HbA1C Increased: Causes & Reasons

Possible Causes for HbA1C Increased

Reductions in HbA1C and RVSP during the first year were greater in patients who experienced an increase of 5% or more in EF at their first postoperative measurement. [ncbi.nlm.nih.gov]

Blood sugar and HbA1c levels remained stable for about a year and then increased again, requiring the introduction of metformin that improved glycemia. [ncbi.nlm.nih.gov]

For every 1% increase in HbA1c level, the risk of death from a diabetes-related cause increases by 21%. [patient.info]

Lipodystrophy

[…] in HbA1c and triglycerides), and in three patients without lipodystrophy who received MYALEPT in clinical studies (excessive weight gain, development of glucose intolerance [novelion.com]

The mean (SE) change in HbA1c at 12 months was –0.88 (0.62)% (95% CI, –2.34, 0.59). [omicsonline.org]

Diabetic Ketotic Coma

Insulin and C-peptide were increased after the intravenous administration of 1 mg of glucagon. HbA1c was normal (5.0%). [academic.oup.com]

Congenital Generalized Lipodystrophy

[…] in HbA1c and triglycerides), and in three patients without lipodystrophy who received MYALEPT in clinical studies (excessive weight gain, development of glucose intolerance [novelion.com]

[…] with loss of endogenous leptin activity and/or loss of efficacy have been identified in two patients with generalized lipodystrophy treated with MYALEPT (severe infections, increases [novelion.com]

Prediabetes

Low circulating vitamin D levels are associated with increased arterial stiffness in prediabetic subjects identified according to HbA1c. [scielo.org.co]

HbA1c increase is associated with higher coronary and peripheral atherosclerotic burden in non diabetic patients. Atherosclerosis [Internet]. 2016; 255(2016):102-8. [scielo.org.co]

Postoperative Infection

An HbA1c level >8.0 mg/dL could serve as a threshold for a markedly increased risk of infection. [ncbi.nlm.nih.gov]

CONCLUSIONS: The risk of deep postoperative infection requiring surgical intervention after TKA in patients with diabetes mellitus increases as the perioperative HbA1c increases [ncbi.nlm.nih.gov]

Our preliminary, subjective, analysis has indicated that infection rates increase steadily as the HbA1c increases toward 7.3%, increase rapidly at an HbA1c of 7.3% to 9.8% [ncbi.nlm.nih.gov]

Hemoglobin D Disease

On interpretation of results, we found that there is a discrepancy between normal fasting glucose level and increased HbA1c percentage. [ijpmonline.org]

HbA1c, but not glycated albumin, is increased in late pregnancy in nondiabetic individuals owing to iron deficiency [6]. [ngsp.org]

HbA1c results from patients with HbSS, HbCC, and HbSC must be interpreted with caution given the pathological processes, including anemia, increased red cell turnover, and [ngsp.org]

Diabetes Mellitus Type 1

A significant decrease in salivary flow was observed with an increase in HbA1c (p = 0.007). [ncbi.nlm.nih.gov]

IL12 serum levels were also found to be decreasing by 52.9 pg/ml with each 1% increase in HbA1c. [ncbi.nlm.nih.gov]

Children with type 1 diabetes showed increased plasma levels of CoQ(10) in comparison to healthy children. [ncbi.nlm.nih.gov]

GCGR-Related Hyperglucagonemia

[…] levels, polydipsia (increased thirst), xerostomia (dry mouth), polyphagia (increased hunger), polyuria (frequent urination), and fatigue. 4. [brevets-patents.ic.gc.ca]

[…] levels, polydipsia (increased thirst), xerostomia (dry mouth), polyphagia (increased hunger), polyuria (frequent urination), and fatigue. 79 17. [brevets-patents.ic.gc.ca]

[…] hypertension, diabetic nephropathy, renal insufficiency, renal failure, hyperphagia, muscle wasting, diabetic neuropathy, diabetic retinopathy, or diabetic coma, excess HbA1c [brevets-patents.ic.gc.ca]

Diabetic Hypoglycemia

The bottom line This study concluded that baseline HbA1c or HbA1c levels after 1 month of treatment were not associated with cardiovascular events. [medivizor.com]

In all treatment groups, the prevalence of any hypoglycemia tended to increase as HbA1c level decreased. [jamanetwork.com]

[…] insulin secretion, decrease glucagon secretion, slow gastric emptying (↑ feeling of satiety, ↓ weight) Clinical characteristics Glycemic efficacy: lowers HbA1c by 0.5–1.5% [amboss.com]

Diabetes Mellitus Type 2

[…] glucose concentration and associated glycemia/HbA1c values, with the strength of the correlation increasing for higher glycemia/HbA1c values. [ncbi.nlm.nih.gov]

Peri-implant pocket depth showed the same tendency to increase in relation to HbA1C but differences between groups did not reach statistical significance. [ncbi.nlm.nih.gov]

HbA1c (P < 0.05). [ncbi.nlm.nih.gov]

Diabetic Cataract

Table 2 Characteristics of cataract cases and controls, nested case-control analysis The risk of a cataract diagnosis rose with higher HbA1c level and was 20% increased for [nature.com]

Increased serum level of glycosylated hemoglobin (HbA1C), as one of the most important diabetic markers, is related to worsening of the clinical course of diabetic retinopathy [go.galegroup.com]

(149–199) 5.46 (1.32–22.55) 0.019 5th quintile (200–990) 6.83 (1.22–38.18) 0.029 CC Age, per year increase 1.14 (1.11–1.18) HbA1c 3rd quintile (7.3–8.4) 2.09 (1.06–4.12) [iovs.arvojournals.org]

Mauriac Syndrome

All had a previous history of poor glycemic control before the diagnosis of MS with glycated hemoglobin (HbA1c) between 8.8 and 12.9%. [comum.rcaap.pt]

Increase of hepatic enzymes was present in all the patients; 4 of them had associated hepatomegaly. All the girls presented puberty delay and cushingoid features. [comum.rcaap.pt]

Congenital Generalized Lipodystrophy Type 2

During follow-up, her HbA1c level has increased to 6.5% at the age of eleven years and three months. [jcrpe.org]

Background bone mineral density was increased. [journals.sagepub.com]

During treatment, the serum leptin level increased from a mean of 1.3±0.3 ng/mL to 11.1±2.5 ng/mL (equivalent to 0.1±0.02 to 0.9±0.2 nmol/mL). [dovepress.com]

Acquired Generalized Lipodystrophy

[…] in HbA1c and/or triglycerides) was seen in these two patients. [astrazeneca-us.com]

Clinical study with GL patients who took metreleptin had increased insulin sensitivity, as indicated by decreased HbA1c and fasting glucose level, and reduced caloric intake [en.wikipedia.org]

[…] in HbA1c and triglycerides), and in three patients without lipodystrophy who received MYALEPT in clinical studies (excessive weight gain, development of glucose intolerance [astrazeneca-us.com]

Lipoatrophic Diabetes Mellitus

Her serum insulin level gradually decreased, her glycemic control worsened, and her HbA1c level increased above 12% even with 1000 U of insulin per day. [endocrine-abstracts.org]

[…] to ketonemia (ketone increase in blood) and ketonuria (ketone increase in urine). What causes metabolic ketoacidosis? [quizlet.com]

Similarly, patients with type 2 diabetes are frequently overweight or obese and, consequently, hyperleptinemic with increased leptin resistance. [dovepress.com]

Diabetic Retinopathy

Among DR patients from haplogroup H, longer diabetes duration and increasing HbA1c were significant risk factors for PDR (P = 0.0001 and P = 0.011, respectively). [ncbi.nlm.nih.gov]

and diabetic duration were deeply associated with increased risk of DR (UACR, odds ratio [OR] = 1.04, 95% confidence interval [CI] = 1.02-1.07; HbA1c, OR = 1.16, 95% CI [ncbi.nlm.nih.gov]

Increased serum level of glycosylated hemoglobin (HbA1C), as one of the most important diabetic markers, is related to worsening of the clinical course of diabetic retinopathy [go.galegroup.com]

Sclerodactyly

The presence of complications, increased proximal nail fold capillarity, HbA1c levels, radiological and histopathological findings were not different among those patients [ncbi.nlm.nih.gov]

Diabetes in Pregnancy

Congenital malformations are already significantly increased in the case of HbA1c values of 2-4SD above the mean, and fetal macrosomia is increasing in incidence. [ncbi.nlm.nih.gov]

Results: Although there was no significant reduction in HbA1c (U= -1.17, p=.238), there were statistically significant increases in self-management (U= -3.80, p<.001) and [dbpia.co.kr]

Aim to maintain glucose 4-7 mmol/L and HbA1c within the normal non-diabetic range. [diabetes.co.uk]

Miglitol

In the placebo group the HbA1c level increased by 0.40+/-1.46% as compared with baseline. [ncbi.nlm.nih.gov]

[…] glycosylated hemoglobin (HbA1c) over time in the miglitol 50 mg 3 times daily monotherapy arm compared to placebo. [centerwatch.com]

Although the side effects were not serious, they were troublesome, leading to a considerable drop-out rate increasing with dose. [ncbi.nlm.nih.gov]

Insulin-Resistance Syndrome Type B

Fasting C-peptide concentration was normal and increased adequately in glucagon stimulation test (0′ 2.87 ng/ml, 6′ 4.56 ng/ml). [endocrine-abstracts.org]

Prior to admission, her DM was under fair control (HbA1c 8.1%) on [sim]100 U/day of insulin. [professional.diabetes.org]

Hmm, […] HbA1c and Diabetes – Glycated Hemoglobin (A1c) Explained Posted July 20, 2015, by Axel F. Sigurdsson MD. [docsopinion.com]

Hyperglycemia

During follow-up, he showed abnormal fasting glucose (113 mg/dL), increased level of HbA1c (6.6%), and negative β-cell antibodies. [ncbi.nlm.nih.gov]

Multivariate linear regression analyses revealed that glycemic indices (FPG and HbA1c) were significantly associated with increased aBMD and decreased TBS, and that HOMA-IR [ncbi.nlm.nih.gov]

OBJECTIVE: This meta-analysis aims to determine whether hemoglobin A1c (HbA1c) and perioperative hyperglycemia are associated with the increased risk of periprosthetic joint [ncbi.nlm.nih.gov]

Microangiopathy

Thus, diabetes was not identified as a risk factor for CM, even though the mean levels of HbA1c and serum glucose were increased in those patients [11], [33]. [journals.plos.org]

Thus, mean serum levels of glucose, and HbA1c had no effect on WML/lacunar infarct grades. Mean serum levels of cholesterol were slightly elevated. [journals.plos.org]

Triglycerides and LDL decreased, while HDL increased across the groups according to WML/lacunar infarct severity, however, there was no significant effect on WML/lacunar infarct [journals.plos.org]

Chronic Periodontitis

To date, periodontal conditions have remained stable and the patient's HbA1c level has increased to 7.5% during SPT. [ncbi.nlm.nih.gov]

[…] depth (PD) and attachment loss (AL) were significantly improved, the serum levels of TNF-α and IL-6 were significantly decreased, and APN and FGF-21 exhibited substantial increases [ncbi.nlm.nih.gov]

The glycated hemoglobin (HbA1c) levels in both groups decreased significantly after 3 months compared with baseline (p < 0.05), but the intervention group exhibited a significantly [ncbi.nlm.nih.gov]

Periodontitis

[…] suggest that periodontitis results in increased HbA1c levels in individuals who do not have diabetes, and is continuing further to identify whether this translates into an [doi.org]

With an increasing severity of periodontitis, a significant increase in HbA1c levels could be observed (p=0.003). [doi.org]

In a longitudinal study, the (non-diabetic) participants with the most advanced periodontitis at baseline were found to have a five times greater increase in their HbA1c values [doi.org]

Rathbun Syndrome

Her HbA1c increased to 6.2% and then to 6.6%. The C-peptide level was 1.3 ng/mL (normal 0.9–6.9 ng/mL). [link.springer.com]

Orthostatic Hypotension

There is an association between the incidence of orthostatic hypotension and increased HbA1c levels in elderly patients with diabetes mellitus. [ncbi.nlm.nih.gov]

Dental Caries

The levels of FPG and HbA1c increased with the number of DT (p for trend = 0.009 and 0.004, respectively). [ncbi.nlm.nih.gov]

RESULTS: The number of DT had a positive association with degree of fasting plasma glucose (FPG) level, and glycated hemoglobin (HbA1c) (p-value = 0.045 and 0.007, respectively [ncbi.nlm.nih.gov]

Drug-Induced Hypoglycemia

[…] by transitioning earlier to more intensive glucose therapy, instead of waiting for a rise in HbA1c and then increasing glucose control. [touchendocrinology.com]

7,59,80,81 The ADA suggests a goal HbA1C below 7% for many adults, although a more stringent goal can be sought in select patients as long as it can be achieved without [ahcmedia.com]

Gliflozin therapy is associated with a reduction in blood glucose and glycosylated hemoglobin (HbA1c). [openaccessjournals.com]

Poorly Controlled Diabetes Mellitus

Patients who have an HbA1c between 5.7 and 6.4 are considered at increased risk for developing diabetes in the future. [mayomedicallaboratories.com]

Peri-implantitis increases with elevated HbA1c. Anner 2010 Retrospective n.d. [journalimplantdent.springeropen.com]

Wide glycemic variability refers to patients who had a reduction in annual mean HbA1c from higher than 9% to less than 7%, followed by an increase to higher than 9%. [cdc.gov]