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78 Possible Causes for Haptoglobin Decreased, Hematocrit Decreased, Reticulocytes Increased

  • Hereditary Spherocytosis

    Reticulocyte count: Increased Treatment: Splenectomy is indicated for moderate to severe cases, but not mild cases.[medical-labs.net] A complete blood count (CBC) may show increased reticulocytes, a sign of increased red blood cell production, and decreased hemoglobin and hematocrit.[en.wikipedia.org] Routine chemistry testing  Bilirubin: Increased  Indirect bilirubin  Urine urobilinogen: increased  Methaemalbumin: Increased  LDH: Increased  Haptoglobin: Decreased[slideshare.net]

  • Autoimmune Hemolytic Anemia

    Over the course of the next 5 days, the Hb and Hct decreased to 4.1 g/dL and 12%, respectively, direct bili increased to 12.3 mg/day, reticulocytes slightly increased to 0.9%[ncbi.nlm.nih.gov] The differential white blood count shows a decrease in most types of cells but not lymphocytes .[labtestsonline.org] Laboratory data showed low hemoglobin levels and slightly increased reticulocyte counts, while direct and indirect antiglobulin tests were positive.[ncbi.nlm.nih.gov]

  • Sickle Cell Disease

    With each course, fetal reticulocytes increased within 48-72 h, peaked in 7-11 d, and fell by 18-21 d.[doi.org] (p 0.001), while hemoglobin and hematocrit remained stable.[ncbi.nlm.nih.gov] This excess amount of hemoglobin and heme saturate their respective scavenging molecules, haptoglobin and hemopexin ( Reiter, et al 2002 ), the levels of which are decreased[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    Erythrocytes fractionated by centrifugation revealed increased glycolytic enzyme activities of hexokinase, G3PD, PGK, TPI, PK, LDH, G6PD, and 6PGD in the reticulocyte-rich[pediatrics.aappublications.org] : Decreased Bilirubin: Elevated unconjugated Urine: Positive for hemosiderin and hemoglobin In addition, further hemolysis parameters, renal function, folic acid and vitamin[symptoma.com] Haptoglobin: usually undetectable Increased Lactate Dehydrogenase (LDH): may be in the thousands Indirect (Unconjugated) Hyperbilirubinemia: usually mildly-moderately elevated[mdnxs.com]

  • Thalassemia Minor

    […] count Normal May be slightly increased Slightly increased ( Mildly increased (5 - 10%) Mildly increased Hb electrophoresis Normal pattern Decreased amount of Hb A Variable[labce.com] Abstract Patients with heterozygous beta-thalassemia minor have a decreased hematocrit (HCT).[ncbi.nlm.nih.gov] […] target cells) Schistocytes Ovalocytes Basophilic stippling Polychromasia Nucleated RBCs Possible hypochromia and microcytosis Codocytes (target cells) Basophilic stippling Reticulocyte[labce.com]

  • Cooley's Anemia

    Children may develop dramatic, often life threatening drops in hematocrit with reticulocyte counts of nearly zero.[de.slideshare.net] The differential white blood count shows a decrease in most types of cells but not lymphocytes .[labtestsonline.org] This "aplastic crisis" often requires emergent transfusion support The effectiveness of present effective strategies has increased the life spans of patients with thalassaemia[de.slideshare.net]

  • Pyruvate Kinase Deficiency

    Char10C mice also display a reduction in anemia phenotypes associated with the PklrG338D mutation including decreased splenomegaly, decreased circulating reticulocytes, increased[ncbi.nlm.nih.gov] PAGE BREAK Patients who achieved at least 1 g/dL increase in hemoglobin also demonstrated an increase in haptoglobin and decrease in lactate dehydrogenase in the first weeks[healio.com] As a result of splenectomy, reticulocyte counts often increase and transfusion needs are reduced.[orpha.net]

  • Atypical Hemolytic Uremic Syndrome

    Lactate dehydrogenase was increased to 1084 U/L ( 460 U/L), reticulocyte count was 8.9%, and haptoglobin was less than 0.4 g/L (.1-.3 g/L).[doi.org] hematocrit and hemoglobin and thrombocytopenia ; schistocytes on peripheral blood smears, elevated LDH, low haptoglobin, elevated indirect bilirrubin, elevated reticulocytes[biomed.uninet.edu] […] hemolysis, which is characterized by elevated LDH levels, decreased haptoglobin, decreased hemoglobin, and/or the presence of schistocytes.[en.wikipedia.org]

  • Alpha-Thalassemia

    Reticulocytes, LDH and bilirubin are increased; haptoglobin is decreased.[lecturio.com] Lastly, a patient may also receive folic acid supplements, particularly if they display increased levels of reticulocytes.[symptoma.com] […] suggestive of beta thalassemia, but it is minor because the child is asymptomatic, no hemolysis and hemoglobin and reticulocyte count are normal.[ashclinicalnews.org]

  • Malaria

    BACKGROUND: Plasmodium knowlesi is increasingly recognized as a cause of human malaria in Southeast Asia but there are no detailed prospective clinical studies of naturally acquired infections. METHODS: In a systematic study of the presentation and course of patients with acute P. knowlesi infection, clinical and[…][ncbi.nlm.nih.gov]

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