Haptoglobin Decreased: Causes & Reasons

Possible Causes for Haptoglobin Decreased

The level of lactate dehydrogenase rose to 1257, the plasma hemoglobin rose to >16 mg per dL, and the haptoglobin decreased to <6 mg per dL. [ncbi.nlm.nih.gov]

Common laboratory features are: hemoglobinemia, hemoglobinuria, decreased serum haptoglobin, unconjugated hyperbilirubinemia, Increased LDH an AST levels, decreased hemoglobin [notifylibrary.org]

[…] fibrinogen Decreased haptoglobin Elevated bilirubin Elevated LDH Hemoglobinemia Hemoglobinuria Plasma discoloration compatible with hemolysis Spherocytes on peripheral smear [clinlabnavigator.com]

Microangiopathic Hemolytic Anemia

(decreased) • Reticulocyte count (appropriate) 21. • PT/PTT (normal; differentiates from DIC) • Stool tests – Shiga toxin, E. coli O157:H7 test • Urine Analysis – Hematuria [slideshare.net]

He was diagnosed with MAHA on the basis of the laboratory findings that revealed anemia with schistocytes, decreased haptoglobin levels, and a negative direct Coombs' test [ncbi.nlm.nih.gov]

There could also be other indicators of hemolysis including: elevated LDH, elevated indirect bilirubin, and decreased haptoglobin. [morningreporttgh.blogspot.com]

Hereditary Spherocytosis

Routine chemistry testing  Bilirubin: Increased  Indirect bilirubin  Urine urobilinogen: increased  Methaemalbumin: Increased  LDH: Increased  Haptoglobin: Decreased [pt.slideshare.net]

Peripheral smear  ANISOCYTOSIS  Spherocyte  POIKILOCYTOSIS  Polychromatic cells  Target cells  Nucleated RBC can be present severe cases  Plt decreased if splenomegaly [pt.slideshare.net]

Anemia due to Glutathione Metabolism Disorder

Decreased Hemoglobinuria Liver function tests Elevated indirect bilirubin Scleral icterus Coombs’ test Negative TABLE 5 Symptoms and Laboratory Evaluation in Patients with [aafp.org]

Total and unconjugated bilirubin : levels are increased due to increased RBC destruction Serum lactate dehydrogenase (LDH) level : increased Serum haptoglobin level : decreased [medcaretips.com]

Methemalbuminemia, hemoglobinemia, hemoglobinuria, unconjugated bilirubinemia, and decreased haptoglobin and GSH levels may be noted. [clinicaladvisor.com]

Autoimmune Hemolytic Anemia

and haptoglobin decreased to less than 8 mg/dL. [ncbi.nlm.nih.gov]

Haptoglobin: -Decreased with intravascular hemolysis. Urine analysis: -When hemolysis has been acute and brisk the patient may have hemoglobinuria. [oncologynurseadvisor.com]

The diagnosis is established by reticulocytosis, increased unconjugated bilirubin and lactate dehydrogenase, decreased haptoglobin, and peripheral blood smear findings. [aafp.org]

Atypical Hemolytic Uremic Syndrome

[…] hemolysis, which is characterized by elevated LDH levels, decreased haptoglobin, decreased hemoglobin, and/or the presence of schistocytes. [en.wikipedia.org]

After 3 years of eculizumab treatment, and without plasma therapy, schistocytes decreased, haptoglobin increased to within normal limits, creatinine levels stabilized, and [ncbi.nlm.nih.gov]

[…] from baseline), microangiopathic hemolytic anemia (decreased haptoglobin, decreased hemoglobin, elevated lactate dehydrogenase, and schistocytes on blood film), proteinuria [sjkdt.org]

Thrombotic Thrombocytopenic Purpura

Pathophys: decreased activity of ADAMTS-13 which normally functions to cleave von Willebrand factor Labs: anemia, thrombocytopenia, increased LDH, decreased haptoglobin, increased [emdaily.cooperhealth.org]

A patient usually presents with thrombocytopenia and microangiopathic hemolytic anemia (i.e. schistocytes, elevated serum lactate dehydrogenase, decreased hemoglobin and haptoglobin [ncbi.nlm.nih.gov]

A low hematocrit with an elevated reticulocyte count, an elevated indirect bilirubin, and decreased haptoglobin are indicative of hemolytic anemia. [academic.oup.com]

Paroxysmal Nocturnal Hemoglobinuria

Decreased Bilirubin: Elevated unconjugated Urine: Positive for hemosiderin and hemoglobin In addition, further hemolysis parameters, renal function, folic acid and vitamin [symptoma.com]

Haptoglobin: usually undetectable Increased Lactate Dehydrogenase (LDH): may be in the thousands Indirect (Unconjugated) Hyperbilirubinemia: usually mildly-moderately elevated [mdnxs.com]

[…] levels of haptoglobin; there can be raised reticulocytes (immature red cells released by the bone marrow to replace the destroyed cells) if there is no iron deficiency present [en.wikipedia.org]

Pyruvate Kinase Deficiency

PAGE BREAK Patients who achieved at least 1 g/dL increase in hemoglobin also demonstrated an increase in haptoglobin and decrease in lactate dehydrogenase in the first weeks [healio.com]

[…] levels of haptoglobin. [orpha.net]

Diagnosis may be considered on the basis of the clinical features and laboratory findings: a variable degree of anemia, reticulocytosis, increased non-conjugated bilirubin, and decreased [orpha.net]

Hemolytic Uremic Syndrome

[…] hemolysis, which is characterized by elevated LDH levels, decreased haptoglobin, decreased hemoglobin, and/or the presence of schistocytes. [en.wikipedia.org]

haptoglobin Elevated C-reactive protein level Hematuria on urinalysis Hemolysis on peripheral smear: burr cells, helmet cells Increased L-lactate dehydrogenase level Leukocytosis [aafp.org]

[…] and a decrease in schistocytes (1% of RBC count). [doi.org]

Disseminated Intravascular Coagulation

haptoglobin Last Update: 2012-04-10 Usage Frequency: 2 Quality: Maltese Tinjettax b’mod intravaskulari English Do not inject intravascularly! [mymemory.translated.net]

[…] marrow Disseminated intravascular coagulation Last Update: 2012-04-10 Usage Frequency: 2 Quality: Maltese Koagulazzjoni intravaskulari mifruxa English Haemolytic anaemia, Decreased [mymemory.translated.net]

Pernicious Anemia

haptoglobin; the negative direct Coombs test excluded an autoimmune etiology for this hemolytic anemia. [scielo.br]

[…] or iron deficiency), could delay the diagnosis.1 8 9 In this case, ineffective erythropoiesis was suspected due to the unconjugated hyperbilirubinemia, elevated LDH, and decreased [scielo.br]

Thalassemia

Reticulocytes, LDH and bilirubin are increased; haptoglobin is decreased. [lecturio.com]

Sickle Cell - Hemoglobin C

[…] or absent haptoglobin, elevated LDH and unconjugated bilirubin, and elevated serum free hemoglobin. [cancertherapyadvisor.com]

This excess amount of hemoglobin and heme saturate their respective scavenging molecules, haptoglobin and hemopexin ( Reiter, et al 2002 ), the levels of which are decreased [ncbi.nlm.nih.gov]

[…] valves or burns infection immunopathologic, such as transfusion reactions, Rhesus/ABO incompatibility, or warm and cold agglutinins Tests indicative of hemolysis include decreased [cancertherapyadvisor.com]

Alpha-Thalassemia

Reticulocytes, LDH and bilirubin are increased; haptoglobin is decreased. [lecturio.com]

Patients would then have the typical presentation of hemolytic anemia, indirect hyperbilirubinemia, elevated LDH, decreased haptoglobin, splenomegaly, hepatomegaly, jaundice [statpearls.com]

Plasmodium Falciparum Malaria

Eight of 20 patients with uncomplicated malaria who were given oral artemisinin-based combination therapy met the definition of posttreatment hemolysis (low haptoglobin level [ncbi.nlm.nih.gov]

Patients with posttreatment hemolysis had a median decrease in hemoglobin level of 1.3 g/dL (interquartile range 0.3-2.0 g/dL) in the posttreatment period, and patients without [ncbi.nlm.nih.gov]

Sickle Cell Anemia

This excess amount of hemoglobin and heme saturate their respective scavenging molecules, haptoglobin and hemopexin ( Reiter, et al 2002 ), the levels of which are decreased [ncbi.nlm.nih.gov]

Hemoglobin C Disease

[…] or absent haptoglobin, elevated LDH and unconjugated bilirubin, and elevated serum free hemoglobin. [clinicaladvisor.com]

Third Trimester Pregnancy

OBJECTIVE: To perform a prospective, observational study in a tertiary center to determine whether anemia (hemoglobin level < 10 g/dL) developing in the third trimester was associated with an increased placental weight/birth weight ratio (placental ratio) and whether the placental ratio correlated with the[…] [ncbi.nlm.nih.gov]

Congestive Heart Failure

Severe congestive heart failure (CHF) patients are prone to hyponatremia. Peritoneal dialysis (PD) is increasingly used for long-term management of refractory CHF patients. The glucose polymer icodextrin was proposed to be a good option for fluid removal in such patients. A small, although statistically significant[…] [ncbi.nlm.nih.gov]

Acute Respiratory Distress Syndrome

Acute respiratory distress syndrome (ARDS) is a clinical syndrome of severe dyspnea of rapid onset, hypoxemia, and diffuse pulmonary infiltrates leading to respiratory failure. ARDS is caused by diffuse lung injury from many underlying medical and surgical disorders. The lung injury may be direct, as occurs in toxic[…] [accessmedicine.mhmedical.com]

Liver Failure

Auxiliary partial orthotopic liver transplantation (APOLT) in acute liver failure acts as a bridge to native liver regeneration with potential for immunosuppression free survival. While technical concerns limit its universal acceptance, the indications in acute liver failure also need to be examined for this procedure to[…] [ncbi.nlm.nih.gov]

Systemic Lupus Erythematosus

Orphanet Journal of Rare Diseases volume 1, Article number: 6 (2006) Cite this article 55k Accesses 735 Citations 3 Altmetric Metrics details Abstract Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease, which is autoimmune in origin and is characterized by the presence of autoantibodies[…] [ojrd.biomedcentral.com]

Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) is the most common leukemia of adults in the Western world. The average age of CLL patients is more than 70 years and it should be noted that a complex clinical picture occurs in more than half of the cases due to coexisting diseases. The CLL itself leads to unspecific symptoms[…] [symptoma.com]

Massive Hepatic Necrosis

Neonatal hemochromatosis (NH) is an uncommon disorder clinicopathologically defined by severe liver disease of intrauterine onset associated with extrahepatic siderosis that spares reticuloendothelial elements. NH phenotypically is a similar disorder to hereditary hemochromatosis. However, its extremely early onset of[…] [ncbi.nlm.nih.gov]

Thalassemia Minor

There are numerous causes for intracranial calcification in children. We describe an unusual cause of intracranial calcification in a child, namely, nephrogenic diabetes insipidus (NDI). A 12-year-old boy presented with seizures and developmental delay. MRI of the brain revealed intracranial calcification. Evaluation showed[…] [ncbi.nlm.nih.gov]

Beta Thalassaemia Major

Funding Profiles Access available for Technion staff. Please sign in to see the Agency profiles (upper left corner) The Cooley’s Anemia Foundation is dedicated to serving people afflicted with various forms of thalassemia, most notably the major form of this genetic blood disease, Cooley’s anemia/thalassemia major.[…] [trdf.co.il]

Chronic Active Hepatitis B

Abstract Hepatitis B virus associated DNA polymerase activity, hepatitis b surface antigen (HBsAg), and serum aspartate aminotransferase were followed in 21 patients with chronic active hepatitis while immunosuppressive therapy (prednisone +/- azathioprine) was being withdrawn. In every case, DNA polymerase activity[…] [ncbi.nlm.nih.gov]

Folate-Deficiency Anemia

Folate-deficiency anemia frequently appears in women of childbearing age, in those who are pregnant or lactating, in alcohol abusers and malnourished individuals, thus proving the necessity of folate oral supplementation. Prevention must be carefully conducted, since the elderly may have difficulties tolerating folate[…] [symptoma.com]

Malaria

What Are the Different Types of Malaria Parasites? Five species of Plasmodium (single-celled parasites) can infect humans and cause illness: Plasmodium falciparum (or P. falciparum) Plasmodium malariae (or P. malariae) Plasmodium vivax (or P. vivax) Plasmodium ovale (or P. ovale) Plasmodium knowlesi (or P. knowlesi)[…] [stanfordhealthcare.org]