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28 Possible Causes for Hemiplegia, Muscle Twitch, Onset of Dysarthria in Third Decade of Life

  • Episodic Ataxia

    Our data show that a heterozygous mutation in EAAT1 can lead to decreased glutamate uptake, which can contribute to neuronal hyperexcitability to cause seizures, hemiplegia[ncbi.nlm.nih.gov] This abnormality can cause muscle cramping, stiffness, and continuous, fine muscle twitching that appears as rippling under the skin.[ghr.nlm.nih.gov] […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.com]

  • Hallervorden-Spatz Syndrome

    Grey Turner グレー・ターナー Grey Turner's sign グレー・ターナー徴候 Grocco グロッコ Grocco triangle グロッコ三角 PietroGrocco(1856-1916) Ialianphysician Gubler-Foville ギュブレール・フォヴィル Gubler-Foville hemiplegia[jams.med.or.jp] They may experience involuntary muscle contractions (dystonia) of the head and neck, resulting in repetitive movements and contortions.[ghr.nlm.nih.gov] Clinical features Dystonia Dysarthria Spasticity Choreoathetosis Parkinsonism Hyperreflexia Extensor toe signs Onset in first to third decade of life Gait change / loss of[ncbi.nlm.nih.gov]

  • Spastic Ataxia with Congenital Miosis

    (90%) Very frequent (99-80%) HP:0007728 3 nystagmus 60 33 frequent (33%) Frequent (79-30%) HP:0000639 4 hyperreflexia 60 33 frequent (33%) Frequent (79-30%) HP:0001347 5 hemiplegia[malacards.org] Muscle findings of only fasiculations and the workup of such* Definition Muscle twitching is caused by minor muscle contractions in the area, or uncontrollable twitching of[flashcardmachine.com] […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com]

  • Autosomal Dominant Spastic Ataxia Type 1

    Seizures, muscle weakness, and paralysis affecting one side of the body (hemiplegia) may also occur during attacks.[diseaseinfosearch.org] (atrophy); and muscle twitches (fasciculations).[ghr.nlm.nih.gov] […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com]

  • Autosomal Dominant Sensory Ataxia

    Weber's syndrome ventral peduncle, PCA Benedikt syndrome ventral tegmentum, PCA Parinaud's syndrome dorsal, tumor Nothnagel's syndrome Claude's syndrome Other Alternating hemiplegia[en.wikipedia.org] The episodes are triggered by stress, being startled, or sudden movement and are often associated with muscle twitching.[disabled-world.com] […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com]

  • Spinocerebellar Ataxia Type 1

    Seizures, muscle weakness, and paralysis affecting one side of the body (hemiplegia) may also occur during attacks.[diseaseinfosearch.org] (atrophy); and muscle twitches (fasciculations).[ghr.nlm.nih.gov] […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.com]

  • Autosomal Recessive Spinocerebellar Ataxia 8

    A novel nonsense mutation in CACNA1A causes episodic ataxia and hemiplegia. Neurology 1999 53:34-37 Ophoff RA and others.[tchain.com] […] of muscles or parts of muscles, without any rhythm or pattern, occurring in various brain disorders) 19q SCA16 39 yrs (20-66) 1-40 years Head and hand tremor 8q SCA17 ( TBP[psychology.wikia.com] […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com]

  • Spinocerebellar Ataxia Type 5

    The onset of symptoms is usually in the third or fourth decade of life; however, more subtle clinical manifestations can start in early childhood.[ncbi.nlm.nih.gov] "Alternating hemiplegia of childhood: no mutations in the second familial hemiplegic migraine gene ATP1A2".[en.wikipedia.org] Those with SCA will also often experience numbness, tingling or pain in their limbs, uncontrolled muscle tensing, muscle wasting and muscle twitching.[indycann.org]

  • Ataxia

    Febrile illness 1- 4 wks before onset of symptoms Lethargy/irritability to coma, associated with multiple neurological deficits inc pyramidal signs, optic neuritis, hemiplegia[rch.org.au] The episodes are triggered by stress, being startled or sudden movement, and often are associated with muscle twitching.[mayoclinic.org] […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com]

  • Adult-Onset Autosomal Recessive Cerebellar Ataxia

    […] of childhood alternating hemiplegia syndrome, see alternating hemiplegia of childhood alveolar capillary dysplasia, see alveolar capillary dysplasia with misalignment of[mygenomics.com] The episodes are triggered by stress, being startled or sudden movement, and often are associated with muscle twitching.[mayoclinic.org] […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com]

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