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550 Possible Causes for Hemoglobin Decreased, Pallor, Splenomegaly

  • Hereditary Spherocytosis

    Due to the membrane defect, there is increased fragility, hemolytic anemia, marked splenomegaly and hyperbilirubinemia.[ncbi.nlm.nih.gov] All experienced an increase in hemoglobin and decrease in reticulocyte count early after LPS and at last follow-up. Twenty-two were sent for genetic analysis.[ncbi.nlm.nih.gov] Pallor (100%), icterus (67%), undocumented fever (28%), splenomegaly (96%) and hepatomegaly (73%) were the most frequent findings. Cholelithiasis was observed in 26%.[ncbi.nlm.nih.gov]

  • Pernicious Anemia

    Some people with Pernicious Anemia may have an abnormally enlarged liver (hepatomegaly) or spleen (splenomegaly).[rarediseases.org] LDH levels decrease and hemoglobin levels increase by about 1 g/dL/wk. A rise in LDH might indicate a relapse.[emedicine.medscape.com] Abstract Pernicious anemia (PA) is an entity initially described in 1849 as a condition that consisted of pallor, weakness, and progressive health decline.[ncbi.nlm.nih.gov]

  • Leukemia

    Five features were present in 50% of children: hepatomegaly (64%), splenomegaly (61%), pallor (54%), fever (53%) and bruising (52%).[ncbi.nlm.nih.gov] The number of red blood cells on a blood count (and the hemoglobin) will be below normal.[childrensnational.org] Physical examination reveals pallor and multiple ecchymoses on his arms, legs, and trunk.[doi.org]

  • Primary Myelofibrosis

    Significant thrombopenia ( KEYWORDS: Myelofibrosis; Palliation; Splenic irradiation; Splenomegaly[ncbi.nlm.nih.gov] Deferasirox treatment improved the hemoglobin level and decreased transfusion requirements in four patients with the myelodysplastic syndrome and primary myelofibrosis.[doi.org] Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy[orpha.net]

  • Splenic Rupture

    Splenomegaly Splenomegaly has traditionally been diagnosed by the physical exam finding of having a palpable spleen but in one study 16% of patients with such were found to[omicsonline.org] Altered Level of Consciousness ) Consider at 24-48 hours if high grade Splenic Injury (Grade 3 or higher) Indications for surgical intervention Continued Hemoglobin decrease[fpnotebook.com] Pain in the upper left abdominal quadrant, hypotension, pallor, tachycardia and abdominal distention are main symptoms.[symptoma.com]

  • Thalassemia

    Approach to the adult patient with splenomegaly and other splenic disorders. . Accessed June 14, 2016. Splenomegaly. Merck Manual Professional Version. .[mayoclinic.org] Clinical Information A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains.[icd9data.com] Clinical description Onset is during infancy with severe anemia, failure to thrive and progressive pallor.[orpha.net]

  • Autoimmune Hemolytic Anemia

    Examination demonstrated scleral icterus, splenomegaly, and anemia. By peripheral blood smear, the patient was diagnosed with Plasmodium ovale.[ncbi.nlm.nih.gov] Laboratory data revealed progressive decrease in hemoglobin during her hospitalization due to pulmonary infection in 2016.[ncbi.nlm.nih.gov] An otherwise seemingly normal girl, who had developed limping at the age of 11 months old, referred to Namazi Hospital, Shiraz, Iran, due to pallor and latitude at the age[ncbi.nlm.nih.gov]

  • Myelodysplasia

    Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which[ncbi.nlm.nih.gov] […] is decreased.[danafarberbostonchildrens.org] Symptoms are referable to the specific cell line most affected and may include fatigue, weakness, pallor (secondary to anemia), increased infections and fever (secondary to[msdmanuals.com]

  • Chronic Lymphocytic Leukemia

    One month later, he presented with progressive leukocytosis (mostly neutrophilia) and splenomegaly.[ncbi.nlm.nih.gov] As the disease progresses, the blood counts (hemoglobin, granulocyte, and platelet counts) may drop.[medicine.duke.edu] We describe a case of a 77-year-old man who presented with fatigue, pallor and lower limb pain and weakness.[ncbi.nlm.nih.gov]

  • Cooley's Anemia

    Splenomegaly, episodes of jaundice and roentgenologic evidence of bone involvement were prominent features.[jamanetwork.com] Cooley's anemia disease causes a dramatic decrease in the production of hemoglobin, resulting in anemia. This anemia can cause people to be more tired than normal.[dshs.state.tx.us] The anemia surfaces in the first few months after birth and becomes progressively more severe leading to pallor and easy fatigability, failure to thrive (grow), bouts of fever[medicinenet.com]

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