Hemolysis: Causes & Reasons

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Possible Causes for Hemolysis

HELLP Syndrome

After hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome was diagnosed in a 35-year-old woman at 39 weeks' gestation, magnetic resonance imaging and [ncbi.nlm.nih.gov]

Hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome has been recognized as a complication of preeclampsia-eclampsia for decades. [ncbi.nlm.nih.gov]

MAY 2004 DOI: 10.1097/01.AOG.0000126245.35811.2a, PMID: 15121574 Issn Print: 0029-7844 Publication Date: 2004/05/01 Checking for direct PDF access through Ovid Abstract Hemolysis [doi.org]

Zieve's Syndrome

Lab studies revealed hemolysis as the cause of anemia. The patient was diagnosed with Zieve's syndrome and managed with supportive measures. [ncbi.nlm.nih.gov]

Discussion The mechanism of hemolysis in Zieve's syndrome is not entirely understood, but alterations in red cell metabolism such as pyruvate kinase instability leave erythrocytes [ncbi.nlm.nih.gov]

[…] setting of alcoholic hepatitis, calculation of discriminant function may lead to misrepresentation of the level of liver injury (since much of the bilirubin may be from hemolysis [ncbi.nlm.nih.gov]

Paroxysmal Cold Hemoglobinuria

2015 ICD-9-CM Diagnosis Code 283.2 Hemoglobinuria due to hemolysis from external causes 2015 Billable Thru Sept 30/2015 Non-Billable On/After Oct 1/2015 ICD-9-CM 283.2 is [icd9data.com]

[…] blood and blood-forming organs and certain disorders involving the immune mechanism › D55-D59 Hemolytic anemias › D59- Acquired hemolytic anemia › Hemoglobinuria due to hemolysis [icd10data.com]

The hemolysis resolved with warmth, and administration of dexamethasone. [ncbi.nlm.nih.gov]

Paroxysmal Nocturnal Hemoglobinuria

Here we have tested our eculizumab-treated PNH patients (n=12) for signs of hemolysis and assessed complement biomarkers. [ncbi.nlm.nih.gov]

2015 ICD-9-CM Diagnosis Code 283.2 Hemoglobinuria due to hemolysis from external causes 2015 Billable Thru Sept 30/2015 Non-Billable On/After Oct 1/2015 ICD-9-CM 283.2 is [icd9data.com]

Antioxidants have been shown to reduce the oxidative stress and inhibit hemolysis as well as platelet activation mediated by activated C'. [ncbi.nlm.nih.gov]

Autoimmune Hemolytic Anemia

Laboratory investigations were suggestive of intravascular hemolysis, and on immuno-hematological evaluation it was diagnosed that the patient had autoantibody with mimicking [ncbi.nlm.nih.gov]

Exposure to cold led to worsening of the patient's hemolysis and hemoglobinuria. [ncbi.nlm.nih.gov]

Two (6.7%) patients' hemolysis was stopped from deteriorating, one (3.3%) patient's hemolysis was not controlled by the treatment due to malignancy, and another (3.3%) patient [ncbi.nlm.nih.gov]

Gilbert Syndrome

[…] from mechanical heart valve replacement) chronic hemolysis can be warranted. [ncbi.nlm.nih.gov]

[…] without anemia, whereas hemolysis is incompletely compensated in moderate HS. [bloodjournal.hematologylibrary.org]

Some patients with hemolysis have a similar abnormality. [annals.org]

Atypical Hemolytic Uremic Syndrome

Shistocytes are fragmented red cells resulting from intravascular hemolysis. Spherocytes are spherical cells found in hemolysis, hereditary spherocytosis and burns. Q2. [lifeinthefastlane.com]

Mechanical hemolysis is a frequent but usually harmless complication of aortic valve replacement. The most common reason is valvular leakage. [ncbi.nlm.nih.gov]

Renal function, proteinuria, and hemolysis all improved, and he was been in remission for more than 15 months. [ncbi.nlm.nih.gov]

Glycogen Storage Disease Type 7

Mutations in the muscle phosphofructokinase gene (PFK-M) result in a metabolic myopathy characterized by exercise intolerance and compensated hemolysis. [ncbi.nlm.nih.gov]

Muscle type phosphofructokinase (M-PFK) deficiency is a rare inherited glycogen storage disease in humans that causes exertional myopathy and hemolysis. [ncbi.nlm.nih.gov]

The hemolytic form of GSDVII is characterized by hemolytic anemia, in which red blood cells are broken down (undergo hemolysis) prematurely, causing a shortage of red blood [ghr.nlm.nih.gov]

Hereditary Elliptocytosis

Between these 2 extremes there lies an indeterminate group in which there is evidence of hemolysis if one looks for it, in which there may or may not be anemia, and in which [pediatrics.aappublications.org]

hemolysis. [symptoma.com]

Their exact relationship to the pathogenesis of the elliptical shape of the red cell, or to the presence of hemolysis, is at present unclear. [ncbi.nlm.nih.gov]

Wilson Disease

In pregnant patients with unrecognized WD, liver failure with hemolysis may be interpreted as the low platelet count (HELLP) syndrome. [ncbi.nlm.nih.gov]

Serum copper, urinary copper excretion, and hemolysis were significantly reduced and renal function improved. [ncbi.nlm.nih.gov]

Short-term plasma exchange may ameliorate the hemolysis. [bloodjournal.org]

Babesiosis

BACKGROUND: Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome is a serious complication of pregnancy associated with significant maternal and fetal [ncbi.nlm.nih.gov]

Specific antibiotic therapy was begun, and severe hemolysis from a high parasite burden required red blood cell exchange which led to rapid abatement of the hemolysis. [ncbi.nlm.nih.gov]

Autoimmune hemolysis in malaria: a report of three cases. J Assoc Physicians India 2012 ;60: 129 - 131 22. [nejm.org]

Beta Thalassaemia Major

Abstract The profound and life-threatening anemia in patients with Cooley's anemia is ascribed primarily to intramedullary hemolysis (ineffective erythropoiesis), the cause [ncbi.nlm.nih.gov]

These indicate excessive hemolysis and ineffective erythropoiesis. [symptoma.com]

In Cooley's anemia, there is increased splenic hemolysis and extramedullary erythropoiesis. [symptoma.com]

Thalassemia Minor

The case of a 17-year-old Italian girl with thalassemia minor and fatal acute Wilson's disease together with severe hemolysis is reported. The fortuitous(?) [ncbi.nlm.nih.gov]

On the other hand, hemolysis by glycerol lysis time (GLT50) is invariably prolonged in thalassemia. The reason for the prolongation of GLT50 is not well understood. [ncbi.nlm.nih.gov]

[…] of microcytic erythrocytes evident with increased LDH levels may be another factor. [6] Our patient had anemia and subtle hemolysis as evidenced by elevated LDH, which could [sjkdt.org]

Malaria

Conditional deletion of the Fpn gene in erythroid cells resulted in accumulation of excess intracellular iron, cellular damage, hemolysis, and increased fatality in malaria-infected [ncbi.nlm.nih.gov]

He recovered naturally from delayed hemolysis. [ncbi.nlm.nih.gov]

Anemia and thrombocytopenia are common, and pallor and jaundice caused by hemolysis may occur. [meddean.luc.edu]

Drowning in Fresh Water

A possible cause of hemolysis is proposed and treatment based on th epathophysiology of pulmonary aspiration of fresh water is discussed. hemolysis near-drowning pulmonary [keio.pure.elsevier.com]

A) Complete recovery B) Development of acute respiratory distress syndrome C) Hemolysis D) Pulmonary hypertension E) Severe neurologic deficit Report Abuse * Re:nbme3. fresh [usmleforum.com]

This causes blood cells to burst ( hemolysis ). [thoughtco.com]

Zinc Poisoning

The workup was negative for hemolysis or bleeding. Her blood alcohol level was normal. B 12 and folate levels were normal. [bloodjournal.org]

Heart Valve Disease

Topics covered include: * rehabilitation * management of thrombosis * hemolysis * rheumatic fever * endocarditis * special considerations such as care of the patient undergoing [routledge.com]

Hemolysis associated with prosthetic heart valves: a review. Cardiol Rev. 2009 May-Jun. 17(3):121-4. [Medline]. Lengyel M. [emedicine.medscape.com]

Acute Respiratory Distress Syndrome

Hemolysis does not occur during ECMO unless there is a problem in the circuit or the patient. [doi.org]

Direct hyperbilirubinemia and biliary calculi may occur secondary to prolonged fasting and total parenteral nutrition (TPN), hemolysis, and diuretics. [doi.org]

Bartonella Infection

[…] infection).The acute phase of the disease is a life threatening disease characterized by massive invasion of bartonella to human red blood cells and consequently an acute hemolysis [lyme-symptoms.com]

Inhalation of Nitric Oxide

[…] decrease pulmonary vascular resistance without affecting systemic blood pressure. 22 Furthermore, it has been shown that—in patients with acute PE—free hemoglobin formed from hemolysis [read.nxtbook.com]

Eperythrozoonosis

[…] construction of purifying is also less, medicine dissociates rule because the difference of drug dose produces different impacts to red corpuscle, even cause erythrocyte hemolysis [patents.google.com]

[…] construction of purifying is also less, medicine dissociates rule because the difference of drug dose produces different impacts to red corpuscle, even causes erythrocyte hemolysis [patents.google.com]

Anemia

Normocytic anemia may be caused by chronic disease, hemolysis, or bone marrow disorders. [aafp.org]

Bilirubin may be normal with moderate extravascular hemolysis, or abnormal in a patient with hepatic dysfunction without any hemolysis. [clinicaladvisor.com]

the Coombs test (autoimmune hemolysis), tests of osmotic fragility (extravascular hemolysis), and tests to rule out hemolysis induced by drugs[ 39 ]. [dx.doi.org]

Hemolytic Anemia

Given that factors other than footstrike cause hemolysis during exercise, these variables as causes of hemolysis during running cannot be eliminated. [doi.org]

hemolysis. [medicalassistantonlineprograms.org]

Mild hemolysis can be asymptomatic while the anemia in severe hemolysis can be life threatening and cause angina and cardiopulmonary decompensation. [emedicine.com]

Preeclampsia

BACKGROUND: Illnesses coincident with pregnancy may present similarly to preeclampsia or may be mistaken for severe preeclampsia or hemolysis, elevated liver enzymes, low [ncbi.nlm.nih.gov]

Abstract Data are presented to define a unique group of preeclamptic/eclamptic patients with the finding of hemolysis (H), elevated liver enzymes (EL), and a low platelet [ncbi.nlm.nih.gov]

Intrauterine fetal demise was diagnosed in the context of severe thrombocytopenia, hypertension, proteinuria, hemolysis, elevated transaminases, and renal failure. [ncbi.nlm.nih.gov]

Hyperkalemia

Administration of packed red blood cells, hemolysis, tissue damage, and acidosis are also common causes of hyperkalemia. [ncbi.nlm.nih.gov]

Abstract Hyperkalemia in young children is a rare phenomenon and in many cases caused by hemolysis in the specimen due to difficulties in obtaining a sample. [ncbi.nlm.nih.gov]

Renal failure (potassium is primarily eliminated by the kidneys) Acidosis Massive cell death (tumor lysis syndrome, rhabdomyolysis, burns, crush injuries, hemolysis) Drugs [coreem.net]

Hereditary Spherocytosis

Although the primary etiology is different in these anemias, oxidative stress mediates several of their pathologies, mainly hemolysis [3]. [clinicaltrials.gov]

However, all of these classical features are not always revealed in the case of mild hemolysis or when hemolysis is well compensated. [ncbi.nlm.nih.gov]

Carriers of the HS trait with mild hemolysis may remain undiagnosed for years. [symptoma.com]

Neonatal Jaundice

(ABO/Rh isoimmunization or hereiditary spherocytosis) Within 48 hours Hemolysis Infection Physiologic After 48 hours Infection Hemolysis Breast Milk Congenital malformation [step2.medbullets.com]

Early causes of hemolysis include blood group incompatibilities like Rh and Kell. On days of life 3-7, hemolysis may result from ABO blood group incompatibilities. [omicsonline.org]

In immune-mediated hemolysis, a Coombs test is positive. [pathophys.org]

Posthemorrhagic Anaemia of the Newborn

[…] for immune-mediated hemolysis or hereditary spherocytosis, Elliptocytosis for iron deficiency or hereditary elliptocytosis and schistocytes for intravascular hemolysis. [en.wikipedia.org]

[…] stenosis and prosthetic) heart valves - Through partially obstructed vessels - Through hemangiomas Mechanical Hemolysis Peripheral Blood Smear shows... [quizlet.com]

Elliptocytes 25 percent or more of red blood cells elliptocytic on peripheral blood smear G6PD deficiency Transient hemolysis following exposure to oxidative drug Normal [aafp.org]

Anemia due to Infection

Keywords: Anemia, infection, chronic inflammation, hemolysis, hepcidin, hemolytic anemia, red cell aplasia, blood loss, Red cell aplasis of bone marrow, Parvo virus, Viral [eurekaselect.com]

Hemolysis also can manifest as jaundice, cholelithiasis, or isolated reticulocytosis. Pathophysiology There are two mechanisms of hemolysis. [aafp.org]

It has also been suggested that erythrocyte membrane proteolysis plays an important role in hemolysis.45 Severe, often fatal hemolysis occurs in patients with C. welchii septicemia [medtextfree.wordpress.com]

Normocytic Normochromic Anemia

Hemolytic Anemia: Hemolysis -Hemolysis results from both hereditary and acquired defects of the red blood cell -All hereditary hemolytic disorders are a result of ... [cram.com]

[…] for immune-mediated hemolysis or hereditary spherocytosis, Elliptocytosis for iron deficiency or hereditary elliptocytosis and schistocytes for intravascular hemolysis. [en.wikipedia.org]

Is the pt on a med that causes hemolysis? Are all of the lines of blood cell production depressed? [allnurses.com]