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55 Possible Causes for Hemolysis, Polychromasia in Peripheral Blood Smear

  • Zieve's Syndrome

    Lab studies revealed hemolysis as the cause of anemia. The patient was diagnosed with Zieve's syndrome and managed with supportive measures.[] The peripheral blood smear revealed polychromasia and nucleated erythrocytes. The parents’ blood counts and smears were normal.[] Discussion The mechanism of hemolysis in Zieve's syndrome is not entirely understood, but alterations in red cell metabolism such as pyruvate kinase instability leave erythrocytes[]

  • Autoimmune Hemolytic Anemia

    Laboratory investigations were suggestive of intravascular hemolysis, and on immuno-hematological evaluation it was diagnosed that the patient had autoantibody with mimicking[] Peripheral blood smear showed polychromasia and spherocytosis. Haptoglobin level was 0.06 g/L ( N 0.16-2). Both hemoglobin electrophoresis and G6PD level were normal.[] All patients had resolution or marked improvement of hemolysis after discontinuation of maintenance of CNI and initiation of sirolimus immunosuppression.[]

  • Congenital Dyserythropoietic Anemia Type 1

    […] endogenous carbon monoxide production as an index of total heme turnover and the erythrocyte 51 Cr survival as an index of peripheral destruction, significant erythrocyte hemolysis[] Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells[] Anemia at birth (Hb blood loss, hemolysis or impaired red cell productio n.[]

  • Paroxysmal Cold Hemoglobinuria

    2015 ICD-9-CM Diagnosis Code 283.2 Hemoglobinuria due to hemolysis from external causes 2015 Billable Thru Sept 30/2015 Non-Billable On/After Oct 1/2015 ICD-9-CM 283.2 is[] Tests include complete blood count (CBC) and peripheral smear.[] The complete blood count usually shows normocytic anemia. Reticulocytosis may be subtle in the acute phase. Peripheral blood smear may show corresponding polychromasia.[]

  • Cold Agglutinin Disease

    Abstract Cold agglutinin disease is a form of direct, extravascular, antiglobulin-positive hemolysis.[] Reticulocytes and Spherocytes The results of the reticulocyte count are usually increased in patients with cold agglutinin disease, with polychromasia in the peripheral blood[] Other laboratory findings include reticulocytosis, positive DAT, auto agglutination and/or rouleaux on peripheral blood smear, polychromasia, and mild to moderate anisocytosis[]

  • Acquired Hemolytic Anemia

    ., some drugs and other ingested substances lead to hemolysis by direct action on RBCs, e.g., ribavirin ) Toxins (e.g., snake venom; plant poisons such as aesculin) Trauma[] blood smear : spherocytes, polychromasia Coombs test : positive Cold agglutinins titer C3 and C4 ; (due to complement activation) Prognosis: spontaneous remission within[] After birth and after successful therapy of hemolysis, cytomegalovirus was not detected in the plasma, strongly suggesting a causal relationship between the hemolysis and[]

  • Atypical Hemolytic Uremic Syndrome

    Mechanical hemolysis is a frequent but usually harmless complication of aortic valve replacement. The most common reason is valvular leakage.[] Anisocytosis, poikilocytosis, polychromasia, helmet cells, marked schistocytes, and rare platelets were observed in the peripheral blood smear, compatible with microangiopathic[] Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by hemolysis, thrombocytopenia, and renal dysfunction.[]

  • Nonimmune Hemolysis

    […] acquired forms of thalassemia or erythrocytic membrane disorders, and hemolysis secondary to a dysfunctioning artificial (prosthetic) cardiac valve.[] blood smear : spherocytes, polychromasia Coombs test : positive Cold agglutinins titer C3 and C4 ; (due to complement activation) Prognosis: spontaneous remission within[] […] and extravascular hemolysis, and renal failure.[]

  • Microangiopathic Hemolytic Anemia

    We postulate that in this case the inability to detect schistocytes in the peripheral smear reflected a low degree of hemolysis.[] The peripheral blood smear revealed polychromasia, poikilocytosis, and many schistocytes. Bone marrow biopsy disclosed metastatic carcinoma.[] Hemosiderinuria is seen in chronic intravascular hemolysis. 4) Examination of blood smear: Careful examination of peripheral blood smear by an experienced person provides[]

  • Congenital Hemolytic Anemia

    Chronic hemolysis often results in the formation of gallstones, and cholecystectomy is often indicated.[] Laboratory The review of the peripheral blood smear revealed no evidence of the schistocytes or fragmented red cells.[] Early phenobarbital treatment may prevent the development of cholelithiasis in patients with chronic hemolysis.[]

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