated skeletal and muscle development, and mature masculine voice Occassionally, estrogen excess features, like gynecomastia[amboss.com]

  • Leydig Cell Tumor of the Testis

    Reinke crystals (eosinophilic cytoplasmic inclusions) Sertoli cell tumors 1% - - Derived from normal Sertoli cells, which facilitate spermatogenesis Multiple Sertoli cells[amboss.com] Some lesions have morphology intermediate to that of the first two subtypes of Sertoli cell tumor just listed.[nature.com] […] like prominent external genitalia, pubic hair growth, accelerated skeletal and muscle development, and mature masculine voice Occassionally, estrogen excess features, like gynecomastia[amboss.com]

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