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43 Possible Causes for Hematocrit Decreased, Osmotic Fragility Increased, Reticulocytes Increased

  • Hereditary Spherocytosis

    Reticulocyte count: Increased Treatment: Splenectomy is indicated for moderate to severe cases, but not mild cases.[medical-labs.net] A complete blood count (CBC) may show increased reticulocytes, a sign of increased red blood cell production, and decreased hemoglobin and hematocrit.[en.wikipedia.org] fragility: increased; basis for diagnostic testing Diagrams / tables Images hosted on other servers: Scatter diagram of CBC Treatment Splenectomy (prolongs survival of red[pathologyoutlines.com]

  • Congenital Hemolytic Anemia

    After partial splenectomy, children overall had decreased transfusion requirements, increased hematocrits, decreased bilirubin levels, decreased reticulocyte counts, and elimination[ncbi.nlm.nih.gov] Osmotic fragility of fresh blood was increased, and postsplenectomy blood showed a fraction of extremely fragile cells.[ncbi.nlm.nih.gov] As a result of splenectomy, reticulocyte counts often increase and transfusion needs are reduced.[orpha.net]

  • Autoimmune Hemolytic Anemia

    Over the course of the next 5 days, the Hb and Hct decreased to 4.1 g/dL and 12%, respectively, direct bili increased to 12.3 mg/day, reticulocytes slightly increased to 0.9%[ncbi.nlm.nih.gov] The differential white blood count shows a decrease in most types of cells but not lymphocytes .[labtestsonline.org] Laboratory data showed low hemoglobin levels and slightly increased reticulocyte counts, while direct and indirect antiglobulin tests were positive.[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    Erythrocytes fractionated by centrifugation revealed increased glycolytic enzyme activities of hexokinase, G3PD, PGK, TPI, PK, LDH, G6PD, and 6PGD in the reticulocyte-rich[pediatrics.aappublications.org] Blockade of terminal complement components presumably prolongs the survival of type III erythrocytes (since there was no simultaneous increase in reticulocytes), which are[nejm.org] Intravascular hemolysis with moderate to severe anemia, an elevated reticulocyte count, and up to a 10-fold increase in lactate dehydrogenase (LDH) is common in classical[bloodjournal.org]

  • Hereditary Elliptocytosis

    His hemoglobin is now practically normal, but he still has a slight but persistent reticulocyte increase.[pediatrics.aappublications.org] Post-splenectomy, patients with HE or HPP exhibit increased hematocrit, decreased reticulocyte counts, and improved clinical symptoms.[cancertherapyadvisor.com] MCHC more than 36% C. increased osmotic fragility D. all of the above D. all of the above spherocytes on the peripheral smear MCHC more than 36% increased osmotic fragility[quizlet.com]

  • Malaria

    BACKGROUND: Plasmodium knowlesi is increasingly recognized as a cause of human malaria in Southeast Asia but there are no detailed prospective clinical studies of naturally acquired infections. METHODS: In a systematic study of the presentation and course of patients with acute P. knowlesi infection, clinical and[…][ncbi.nlm.nih.gov]

  • Glycogen Storage Disease Type 1

    Glycogen storage disease type 1 (GSD1) is an inborn error of metabolism caused by deficiency of glucose-6-phosphatase, the enzyme catalysing the conversion of glucose-6-phosphate (G6P) to glucose. GSD1 is associated with severe hyperlipidaemia and hepatic steatosis. The underlying mechanisms responsible for these[…][ncbi.nlm.nih.gov]

  • Fetal Erythroblastosis

    He or she will be anemic, with increased reticulocyte count, anisocytosis, spherocytosis, and young (nucleated, immature) red blood cells released into circulation.[symptoma.com] Both the newborns further showed progressive decrease in hematocrit (HCT) and later developed hepatosplenomegaly.[doi.org] Peripheral blood morphology shows increased reticulocytes. Erythroblasts (also known as nucleated red blood cells) occur in moderate and severe disease.[moondragon.org]

  • Pyruvate Kinase Deficiency

    Char10C mice also display a reduction in anemia phenotypes associated with the PklrG338D mutation including decreased splenomegaly, decreased circulating reticulocytes, increased[ncbi.nlm.nih.gov] Partial PK deficiency was associated with decreased red cell ATP content and markedly increased osmotic fragility.[ncbi.nlm.nih.gov] As a result of splenectomy, reticulocyte counts often increase and transfusion needs are reduced.[orpha.net]

  • Hypersplenism

    Normocytic, normochromic anemia Reticulocytes increased Increased MCV is due to prominent reticulocytosis Spherocytes Bone marrow Hypercellular with erythroid precursors[5minuteconsult.com] In hereditary spherocytosis there are spherocytes, osmotic fragility is increased, and platelets and white cells are normal.[for-surgeons.com] […] in red cell production usually is evident by an increase in the reticulocyte count.[medtextfree.wordpress.com]

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