Hemolysis: Causes & Reasons

Possible Causes for Hemolysis

Hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome has been recognized as a complication of preeclampsia-eclampsia for decades. [ncbi.nlm.nih.gov]

MAY 2004 DOI: 10.1097/01.AOG.0000126245.35811.2a, PMID: 15121574 Issn Print: 0029-7844 Publication Date: 2004/05/01 Checking for direct PDF access through Ovid Abstract Hemolysis [doi.org]

Pregnancies complicated by hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome require a well-formulated management plan. [ncbi.nlm.nih.gov]

Zieve's Syndrome

Lab studies revealed hemolysis as the cause of anemia. The patient was diagnosed with Zieve's syndrome and managed with supportive measures. [doi.org]

Discussion The mechanism of hemolysis in Zieve's syndrome is not entirely understood, but alterations in red cell metabolism such as pyruvate kinase instability leave erythrocytes [ncbi.nlm.nih.gov]

[…] setting of alcoholic hepatitis, calculation of discriminant function may lead to misrepresentation of the level of liver injury (since much of the bilirubin may be from hemolysis [ncbi.nlm.nih.gov]

Paroxysmal Cold Hemoglobinuria

2015 ICD-9-CM Diagnosis Code 283.2 Hemoglobinuria due to hemolysis from external causes 2015 Billable Thru Sept 30/2015 Non-Billable On/After Oct 1/2015 ICD-9-CM 283.2 is [icd9data.com]

[…] blood and blood-forming organs and certain disorders involving the immune mechanism › D55-D59 Hemolytic anemias › D59- Acquired hemolytic anemia › Hemoglobinuria due to hemolysis [icd10data.com]

The hemolysis resolved with warmth, and administration of dexamethasone. [ncbi.nlm.nih.gov]

Paroxysmal Nocturnal Hemoglobinuria

Here we have tested our eculizumab-treated PNH patients (n=12) for signs of hemolysis and assessed complement biomarkers. [ncbi.nlm.nih.gov]

2015 ICD-9-CM Diagnosis Code 283.2 Hemoglobinuria due to hemolysis from external causes 2015 Billable Thru Sept 30/2015 Non-Billable On/After Oct 1/2015 ICD-9-CM 283.2 is [icd9data.com]

Antioxidants have been shown to reduce the oxidative stress and inhibit hemolysis as well as platelet activation mediated by activated C'. [ncbi.nlm.nih.gov]

Autoimmune Hemolytic Anemia

Laboratory investigations were suggestive of intravascular hemolysis, and on immuno-hematological evaluation it was diagnosed that the patient had autoantibody with mimicking [ncbi.nlm.nih.gov]

TTP can present with renal dysfunction and fever Drug-induced hemolysis - Drug-induced hemolysis is common and the list of medications of each patient with AIHA should be [cancertherapyadvisor.com]

The differential should include other causes of hemolysis, such as that found in non-immune hemolytic anemia including intrinsic red cell defects, hemolysis due to extrinsic [pedclerk.bsd.uchicago.edu]

Gilbert Syndrome

[…] from mechanical heart valve replacement) chronic hemolysis can be warranted. [ncbi.nlm.nih.gov]

[…] without anemia, whereas hemolysis is incompletely compensated in moderate HS. [bloodjournal.hematologylibrary.org]

Some patients with hemolysis have a similar abnormality. [annals.org]

Glycogen Storage Disease Type 7

In addition to causing hemolysis and exertional myopathy, heart disease may be a prominent clinical component of PFK deficiency in this breed and has not been previously recognized [doi.org]

Homozygous deficiency of the M subunit in man results in glycogen storage disease (GSD) type VII, which is characterized by exertional muscle weakness and compensated hemolysis [ncbi.nlm.nih.gov]

In contrast, presence of hemolysis despite residual P4 and hybrids of P and L in the erythrocytes may be inferred to result in severe glycolytic handicap under existing intraerythrocytic [ncbi.nlm.nih.gov]

Atypical Hemolytic Uremic Syndrome

Shistocytes are fragmented red cells resulting from intravascular hemolysis. Spherocytes are spherical cells found in hemolysis, hereditary spherocytosis and burns. Q2. [lifeinthefastlane.com]

Mechanical hemolysis is a frequent but usually harmless complication of aortic valve replacement. The most common reason is valvular leakage. [ncbi.nlm.nih.gov]

Eculizumab must be administered intravenously, and moreover some patients with paroxysmal nocturnal hemoglobinuria on eculizumab have symptomatic extravascular hemolysis, [ncbi.nlm.nih.gov]

Hypophosphatemia

Stomatocytes in the peripheral blood and hemolysis disappear within 2 weeks of alcohol withdrawal. [msdmanuals.com]

23 pathway (such as hypophosphatemic rickets), hypophosphatemia is a frequent condition encountered in daily practice, and untreated critical hypophosphatemia can induce hemolysis [ncbi.nlm.nih.gov]

Stomatocytosis may be Congenital Acquired Both congenital and acquired stomatocytosis may be asymptomatic or cause hemolysis. [msdmanuals.com]

Beta Thalassaemia Major

Abstract The profound and life-threatening anemia in patients with Cooley's anemia is ascribed primarily to intramedullary hemolysis (ineffective erythropoiesis), the cause [ncbi.nlm.nih.gov]

Patients with β-thalassemia major are prone to repeated attacks of intravascular hemolysis that requires repeated hospitalization and blood transfusions. [link.springer.com]

These indicate excessive hemolysis and ineffective erythropoiesis. [symptoma.com]

Wilson Disease

In pregnant patients with unrecognized WD, liver failure with hemolysis may be interpreted as the low platelet count (HELLP) syndrome. [ncbi.nlm.nih.gov]

Short-term plasma exchange may ameliorate the hemolysis. [bloodjournal.org]

Serum copper, urinary copper excretion, and hemolysis were significantly reduced and renal function improved. [ncbi.nlm.nih.gov]

Hereditary Elliptocytosis

Between these 2 extremes there lies an indeterminate group in which there is evidence of hemolysis if one looks for it, in which there may or may not be anemia, and in which [pediatrics.aappublications.org]

hemolysis. [symptoma.com]

Their exact relationship to the pathogenesis of the elliptical shape of the red cell, or to the presence of hemolysis, is at present unclear. [ncbi.nlm.nih.gov]

Thalassemia Minor

The case of a 17-year-old Italian girl with thalassemia minor and fatal acute Wilson's disease together with severe hemolysis is reported. The fortuitous(?) [ncbi.nlm.nih.gov]

On the other hand, hemolysis by glycerol lysis time (GLT50) is invariably prolonged in thalassemia. The reason for the prolongation of GLT50 is not well understood. [ncbi.nlm.nih.gov]

[…] of microcytic erythrocytes evident with increased LDH levels may be another factor. [6] Our patient had anemia and subtle hemolysis as evidenced by elevated LDH, which could [sjkdt.org]

Babesiosis

BACKGROUND: Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome is a serious complication of pregnancy associated with significant maternal and fetal [ncbi.nlm.nih.gov]

Specific antibiotic therapy was begun, and severe hemolysis from a high parasite burden required red blood cell exchange which led to rapid abatement of the hemolysis. [ncbi.nlm.nih.gov]

Autoimmune hemolysis in malaria: a report of three cases. J Assoc Physicians India 2012 ;60: 129 - 131 22. [nejm.org]

Malaria

Conditional deletion of the Fpn gene in erythroid cells resulted in accumulation of excess intracellular iron, cellular damage, hemolysis, and increased fatality in malaria-infected [ncbi.nlm.nih.gov]

He recovered naturally from delayed hemolysis. [ncbi.nlm.nih.gov]

(destruction of the red blood cells) Hemoglobinuria (hemoglobin in the urine) due to hemolysis Acute respiratory distress syndrome (ARDS), an inflammatory reaction in the [cdc.gov]

Drowning in Fresh Water

A possible cause of hemolysis is proposed and treatment based on th epathophysiology of pulmonary aspiration of fresh water is discussed. hemolysis near-drowning pulmonary [keio.pure.elsevier.com]

A) Complete recovery B) Development of acute respiratory distress syndrome C) Hemolysis D) Pulmonary hypertension E) Severe neurologic deficit Report Abuse * Re:nbme3. fresh [usmleforum.com]

This causes blood cells to burst ( hemolysis ). [thoughtco.com]

Zinc Poisoning

The workup was negative for hemolysis or bleeding. Her blood alcohol level was normal. B 12 and folate levels were normal. [bloodjournal.org]

Bartonella Infection

[…] mean reticulocyte count of 18.2 × 10 9 cells/L at the time of initial evaluation and negative results of a Coombs' test in 17 of the 18 patients tested suggests massive hemolysis [doi.org]

[…] infection).The acute phase of the disease is a life threatening disease characterized by massive invasion of bartonella to human red blood cells and consequently an acute hemolysis [lyme-symptoms.com]

BACILLIFORMIS Oroya fever (acute Carrion's disease) B. bacilliformis is a sandfly-transmitted Bartonella species ( 3 ) that is responsible for life-threatening septicemia with acute hemolysis [doi.org]

Heart Valve Disease

Topics covered include: * rehabilitation * management of thrombosis * hemolysis * rheumatic fever * endocarditis * special considerations such as care of the patient undergoing [routledge.com]

Hemolysis associated with prosthetic heart valves: a review. Cardiol Rev. 2009 May-Jun. 17(3):121-4. [Medline]. Lengyel M. [emedicine.medscape.com]

Acute Respiratory Distress Syndrome

Hemolysis does not occur during ECMO unless there is a problem in the circuit or the patient. [doi.org]

Direct hyperbilirubinemia and biliary calculi may occur secondary to prolonged fasting and total parenteral nutrition (TPN), hemolysis, and diuretics. [doi.org]

Inhalation of Nitric Oxide

[…] decrease pulmonary vascular resistance without affecting systemic blood pressure. 22 Furthermore, it has been shown that—in patients with acute PE—free hemoglobin formed from hemolysis [read.nxtbook.com]

Anemia

Normocytic anemia may be caused by chronic disease, hemolysis, or bone marrow disorders. [aafp.org]

Bilirubin may be normal with moderate extravascular hemolysis, or abnormal in a patient with hepatic dysfunction without any hemolysis. [clinicaladvisor.com]

Jaundice may be present with hemolysis. [merckmanuals.com]

Hyperkalemia

The degree of K+ increase is dependent on the extent of hemolysis. [aacc.org]

Contributing factors include repeated fist clenching, hemolysis, and marked leukocytosis or thrombocytosis. [unboundmedicine.com]

Definition: A serum potassium level > 5.5 mEq/L Epidemiology Common electrolyte disorder 10% of hospitalized patients (Elliott 2010) Causes Pseudohyperkalemia: extravascular hemolysis [coreem.net]

Hemolytic Anemia

Given that factors other than footstrike cause hemolysis during exercise, these variables as causes of hemolysis during running cannot be eliminated. [doi.org]

hemolysis. [medicalassistantonlineprograms.org]

Mild hemolysis can be asymptomatic while the anemia in severe hemolysis can be life threatening and cause angina and cardiopulmonary decompensation. [emedicine.medscape.com]

Preeclampsia

BACKGROUND: Illnesses coincident with pregnancy may present similarly to preeclampsia or may be mistaken for severe preeclampsia or hemolysis, elevated liver enzymes, low [ncbi.nlm.nih.gov]

Abstract Data are presented to define a unique group of preeclamptic/eclamptic patients with the finding of hemolysis (H), elevated liver enzymes (EL), and a low platelet [ncbi.nlm.nih.gov]

Hemolysis is destruction of red blood cells in the liver. [medbroadcast.com]

Cholelithiasis

Cirrhosis of liver and recurrent episodes of hemolysis--these two common complications of Wilson's disease make an ideal setting for gall stone formation. [ncbi.nlm.nih.gov]

AIMS AND BACKGROUND: Hyperbilirubinemia is often observed in chronic hemolysis and results in the formation of pigment cholelithiasis that could be increased by the presence [ncbi.nlm.nih.gov]

Abstract Cholelithiasis in infants is rare, and has usually been associated with hemolysis, ileal disease, congenital anomalies of the biliary tree, hyperalimentation, and [jpedsurg.org]

Hereditary Spherocytosis

Hereditary spherocytosis is characterized by hemolysis of spheroidal RBCs and anemia. [merckmanuals.com]

Although the primary etiology is different in these anemias, oxidative stress mediates several of their pathologies, mainly hemolysis [3]. [clinicaltrials.gov]

Hemolysis is usually absent or slight, with little or no anemia except in some homozygous patients (hereditary pyropoikilocytosis). [msdmanuals.com]

Posthemorrhagic Anaemia of the Newborn

[…] for immune-mediated hemolysis or hereditary spherocytosis, Elliptocytosis for iron deficiency or hereditary elliptocytosis and schistocytes for intravascular hemolysis. [en.wikipedia.org]

[…] stenosis and prosthetic) heart valves - Through partially obstructed vessels - Through hemangiomas Mechanical Hemolysis Peripheral Blood Smear shows... [quizlet.com]

Elliptocytes 25 percent or more of red blood cells elliptocytic on peripheral blood smear G6PD deficiency Transient hemolysis following exposure to oxidative drug Normal [aafp.org]

Neonatal Jaundice

Exchange transfusion removes bilirubin and antibodies causing hemolysis. [hawaii.edu]

Early causes of hemolysis include blood group incompatibilities like Rh and Kell. On days of life 3-7, hemolysis may result from ABO blood group incompatibilities. [omicsonline.org]

DIC Polycythemia and consequent hemolysis Extravasated blood, inc. cephalhematoma & swallowed blood; peaks 3-7d IV. [faculty.washington.edu]

Anemia due to Infection

Hemolysis also can manifest as jaundice, cholelithiasis, or isolated reticulocytosis. Pathophysiology There are two mechanisms of hemolysis. [aafp.org]

It has also been suggested that erythrocyte membrane proteolysis plays an important role in hemolysis.45 Severe, often fatal hemolysis occurs in patients with C. welchii septicemia [medtextfree.wordpress.com]

Keywords: Anemia, infection, chronic inflammation, hemolysis, hepcidin, hemolytic anemia, red cell aplasia, blood loss, Red cell aplasis of bone marrow, Parvo virus, Viral [eurekaselect.com]