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61 Possible Causes for Heart Murmur, Tendon Xanthomas

  • Homozygous Familial Hypercholesterolemia

    The condition is characterized by exceptionally high LDL cholesterol levels, cutaneous and tendon xanthomas, and valvular and supravalvular stenosis, and accelerated atherosclerosis[] Xanthomas The high cholesterol level may result in the build-up of cholesterol deposits in the skin and tendons as well – xanthomas.[] RESULTS: The index cases were 24-year-old identical twin sisters with long-standing tendon xanthomas and high low-density lipoprotein cholesterol (LDL-C 10 mmol/L) but no[]

  • Aortic Valve Stenosis

    She was diagnosed as heterozygous familial hypercholesterolemia, because of Achilles tendon xanthoma and a family history of primary hypercholesterolemia.[] A heart murmur is a sound created by turbulent blood flow through narrowed or leaking heart valves or through abnormal heart structures.[] When to see a doctor If you have a heart murmur, your doctor may recommend that you visit a cardiologist.[]

  • Familial Hypercholesterolemia

    The case presented here is of a 48-year old male with large tendon xanthomas attributable to CTX.[] A short-lived cardiac sound having little duration (less than 0.12 second) as distinct from a murmur; e.g., first, second, third, and fourth heart sounds, clicks, and opening[] BACKGROUND AND AIMS: The effect of LDLc lowering with PCSK9 antibodies on tendon xanthomas (TX) is unknown.[]

  • Supravalvular Aortic Stenosis

    On physical examination, arcus cornealis, and extensor tendon xanthomas were observed. Blood pressure was 160/90 in the right arm and 140/70 in the left arm.[] The main sign of heart valve disease is an unusual heartbeat sound called a heart murmur. Your doctor can hear a heart murmur with a stethoscope.[] […] skin xanthomas, and premature atherosclerosis disease-beginning in childhood and including supravalvular aortic stenosis.[]

  • Coronary Atherosclerosis

    These mutations cause a decreased number of LDLR, elevated levels of serum total and LDL cholesterol, and phenotypes of tendon xanthomas, premature CAD, MI and stroke.[] […] axilla; see Heart Murmurs Topic Review.[] Xanthoma are sharply demarcated yellowish collection of cholesterol under the skin, that can occur anywhere on the body, but are most often seen on the elbows, joints, tendons[]

  • Alagille Syndrome

    Xanthomas may appear anywhere on the body. However, xanthomas are usually found on the elbows, joints, tendons, knees, hands, feet, or buttocks.[] murmur, skeletal abnormalities, ocular abnormalities, characteristic facial features, and renal abnormalities).[] Narrowing of the blood vessel connecting the heart to the lungs leads to heart murmurs but rarely causes problems in heart function.[]

  • Hyperlipoproteinemia Type 1

    “Dermal, subcutaneous, and tendon xanthomas: diagnostic markers for specific lipoprotein disorders”. J Am Acad Dermatol. vol. 19. 1988. pp. 95-111.[] Murmur: Turbulent blood flow across a heart valve creating a "swishing" sound heard by a stethoscope.[] Clinical findings: Tendon xanthomas, Xanthelasma, premature coronary artery disease and stroke.[]

  • Mucolipidosis

    Tendon xanthoma Triglyceride storage disease with ichthyosis Xanthoma tendinosum Clinical Information Autosomal recessive disorder caused by deficiency of the enzyme glucocerebrosidase[] In most ML II patients, the clinical conditions 'stand alone', 'walk without support' and 'speak single words' were impaired; however, the frequency of 'heart murmur', 'inguinal[] Clinical manifestations, such as ‘heart murmur’, ‘inguinal hernia’ and ‘hepatomegaly and/or splenomegaly’, were found in both ML II and III.[]

  • Abdominal Aortic Aneurysm

    A physical examination revealed prominent Achilles tendon thickness and plantar xanthomas.[] […] may present with congestive heart failure.[] He had no familial history of high low-density lipoprotein cholesterol, tendon xanthomas, or premature atherosclerosis.[]

  • Sneddon's Syndrome

    Juvenile xanthogranuloma Necrobiotic xanthogranuloma Reticulohistiocytoma Benign cephalic histiocytosis Giant cell tumor of the tendon sheath Giant cell tumor of the skin[] Heart murmurs, heart disease resulting from reduced blood flow to heart tissue (ischemic heart disease), or thickening of the valves between the chambers of the heart (valvular[] […] leiomyomas Leiomyosarcoma Rhabdomyoma, rhabdomyomatous mesenchymal hamartoma Adenoma (angiofibroma) sebaceum Pringle Pearly penile papules Histiocytic tumors and proliferations Xanthoma[]

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