Hemolysis: Causes & Reasons

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Possible Causes for hemolysis

Anemia

Normocytic anemia may be caused by chronic disease, hemolysis, or bone marrow disorders. [aafp.org]

the Coombs test (autoimmune hemolysis), tests of osmotic fragility (extravascular hemolysis), and tests to rule out hemolysis induced by drugs[ 39 ]. [dx.doi.org]

Acute anemia denotes a precipitous drop in the RBC population due to hemolysis or acute hemorrhage. [emedicine.com]

Hemolytic Anemia

Given that factors other than footstrike cause hemolysis during exercise, these variables as causes of hemolysis during running cannot be eliminated. [doi.org]

hemolysis. [medicalassistantonlineprograms.org]

From Wikidata Jump to navigation Jump to search form of anemia due to hemolysis haemolytic anaemia ANEMIA HEMOLYTIC secondary anemia from hemolysis Hemolytic Anemia Anemia [wikidata.org]

Acute Respiratory Distress Syndrome

Hemolysis does not occur during ECMO unless there is a problem in the circuit or the patient. [doi.org]

Direct hyperbilirubinemia and biliary calculi may occur secondary to prolonged fasting and total parenteral nutrition (TPN), hemolysis, and diuretics. [doi.org]

Hyperkalemia

Administration of packed red blood cells, hemolysis, tissue damage, and acidosis are also common causes of hyperkalemia. [ncbi.nlm.nih.gov]

Abstract Hyperkalemia in young children is a rare phenomenon and in many cases caused by hemolysis in the specimen due to difficulties in obtaining a sample. [ncbi.nlm.nih.gov]

Hemolysis may be reported by the laboratory. [msdmanuals.com]

Cholelithiasis

Cirrhosis of liver and recurrent episodes of hemolysis--these two common complications of Wilson's disease make an ideal setting for gall stone formation. [ncbi.nlm.nih.gov]

AIMS AND BACKGROUND: Hyperbilirubinemia is often observed in chronic hemolysis and results in the formation of pigment cholelithiasis that could be increased by the presence [ncbi.nlm.nih.gov]

‘Splenectomy effectively arrests the extravascular hemolysis and prevents its long-term complications, such as cholelithiasis and aplastic crises.’ [en.oxforddictionaries.com]

HELLP Syndrome

After hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome was diagnosed in a 35-year-old woman at 39 weeks' gestation, magnetic resonance imaging and [ncbi.nlm.nih.gov]

HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome is a severe manifestation of pre-eclampsia with significant morbidity and mortality for pregnant women and [ncbi.nlm.nih.gov]

This report describes the clinical course of a patient considered to have hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome but later determined to have thrombotic [ncbi.nlm.nih.gov]

Heart Valve Disease

Topics covered include: * rehabilitation * management of thrombosis * hemolysis * rheumatic fever * endocarditis * special considerations such as care of the patient undergoing [routledge.com]

Hemolysis associated with prosthetic heart valves: a review. Cardiol Rev. 2009 May-Jun. 17(3):121-4. [Medline]. Lengyel M. [emedicine.medscape.com]

Zieve's Syndrome

Lab studies revealed hemolysis as the cause of anemia. The patient was diagnosed with Zieve's syndrome and managed with supportive measures. [doi.org]

Discussion The mechanism of hemolysis in Zieve's syndrome is not entirely understood, but alterations in red cell metabolism such as pyruvate kinase instability leave erythrocytes [ncbi.nlm.nih.gov]

[…] setting of alcoholic hepatitis, calculation of discriminant function may lead to misrepresentation of the level of liver injury (since much of the bilirubin may be from hemolysis [ncbi.nlm.nih.gov]

Iron Deficiency

Ficoll preparations of the products after freeze-thaw showed RBC contamination and hemolysis. Postthaw viability exceeded 95%. [ncbi.nlm.nih.gov]

Through your feet – First, a process called foot strike hemolysis occurs in runners, especially those who run high mileage. [runnersconnect.net]

HPC-A collection from a patient with TEMPI syndrome was complicated by microcytic erythrocytosis, leading to RBC contamination and hemolysis in the product. [ncbi.nlm.nih.gov]

Preeclampsia

BACKGROUND: Illnesses coincident with pregnancy may present similarly to preeclampsia or may be mistaken for severe preeclampsia or hemolysis, elevated liver enzymes, low [ncbi.nlm.nih.gov]

Abstract Data are presented to define a unique group of preeclamptic/eclamptic patients with the finding of hemolysis (H), elevated liver enzymes (EL), and a low platelet [ncbi.nlm.nih.gov]

Intrauterine fetal demise was diagnosed in the context of severe thrombocytopenia, hypertension, proteinuria, hemolysis, elevated transaminases, and renal failure. [ncbi.nlm.nih.gov]

Paroxysmal Nocturnal Hemoglobinuria

Here we have tested our eculizumab-treated PNH patients (n 12) for signs of hemolysis and assessed complement biomarkers. [ncbi.nlm.nih.gov]

Antioxidants have been shown to reduce the oxidative stress and inhibit hemolysis as well as platelet activation mediated by activated C'. [ncbi.nlm.nih.gov]

Biochemical Indicators of Hemolysis Figure 2. Figure 2. [nejm.org]

Paroxysmal Cold Hemoglobinuria

2015 ICD-9-CM Diagnosis Code 283.2 Hemoglobinuria due to hemolysis from external causes 2015 Billable Thru Sept 30/2015 Non-Billable On/After Oct 1/2015 ICD-9-CM 283.2 is [icd9data.com]

The hemolysis resolved with warmth, and administration of dexamethasone. [ncbi.nlm.nih.gov]

Paroxysmal cold hemoglobinuria (PCH) is an autoimmune hemolytic anemia featured by complement-mediated intravascular hemolysis after cold exposure. [en.wikipedia.org]

Autoimmune Hemolytic Anemia

Laboratory investigations were suggestive of intravascular hemolysis, and on immuno-hematological evaluation it was diagnosed that the patient had autoantibody with mimicking [ncbi.nlm.nih.gov]

Exposure to cold led to worsening of the patient's hemolysis and hemoglobinuria. [ncbi.nlm.nih.gov]

Two (6.7%) patients' hemolysis was stopped from deteriorating, one (3.3%) patient's hemolysis was not controlled by the treatment due to malignancy, and another (3.3%) patient [ncbi.nlm.nih.gov]

Thalassemia Minor

The case of a 17-year-old Italian girl with thalassemia minor and fatal acute Wilson's disease together with severe hemolysis is reported. The fortuitous(?) [ncbi.nlm.nih.gov]

On the other hand, hemolysis by glycerol lysis time (GLT50) is invariably prolonged in thalassemia. The reason for the prolongation of GLT50 is not well understood. [ncbi.nlm.nih.gov]

[…] of microcytic erythrocytes evident with increased LDH levels may be another factor. [6] Our patient had anemia and subtle hemolysis as evidenced by elevated LDH, which could [sjkdt.org]

Streptococcus Pyogenes

Generally, S. pyogenes forms colonies having non-mucoid matt appearances based on β-hemolysis of sheep's blood agar. [ncbi.nlm.nih.gov]

Beta -hemolysis is associated with complete lysis of red cells surrounding the colony, whereas alpha-hemolysis is a partial or "green" hemolysis associated with reduction [textbookofbacteriology.net]

Colonies are surroundend by a zone of beta-hemolysis. [bacteriainphotos.com]

Beta Thalassaemia Major

Abstract The profound and life-threatening anemia in patients with Cooley's anemia is ascribed primarily to intramedullary hemolysis (ineffective erythropoiesis), the cause [ncbi.nlm.nih.gov]

These indicate excessive hemolysis and ineffective erythropoiesis. [symptoma.com]

Patients with β-thalassemia major are prone to repeated attacks of intravascular hemolysis that requires repeated hospitalization and blood transfusions. [link.springer.com]

Hereditary Spherocytosis

Although the primary etiology is different in these anemias, oxidative stress mediates several of their pathologies, mainly hemolysis [3]. [clinicaltrials.gov]

However, all of these classical features are not always revealed in the case of mild hemolysis or when hemolysis is well compensated. [ncbi.nlm.nih.gov]

LPS children had lower preoperative hemoglobin levels, indicating more severe hemolysis. [ncbi.nlm.nih.gov]

Gilbert Syndrome

[…] from mechanical heart valve replacement) chronic hemolysis can be warranted. [ncbi.nlm.nih.gov]

[…] without anemia, whereas hemolysis is incompletely compensated in moderate HS. [bloodjournal.hematologylibrary.org]

Some patients with hemolysis have a similar abnormality. [annals.org]

Glycogen Storage Disease Type 7

In addition to causing hemolysis and exertional myopathy, heart disease may be a prominent clinical component of PFK deficiency in this breed and has not been previously recognized [doi.org]

Mutations in the muscle phosphofructokinase gene (PFK-M) result in a metabolic myopathy characterized by exercise intolerance and compensated hemolysis. [ncbi.nlm.nih.gov]

Muscle type phosphofructokinase (M-PFK) deficiency is a rare inherited glycogen storage disease in humans that causes exertional myopathy and hemolysis. [ncbi.nlm.nih.gov]

Neonatal Jaundice

(ABO/Rh isoimmunization or hereiditary spherocytosis) Within 48 hours Hemolysis Infection Physiologic After 48 hours Infection Hemolysis Breast Milk Congenital malformation [step2.medbullets.com]

Early causes of hemolysis include blood group incompatibilities like Rh and Kell. On days of life 3-7, hemolysis may result from ABO blood group incompatibilities. [omicsonline.org]

[…] conditions of oxidative stress, the residual G6PD and complimentary antioxidant mechanisms may become insufficient to neutralize the large amounts of ROS and to prevent severe hemolysis [ncbi.nlm.nih.gov]

Malaria

Conditional deletion of the Fpn gene in erythroid cells resulted in accumulation of excess intracellular iron, cellular damage, hemolysis, and increased fatality in malaria-infected [ncbi.nlm.nih.gov]

He recovered naturally from delayed hemolysis. [ncbi.nlm.nih.gov]

Anemia and thrombocytopenia are common, and pallor and jaundice caused by hemolysis may occur. [meddean.luc.edu]

Normocytic Normochromic Anemia

Hemolytic Anemia: Hemolysis -Hemolysis results from both hereditary and acquired defects of the red blood cell -All hereditary hemolytic disorders are a result of ... [cram.com]

Is the pt on a med that causes hemolysis? Are all of the lines of blood cell production depressed? [allnurses.com]

[…] of anemia to detect hemolysis will overlook most hemolytic destruction; anemia as evidence of hemolysis requires an RBC lifespan of ... days or less -Anemia as a result of [cram.com]

Wilson Disease

In pregnant patients with unrecognized WD, liver failure with hemolysis may be interpreted as the low platelet count (HELLP) syndrome. [ncbi.nlm.nih.gov]

Serum copper, urinary copper excretion, and hemolysis were significantly reduced and renal function improved. [ncbi.nlm.nih.gov]

Sudden, severe hemolysis in a patient of thalassemia may be explained by the coexistence of additional pathology, in this case WD. [ncbi.nlm.nih.gov]

Posthemorrhagic Anaemia of the Newborn

Anemia may be a consequence of three fundamental mechanisms: (1) loss of RBCs (hemorrhage); (2) rapid destruction of RBCs (hemolysis); or (3) underproduction of RBCs. [pedsinreview.aappublications.org]

[…] for immune-mediated hemolysis or hereditary spherocytosis, Elliptocytosis for iron deficiency or hereditary elliptocytosis and schistocytes for intravascular hemolysis. [en.wikipedia.org]

[…] stenosis and prosthetic) heart valves - Through partially obstructed vessels - Through hemangiomas Mechanical Hemolysis Peripheral Blood Smear shows... [quizlet.com]

Anemia due to Infection

It has also been suggested that erythrocyte membrane proteolysis plays an important role in hemolysis.45 Severe, often fatal hemolysis occurs in patients with C. welchii septicemia [medtextfree.wordpress.com]

Keywords: Anemia, infection, chronic inflammation, hemolysis, hepcidin, hemolytic anemia, red cell aplasia, blood loss, Red cell aplasis of bone marrow, Parvo virus, Viral [eurekaselect.com]

Streptococcus 12, 42–45 Toxoplasma 12 Trypanosoma brucei 46 Varicella virus 10, 47 Vibrio cholerae 12 Yersinia enterocolitica 48 Several distinct mechanisms may lead to hemolysis [mhmedical.com]

Acquired Hemolytic Anemia

some drugs and other ingested substances lead to hemolysis by direct action on RBCs, e.g., ribavirin ) Toxins (e.g., snake venom; plant poisons such as aesculin) Trauma [en.wikipedia.org]

[…] hymenoptera stings (bees) lead to acute tubular necrosis and renal failure, hemolysis, rhabdo, shock tx with PlEx -brown recluse spider: hemolysis, tx with steroids -pit [brainscape.com]

Major tool for diagnosing autoimmune hemolysis. [slideshare.net]

Evans Syndrome

The relationship between MM and hemolysis remain unclear. [ncbi.nlm.nih.gov]

In addition, ITP can be associated with AIHA as Evans syndrome, with hemolysis usually preceding thrombocytopenia [ 10 ]. [panafrican-med-journal.com]

TTP can present with renal dysfunction and fever Drug-induced hemolysis – Drug-induced hemolysis is common and the list of medications of each patient with AIHA should be [cancertherapyadvisor.com]

Atypical Hemolytic Uremic Syndrome

Mechanical hemolysis is a frequent but usually harmless complication of aortic valve replacement. The most common reason is valvular leakage. [ncbi.nlm.nih.gov]

Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by hemolysis, thrombocytopenia, and renal dysfunction. [ncbi.nlm.nih.gov]

Renal function, proteinuria, and hemolysis all improved, and he was been in remission for more than 15 months. [ncbi.nlm.nih.gov]

Leukoerythroblastic Anemia

The two patients had brisk intravascular hemolysis with direct Coombs' tests positive for complement and with peripheral blood smears showing spherocytosis, erythrophagocytosis [ncbi.nlm.nih.gov]

Microangiopathic hemolysis was seen in only 2 of 91 patients (2.1%). [ncbi.nlm.nih.gov]

1 An elderly man with hemolysis and myelophthisic anemia. ( 28697949 ) Horn R....Cherian S.V. 2017 2 Case of metastatic basal cell carcinoma to bone marrow, resulting in myelophthisic [malacards.org]

Cold Agglutinin Disease

Lytic components of complement C5-C9 generally do not form on these cells, and intravascular hemolysis by complement is less likely to occur. [15] Hemolysis develops acutely [emedicine.medscape.com]

Complement levels in hemolysis In chronic cold agglutinin disease, complement tends to be depleted. [emedicine.medscape.com]

Temporary increases in complement levels, as can occur with intercurrent febrile illnesses, can increase hemolysis. [emedicine.medscape.com]