Heinz Bodies: Causes & Reasons

Possible Causes for Heinz Bodies

CHBHA stands for "Congenital Heinz Body Hemolytic Anemia" How to abbreviate Congenital Heinz Body Hemolytic Anemia? [allacronyms.com]

Abstract The mechanisms of hemoglobin precipitation into Heinz bodies and hemolytic anemia that characterize congenital Heinz body hemolytic anemia (CHBHA) were studied in [ncbi.nlm.nih.gov]

One of the meanings of CHBHA is "Congenital Heinz Body Hemolytic Anemia" What is the abbreviation for Congenital Heinz Body Hemolytic Anemia? [allacronyms.com]

Anemia due to Glutathione Metabolism Disorder

Heinz bodies (intracellular hemoglobin precipitates) form from oxidized, denatured hemoglobin which is no longer soluble. [pathophys.org]

- causes RBC rigidity and removal by macrophages. - Macrophages come along and pluck heinz bodies out of red blood cells = get "bite cells" - Heinz bodies cause RBC to [quizlet.com]

bodies on exposure to acetylphenylhydrazine developed. [annals.org]

Thalassaemia-Haemoglobin C Disease

body anemia Hb-C disease Hb-D disease Hb-E disease Hemoglobinopathy NOS Unstable hemoglobin hemolytic disease Type 1 Excludes familial polycythemia ( D75.0 ) Hb-M disease [icd10data.com]

body anemia Hemoglobin C disease Hemoglobin D disease Hemoglobin E - beta-thalassemia Hemoglobin E disease Hemoglobin Lepore - beta-thalassemia Sickle cell - beta-thalassemia [csbg.cnb.csic.es]

Heinz bodies -target cells -Howell-Jolly bodies -leukocytosis Sickle gene offers some protection against malaria What is the probable etiologic association between malaria [quizlet.com]

Naphthalene Poisoning

Red cells may contain Heinz bodies and the cells may be fragmented showing anisocytosis and poikilocytosis. Serum bilirubin is elevated. [flipper.diff.org]

Heinz body was positive. Urine was dark brown, and it was positive for Hb, whereas urine microscopy did not show any RBCs. [jahjournal.org]

Heinz bodies appear before haemolytic process becomes evident and hence has a prognostic valve for development of haemolysis 10. [jpma.org.pk]

Toxic Hemolytic Anemia

Red cells may contain Heinz bodies and the cells may be fragmented showing anisocytosis and poikilocytosis. Serum bilirubin is elevated. [flipper.diff.org]

bodies. [path.upmc.edu]

More severe reactions also include Heinz body formation, haemoglobinuria and mild methaemoglobinaemia. The haemolytic episode tend to be self limiting. [flipper.diff.org]

Aniline Poisoning

[…] but also in vitro 3, and ascorbic acid is able to produce Heinz bodies in vitro without any toxic agents 4. [nature.com]

Aniline induces the formation of Heinz bodies. [wwwn.cdc.gov]

We have found that in rats poisoned with aniline the formation of Heinz bodies is promoted by treatment with ascorbic acid. [nature.com]

Thalassemia

Six rare mutations, despite being heterozygote, showed hemolytic anemia which is also called, "dominant-type thalassemia", and some of them demonstrated Heinz bodies in the [ci.nii.ac.jp]

Six rare mutations, despite being heterozygote, showed hemolytic anemia which is also called, ”dominant-type thalassemia”, and some of them demonstrated Heinz bodies in the [petit.lib.yamaguchi-u.ac.jp]

bodies from HbH β-thalassemia minor target, hypochromic, microcytic cells β-thalassemia major nucleated RBCs target, hypochromic, microcytic cells Hemoglobin gel-electrophoresis [medbullets.com]

Arsine Poisoning

bodies, and ghost cells. [sccgov.org]

bodies) Low haptoglobin Elevated plasma-free hemoglobin levels Elevated urinary hemoglobin Elevated BUN and creatinine Abnormal liver function tests Thrombocytopenia Elevated [emergency.cdc.gov]

At 90 days, the concentration of methemoglobin was increased along with an increase in intracellular denatured proteins, or Heinz bodies. [emedicine.medscape.com]

Thalassemia Minor

Six rare mutations, despite being heterozygote, showed hemolytic anemia which is also called, "dominant-type thalassemia", and some of them demonstrated Heinz bodies in the [ci.nii.ac.jp]

bodies from HbH β-thalassemia minor target, hypochromic, microcytic cells β-thalassemia major nucleated RBCs target, hypochromic, microcytic cells Hemoglobin gel-electrophoresis [medbullets.com]

These inclusions are termed Heinz bodies, depicted below. [emedicine.medscape.com]

Beta Thalassaemia Major

Six rare mutations, despite being heterozygote, showed hemolytic anemia which is also called, "dominant-type thalassemia", and some of them demonstrated Heinz bodies in the [ci.nii.ac.jp]

Heinz bodies, which indicate denatured hemoglobin, may also be present on a peripheral blood film. [symptoma.com]

Acquired Toxic Hemolytic Anemia

bodies (oxidative stress in G6PD deficiency, liver disease, thalassemia, splenectomy) G6PD deficiency history of drug + at risk ethnic group Heinz body prep G6PD level once [lifeinthefastlane.com]

Most are autosomal dominant mutations that alter the solubility of hemoglobin in the red cell – Most lead to alterations in tertiary or quaternary structure of hemoglobin Heinz [slideplayer.com]

[…] cells (oxidative damage in G6PD deficiency) schistocytes (TTP or DIC with thrombocytopenia) or heart valve hemolysis (with thrombocytopenia) acanthocytes (liver disease) Heinz [lifeinthefastlane.com]

Pyruvate Kinase Deficiency

Heinz bodies and spherocytes are absent. Osmotic fragility testing may serve as a useful screen for PKD. [clinicaladvisor.com]

Sickle Cell Crisis

None of these patients presented with the classical “coca-cola” coloured urine or presence of Heinz bodies on reticulocyte preparations that are so characteristic of this [adc.bmj.com]

Sickle Cell Anemia

Sickle cell disease (sickle cell anemia, drepanocytosis) is an autosomal recessive blood disorder, characterized by sickle-shaped erythrocytes. Chronic anemia is present in all individuals with sickle cell disease. It is generally asymptomatic, though patients report chronic fatigue and exercise intolerance.[…] [symptoma.com]

Glycogen Storage Disease Type 1

Glycogen storage disease type 1 (GSD1) is an inborn error of metabolism caused by deficiency of glucose-6-phosphatase, the enzyme catalysing the conversion of glucose-6-phosphate (G6P) to glucose. GSD1 is associated with severe hyperlipidaemia and hepatic steatosis. The underlying mechanisms responsible for these[…] [ncbi.nlm.nih.gov]

Acquired Spherocytosis

Heinz body haemolytic anaemia in Wilson's disease. British Journal of Haematology, Mar 1999, Vol. 104 Issue 4, p647-647, Kutlar, F. [iqb.es]

bodies) "Stress makes me eat bites of Fava Beans with Heinz Ketchup" -Oxidative Stress -Bite Cells -Fava Beans -Heinz Bodies G6PD Deficiency Diagnosis -blood smears shows [quizlet.com]

Bite cell anemia Heinz body 30. Small (1 mm), round, dense, basophilic bodies in RBCs. [slideshare.net]

Acute Radiation Sickness

Biosecur Bioterror. 2011 Dec;9(4):345-50. doi: 10.1089/bsp.2011.0042. Epub 2011 Oct 11. Author information 1 Center for Biosecurity of UPMC, Baltimore, Maryland 21202, USA. aadalja@biosecurity-upmc.org Abstract After the detonation of an improvised nuclear device, several key actions will be necessary to save the[…] [ncbi.nlm.nih.gov]

Hemoglobinopathy

body anemia Acquired hemoglobinopathy Arthropathy secondary to hemoglobinopathy Decreased erythrocyte life span Double heterozygous sickling disorder Heinz bodies Hematopoietic [icd9data.com]

[…] cell destruction finding Sickle cell retinopathy Thalassemia-hemoglobin C disease Unstable hemoglobin disease 282.7 Excludes Applies To Abnormal hemoglobin NOS Congenital Heinz-body [icd9data.com]

Body Stain Hemoglobinopathies Unstable Hemoglobinopathies, Hemolytic Anemias 0049020 Hemoglobin, Unstable Hemoglobinopathies HGB UNSTAB 2002984 Oxygen Dissociation (P50) [aruplab.com]

Water Intoxication

A case of water intoxication with remarkable hyponatremia was investigated with a special reference to EEG changes during and after the episode. The patient recovered his EEG as his consciousness disturbance had improved through an intravenous infusion of high osmolality saline, correlating with the serum sodium[…] [ncbi.nlm.nih.gov]

Extensive Burns

Acquired factor X deficiency is an extremely rare situation. It has shown to be associated with systemic amyloidosis, respiratory mycoplasma infection, factor X inhibitors, antiphospholipid antibodies, vitamin K deficiency/liver disease as well as the use of certain medications (meropenem, valproic acid). The pathogenesis[…] [ncbi.nlm.nih.gov]

Glucose-6-Phosphate Dehydrogenase Deficiency

Diagnostic findings include signs of intravascular hemolysis (e.g., normocytic anemia, ↑ LDH, and ↓ haptoglobin ), Heinz bodies, and bite cells on blood smear. [amboss.com]

Bodies [ Figure 1 ]) Figure 1 Heinz Bodies (oxidized, denatured hemoglobin, precipitated out of solution into dense intracellular granules, in a patient with G6PD deficiency [cancertherapyadvisor.com]

Peripheral blood smear revealed bite cells, Heinz bodies and spherocytes. Thus a diagnosis of hemolytic anemia with hemoglobinuria was made. [ncbi.nlm.nih.gov]

Nitrobenzene Poisoning

body in erythrocytes， increase in serum-albumin-ratio， increase in osmotic fragility of erythrocytes， porphyrinuria， urobilinogen excretion in urin， hemoglobinuria， appearance [darch.isl.or.jp]

The other effects include hepatosplenomegaly, altered liver functions, Heinz body hemolytic anemia and contact dermatitis(12). [indianpediatrics.net]

Altered liver function tests, hepato-splenomegaly, and Heinz body haemolytic ficant features [4, 21, ]. [documents.tips]

Benzene Poisoning

Abstract DNA damage induced by benzene reactive metabolites is thought of as an important mechanism underlying benzene hematotoxicity and genotoxicity, and genetic variation in cell-cycle control genes may contribute to susceptibility to chronic benzene poisoning (CBP). Using a case-control study that included 307[…] [ncbi.nlm.nih.gov]

Favism

bodies. [ncbi.nlm.nih.gov]

Heinz bodies and Bite cells are characteristic of these cases but their absence does not exclude the diagnosis. [shmabstracts.com]

The cross-linked hemoglobin forms what is referred to histologically as Heinz bodies. [themedicalbiochemistrypage.org]

Anemia due to Other Disorders of Glutathione Metabolism

To see the actual Heinz bodies, you need to do a supravital stain (see the image above – the Heinz bodies appear as green dots). Therapy is pretty straightforward. [pathologystudent.com]

Diagnostic findings include signs of intravascular hemolysis (e.g., normocytic anemia, ↑ LDH, and ↓ haptoglobin ), Heinz bodies, and bite cells on blood smear. [amboss.com]

Heinz bodies (intracellular hemoglobin precipitates) form from oxidized, denatured hemoglobin which is no longer soluble. [pathophys.org]

Acquired Hemolytic Anemia

[…] cause extravascular and intravascular How does G6PD deficiency cause extravascular hemolysis Heinz bodies destroyed by spleen How does G6PD deficiency cause intravascular [memorize.com]

bodies, hemolysis ghost and bite cells + heinz body prep Dx via enzyme assay, if A- variant, cannot dx when ox stress removed bc young blood cells have G6PD In med type, [quizlet.com]

Hemoglobin Chesapeake

body hemolytic anemia) Abnormal chains produce molecular instability ↓ Precipitation of abnormal hemoglobin (Heinz bodies) & they attach to inner surface of membrane ↓ Pitting [sites.google.com]

Body Hemolytic Anemia Hemoglobin becomes unstable -Forms Heinz Bodies Term Definition Causes the RBC’s to sickle in low oxygen situations Causes a lot of pain Can cause a [flashcardmachine.com]

Idiopathic Heinz body anaemia: Hb-Bristol (beta67 (E11) Val to Asp). Br J Haematol. 1970 Apr;18(4):435–446. [ncbi.nlm.nih.gov]

Traumatic Hemolytic Anemia

Review Topic QID: 101434 1 Bite cells and Heinz bodies 2 Sickle cells and target cells 3 RBC fragments and schistocytes 4 Round macrocytes and target cells 5 Macrocytes and [medbullets.com]

bodies with G6PD deficiency, and basophilic stipplings with lead poisoning, thalassemia, and Wilson's disease, among others. 4 Thus, if the PBS is abnormal, the family history [ncbi.nlm.nih.gov]

Sickle Cell - Hemoglobin E

body anemia Hemoglobin C - beta-thalassemia Hemoglobin C disease Hemoglobin D disease Hemoglobin E - beta-thalassemia Hemoglobin E disease Hemoglobin Lepore - beta-thalassemia [csbg.cnb.csic.es]

Heinz bodies are visible as faint blue blushes in the RBCs. A recticulocyte is seen at lower left. [med-ed.virginia.edu]

body anemia Hb-C disease Hb-D disease Hb-E disease Hemoglobinopathy NOS Unstable hemoglobin hemolytic disease Type 1 Excludes familial polycythemia ( D75.0 ) Hb-M disease [icd10data.com]

Normocytic Normochromic Anemia

[…] denatured hemoglobin in RBCs RBCs which have had Heinz bodies "pitted" in the spleen Bite cells are usually seen in patients with what anemia? [brainscape.com]

Labs During an episode retic count and indirect bilirubin will be elevated Peripheral smear Bite cells Heinz bodies Reduced levels of G6PD between hemolytic episodes Treatment [physicianassistantexamreview.com]

Heinz bodies, erythrocytes containing parasites etc. 16. Anaplasma Babasia Heinz Bodies Normal Erythrocytes 17. [slideshare.net]