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144 Possible Causes for Heat Intolerance, Hypomyelination

  • Peripheral Neuropathy

    Magnetic resonance imaging showed cortical disturbances in addition to profound hypomyelination and cerebellar atrophy.[] intolerance Excessive sweating or not being able to sweat Bowel, bladder or digestive problems Changes in blood pressure, causing dizziness or lightheadedness Peripheral[] […] asymmetric demyelinating-type peripheral neuropathy, and sural nerve biopsy documented reduced myelinated nerve fiber density with uniformly thin myelin sheaths, suggesting hypomyelination[]

  • Multiple Sclerosis

    Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice. Development. 1999; 126 :457–67. [ PubMed ] [ Google Scholar ] 28.[] Weakness, particularly in the lower extremity, balance deficits, fatigue, posture, contractures, sensation deficits, heat intolerance, among other deficits, can impede an[] intolerance Constitutional symptoms: Especially fatigue (70% of cases) and dizziness Pain: Occurs in 30–50% of patients at some point in their illness Subjective cognitive[]

  • Dysautonomia

    : Neuropathies Sensory ataxia, Dominant SPG8 Triglycerides Tuberculosis Vasculitis: Treatment Oct 2006 Coenzyme Q 10 deficiency COQ2 PDSS2 Fukutin Cardiomyopathy LGMD 2L Hypomyelination[] While such patients may also experience symptoms including fatigue, sleep disturbances, altered cognitive function (brain fog), cold or heat intolerance, headaches, and bladder[] She also often felt weak and lightheaded and struggled with symptoms like memory issues , abnormal dilation of the pupils, heat intolerance, anxiety and frequent urination[]

  • Demyelinating Disease

    DVM, DACVIM, Professor and Hospital Director, Center for Veterinary Health Sciences, Oklahoma State University Demyelinating Disorders Overview of Demyelinating Disorders Hypomyelination[] Heat, pressure, overwork, and lack of sleep may aggravate this symptom. The pain is described as extremely intense and intolerable during the night.[] DeBoy, Pharmacological approaches to intervention in hypomyelinating and demyelinating white matter pathology, Neuropharmacology, 10.1016/j.neuropharm.2015.06.008, 110, (605[]

  • Alexander Disease

    Histopathology shows a lack of myelin in the affected white matter, variably interpreted as hypomyelination or demyelination.[] The patient developed symptoms of OH, erectile dysfunction, and heat intolerance soon after his diagnosis.[] It can be considered, in large part, as a deficiency of normal myelination or hypomyelination, rather than demyelination.[]

  • Polyglucosan Body Myopathy Type 2

    4 (HLD4) – Spastic paraplegia 13 Leukodystrophy, hypomyelinating, 3 (HLD3) Limb-girdle muscular dystrophy type 2B Limb-Girdle Muscular Dystrophy type 2C Limb-Girdle Muscular[] Very general symptoms/signs would include: Failure to grow Heat intolerance Exercise intolerance Hypoglycemia Hepatomegaly Low muscle tone Acidosis Hyperlipidemia.[] CMT4e (congenital hypomyelinating neuropathy) PMP22, MPZ, ERG-2 g. CMT4f Periaxin 19q13.1-13.3 h. CMT4g 10q23.2 i.[]

  • Dilated Cardiomyopathy 1R

    […] absence of the vas deferens Congenital Cataracts, Facial Dysmorphism, and Neuropathy Congenital central hypoventilation Congenital ectodermal dysplasia of face Congenital hypomyelinating[] Other symptoms include fatigue, weight loss, heat intolerance, and diarrhea.[] […] neurofibromin 2 (merlin) Enf-600 Neuromuscular disease, congenital, with uniform type 1 fiber 117000 RYR1 ryanodine receptor 1 (skeletal) Enf-601 Neuropathy, congenital hypomyelinating[]

  • Oculodentodigital Dysplasia

    James Barkovich and Sean Deon, Reprint of “Hypomyelinating disorders: An MRI approach, Neurobiology of Disease, 10.1016/j.nbd.2015.10.022, 92, (46-54), (2016). A.[] Chronic cheilitis and perléche are common, whereas hair and nail dystrophy, scarring alopecia, dental anomalies and heat intolerance are less frequent.[] James Barkovich and Sean Deon, Hypomyelinating disorders: An MRI approach, Neurobiology of Disease, 10.1016/j.nbd.2015.10.015, 87, (50-58), (2016). A.[]

  • Allan-Herndon-Dudley Syndrome

    […] mutations cause an X-linked syndromic disorder known as Allan-Herndon-Dudley syndrome (AHDS) that is characterized by severe psychomotor delays, abnormal thyroid function, and hypomyelinated[] They are: Fatigue, heat intolerance, weight loss, fever, increased appetite, and excessive sweating Muscle weakness, tremors Increased heart rate and blood pressure, palpitations[] Three patients in our study displayed hypomyelination on MRI.[]

  • Combined Oxidative Phosphorylation Defect Type 14

    […] with atrophy of basal ganglia and cerebellum Hypomyelination with brain stem and spinal cord involvement and leg spasticity Hypotonia with lactic acidemia and hyperammonemia[] Click Here to download this mito profile (PDF) Links: NINDS OMIM , X-linked: OMIM , Adult-onset: OMIM Symptoms: Hypermetabolism, with fever, heat intolerance, profuse perspiration[] Conventional MRI of the brain in neonatal metabolic disorders usually shows non-specific abnormalities (brain swelling, atrophy, delayed or hypomyelination).[]

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