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97 Possible Causes for Hematocrit Decreased, Lactate Dehydrogenase Increased, Reticulocytes Increased

  • Hereditary Spherocytosis

    Reticulocytosis, increased bilirubin, increased lactate dehydrogenase, increased urinary and fecal urobilinogen, and decreased haptoglobin, reflect increased erythrocyte production[clinicaladvisor.com] Reticulocyte count: Increased Treatment: Splenectomy is indicated for moderate to severe cases, but not mild cases.[medical-labs.net] A complete blood count (CBC) may show increased reticulocytes, a sign of increased red blood cell production, and decreased hemoglobin and hematocrit.[en.wikipedia.org]

  • HELLP Syndrome

    Although a significant trend was apparent in increasing levels of lactate dehydrogenase, aspartate aminotransferase, and uric acid as HELLP syndrome worsened, there was considerable[ncbi.nlm.nih.gov] Blood smears have shown contracted red cells w/ spicula, polychromatic red cells, and increased reticulocyte counts.[physio-pedia.com] The laboratory investigations before death revealed evidence of hemolysis, which is decreased hematocrit, elevated lactate dehydrogenase (865 U/L), and low platelet count[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    The latter was associated more frequently with anaemia, thrombocytopenia, peripheral blood blasts and increased lactate dehydrogenase levels.[ncbi.nlm.nih.gov] The percentage of reticulocytes is mildly increased but may vary widely in a given case.[patient-help.com] […] the hematocrit, but not the WBC count.[clevelandclinicmeded.com]

  • Cold Agglutinin Disease

    LDH (lactate dehydrogenase) Increased DAT (direct anti-globulin test) for anti-C3d (antibody to complement protein C3d) Present Haptoglobin Decreased Cold agglutinin titers[cancertherapyadvisor.com] Typical bloodwork results would show: decreased hemoglobin (due to the red cell lysis) increased reticulocyte count (reflecting the marrow kicking red cell production into[transfusion.ca] The MCHC and MCH values will be increased due to decreased hematocrit and RBC count. Other causes of invalid red cell indices have to be ruled out.[keralamedicaljournal.com]

  • Autoimmune Hemolytic Anemia

    Unconjugated bilirubin is usually, but not always, elevated and urine urobilinogen is increased. Lactate dehydrogenase is usually elevated into the thousands.[clinlabnavigator.com] Over the course of the next 5 days, the Hb and Hct decreased to 4.1 g/dL and 12%, respectively, direct bili increased to 12.3 mg/day, reticulocytes slightly increased to 0.9%[ncbi.nlm.nih.gov] The differential white blood count shows a decrease in most types of cells but not lymphocytes .[labtestsonline.org]

  • Cooley's Anemia

    […] and a decreasing trend in the serum lactate dehydrogenase (LDH) and serum unconjugated bilirubin levels.[onlinelibrary.wiley.com] Children may develop dramatic, often life threatening drops in hematocrit with reticulocyte counts of nearly zero.[de.slideshare.net] The differential white blood count shows a decrease in most types of cells but not lymphocytes .[labtestsonline.org]

  • Paroxysmal Nocturnal Hemoglobinuria

    The effect of eculizumab on intravascular hemolysis was demonstrated by a reduction in lactate dehydrogenase levels at all measurements after baseline.[ncbi.nlm.nih.gov] Erythrocytes fractionated by centrifugation revealed increased glycolytic enzyme activities of hexokinase, G3PD, PGK, TPI, PK, LDH, G6PD, and 6PGD in the reticulocyte-rich[pediatrics.aappublications.org] […] in lactate dehydrogenase levels.[nejm.org]

  • Sickle Cell Disease

    With each course, fetal reticulocytes increased within 48-72 h, peaked in 7-11 d, and fell by 18-21 d.[doi.org] (p 0.001), while hemoglobin and hematocrit remained stable.[ncbi.nlm.nih.gov] On her third day of admission, due to hemoglobin (Hb) value of 6.9 g/dL with increase in reticulocytes, the patient was transfused with one unit of compatible leukodepleted[ncbi.nlm.nih.gov]

  • Familial Myelofibrosis

    […] serum LDH (lactate dehydrogenase) Anemia Splenomegaly Laboratory Anemia, leukocytosis, thrombocytosis, increased LDH Prognostic factors Histologic stage at diagnosis (prefibrotic[pathologyoutlines.com] At the same time, the number of immature cells in peripheral blood is increased.[symptoma.com] […] secondary to infection, autoimmune / inflammatory conditions, toxicity, hairy cell leukemia, lymphoid neoplasms or other malignancy Minor criteria: Leukoerythroblastosis Increased[pathologyoutlines.com]

  • Chronic Myeloid Leukemia

    […] serum lactate dehydrogenase level, anemia, and palpable splenomegaly.[doi.org] […] numbers of eosinophils and basophils Differential WCC shows granulocytes at all stages of development Anaemia (normocytic/normochromic) Biochemistry: Lactate dehydrogenase[geekymedics.com] (malignant) myelofibrosis or panmyelosis with myelofibrosis usually present with severe constitutional symptoms, pancytopenia, and mild or no splenomegaly and feature an increase[doi.org]

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