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197 Possible Causes for Heparin Resistance

  • Acute Massive Pulmonary Embolism

    In both groups, heparin infusion was started at the end of thrombolytic infusion and adapted thereafter. Total pulmonary resistance was monitored over a 12-h period.[] The primary objective was to compare the resolution of pulmonary embolism as judged by the change in total pulmonary resistance over the initial 2 h.[] 4,400 U/kg as an intravenous bolus infusion, then 4,400 U/kg per h over 12 h; n 29) or alteplase (10 mg as an intravenous bolus infusion, then 90 mg over 2 h) followed by heparin[]

  • Thromboembolism

    BACKGROUND: Full- or lower-dose anticoagulant therapy or aspirin can be used for extended therapy in patients with venous thromboembolism (VTE), but information on their relative benefit-risk profiles is limited. METHODS: Data from the EINSTEIN-CHOICE trial were used to compare the benefit-risk profiles of extended[…][]

  • Recurrent Thrombophlebitis due to Hereditary Disorders

    The most common hereditary disorders of hemostasis in this respect appear to be deficiencies of antithrombin III, protein C, and protein S, and activated protein C resistance[] Heparin-induced thrombocytopenia Full blood count, HITT's antibody screen and confirmatory testing.[] Superficial thrombophlebitis and low-molecularweight heparins. Angiology. 2002;53:659-663. 75. Denzel C, Lang W.[]

  • Hereditary Deficiency of Antithrombin

    Protein C Protein S Applies to Heparin; Heparin Cofactor II; Heparin Resistance Replaces Antithrombin III Assay Abstract A deficiency of antithrombin, a natural anticoagulant[] It is probably not cost-effective to give antithrombin substitution to patients requiring heparin, in order to overcome presumed heparin resistance.[] In some circumstances, a patient can be “heparin resistant” and will not respond effectively to heparin at all – even at higher doses.[]

  • Raynaud's Disease

    Treatment of the Raynaud phenomenon resistant to initial therapy [Internet]. [citado 2014 julio 15]. Disponible en: . Denton C, Howell K, Stratton R, Black C.[] Long-term low molecular weight heparin therapy for severe Raynaud's phenomenon: a pilot study. Clin Exp Rheumatol. 2000;18:499-502. Abou-Raya A, Abou-Raya S, Helmii M.[]

  • Thrombocytopenia

    Finally, in some patients with HIT resistance to heparin may occur, meaning that an increasing dose of heparin dose is required to maintain the activated partial thromboplastin[] References 1 Antibiotic resistance in gram-positive cocci, Int J Antimicrob Agents, 2000 , vol. 16 (pg. 473 - 8 ) 2 Nosocomial bloodstream infections in United States hospitals[] References 1 Antibiotic resistance in gram-positive cocci , Int J Antimicrob Agents , 2000 , vol. 16 (pg. 473 - 8 ) 2 Nosocomial bloodstream infections in United States hospitals[]

  • Thrombosis

    Krajewski, Achievement of Therapeutic Anti-Xa Levels in a Proven Heparin-Resistant Patient Through the Use of Nontraditional High-Dose Enoxaparin, Annals of Pharmacotherapy[] At the intensive care unit, heparin was continually infused until postoperative day 12 and was then switched to warfarin.[] Additional preoperative laboratory review revealed findings for activated protein C resistance, low protein S activity, antinuclear antibody ( 1:160), anti-cardiolipin IgM[]

  • Cerebral Thrombosis

    The resistance to heparin was carefully checked by the delay to reach an adequate aPTT (activated partial thrombin time) (between two to three times of control).[] Treatment of CVT was based on heparin anticoagulation at therapeutic dose for all patients.[]

  • Coagulation Abnormalities

    These patients not only have increased thrombotic tendency but also have resistance to heparin. A low plasma concentration of antithrombin III confirms the diagnosis.[]

  • Hypothyroidism

    […] to heparin resistance and pro-coagulation state ( 94 – 96 ).[] Atrial fibrillation is observed in up to 40% of TS patients ( 55 ), in whom heparin therapy is obviously indicated; however, changes occurring in patients with TS may lead[]

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