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61 Possible Causes for Hemoglobin Electrophoresis Abnormal, Hypersplenism, Mild Anemia

  • Thalassemia

    Thalassemia is usually diagnosed through the use of blood tests showing small abnormally shaped red blood cells and/or a hemoglobin electrophoresis showing abnormal hemoglobin[helpthals.org] Mild anemia can make you feel tired. Mild anemia caused by alpha thalassemia trait might be mistaken for iron-deficiency anemia.[web.archive.org] Hypersplenism, cholelithiasis, extramedullary hematopoiesis, thrombotic complications and progressive iron overload are the main clinical features that may complicate the[orpha.net]

  • Haemoglobin E Disease

    Hemoglobin S and hemoglobin C are the most common types of abnormal hemoglobin that may be found by an electrophoresis test.[northshore.org] Homozygotes display mild hemolytic anemia and splenomegaly (enlarged spleen). The HbCSpr trait is asymptomatic.[wikilectures.eu] Extramedullary hematopoiesis and hemolysis causes splenomegaly, which produces hypersplenism, and more hemolysis.[web2.iadfw.net]

  • Alpha-Thalassemia

    […] in Alkaline Electrophoresis Normal Hemoglobin Electrophoresis Sample Alkaline Hemoglobin Electrophoresis Densitometer Tracings In what order do normal and abnormal hemoglobins[medialabinc.net] The heterozygous form may be asymptomatic or marked by mild anemia. β-thalassemia ( beta-thalassemia ) that caused by diminished synthesis of beta chains of hemoglobin.[medical-dictionary.thefreedictionary.com] Hypersplenism and gallstones are also found, as well as acute episodes of hemolysis in response to oxidant drugs and infections.[orpha.net]

  • Congenital Heinz Body Hemolytic Anemia

    For more information see HAEVP / Hemolytic Anemia Evaluation; or HBELC / Hemoglobin Electrophoresis Cascade, Blood; or THEVP / Thalassemia and Hemoglobinopathy Evaluation;[mayomedicallaboratories.com] Resolves with aging as adult hemoglobin replaces fetal hemoglobin Other presentations Congenital anemia, splenomegaly, pigmented gallstones Mild or minimal anemia with reticulocytosis[arupconsult.com] Nonimmune Causes Microangiopathic Hemolytic Anemia Hypersplenism Toxic Causes Drugs (e.g., vitamin K, phenacetin, sulfones, benzenes, phenylhydralazine) Lead Venoms Infectious[obgynkey.com]

  • Hemoglobinopathy

    It is estimated that approximately 2 percent of African-Americans possess one gene for C hemoglobin. This is usually demonstrated on hemoglobin electrophoresis.[ncbi.nlm.nih.gov] A 52-year-old African-American man had a mild anemia (hemoglobin of 103 g/L) and target cells on the peripheral blood smear as shown.[bloodjournal.org] Also, Splenectomy reduces transfusion requirements in the first year after surgery in patients with thalassemia major and hypersplenism [ 30 ].[intechopen.com]

  • Hemoglobin E-Thalassemia

    Usually the diagnosis is confirmed by a blood test called a hemoglobin electrophoresis and/or a DNA test for abnormal hemoglobin genes.[kidshealth.org] Homozygous HbE is common in Southeast Asia and presents with very mild anemia, seldom requiring transfusion.[labce.com] Splenomegaly may be associated with an overactive spleen (hypersplenism), a condition that can develops because too many blood cells build up and are destroyed within the[rarediseases.org]

  • Hemolytic Anemia

    Cation exchange HPLC, capillary electrophoresis, and hemoglobin stability studies will always be performed.[mayomedicallaboratories.com] All the children presented with neonatal hemolytic anemia. Beyond the neonatal period, they did not have jaundice or hemolysis, but continued to have mild anemia.[ncbi.nlm.nih.gov] The condition is termed, somewhat vaguely, hypersplenism.[medicalassistantonlineprograms.org]

  • Beta Thalassemia

    A small sample of blood is checked under a microscope to see if they look abnormal. Hemoglobin electrophoresis. This test measures the types and amount of hemoglobin.[childrensnational.org] The heterozygous form may be asymptomatic or marked by mild anemia. β-thalassemia ( beta-thalassemia ) that caused by diminished synthesis of beta chains of hemoglobin.[medical-dictionary.thefreedictionary.com] Anaesthetic management of beta thalassemia major with hypersplenism for splenectomy in pediatric age group: Report of four cases.[aeronline.org]

  • Anemia

    Hemoglobin electrophoresis : This identifies any abnormal types of hemoglobin and helps diagnose sickle cell disease, thalassemia, and other inherited forms of anemia.[kidshealth.org] There are many types and causes of anemia. Mild anemia is a common and treatable condition that can occur in anyone.[nhlbi.nih.gov] […] etiologies of hemolysis include: Autoimmune hemolytic anemias Drug, or toxin induced hemolysis Sepsis and burns with multifactorial shortening of RBC survival Cirrhosis, and hypersplenism[clinicaladvisor.com]

  • Normocytic Normochromic Anemia

    Electrophoresis will confirm the diagnosis, depending upon the precise hemoglobin variant discovered. (See Table 4.)[ahcmedia.com] The mild anemias associated with deficiencies of anterior pituitary, thyroid, adrenocortical, or testicular hormones usually are normocytic.[britannica.com] […] committed erythroid stem cell. 12 Other causes of Normocytic Normochromic Anemia Myelopthesic anemia – replacement of bone marrow by fibrotic, granulomatous, or neoplastic cells Hypersplenism[slideplayer.com]

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