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75 Possible Causes for Haptoglobin Decreased, Hypercellular Bone Marrow

  • Hereditary Spherocytosis

    Routine chemistry testing  Bilirubin: Increased  Indirect bilirubin  Urine urobilinogen: increased  Methaemalbumin: Increased  LDH: Increased  Haptoglobin: Decreased[] Other biochemical changes of hemolysis also are also present, including: increased lactate dehydrogenase (LDH) increased unconjugated bilirubin decreased serum haptoglobin[] Peripheral smear  ANISOCYTOSIS  Spherocyte  POIKILOCYTOSIS  Polychromatic cells  Target cells  Nucleated RBC can be present severe cases  Plt decreased if splenomegaly[]

  • Paroxysmal Nocturnal Hemoglobinuria

    These patients tend to have a normocellular to hypercellular bone marrow with erythroid hyperplasia, an elevated reticulocyte count, a large population of PNH cells (usually[] : Decreased Bilirubin: Elevated unconjugated Urine: Positive for hemosiderin and hemoglobin In addition, further hemolysis parameters, renal function, folic acid and vitamin[] Haptoglobin: usually undetectable Increased Lactate Dehydrogenase (LDH): may be in the thousands Indirect (Unconjugated) Hyperbilirubinemia: usually mildly-moderately elevated[]

  • Autoimmune Hemolytic Anemia

    Subsequently, the patient underwent a bone marrow biopsy that showed a hypercellular marrow with erythroid hyperplasia, but no evidence of dysplasia or lymphoma.[] , and haptoglobin decreased to less than 8 mg/dL.[] Haptoglobin: -Decreased with intravascular hemolysis. Urine analysis: -When hemolysis has been acute and brisk the patient may have hemoglobinuria.[]

  • Pernicious Anemia

    OBJECTIVE: This study evaluated whether all the patients with serum gastric parietal cell antibody (GPCA) positivity had pernicious anemia (PA). MATERIALS AND METHODS: The blood hemoglobin (Hb), iron, and vitamin B12 concentrations, and mean corpuscular volume (MCV) in 124 GPCA-positive patients were measured and[…][]

  • Sickle Cell Disease

    This excess amount of hemoglobin and heme saturate their respective scavenging molecules, haptoglobin and hemopexin ( Reiter, et al 2002 ), the levels of which are decreased[]

  • Acute Leukemia

    ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[] Bone marrow aspirate examination revealed hypercellularity with 70% blast cells.[] Bone marrow aspiration demonstrated hypercellular marrow (nucleated cell count 1.84 104/μL) and 89.0% of blast-like cells of all nucleated cells.[]

  • Cooley's Anemia

    Cooley's anemia is also known as beta-thalassemia major and is the most severe type of beta-thalassemia, characterized by a total absence of beta globin chains in the hemoglobin. It may result in severe anemia, which may require regular blood transfusions. There are three forms of beta thalassemias: beta[…][]

  • Microangiopathic Hemolytic Anemia

    (decreased) • Reticulocyte count (appropriate) 21. • PT/PTT (normal; differentiates from DIC) • Stool tests – Shiga toxin, E. coli O157:H7 test • Urine Analysis – Hematuria[] He was diagnosed with MAHA on the basis of the laboratory findings that revealed anemia with schistocytes, decreased haptoglobin levels, and a negative direct Coombs' test[] There could also be other indicators of hemolysis including: elevated LDH, elevated indirect bilirubin, and decreased haptoglobin.[]

  • Pyruvate Kinase Deficiency

    PAGE BREAK Patients who achieved at least 1 g/dL increase in hemoglobin also demonstrated an increase in haptoglobin and decrease in lactate dehydrogenase in the first weeks[] […] levels of haptoglobin.[] Diagnosis may be considered on the basis of the clinical features and laboratory findings: a variable degree of anemia, reticulocytosis, increased non-conjugated bilirubin, and decreased[]

  • Folate-Deficiency Anemia

    marrow biopsy and aspirate may show a hypercellular bone marrow with a megaloblastic maturation of cells, which morphologically resembles changes of vitamin B12 deficiency[] Bone marrow aspirate and biopsy: Marrow is hypercellular with characteristic features of megaloblastic erythropoiesis and presence of large metamyelocytes.[] Important to rule out cobalamin (Vitamin B12) deficiency because folate treatment will not improve neurologic abnormalities due to cobalamin deficiency Cytology description Bone[]

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