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12 Possible Causes for Hemoglobin Decreased, Pancytopenia, Polyclonal Hyperglobulinemia

  • Primary Myelofibrosis

    Deferasirox treatment improved the hemoglobin level and decreased transfusion requirements in four patients with the myelodysplastic syndrome and primary myelofibrosis.[doi.org] This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[aoporphan.com] Polyclonal hyperglobulinemia may be present. Patients with sporadic idiopathic or familial pulmonary hypertension have significant marrow fibrosis.[patient-help.com]

  • Multicentric Castleman's Disease

    (anemia), low platelet count (thrombocytopenia) Elevated lymphocytes and plasma cells (polyclonal lymphocytosis and plasmacytosis) Elevated BUN and creatinine (decreased[cdcn.org] Diffuse lymph-node enlargement, splenomegaly and pancytopenia were detected. Induction with Rituximab was made because pancytopenia was present.[ncbi.nlm.nih.gov] hyperglobulinemia, elevated transaminases and renal disease. 2 , 5 , 7 Dispenzieri et al. 8 analyzed the clinical spectrum of Castleman’s disease in 113 patients.[pagepress.org]

  • Castleman Disease

    (anemia), low platelet count (thrombocytopenia) Elevated lymphocytes and plasma cells (polyclonal lymphocytosis and plasmacytosis) Elevated BUN and creatinine (decreased[cdcn.org] There is often significant anemia which may be hemolytic, often reflecting pancytopenia or hemophagocytic syndrome (Stebbing 2009).[hivbook.com] The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy.[ncbi.nlm.nih.gov]

  • Pediatric Chronic Granulomatous Disease

    He developed pancytopenia, hypofibrinogenemia, transaminitis, and elevated ferritin of 11 783 ng/mL.[pediatrics.aappublications.org] Polyclonal hyperglobulinemia 3. Elevated acute phase reactants such as ESR or CRP 4. Normal studies of T and B lymphocyte immunity Diagnostic test 1.[clinicalmolecularallergy.biomedcentral.com] ; rare with 200 cases reported; multisystem disorder with clinical characteristics that include mild coagulopathy, peripheral and cranial neuropathy, hepatosplenomegaly, pancytopenia[hawaii.edu]

  • Congenital Intrinsic Factor Deficiency

    All the signs noted for pernicious anemia and megaloblastic anemia can be noted here: Hemogram would show decreased hemoglobin content but normal RBC count.[symptoma.com] Gene GIF (AR) Diagnostic Test Plasma Vitamin B12, Folate Neurological Ataxia, dystonia Non-Neurological Megaloblastic anemia, pancytopenia Treatment HydroxyCobalamin Level[treatable-id.org] NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[en.wikisource.org]

  • Posthemorrhagic Anaemia of the Newborn

    Recombinant human erythropoietin, a hematological growth factor, increases hemoglobin and decreases the need for RBC transfusions.[nurseslabs.com] […] with malformations 284.1 Pancytopenia Excludes: pancytopenia (due to) (with): aplastic anemia NOS (284.9) bone marrow infiltration (284.2) constitutional red blood cell aplasia[theodora.com] NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[en.wikisource.org]

  • Angioimmunoblastic Lymphadenopathy

    Admission labs showed mild anemia (hemoglobin 9.8 g/dL) and thrombocytopenia (platelets 62,000/L).[citeulike.org] In one series, other symptoms included weight loss (58%), hepatomegaly (60%), polyclonal hyperglobulinemia (65%), and generalized adenopathy (87%).[emedicine.medscape.com] Laboratory findings included progressive pancytopenia, hyperuricemia, and acute renal failure. Bone marrow biopsy showed a T cell lymphoid neoplasm that had ...[citeulike.org]

  • Hemolytic Anemia due to a Disorder of Glycolytic Enzymes

    It decreases the O 2 affinity of hemoglobin, promoting the release of O 2 in peripheral tissue.[doctorlib.info] […] and thrombotic emboli (e.g., infarctions, Budd-Chiari syndrome ) Risk of acute leukemias Think of PNH if a patient presents with hemolytic anemia, venous thrombosis, and pancytopenia[amboss.com] NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[en.wikisource.org]

  • Polycythemia Neonatorum

    A large volume of extravasated blood is the exception, where increased reticulocytes and decreased hemoglobin may be observed.[pathophys.org] Excludes1: pancytopenia (due to) (with): aplastic anemia (D61.-) bone marrow infiltration (D61.82) congenital (pure) red cell aplasia (D61.01) drug induced (D61.1) hairy[en.wikisource.org] pancytopenia D61.82 Myelophthisis Includes: Leukoerythroblastic anemia Myelophthisic anemia Panmyelophthisis Excludes 1: idiopathic myelofibrosis (D47.1) myelofibrosis NOS[app.drchrono.com]

  • Hyperglobulinemic Purpura

    With decreased oxygen tension, the abnormal hemoglobin polymerizes, forming fluid polymers (tactoids) that cause the red cells to deform into a characteristic sickle shape[ijdr.in] Excludes1: pancytopenia (due to) (with): aplastic anemia (D61.-) bone marrow infiltration (D61.82) congenital (pure) red cell aplasia (D61.01) drug induced (D61.1) hairy[en.wikisource.org] Other immunologic abnormalities include a polyclonal hyperglobulinemia and positive tests for cryoglobulins; these cryoglobulins may contain monoclonal IgMK proteins.[enotes.tripod.com]

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