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13 Possible Causes for Heart Murmur, Impaired Exercise Tolerance, Midline Defects

  • Atrial Septal Defect

    At the initial visit, he presented with recurrent lower respiratory infection, heart murmur, psychomotor retardation, inverted nipples, and cerebellar atrophy.[ncbi.nlm.nih.gov] Surgical atrial septal defect treatment is performed by an open heart surgery, done using an up-and-down (vertical) incision in the midline of the chest.[childrens.memorialhermann.org] There are many other different causes of heart murmurs, including normal causes.[pediatricheartspecialists.com]

  • Congenital Heart Disease

    Node and midline defects are associated with left-right development in Delta1 mutant embryos. Development. 2003 ; 130 : 3–13.[doi.org] Your doctor can hear a heart murmur with a stethoscope. However, not all murmurs are signs of congenital heart defects. Many healthy children have heart murmurs.[web.archive.org] However, not all murmurs are signs of congenital heart defects. Many healthy children have heart murmurs.[web.archive.org]

  • Cyanotic Congenital Heart Disease

    Acyanotic lesions (such as atrial or ventricular septal defects) are typically able to maintain appropriate oxygen saturations despite a left-to-right shunt.[learn.pediatrics.ubc.ca] Auscultation findings may include tachycardic or bradycardic sounds;heart murmurs- their location, intensity, musical qualities and lack of variability with respiratory movements[symptoma.com] Heart murmurs. See also separate Heart Murmurs in Children article: Not all murmurs are pathological.[patient.info]

  • Scoliosis

    Abstract Cantrell's pentalogy (CP) is a rare syndrome characterized by defects in the lower sternum with ectopia cordis, anterior diaphragm defects, midline supraumbilical[ncbi.nlm.nih.gov] tolerance test.[doi.org] The location is defined by the vertebra that is most deviated and rotated from midline, called the apical vertebra.[symptoma.com]

  • Mitral Valve Prolapse

    Cardiac malformations and midline skeletal defects in mice lacking filamin A. Hum Mol Genet. 2006; 15 :2457–2467. [ PubMed ] [ Google Scholar ] 10.[ncbi.nlm.nih.gov] Objective exercise testing usually does not show impaired exercise tolerance, and many patients exhibit distinct episodes of hyperventilation. 3, 5 Neuropsychiatric symptoms[aafp.org] The occurrence of total MVP tended to be higher in the group with MVI (47%, 9/19), when compared with the younger CKCS without heart murmurs (13%, 2/15, P 0.06).[ncbi.nlm.nih.gov]

  • Funnel Chest

    Other notable findings include a pot-belly posture, forward-drifted shoulders, a heart murmur on cardiac auscultation and arrhythmia in severe cases.[symptoma.com] We performed concomitant repair of pectus excavatum and an atrial septal defect through a short midline incision in an adult [5].[wikigenes.org] But overall exercise tolerance is usually impaired.[medsafecare.com]

  • Danon Disease

    […] of midline structures and postzygotic changes in the genetic material, including somatic mutations [ 62 ].[ojrd.biomedcentral.com] Clinical recognition in 6 patients occurred by virtue of heart murmur, family screening, and findings on routine electrocardiogram (ECG) or by symptoms (chest pain or syncope[jama.ama-assn.org] There are many other possible explanations for discordant phenotypes between monozygotic twins: environmental causes, several embryologic mechanisms, vascular abnormalities, defect[ojrd.biomedcentral.com]

  • Ventricular Bigeminy

    Aneurysms are not usually associated with other congenital malformations, whereas diverticula may be associated with thoracic and abdominal midline defects [ 1 ].[oapublishinglondon.com] The routine investigations should include resting 12-lead ECG, echocardiography, ambulatory Holter recordings, and exercise tolerance test.[karnatakaanaesthj.org] Heart murmur. Significant underlying problem - eg, endocrine or metabolic disorder, infection.[patient.info]

  • Pericardial Effusion

    Carmi R, Boughman JA: Pentalogy of Cantrell and associated midline anomalies: a possible ventral midline developmental field. Am J Med Genet 1992;42:90-95.[karger.com] Dyspnea and reduced exercise tolerance will be early signs, progressing to severe impaired cardiac output and death in severe cases (e.g. cardiac tamponade ).[radiopaedia.org] Chest X-ray: This can reveal whether there is any enlargement of the heart or not which can rule in or rule out cardiomegaly as a cause of the heart murmur.[epainassist.com]

  • Fabry Disease

    […] of midline structures and postzygotic changes in the genetic material, including somatic mutations [ 62 ].[ncbi.nlm.nih.gov] Diastolic dysfunction is probably the commonest cause of exertional dyspnoea and reduced exercise tolerance in patients and may be present before the development of overt[doi.org] murmur (arrhythmia) Fabry crises may increase in intensity when your baby has a fever, is physically active, or under fatigue or stress.[babysfirsttest.org]

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