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25 Possible Causes for Hematocrit Decreased, Mean Corpuscular Volume Increased, Pernicious Anemia not due to Intrinsic Factor Deficiency

  • Pernicious Anemia

    Technically, the term "pernicious anemia" refers to vitamin B12 deficiency due to a lack of intrinsic factor.[web.archive.org] Diagnostic methods Diagnosis depends on blood tests that show low serum levels of cobalamin and megaloblastic anemia (decreased red blood cell count and increased mean corpuscular[orpha.net] […] in serum vitamin B 12 and the decline in hematocrit.[aafp.org]

  • Megaloblastic Anemia

    Hematocrit – decreased3. RBC count – decreased/normal4. MCV - 100fl ( normal 82-98fl)5. MCH –increased6. MCHC – NORMAL7. Reticulocytopenia.8.[slideshare.net] Megaloblastic anemia that arises due to lack of intrinsic factor is called pernicious anemia .[medindia.net] Physicians caring for patients who receive low-dose methotrexate should be aware that an increase in the erythrocyte mean corpuscular volume may be a useful indicator of folate[ncbi.nlm.nih.gov]

  • Malabsorption Syndrome

    Vitamin B12 (cobalamin) deficiency due to pernicious anemia is caused by a lack of intrinsic factor and by pancreatic enzyme deficiency.[emedicine.medscape.com]

  • Subacute Combined Degeneration of Spinal Cord

    anemia 2016 2017 2018 2019 Billable/Specific Code Applicable To Vegan anemia D51.3 ) pernicious ( ICD-10-CM Diagnosis Code D51.0 Vitamin B12 deficiency anemia due to intrinsic[icd10data.com] , [3] and copper deficiency. [4] It is usually associated with pernicious anemia.[ipfs.io] Vitamin B12 deficiency, in turn, may be caused by malabsorption due to intrinsic factor-related pathologies.[symptoma.com]

  • Congenital Intrinsic Factor Deficiency

    anemia - Gastric intrinsic factor deficiency - Hereditary juvenile meganoblastic anemia due to intrinsic factor deficiency - IFD - Intrinsic factor deficiency Classification[csbg.cnb.csic.es] Diagnostic methods Diagnosis depends on blood tests that show low serum levels of cobalamin and megaloblastic anemia (decreased red blood cell count and increased mean corpuscular[orpha.net] […] in serum vitamin B 12 and the decline in hematocrit.[aafp.org]

  • Vitamin B12 Deficiency

    In pernicious anemia, the intrinsic factor necessary for vitamin B12 absorption is lacking, often due to an autoimmune factor.[livestrong.com] Hematological presentation of cobalamin deficiency ranges from the incidental increase of mean corpuscular volume and neutrophil hypersegmentation to symptoms due to severe[ncbi.nlm.nih.gov] […] in serum vitamin B 12 and the decline in hematocrit.[aafp.org]

  • Anemia

    Pernicious anemia is caused by a lack of intrinsic factor, which is required to absorb vitamin B12 from food.[en.wikipedia.org] (MCV mean corpuscular volume.) An Hgb increase of more than 1 g per dL (10 g per L) after iron therapy has been started confirms the diagnosis of iron deficiency.[aafp.org] Throughout fetal life, erythrocytes decrease in size and increase in number: hematocrit increases from 30% to 40% during the second trimester to 50% to 63% at term.[pedsinreview.aappublications.org]

  • Iron Deficiency Anemia

    A vitamin B12 deficiency due to pernicious anemia (positive intrinsic factor antibodies) was also highlighted, but this was not enough to explain the anemia without macrocytosis[ncbi.nlm.nih.gov] IV iron sucrose resulted in a statistically significant and clinically meaningful increase in hemoglobin, mean corpuscular volume, serum iron, ferritin, and % iron saturation[ncbi.nlm.nih.gov] ; normal unless infection is present Cells are iron deficient; as hematocrit falls below 30%, hypochromic microcytic cells appear, followed by a decrease in MCV White blood[medical-dictionary.thefreedictionary.com]

  • Megaloblastic Anaemia in Pregnancy

    It results in a malignant condition named pernicious anemia due to major vitamin B12 deficiency as the intrinsic factor is responsible for absorbing the vitamin in the intestine[pregmed.org] In a recent study, 7 percent of patients had a mean corpuscular volume greater than 96 fL, and 1.7 percent had a mean corpuscular volume greater than 100 fL. 2 With the advent[aafp.org] This accelerates erythropoiesis, but hemoglobin concentration and hematocrit decrease. 3. Iron metabolism In adult men, there is usually little iron loss from the body.[intechopen.com]

  • Thrombotic Thrombocytopenic Purpura

    Severe vitamin B 12 deficiency is most often caused by a loss of intrinsic factor due to autoimmune gastritis (“pernicious anemia”), 2 as was the case with our patient.[consultant360.com] A low hematocrit with an elevated reticulocyte count, an elevated indirect bilirubin, and decreased haptoglobin are indicative of hemolytic anemia.[academic.oup.com] Additional laboratory data confirming pernicious anemia included a positive intrinsic factor antibody test result (1.8 AU/mL). Discussion.[consultant360.com]