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154 Possible Causes for Headache, Massive Splenomegaly, Pancytopenia

  • Leukemia

    Pounding headaches iStock/AZarubaika Although not common, frequent pounding headaches may be a sign of leukemia-related anemia or even a life-threatening case of bleeding[rd.com] Splenomegaly can be massive, consistency high, with the fibrous thickening of the capsule.[ncbi.nlm.nih.gov] This fact sheet discusses the theory that intermittent fasting may reduce the risk of cancer or improve outcomes with anticancer treatments. more » A 47-Year-Old Woman with Pancytopenia[cancertherapyadvisor.com]

  • Paroxysmal Nocturnal Hemoglobinuria

    Our case is a 44-year-old woman who presented with a 2 day history of headaches, nausea, and seizures followed by a Todd s paresis; she had been diagnosed as paroxysmal nocturnal[ncbi.nlm.nih.gov] We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly.[ncbi.nlm.nih.gov] We report a 19-year-old female patient admitted to the hospital with pancytopenia. Workout of pancytopenia disclosed paroxysmal nocturnal hemoglobinuria.[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    […] as the normal cells are pushed out, primary myelofibrosis may manifest itself in the following ways: Anemia Fatigue Shortness of breath Weakness Lightheadedness Pale skin Headaches[patientworthy.com] She also underwent splenectomy when she was 13 years old, due to massive splenomegaly, anemia and various infection disease episodes.[ncbi.nlm.nih.gov] This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[aoporphan.com]

  • Chronic Lymphocytic Leukemia

    […] in which Wegener's granulomatosis is associated in a patient with chronic lymphocytic leukemia, who is admitted in the Infectious Disease Department for fever, diplopia, headache[ncbi.nlm.nih.gov] splenomegaly and occasionally lymphadenopathy; prognosis is often poor.[medical-dictionary.thefreedictionary.com] The symptoms of this infection range from a silent infection to fever, enlargement of the liver and spleen, weight loss, and pancytopenia.[ncbi.nlm.nih.gov]

  • Myeloproliferative Disease

    Symptoms resulting from hypervolemia and hyperviscosity, such as headache, dizziness, visual disturbances and paresthesias, are sometimes present.[medindia.net] Four years later, at the age of 16, her brother was diagnosed as having acute myelofibrosis, and some months afterwards he died from fulminant pneumonia coincidently with pancytopenia[ncbi.nlm.nih.gov] Patients may experience headaches, dizziness, fatigue , chest pains, or weakness and cramping in the calves while walking.[encyclopedia.com]

  • Non-Hodgkin Lymphoma

    This syndrome causes symptoms such as fever, nausea, chills, tachycardia, and headache.[cnn.com] […] antibiotic therapy may result in remission of the disease.[ 97 ] Splenic marginal zone lymphoma Splenic marginal zone lymphoma is an indolent lymphoma that is marked by massive[web.archive.org] Leukemia commonly occurring after alkylating agent treatment; manifestations include pancytopenia, megaloblastic bone marrow, and nucleated red cells in peripheral marrow;[icd9data.com]

  • Chronic Myeloid Leukemia

    […] chronic myeloid leukemia (CML) on Imatinib for the past four years and in complete clinical, hematological and molecular remission who presented to us with sudden onset of headache[ncbi.nlm.nih.gov] Chronic myeloid leukemia (CML) is a chronic myeloproliferative disorder that usually presents with high white blood cell counts and massive splenomegaly.[ncbi.nlm.nih.gov] We present a case of 29-year-old white male farmer, with chronic myeloid leukemia treated with imatinib who developed significant pancytopenia, leading to discontinuation[ncbi.nlm.nih.gov]

  • Waldenstrom Macroglobulinemia

    Clinically, patients may present with fatigue, weight loss, peripheral neuropathy or symptoms of hyperviscosity, including headache, blurred vision or epistaxis.[ncbi.nlm.nih.gov] Case report. 41M with WM, massive splenomegaly.[en.wikibooks.org] She showed improvement in muscle spasms post-chemotherapy, which was discontinued due to pancytopenia.[ncbi.nlm.nih.gov]

  • Familial Myelofibrosis

    Common ET Symptoms related to small vessel disturbances may include: Headache Vision disturbances or silent migraines Dizziness or lightheadedness Coldness or blueness of[mpnresearchfoundation.org] Massive splenomegaly 22 cm may predict TRM and relapse (Bacigalupo et al, 2010 ).[onlinelibrary.wiley.com] The illness presented with pallor, haemorrhagic symptoms, and hepatosplenomegaly, and the blood picture was that of pancytopenia and leucoerythroblastosis.[ncbi.nlm.nih.gov]

  • Sarcoidosis

    This can cause a number of symptoms, such as abnormal heartbeats, shortness of breath, headaches, and vision problems.[web.archive.org] The laboratory investigations showed pancytopenia, and imaging tests revealed hepatosplenomegaly and ascites.[ncbi.nlm.nih.gov] This can cause many symptoms, such as abnormal heartbeats, shortness of breath, headaches, and vision problems.[web.archive.org]

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