Hemolysis: Causes & Reasons

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Possible Causes for Hemolysis

HELLP Syndrome

After hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome was diagnosed in a 35-year-old woman at 39 weeks' gestation, magnetic resonance imaging and [ncbi.nlm.nih.gov]

HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome is a severe manifestation of pre-eclampsia with significant morbidity and mortality for pregnant women and [ncbi.nlm.nih.gov]

Pregnancies complicated by hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome require a well-formulated management plan. [ncbi.nlm.nih.gov]

Zieve's Syndrome

Lab studies revealed hemolysis as the cause of anemia. The patient was diagnosed with Zieve's syndrome and managed with supportive measures. [ncbi.nlm.nih.gov]

Discussion The mechanism of hemolysis in Zieve's syndrome is not entirely understood, but alterations in red cell metabolism such as pyruvate kinase instability leave erythrocytes [ncbi.nlm.nih.gov]

[…] setting of alcoholic hepatitis, calculation of discriminant function may lead to misrepresentation of the level of liver injury (since much of the bilirubin may be from hemolysis [ncbi.nlm.nih.gov]

Paroxysmal Cold Hemoglobinuria

2015 ICD-9-CM Diagnosis Code 283.2 Hemoglobinuria due to hemolysis from external causes 2015 Billable Thru Sept 30/2015 Non-Billable On/After Oct 1/2015 ICD-9-CM 283.2 is [icd9data.com]

[…] blood and blood-forming organs and certain disorders involving the immune mechanism › D55-D59 Hemolytic anemias › D59- Acquired hemolytic anemia › Hemoglobinuria due to hemolysis [icd10data.com]

Hemoglobinuria: from exertion march paroxysmal (cold) (nocturnal) due to other hemolysis Marchiafava-Micheli syndrome Use Additional Use additional E code to identify cause [icd9data.com]

Paroxysmal Nocturnal Hemoglobinuria

2015 ICD-9-CM Diagnosis Code 283.2 Hemoglobinuria due to hemolysis from external causes 2015 Billable Thru Sept 30/2015 Non-Billable On/After Oct 1/2015 ICD-9-CM 283.2 is [icd9data.com]

Here we have tested our eculizumab-treated PNH patients (n=12) for signs of hemolysis and assessed complement biomarkers. [ncbi.nlm.nih.gov]

Eculizumab reduced the presence of hemolysis, thrombosis and the need for red blood cell transfusions in patients with paroxysmal nocturnal hemoglobinuria, according to data [healio.com]

Autoimmune Hemolytic Anemia

Laboratory investigations were suggestive of intravascular hemolysis, and on immuno-hematological evaluation it was diagnosed that the patient had autoantibody with mimicking [ncbi.nlm.nih.gov]

Exposure to cold led to worsening of the patient's hemolysis and hemoglobinuria. [ncbi.nlm.nih.gov]

Two (6.7%) patients' hemolysis was stopped from deteriorating, one (3.3%) patient's hemolysis was not controlled by the treatment due to malignancy, and another (3.3%) patient [ncbi.nlm.nih.gov]

Gilbert Syndrome

[…] from mechanical heart valve replacement) chronic hemolysis can be warranted. [ncbi.nlm.nih.gov]

[…] without anemia, whereas hemolysis is incompletely compensated in moderate HS. [bloodjournal.hematologylibrary.org]

Some patients with hemolysis have a similar abnormality. [annals.org]

Glycogen Storage Disease Type 7

Mutations in the muscle phosphofructokinase gene (PFK-M) result in a metabolic myopathy characterized by exercise intolerance and compensated hemolysis. [ncbi.nlm.nih.gov]

Muscle type phosphofructokinase (M-PFK) deficiency is a rare inherited glycogen storage disease in humans that causes exertional myopathy and hemolysis. [ncbi.nlm.nih.gov]

The hemolytic form of GSDVII is characterized by hemolytic anemia, in which red blood cells are broken down (undergo hemolysis) prematurely, causing a shortage of red blood [ghr.nlm.nih.gov]

Thalassemia Minor

The case of a 17-year-old Italian girl with thalassemia minor and fatal acute Wilson's disease together with severe hemolysis is reported. The fortuitous(?) [ncbi.nlm.nih.gov]

On the other hand, hemolysis by glycerol lysis time (GLT50) is invariably prolonged in thalassemia. The reason for the prolongation of GLT50 is not well understood. [ncbi.nlm.nih.gov]

Atypical Hemolytic Uremic Syndrome

Shistocytes are fragmented red cells resulting from intravascular hemolysis. Spherocytes are spherical cells found in hemolysis, hereditary spherocytosis and burns. Q2. [lifeinthefastlane.com]

Mechanical hemolysis is a frequent but usually harmless complication of aortic valve replacement. The most common reason is valvular leakage. [ncbi.nlm.nih.gov]

Renal function, proteinuria, and hemolysis all improved, and he was been in remission for more than 15 months. [ncbi.nlm.nih.gov]

Wilson Disease

In pregnant patients with unrecognized WD, liver failure with hemolysis may be interpreted as the low platelet count (HELLP) syndrome. [ncbi.nlm.nih.gov]

Serum copper, urinary copper excretion, and hemolysis were significantly reduced and renal function improved. [ncbi.nlm.nih.gov]

Short-term plasma exchange may ameliorate the hemolysis. [bloodjournal.org]

Beta Thalassaemia Major

Abstract The profound and life-threatening anemia in patients with Cooley's anemia is ascribed primarily to intramedullary hemolysis (ineffective erythropoiesis), the cause [ncbi.nlm.nih.gov]

These indicate excessive hemolysis and ineffective erythropoiesis. [symptoma.com]

In Cooley's anemia, there is increased splenic hemolysis and extramedullary erythropoiesis. [symptoma.com]

Hereditary Elliptocytosis

Between these 2 extremes there lies an indeterminate group in which there is evidence of hemolysis if one looks for it, in which there may or may not be anemia, and in which [pediatrics.aappublications.org]

hemolysis. [symptoma.com]

Their exact relationship to the pathogenesis of the elliptical shape of the red cell, or to the presence of hemolysis, is at present unclear. [ncbi.nlm.nih.gov]

Babesiosis

BACKGROUND: Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome is a serious complication of pregnancy associated with significant maternal and fetal [ncbi.nlm.nih.gov]

Specific antibiotic therapy was begun, and severe hemolysis from a high parasite burden required red blood cell exchange which led to rapid abatement of the hemolysis. [ncbi.nlm.nih.gov]

As in malaria, erythrocyte parasitemia is often associated with nonimmune hemolysis, and can be treated with erythrocytapheresis. [ncbi.nlm.nih.gov]

Malaria

Conditional deletion of the Fpn gene in erythroid cells resulted in accumulation of excess intracellular iron, cellular damage, hemolysis, and increased fatality in malaria-infected [ncbi.nlm.nih.gov]

He recovered naturally from delayed hemolysis. [ncbi.nlm.nih.gov]

Anemia and thrombocytopenia are common, and pallor and jaundice caused by hemolysis may occur. [meddean.luc.edu]

Drowning in Fresh Water

A possible cause of hemolysis is proposed and treatment based on th epathophysiology of pulmonary aspiration of fresh water is discussed. hemolysis near-drowning pulmonary [keio.pure.elsevier.com]

A) Complete recovery B) Development of acute respiratory distress syndrome C) Hemolysis D) Pulmonary hypertension E) Severe neurologic deficit Report Abuse * Re:nbme3. fresh [usmleforum.com]

This causes blood cells to burst ( hemolysis ). [thoughtco.com]

Heart Valve Disease

Topics covered include: * rehabilitation * management of thrombosis * hemolysis * rheumatic fever * endocarditis * special considerations such as care of the patient undergoing [routledge.com]

Hemolysis associated with prosthetic heart valves: a review. Cardiol Rev. 2009 May-Jun. 17(3):121-4. [Medline]. Lengyel M. [emedicine.medscape.com]

Zinc Poisoning

The workup was negative for hemolysis or bleeding. Her blood alcohol level was normal. B 12 and folate levels were normal. [bloodjournal.org]

Acute Respiratory Distress Syndrome

Hemolysis does not occur during ECMO unless there is a problem in the circuit or the patient. [doi.org]

Direct hyperbilirubinemia and biliary calculi may occur secondary to prolonged fasting and total parenteral nutrition (TPN), hemolysis, and diuretics. [doi.org]

Eperythrozoonosis

[…] construction of purifying is also less, medicine dissociates rule because the difference of drug dose produces different impacts to red corpuscle, even cause erythrocyte hemolysis [patents.google.com]

[…] construction of purifying is also less, medicine dissociates rule because the difference of drug dose produces different impacts to red corpuscle, even causes erythrocyte hemolysis [patents.google.com]

Bartonella Infection

[…] infection).The acute phase of the disease is a life threatening disease characterized by massive invasion of bartonella to human red blood cells and consequently an acute hemolysis [lyme-symptoms.com]

Inhalation of Nitric Oxide

[…] decrease pulmonary vascular resistance without affecting systemic blood pressure. 22 Furthermore, it has been shown that—in patients with acute PE—free hemoglobin formed from hemolysis [read.nxtbook.com]

Etomidate Toxicity

Copper Poisoning

Castor Bean Poisoning

Castor bean poisoning is associated with severe gastroenteritis, multiorgan failure, and cardiovascular shock. The poisoning is attributed to ricin, which is the toxic substance found in castor beans. Castor beans contain ricin, a toxic compound responsible for the poisoning that ensues with the exposure. Found in[…] [symptoma.com]

Nonsteroidal Antiinflammatory Drug

Adverse effects of nonsteroidal antiinflammatory drugs can occur throughout the whole gastrointestinal tract. Recently, several cases of "diaphragmlike" thin ileal strictures have been reported. These strictures seem to result from nonsteroidal antiinflammatory drug-induced inflammatory changes and apparently[…] [ncbi.nlm.nih.gov]

Hereditary Disease

Medullary thyroid carcinoma (MTC), a tumor arising from calcitonin-secreting C cells, appears in either a sporadic nonfamilial or a hereditary form as a component of a multiple endocrine neoplasia syndrome or familial non-multiple endocrine neoplasia MTC. Screening kindred of a patient with familial MTC to detect MTC in[…] [ncbi.nlm.nih.gov]

Anemia

Normocytic anemia may be caused by chronic disease, hemolysis, or bone marrow disorders. [aafp.org]

Bilirubin may be normal with moderate extravascular hemolysis, or abnormal in a patient with hepatic dysfunction without any hemolysis. [clinicaladvisor.com]

However, he has no history and is not jaundiced, which makes hemolysis unlikely. [aafp.org]

Hyperkalemia

Administration of packed red blood cells, hemolysis, tissue damage, and acidosis are also common causes of hyperkalemia. [ncbi.nlm.nih.gov]

Abstract Hyperkalemia in young children is a rare phenomenon and in many cases caused by hemolysis in the specimen due to difficulties in obtaining a sample. [ncbi.nlm.nih.gov]

Renal failure (potassium is primarily eliminated by the kidneys) Acidosis Massive cell death (tumor lysis syndrome, rhabdomyolysis, burns, crush injuries, hemolysis) Drugs [coreem.net]

Hemolytic Anemia

Given that factors other than footstrike cause hemolysis during exercise, these variables as causes of hemolysis during running cannot be eliminated. [doi.org]

hemolysis. [medicalassistantonlineprograms.org]

Mild hemolysis can be asymptomatic while the anemia in severe hemolysis can be life threatening and cause angina and cardiopulmonary decompensation. [emedicine.com]

Cholelithiasis

Cirrhosis of liver and recurrent episodes of hemolysis--these two common complications of Wilson's disease make an ideal setting for gall stone formation. [ncbi.nlm.nih.gov]

‘Splenectomy effectively arrests the extravascular hemolysis and prevents its long-term complications, such as cholelithiasis and aplastic crises.’ [en.oxforddictionaries.com]

AIMS AND BACKGROUND: Hyperbilirubinemia is often observed in chronic hemolysis and results in the formation of pigment cholelithiasis that could be increased by the presence [ncbi.nlm.nih.gov]