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1,456 Possible Causes for Hemoglobinuria, Progressive or Intermittent Jaundice, Scleral Icterus

  • Autoimmune Hemolytic Anemia

    March hemoglobinuria Paroxysmal cold hemoglobinuria Type 1 Excludes hemoglobinuria NOS ( R82.3 ) Use Additional code (Chapter 20) to identify external cause D59.6 ) The following[icd10data.com] Examination demonstrated scleral icterus, splenomegaly, and anemia. By peripheral blood smear, the patient was diagnosed with Plasmodium ovale.[ncbi.nlm.nih.gov] His physical examination was remarkable for scleral icterus, shifting dullness, hepatosplenomegaly and bilateral lower-extremity pitting edema.[jmedicalcasereports.com]

    Missing: Progressive or Intermittent Jaundice
  • Cholestatic Jaundice

    Paroxysmal nocturnal hemoglobinuria (PNH) makes patients susceptible to intravascular hemolysis and thrombosis, and it can be life-threatening in stressful situations.[ncbi.nlm.nih.gov] (ie, progressive, intermittent, fluctuating) The presence of systemic symptoms (eg, fever, anorexia, weight loss) Symptoms of gastric stasis (eg, early satiety, vomiting,[emedicine.medscape.com] […] of urine and scleral icterus precede yellowing of skin Other causes of yellow skin carotenemia. carotenemia does not cause scleral icterus Hyperbilirubinemia per se has no[meddean.luc.edu]

  • Plasmodium Falciparum Malaria

    In severe disease, intravascular hemolysis in the kidney can cause hemoglobinemia and hemoglobinuria and dark colored urine called blackwater fever.[atsu.edu] Her physical examination was remarkable for scleral icterus, dry mucous membranes, and tachycardia.[ncbi.nlm.nih.gov] These were severe anemia, 36 (18%), prostration, 41 (24%), hyperpyrexia, 16 (8%), respiratory distress, 10 (5%), hemoglobinuria, 14 (7%), persistent vomiting, 16 (8%), and[ncbi.nlm.nih.gov]

    Missing: Progressive or Intermittent Jaundice
  • Hemolytic Uremic Syndrome

    Anemia, edema, oliguria, hemoglobinuria and hypertension were the most common manifestations.[ncbi.nlm.nih.gov] Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria.[dx.doi.org] The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria. N Engl J Med. 2006; 355(12) 1233-1243 9 Shin J I, Lee J S.[dx.doi.org]

    Missing: Progressive or Intermittent Jaundice
  • Fetal Erythroblastosis

    If the red color is due to hemoglobinuria, the urine sample remains clear red after centrifugation.[emedicine.medscape.com] The first clinical signs of these delayed reactions, which include dark urine/hemoglobinuria, appear a median of 9.4 days after the triggering transfusion.[emedicine.medscape.com] The onset of red urine during or shortly after a blood transfusion may represent hemoglobinuria (indicating an acute hemolytic reaction) or hematuria (indicating bleeding[emedicine.medscape.com]

    Missing: Progressive or Intermittent Jaundice
  • Malaria

    Hemoglobinuria (blackwater fever), a darkening of the urine seen with severe RBC hemolysis, results from high parasitemia and is often a sign of impending renal failure and[emedicine.com]

    Missing: Progressive or Intermittent Jaundice
  • Microangiopathic Hemolytic Anemia

    We present a case of severe microangiopathic hemolytic anemia and thrombocytopenia with epistaxis, gross hematuria, hemoglobinuria, and skin purpura in a child with Brucella[ncbi.nlm.nih.gov] […] syndrome") Kasabach–Merritt syndrome Insertion of foreign bodies Drugs (e.g. cancer chemotherapy) others diseases: eclampsia, renal allograft rejection, paroxysmal nocturnal hemoglobinuria[en.wikipedia.org] Dark urine is often encountered as a result of hemoglobinuria.[symptoma.com]

    Missing: Progressive or Intermittent Jaundice
  • Blackwater Fever

    Abstract Between January 1985 and March 1986, in the high altitude area of Kivu, Eastern Zaïre, 38 patients presenting with hemoglobinuria as main manifestation were investigated[ncbi.nlm.nih.gov] All patients had macroscopic hemoglobinuria, jaundice, and anemia. Acute renal failure occurred in 15 patients (71%), 7 of whom required dialysis.[ncbi.nlm.nih.gov] All patients had fever and hemoglobinuria, 40 (80%) were jaundiced, 25 (50%) had hepatomegaly, 15 (34%) had splenomegaly, and 9 (18%) had hepatosplenomegaly.[ncbi.nlm.nih.gov]

    Missing: Progressive or Intermittent Jaundice
  • Plasmodium Vivax Malaria

    Hemoglobinuria (blackwater fever), a darkening of the urine seen with severe RBC hemolysis, results from high parasitemia and is often a sign of impending renal failure and[emedicine.medscape.com] […] normocytic anemia [hemoglobin 7], acute kidney injury, acute respiratory distress syndrome, hypotension, disseminated intravascular coagulation, spontaneous bleeding, acidosis, hemoglobinuria[cdc.gov]

    Missing: Progressive or Intermittent Jaundice
  • Glycogen Storage Disease Type 1

    Glycogen storage disease type 1 (GSD1) is an inborn error of metabolism caused by deficiency of glucose-6-phosphatase, the enzyme catalysing the conversion of glucose-6-phosphate (G6P) to glucose. GSD1 is associated with severe hyperlipidaemia and hepatic steatosis. The underlying mechanisms responsible for these[…][ncbi.nlm.nih.gov]

    Missing: Progressive or Intermittent Jaundice

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