Heinz Bodies: Causes & Reasons

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Possible Causes for Heinz Bodies

Congenital Heinz Body Hemolytic Anemia

CHBHA stands for "Congenital Heinz Body Hemolytic Anemia" How to abbreviate Congenital Heinz Body Hemolytic Anemia? [allacronyms.com]

Abstract The mechanisms of hemoglobin precipitation into Heinz bodies and hemolytic anemia that characterize congenital Heinz body hemolytic anemia (CHBHA) were studied in [ncbi.nlm.nih.gov]

One of the meanings of CHBHA is "Congenital Heinz Body Hemolytic Anemia" What is the abbreviation for Congenital Heinz Body Hemolytic Anemia? [allacronyms.com]

Anemia due to Glutathione Metabolism Disorder

- causes RBC rigidity and removal by macrophages. - Macrophages come along and pluck heinz bodies out of red blood cells = get "bite cells" - Heinz bodies cause RBC to [quizlet.com]

Heinz bodies (intracellular hemoglobin precipitates) form from oxidized, denatured hemoglobin which is no longer soluble. [pathophys.org]

bodies on exposure to acetylphenylhydrazine developed. [annals.org]

Naphthalene Poisoning

Red cells may contain Heinz bodies and the cells may be fragmented showing anisocytosis and poikilocytosis. Serum bilirubin is elevated. [flipper.diff.org]

Heinz body was positive. Urine was dark brown, and it was positive for Hb, whereas urine microscopy did not show any RBCs. [jahjournal.org]

Heinz bodies appear before haemolytic process becomes evident and hence has a prognostic valve for development of haemolysis 10. [jpma.org.pk]

Thalassaemia-Haemoglobin C Disease

body anemia Hb-C disease Hb-D disease Hb-E disease Hemoglobinopathy NOS Unstable hemoglobin hemolytic disease Type 1 Excludes familial polycythemia ( D75.0 ) Hb-M disease [icd10data.com]

body anemia Hemoglobin C disease Hemoglobin D disease Hemoglobin E - beta-thalassemia Hemoglobin E disease Hemoglobin Lepore - beta-thalassemia Sickle cell - beta-thalassemia [csbg.cnb.csic.es]

Heinz bodies -target cells -Howell-Jolly bodies -leukocytosis Sickle gene offers some protection against malaria What is the probable etiologic association between malaria [quizlet.com]

Toxic Hemolytic Anemia

Red cells may contain Heinz bodies and the cells may be fragmented showing anisocytosis and poikilocytosis. Serum bilirubin is elevated. [flipper.diff.org]

bodies. [path.upmc.edu]

More severe reactions also include Heinz body formation, haemoglobinuria and mild methaemoglobinaemia. The haemolytic episode tend to be self limiting. [flipper.diff.org]

Thalassemia

Six rare mutations, despite being heterozygote, showed hemolytic anemia which is also called, "dominant-type thalassemia", and some of them demonstrated Heinz bodies in the [ci.nii.ac.jp]

Six rare mutations, despite being heterozygote, showed hemolytic anemia which is also called, ”dominant-type thalassemia”, and some of them demonstrated Heinz bodies in the [petit.lib.yamaguchi-u.ac.jp]

When the hemoglobin destabilizes, it forms up into erythrocyte inclusions called Heinz bodies. [web2.iadfw.net]

Aniline Poisoning

[…] but also in vitro 3, and ascorbic acid is able to produce Heinz bodies in vitro without any toxic agents 4. [nature.com]

We have found that in rats poisoned with aniline the formation of Heinz bodies is promoted by treatment with ascorbic acid. [nature.com]

It is known that ascorbic acid promotes the rate of hydroxylation of aniline to p -aminophenol 2, which is a potent agent in the production of Heinz bodies not only in vivo [nature.com]

Thalassemia Minor

Six rare mutations, despite being heterozygote, showed hemolytic anemia which is also called, "dominant-type thalassemia", and some of them demonstrated Heinz bodies in the [ci.nii.ac.jp]

bodies from HbH β-thalassemia minor target, hypochromic, microcytic cells β-thalassemia major nucleated RBCs target, hypochromic, microcytic cells Hemoglobin gel-electrophoresis [medbullets.com]

These inclusions are termed Heinz bodies, depicted below. [emedicine.medscape.com]

Arsine Poisoning

bodies) Low haptoglobin Elevated plasma-free hemoglobin levels Elevated urinary hemoglobin Elevated BUN and creatinine Abnormal liver function tests Thrombocytopenia Elevated [emergency.cdc.gov]

bodies, and ghost cells. [sccgov.org]

At 90 days, the concentration of methemoglobin was increased along with an increase in intracellular denatured proteins, or Heinz bodies. [emedicine.medscape.com]

Beta Thalassaemia Major

Six rare mutations, despite being heterozygote, showed hemolytic anemia which is also called, "dominant-type thalassemia", and some of them demonstrated Heinz bodies in the [ci.nii.ac.jp]

Heinz bodies, which indicate denatured hemoglobin, may also be present on a peripheral blood film. [symptoma.com]

Acquired Toxic Hemolytic Anemia

bodies (oxidative stress in G6PD deficiency, liver disease, thalassemia, splenectomy) G6PD deficiency history of drug + at risk ethnic group Heinz body prep G6PD level once [lifeinthefastlane.com]

Most are autosomal dominant mutations that alter the solubility of hemoglobin in the red cell – Most lead to alterations in tertiary or quaternary structure of hemoglobin Heinz [slideplayer.com]

[…] cells (oxidative damage in G6PD deficiency) schistocytes (TTP or DIC with thrombocytopenia) or heart valve hemolysis (with thrombocytopenia) acanthocytes (liver disease) Heinz [lifeinthefastlane.com]

Pyruvate Kinase Deficiency

Heinz bodies and spherocytes are absent. Osmotic fragility testing may serve as a useful screen for PKD. [clinicaladvisor.com]

Sickle Cell Crisis

None of these patients presented with the classical “coca-cola” coloured urine or presence of Heinz bodies on reticulocyte preparations that are so characteristic of this [adc.bmj.com]

Sickle Cell Anemia

Sickle cell disease (SCD) usually manifests early in childhood. For the first 6 months of life, infants are protected largely by elevated levels of Hb F; soon thereafter, the condition becomes evident. The most common clinical manifestation of SCD is vaso-occlusive crisis. A vaso-occlusive crisis occurs when the[…] [emedicine.medscape.com]

Glycogen Storage Disease Type 1

Glycogen storage disease type 1 (GSD1) is an inborn error of metabolism caused by deficiency of glucose-6-phosphatase, the enzyme catalysing the conversion of glucose-6-phosphate (G6P) to glucose. GSD1 is associated with severe hyperlipidaemia and hepatic steatosis. The underlying mechanisms responsible for these[…] [ncbi.nlm.nih.gov]

Acquired Spherocytosis

Heinz body haemolytic anaemia in Wilson's disease. British Journal of Haematology, Mar 1999, Vol. 104 Issue 4, p647-647, Kutlar, F. [iqb.es]

bodies) "Stress makes me eat bites of Fava Beans with Heinz Ketchup" -Oxidative Stress -Bite Cells -Fava Beans -Heinz Bodies G6PD Deficiency Diagnosis -blood smears shows [quizlet.com]

Bite cell anemia Heinz body 30. Small (1 mm), round, dense, basophilic bodies in RBCs. [slideshare.net]

Acute Radiation Sickness

Acute radiation sickness occurs to subjects after exposure to internal and external radiation. Major nuclear plant catastrophes are best descriptive of possible situations where high dosage of radiation may come in contact with a human body and develop this disease. Acute radiation sickness (ARS) or acute[…] [symptoma.com]

Water Intoxication

A case of water intoxication with remarkable hyponatremia was investigated with a special reference to EEG changes during and after the episode. The patient recovered his EEG as his consciousness disturbance had improved through an intravenous infusion of high osmolality saline, correlating with the serum sodium[…] [ncbi.nlm.nih.gov]

Extensive Burns

Abstract To investigate circulating cytokine responsiveness in major burns in association with the systemic stress response system, we tested hypothalamic-pituitary-adrenal (HPA) axis markers in extensive burn cases treated in the Department of Plastic and Reconstructive Surgery at Nagasaki University. The HPA[…] [ncbi.nlm.nih.gov]

Glucose-6-Phosphate Dehydrogenase Deficiency

Peripheral blood smear revealed bite cells, Heinz bodies and spherocytes. Thus a diagnosis of hemolytic anemia with hemoglobinuria was made. [ncbi.nlm.nih.gov]

This NADPH loss could have enhanced the rate of all factors such as methaemoglobin generation, Heinz body formation, and lipid peroxidation, which occur in G6PD deficient [ncbi.nlm.nih.gov]

Diagnostic findings include signs of intravascular hemolysis (e.g., normocytic anemia, ↑ LDH, and ↓ haptoglobin ), Heinz bodies, and bite cells on blood smear. [amboss.com]

Benzene Poisoning

Abstract Metabolic enzymes involved in benzene activation or detoxification, including NAD(P)H, quinone oxidoreductase 1 (NQO1), cytochrome P450 2E1 (CYP2E1), myeloperoxidase (MPO), glutathione-S-transferase mu-1 (GSTM1), and glutathione-S-transferase theta-1 (GSTT1), were studied for their roles in human[…] [ncbi.nlm.nih.gov]

Favism

bodies. [ncbi.nlm.nih.gov]

The cross-linked hemoglobin forms what is referred to histologically as Heinz bodies. [themedicalbiochemistrypage.org]

Heinz bodies and Bite cells are characteristic of these cases but their absence does not exclude the diagnosis. [shmabstracts.com]

Hemoglobin Lepore-Beta-Thalassemia Syndrome

body anemia Hemoglobin C - beta-thalassemia Hemoglobin C disease Hemoglobin D disease Hemoglobin E - beta-thalassemia Hemoglobin E disease Sickle cell - beta-thalassemia [csbg.cnb.csic.es]

bodies These Heinz bodies damage the red blood cells. [de.slideshare.net]

[…] hemoglobin - beta-thalassemia Hereditary persistence of fetal hemoglobin - sickle cell disease Beta-thalassemia intermedia Beta-thalassemia major Dominant beta-thalassemia Heinz [csbg.cnb.csic.es]

Anemia due to Other Disorders of Glutathione Metabolism

To see the actual Heinz bodies, you need to do a supravital stain (see the image above – the Heinz bodies appear as green dots). Therapy is pretty straightforward. [pathologystudent.com]

Diagnostic findings include signs of intravascular hemolysis (e.g., normocytic anemia, ↑ LDH, and ↓ haptoglobin ), Heinz bodies, and bite cells on blood smear. [amboss.com]

Heinz bodies (intracellular hemoglobin precipitates) form from oxidized, denatured hemoglobin which is no longer soluble. [pathophys.org]

Hemoglobinopathy

body anemia Acquired hemoglobinopathy Arthropathy secondary to hemoglobinopathy Decreased erythrocyte life span Double heterozygous sickling disorder Heinz bodies Hematopoietic [icd9data.com]

[…] cell destruction finding Sickle cell retinopathy Thalassemia-hemoglobin C disease Unstable hemoglobin disease 282.7 Excludes Applies To Abnormal hemoglobin NOS Congenital Heinz-body [icd9data.com]

body D58.2 Heinz body, congenital D58.2 Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute) M19.90 ICD-10-CM Diagnosis Code M19.90 Unspecified osteoarthritis, [icd10data.com]

Nitrobenzene Poisoning

body in erythrocytes， increase in serum-albumin-ratio， increase in osmotic fragility of erythrocytes， porphyrinuria， urobilinogen excretion in urin， hemoglobinuria， appearance [darch.isl.or.jp]

The other effects include hepatosplenomegaly, altered liver functions, Heinz body hemolytic anemia and contact dermatitis(12). [indianpediatrics.net]

Altered liver function tests, hepato-splenomegaly, and Heinz body haemolytic ficant features [4, 21, ]. [documents.tips]

Acquired Hemolytic Anemia

[…] cause extravascular and intravascular How does G6PD deficiency cause extravascular hemolysis Heinz bodies destroyed by spleen How does G6PD deficiency cause intravascular [memorize.com]

bodies, hemolysis ghost and bite cells + heinz body prep Dx via enzyme assay, if A- variant, cannot dx when ox stress removed bc young blood cells have G6PD In med type, [quizlet.com]

Hemoglobin Chesapeake

body hemolytic anemia) Abnormal chains produce molecular instability ↓ Precipitation of abnormal hemoglobin (Heinz bodies) & they attach to inner surface of membrane ↓ Pitting [sites.google.com]

Body Hemolytic Anemia Hemoglobin becomes unstable -Forms Heinz Bodies Term Definition Causes the RBC’s to sickle in low oxygen situations Causes a lot of pain Can cause a [flashcardmachine.com]

Body CHBA (Chronic Heinz Body anemia) 1. Autosomal dominant inheritance 2. Moderate –severe hemolytic anemia 3. Hemolytic jaundice(spleeno meghaly ) 4. [de.slideshare.net]

Traumatic Hemolytic Anemia

Review Topic QID: 101434 1 Bite cells and Heinz bodies 2 Sickle cells and target cells 3 RBC fragments and schistocytes 4 Round macrocytes and target cells 5 Macrocytes and [medbullets.com]

bodies with G6PD deficiency, and basophilic stipplings with lead poisoning, thalassemia, and Wilson's disease, among others. 4 Thus, if the PBS is abnormal, the family history [ncbi.nlm.nih.gov]

Sickle Cell - Hemoglobin E

Heinz bodies are visible as faint blue blushes in the RBCs. A recticulocyte is seen at lower left. [med-ed.virginia.edu]

body anemia Hemoglobin C - beta-thalassemia Hemoglobin C disease Hemoglobin D disease Hemoglobin E - beta-thalassemia Hemoglobin E disease Hemoglobin Lepore - beta-thalassemia [csbg.cnb.csic.es]

body anemia Hb-C disease Hb-D disease Hb-E disease Hemoglobinopathy NOS Unstable hemoglobin hemolytic disease Type 1 Excludes familial polycythemia ( D75.0 ) Hb-M disease [icd10data.com]