Possible Causes for heinz bodies Thalassemia Six rare mutations, despite being heterozygote, showed hemolytic anemia which is also called, "dominant-type thalassemia", and some of them demonstrated Heinz bodies in the [ci.nii.ac.jp] When the hemoglobin destabilizes, it forms up into erythrocyte inclusions called Heinz bodies. [web2.iadfw.net] bodies from HbH β-thalassemia minor target, hypochromic, microcytic cells β-thalassemia major nucleated RBCs target, hypochromic, microcytic cells Hemoglobin gel-electrophoresis [medbullets.com] Thalassemia Minor Six rare mutations, despite being heterozygote, showed hemolytic anemia which is also called, "dominant-type thalassemia", and some of them demonstrated Heinz bodies in the [ci.nii.ac.jp] body anemia Hb-C disease Hb-D disease Hb-E disease Hemoglobinopathy NOS Unstable hemoglobin hemolytic disease Type 1 Excludes familial polycythemia ( D75.0 ) Hb-M disease [icd10data.com] These inclusions are termed Heinz bodies, depicted below. [emedicine.medscape.com] Beta Thalassaemia Major Heinz bodies, which indicate denatured hemoglobin, may also be present on a peripheral blood film. [symptoma.com] Six rare mutations, despite being heterozygote, showed hemolytic anemia which is also called, ”dominant-type thalassemia”, and some of them demonstrated Heinz bodies in the [petit.lib.yamaguchi-u.ac.jp] Six rare mutations, despite being heterozygote, showed hemolytic anemia which is also called, "dominant-type thalassemia", and some of them demonstrated Heinz bodies in the [ci.nii.ac.jp] Sickle Cell Crisis None of these patients presented with the classical “coca-cola” coloured urine or presence of Heinz bodies on reticulocyte preparations that are so characteristic of this [adc.bmj.com] Toxic Hemolytic Anemia Red cells may contain Heinz bodies and the cells may be fragmented showing anisocytosis and poikilocytosis. Serum bilirubin is elevated. [flipper.diff.org] bodies. [path.upmc.edu] More severe reactions also include Heinz body formation, haemoglobinuria and mild methaemoglobinaemia. The haemolytic episode tend to be self limiting. [flipper.diff.org] Acquired Toxic Hemolytic Anemia bodies (oxidative stress in G6PD deficiency, liver disease, thalassemia, splenectomy) G6PD deficiency history of drug at risk ethnic group Heinz body prep G6PD level once [lifeinthefastlane.com] Most are autosomal dominant mutations that alter the solubility of hemoglobin in the red cell – Most lead to alterations in tertiary or quaternary structure of hemoglobin Heinz [slideplayer.com] […] cells (oxidative damage in G6PD deficiency) schistocytes (TTP or DIC with thrombocytopenia) or heart valve hemolysis (with thrombocytopenia) acanthocytes (liver disease) Heinz [lifeinthefastlane.com] Naphthalene Poisoning Red cells may contain Heinz bodies and the cells may be fragmented showing anisocytosis and poikilocytosis. Serum bilirubin is elevated. [flipper.diff.org] Heinz body was positive. Urine was dark brown, and it was positive for Hb, whereas urine microscopy did not show any RBCs. [jahjournal.org] Heinz bodies appear before haemolytic process becomes evident and hence has a prognostic valve for development of haemolysis 10. [jpma.org.pk] Sickle Cell Anemia Sickle cell disease (sickle cell anemia, drepanocytosis) is an autosomal recessive blood disorder, characterized by sickle-shaped erythrocytes. Chronic anemia is present in all individuals with sickle cell disease. It is generally asymptomatic, though patients report chronic fatigue and exercise intolerance.[…] [symptoma.com] Congenital Heinz Body Hemolytic Anemia Abstract The mechanisms of hemoglobin precipitation into Heinz bodies and hemolytic anemia that characterize congenital Heinz body hemolytic anemia (CHBHA) were studied in [ncbi.nlm.nih.gov] CHBHA stands for "Congenital Heinz Body Hemolytic Anemia" How to abbreviate Congenital Heinz Body Hemolytic Anemia? [allacronyms.com] Heinz bodies, reflecting the heightend precipitability of heme-deficient globin, attach to, thereby depleting, membrane sulfhydryl groups. [ncbi.nlm.nih.gov] Thalassaemia-Haemoglobin C Disease body anemia Hemoglobin C disease Hemoglobin D disease Hemoglobin E - beta-thalassemia Hemoglobin E disease Hemoglobin Lepore - beta-thalassemia Sickle cell - beta-thalassemia [csbg.cnb.csic.es] body anemia Hb-C disease Hb-D disease Hb-E disease Hemoglobinopathy NOS Unstable hemoglobin hemolytic disease Type 1 Excludes familial polycythemia ( D75.0 ) Hb-M disease [icd10data.com] Heinz bodies -target cells -Howell-Jolly bodies -leukocytosis Sickle gene offers some protection against malaria What is the probable etiologic association between malaria [quizlet.com] Glycogen Storage Disease Type 1 Glycogen storage disease type 1 (GSD1) is an inborn error of metabolism caused by deficiency of glucose-6-phosphatase, the enzyme catalysing the conversion of glucose-6-phosphate (G6P) to glucose. GSD1 is associated with severe hyperlipidaemia and hepatic steatosis. The underlying mechanisms responsible for these[…] [ncbi.nlm.nih.gov] Aniline Poisoning […] but also in vitro 3, and ascorbic acid is able to produce Heinz bodies in vitro without any toxic agents 4. [nature.com] We have found that in rats poisoned with aniline the formation of Heinz bodies is promoted by treatment with ascorbic acid. [nature.com] It is known that ascorbic acid promotes the rate of hydroxylation of aniline to p -aminophenol 2, which is a potent agent in the production of Heinz bodies not only in vivo [nature.com] Pyruvate Kinase Deficiency Heinz bodies and spherocytes are absent. Osmotic fragility testing may serve as a useful screen for PKD. [clinicaladvisor.com] Anemia due to Glutathione Metabolism Disorder Heinz bodies (intracellular hemoglobin precipitates) form from oxidized, denatured hemoglobin which is no longer soluble. [pathophys.org] - causes RBC rigidity and removal by macrophages. - Macrophages come along and pluck heinz bodies out of red blood cells get "bite cells" - Heinz bodies cause RBC to become [quizlet.com] bodies on exposure to acetylphenylhydrazine developed. [annals.org] Acquired Spherocytosis Heinz body haemolytic anaemia in Wilson's disease. British Journal of Haematology, Mar 1999, Vol. 104 Issue 4, p647-647, Kutlar, F. [iqb.es] bodies) "Stress makes me eat bites of Fava Beans with Heinz Ketchup" -Oxidative Stress -Bite Cells -Fava Beans -Heinz Bodies G6PD Deficiency Diagnosis -blood smears shows [quizlet.com] Bite cell anemia Heinz body 30. Small (1 mm), round, dense, basophilic bodies in RBCs. [slideshare.net] Acute Radiation Sickness A follow-up study aimed primarily at investigating late radiation effects on the genital organs and eye lenses was performed between 1999 and 2010 on three individuals who suffered from acute radiation sickness in China. The examination included a medical history, a physical examination, ultrasonography, laboratory[…] [ncbi.nlm.nih.gov] Hemoglobinopathy body anemia Acquired hemoglobinopathy Arthropathy secondary to hemoglobinopathy Decreased erythrocyte life span Double heterozygous sickling disorder Heinz bodies Hematopoietic [icd9data.com] […] cell destruction finding Sickle cell retinopathy Thalassemia-hemoglobin C disease Unstable hemoglobin disease 282.7 Excludes Applies To Abnormal hemoglobin NOS Congenital Heinz-body [icd9data.com] body D58.2 Heinz body, congenital D58.2 Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute) M19.90 ICD-10-CM Diagnosis Code M19.90 Unspecified osteoarthritis, [icd10data.com] Arsine Poisoning At 90 days, the concentration of methemoglobin was increased along with an increase in intracellular denatured proteins, or Heinz bodies. [emedicine.medscape.com] bodies) Low haptoglobin Elevated plasma-free hemoglobin levels Elevated urinary hemoglobin Elevated BUN and creatinine Abnormal liver function tests Thrombocytopenia Elevated [emergency.cdc.gov] bodies, and ghost cells. [sccgov.org] Water Intoxication A case of water intoxication with remarkable hyponatremia was investigated with a special reference to EEG changes during and after the episode. The patient recovered his EEG as his consciousness disturbance had improved through an intravenous infusion of high osmolality saline, correlating with the serum sodium[…] [ncbi.nlm.nih.gov] Extensive Burns Abstract Classic determinants of burn mortality are age, burn size, and the presence of inhalation injury. Our objective was to describe temporal trends in patient and burn characteristics, inpatient mortality, and the relationship between these characteristics and inpatient mortality over time. All patients aged 18[…] [ncbi.nlm.nih.gov] Heinz Body Anemia About a year after this treatment she developed a generalized weakness without renewal of the diarrhea; the diagnosis of Heinz body hemolytic anemia was established. [ncbi.nlm.nih.gov] Heinz bodies grow by coalescence and condensation and finally come to lie just beneath the cell surface. [bloodjournal.org] A patient with massive intravascular Heinz-body hemolytic anemia associated with the presence of bizarre-looking erythrocytes following the oral ingestion of approximately [ncbi.nlm.nih.gov] Glucose-6-Phosphate Dehydrogenase Deficiency Peripheral blood smear revealed bite cells, Heinz bodies and spherocytes. Thus a diagnosis of hemolytic anemia with hemoglobinuria was made. [ncbi.nlm.nih.gov] This NADPH loss could have enhanced the rate of all factors such as methaemoglobin generation, Heinz body formation, and lipid peroxidation, which occur in G6PD deficient [ncbi.nlm.nih.gov] Heinz bodies can be induced in vitro by compounds such as phenylhydrazine or acetyl phenylhydrazine, and we were able to show that the pattern of in vitro Heinz body formation [bloodjournal.hematologylibrary.org] Benzene Poisoning Abstract Metabolic enzymes involved in benzene activation or detoxification, including NAD(P)H, quinone oxidoreductase 1 (NQO1), cytochrome P450 2E1 (CYP2E1), myeloperoxidase (MPO), glutathione-S-transferase mu-1 (GSTM1), and glutathione-S-transferase theta-1 (GSTT1), were studied for their roles in human[…] [ncbi.nlm.nih.gov] Hemolytic Anemia A recent study showed that Heinz bodies were frequently observed in his red cells, however, no abnormal band was separated by isoelectric focusing (IEF), and the isopropanol [ncbi.nlm.nih.gov] Heinz bodies are present in erythrocytes on an unstained peripheral smear. [clinicaladvisor.com] Anemias associated with Heinz bodies. [doi.org] Acquired Hemolytic Anemia […] cause extravascular and intravascular How does G6PD deficiency cause extravascular hemolysis Heinz bodies destroyed by spleen How does G6PD deficiency cause intravascular [memorize.com] bodies, hemolysis ghost and bite cells heinz body prep Dx via enzyme assay, if A- variant, cannot dx when ox stress removed bc young blood cells have G6PD In med type, G6PD [quizlet.com] bodies (oxidative stress in G6PD deficiency, liver disease, thalassemia, splenectomy) G6PD deficiency history of drug at risk ethnic group Heinz body prep G6PD level once [lifeinthefastlane.com] Anemia due to Other Disorders of Glutathione Metabolism To see the actual Heinz bodies, you need to do a supravital stain (see the image above – the Heinz bodies appear as green dots). Therapy is pretty straightforward. [pathologystudent.com] normocytic anemia, LDH, and haptoglobin ), Heinz bodies, and bite cells on blood smear. Management mainly consists of preventing hemolysis by avoiding triggers. [amboss.com] Heinz bodies (intracellular hemoglobin precipitates) form from oxidized, denatured hemoglobin which is no longer soluble. [pathophys.org] Nitrobenzene Poisoning Altered liver function tests, hepato-splenomegaly, and Heinz body haemolytic ficant features [4, 21, ]. [documents.tips] body haemolytic more than 7 mg/kg, and therefore, may causeanaemia are other significant features [4, 21, methaemoglobinaemia in susceptible patients22]. [pubhtml5.com] body in erythrocytes， increase in serum-albumin-ratio， increase in osmotic fragility of erythrocytes， porphyrinuria， urobilinogen excretion in urin， hemoglobinuria， appearance [darch.isl.or.jp] Hemoglobin Lepore-Beta-Thalassemia Syndrome When the hemoglobin destabilizes, it forms up into erythrocyte inclusions called Heinz bodies. [web2.iadfw.net] body anemia Hemoglobin C - beta-thalassemia Hemoglobin C disease Hemoglobin D disease Hemoglobin E - beta-thalassemia Hemoglobin E disease Sickle cell - beta-thalassemia [csbg.cnb.csic.es] bodies These Heinz bodies damage the red blood cells. [de.slideshare.net] Normocytic Normochromic Anemia […] denatured hemoglobin in RBCs RBCs which have had Heinz bodies "pitted" in the spleen Bite cells are usually seen in patients with what anemia? [brainscape.com] Heinz bodies, erythrocytes containing parasites etc. 16. Anaplasma Babasia Heinz Bodies Normal Erythrocytes 17. [slideshare.net] Labs During an episode retic count and indirect bilirubin will be elevated Peripheral smear Bite cells Heinz bodies Reduced levels of G6PD between hemolytic episodes Treatment [physicianassistantexamreview.com] Vitamin D Deficiency Bischof MG, Heinze G, Vierhapper H. Vitamin D status and its relation to age and body mass index. Horm Res 2006;66:211-5. Ward LM. [cps.ca]
