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1,117 Possible Causes for Hemolysis, Hepatomegaly

  • Pharyngitis

    They exhibit β -hemolysis (complete hemolysis) when grown on blood agar plates.[cdc.gov] It is characterised by : Sore throat Fever Enlarged cervical lymph nodes Enlarged tonsils and fatigue Other clinical manifestations are splenomegaly (enlarged spleen), hepatomegaly[singhealth.com.sg] Splenomegaly and/or hepatomegaly can be present in more than 50% of patients.[infectiousdiseaseadvisor.com]

  • Paroxysmal Nocturnal Hemoglobinuria

    Here we have tested our eculizumab-treated PNH patients (n 12) for signs of hemolysis and assessed complement biomarkers.[ncbi.nlm.nih.gov] […] characterized by episodes of hemolytic anemia, hemoglobinuria (chiefly at night), pallor, icterus or bronzing of the skin, a moderate degree of splenomegaly, and sometimes hepatomegaly[medical-dictionary.thefreedictionary.com] Depending on their localization, thromboses (which affect 30-40 % of untreated patients) may manifest as abdominal pain, hepatomegaly, ascites and headaches.[orpha.net]

  • Malaria

    Conditional deletion of the Fpn gene in erythroid cells resulted in accumulation of excess intracellular iron, cellular damage, hemolysis, and increased fatality in malaria-infected[ncbi.nlm.nih.gov] Patients with heavy hepatocyte load may present with hepatomegaly.[symptoma.com] He recovered naturally from delayed hemolysis.[ncbi.nlm.nih.gov]

  • Wilson Disease

    In pregnant patients with unrecognized WD, liver failure with hemolysis may be interpreted as the low platelet count (HELLP) syndrome.[ncbi.nlm.nih.gov] She had no hepatomegaly and no splenomegaly. Breast and pubic hair development was concomitant with Tanner stage 4.[ncbi.nlm.nih.gov] Wilson disease can present with only significantly increased transaminases activity and hepatomegaly or liver failure, but neurological symptoms are very rare in children.[ncbi.nlm.nih.gov]

  • Babesiosis

    Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome is a serious complication of pregnancy associated with significant maternal and fetal morbidity[ncbi.nlm.nih.gov] On physical examination, fever, splenomegaly, hepatomegaly, or jaundice may be observed.[aldf.com] Specific antibiotic therapy was begun, and severe hemolysis from a high parasite burden required red blood cell exchange which led to rapid abatement of the hemolysis.[ncbi.nlm.nih.gov]

  • Autoimmune Hemolytic Anemia

    Laboratory investigations were suggestive of intravascular hemolysis, and on immuno-hematological evaluation it was diagnosed that the patient had autoantibody with mimicking[ncbi.nlm.nih.gov] […] involvement (84% vs 31%, p   0.001), fever (65% vs 26%, p   0.001), weight loss   2 kg (39% vs 6%, p   0.001), reticuloendothelial manifestations (48% vs 8%, p   0.001), hepatomegaly[ncbi.nlm.nih.gov] All patients had resolution or marked improvement of hemolysis after discontinuation of maintenance of CNI and initiation of sirolimus immunosuppression.[ncbi.nlm.nih.gov]

  • Cooley's Anemia

    The profound and life-threatening anemia in patients with Cooley's anemia is ascribed primarily to intramedullary hemolysis (ineffective erythropoiesis), the cause of which[ncbi.nlm.nih.gov] Hepatomegaly can result from a number of mechanisms; extramedullary erthyropoiesis, hepatitis due to chronic transfusion associated infections, and iron overload.[pathophys.org] Patients with β-thalassemia major are prone to repeated attacks of intravascular hemolysis that requires repeated hospitalization and blood transfusions.[link.springer.com]

  • Liver Abscess

    Iron deficiency and evidence of hemolysis were not present and the findings are consistent with those described in the anemia of infection.[ajtmh.org] We report a case of a 63-year-old male with a history of anorexia for 3 weeks, fever for 4 days and examination findings of tender hepatomegaly with a liver span of 15 cm[ncbi.nlm.nih.gov] The main clinical features were fever (100%), right hypochodric pain (100%), tender hepatomegaly (90%) and intercostal tenderness (60%).[ncbi.nlm.nih.gov]

  • Viral Hepatitis

    Stainable iron in the liver (hemosiderosis) is most commonly seen in individuals with homozygous genetic hemochromatosis, prior transfusion, hemolysis, porphyria cutanea tarda[ncbi.nlm.nih.gov] Three patients presented only jaundice and hepatomegaly; one also had liver failure.[ncbi.nlm.nih.gov] In the icteric phase, the patients develop jaundice, gastrointestinal disturbance, dark urine, gray-colored stools, right upper quadrant pain, and hepatomegaly.[symptoma.com]

  • Peliosis Hepatis

    […] slightly elevated serum bilirubin level (2 mg per deciliter [34.2 mmol per liter]) and elevated serum lactate dehydrogenase concentration (450 U per liter) attributed to hemolysis[nejm.org] Her symptoms included abdominal pain and weight loss; the only finding of a physical examination was hepatomegaly.[ncbi.nlm.nih.gov] The cause of the huge hepatomegaly encountered in the present case may be attributable to peliosis due to severe infection.[ncbi.nlm.nih.gov]

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