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10 Possible Causes for Heart Murmur, Neonatal Hypotonia, Wide Space Between the First and Second Toe

  • Down Syndrome

    The doctor may hear a heart murmur when listening to the baby's chest with a stethoscope.[nlm.nih.gov] Frequently the first feature noticed is hypotonia. Neonatal features of Down's syndrome General: Hyperflexibility. Muscular hypotonia.[patient.info] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org]

  • Atelosteogenesis Type 2

    Hydrocephalus Seizures Survival beyond neonatal period Normal karyotvpe - t 111 3 I4 0 19 2 I5 t - 515 10110 5 I5 NR 315 014 215 0 I4 515 013 414 NR 515 111 415 212 515 111[documents.tips] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] murmur 82.[tawnymullins77.blogspot.com]

  • Familial Congenital Nasolacrimal Duct Obstruction

    Patients with FOXG1 pathogenic variants often demonstrate normal birth parameters, followed by hypotonia and extreme irritability in the neonatal period.[chginc.org] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org] murmurs reflect underlying heart disease.[quizlet.com]

  • Adactyly of Foot

    […] criteria provided, single submitterCongenital giant melanocytic nevus, Obesity, Behavioral abnormality, Scoliosis, Abnormal facial shape, Hyperpigmentation of the skin, Neonatal[ncbi.nlm.nih.gov] Synonyms:Anterior Polydactyly Replaces: Anterior Duplication of the Limb, Tibial Polydactyly Foot, Preaxial Polydactyly of Subjective: A widely spaced gap between the first[quizlet.com] Congenital heart disease is something you are born with, such as a murmur. If her artery is becoming slowly blocked, she does not have congenital disease.[lookfordiagnosis.com]

  • Trisomy 10p

    murmur Renal defect Genital defect Cryptorchidism Limb defects Clinodactyly Syndactyly Club foot Wide sandal gap Nail dysplasia Anemia Extra / single palmar creases Narrow[e-sciencecentral.org] Prader–Willi patients typically present with neonatal hypotonia and poor feeding.[plasticsurgerykey.com] spaced, inverted nipples, mild pectus excavatum; and a sandal gap between the first and second toes.[jmg.bmj.com]

  • Macrocephaly-Developmental Delay Syndrome

    Out of these clinical criterion, seven clinical findings (neonatal hypotonia, midline facial nevus flammeus, connective tissue defect, developmental delay, toe syndactyly[ijpd.in] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org] 46, XY, der(7)t(7;21)(q31;qter) pat growth and developmental delay, bilateral cataracts, frontal bossing, low-set ears, micrognathia, heart murmur, dysplastic hip, scoliosis[chr7.org]

  • Baraitser Syndrome

    The first girl had neonatal hypotonia, mental retardation, and generalized tonic-clonic seizures.[omim.org] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Left ventricular hypertrophy Gonadal dysgenesis Abnormality of the coagulation cascade Abnormality of the vertebral column Abnormality of blood and blood-forming tissues Heart[mendelian.co]

  • MORM Syndrome

    hypotonia Low muscle tone, in neonatal onset 0001319 Pes planus Flat feet Flat foot [ more ] 0001763 Reduced visual acuity Decreased clarity of vision 0007663 Short metacarpal[rarediseases.info.nih.gov] murmurs Extreme nearsightedness An abnormally curved spine Flat feet When to see a doctor If you think that you or your child may have Marfan syndrome, talk to your doctor[mayoclinic.org] Hypotonia Miles-Carpenter syndrome miliaria Milner Khallouf Gibson Syndrome Mirhosseini-Holmes-Walton Syndrome Mirizzi Syndrome Mitchell-Riley Syndrome mitochondrial DNA[rgd.mcw.edu]

  • Tricho-Oculo-Dermo-Vertebral Syndrome

    hypotonia Visual loss Edema Microglossia Retinal dysplasia Stridor Selective tooth agenesis Lacrimal duct atresia Patchy alopecia Oval face Hyperconvex nail Ankyloblepharon[mendelian.co] space between the first and second toes, and fusion of carpal and tarsal bones.[findzebra.com] […] an alternative anatomic explanation, or • abscess, or • new partial dehiscence of prosthetic valve or 2- New valvular regurgitation (worsening or changing of preexisting murmur[cram.com]

  • Mild Dysmorphic Features

    Hypotonia, joint hyperextensibility, neonatal jaundice, simian crease, shortened digits, and excess skin on the back of the neck contribute to the clinical features.[emedicine.medscape.com] , fourth, and fifth fingers; feet held in eversion, prominent heels; wide space between the first and second toes; proximally placed fifth toes; hypotonia; increased skin[ssmc-tl.com] Classic clinical features include neonatal and infantile hypotonia, feeding problems or failure to thrive in infancy, excessive weight gain with hyperphagia beginning between[emedicine.medscape.com]

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