Hepatic Necrosis: Causes & Reasons

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Possible Causes for Hepatic Necrosis

Massive Hepatic Necrosis

Hepatic necrosis after ethanol ablation for hepatocellular carcinoma (HCC), although rare, is well known and described, particularly in patients with chronic liver disease [ncbi.nlm.nih.gov]

Numerology Chaldean Numerology The numerical value of massive hepatic necrosis in Chaldean Numerology is: 7 Pythagorean Numerology The numerical value of massive hepatic necrosis [definitions.net]

Abstract Serum concentrations of alpha-fetoprotein (AFP) were measured by radioimmunoassay in 12 patients with massive hepatic necrosis, 11 of whom died. [ncbi.nlm.nih.gov]

Aflatoxicosis

[…] will present with acute hepatic necrosis within a short period of time. [visualdx.com]

The toxic effects of AFB1 are mainly localized in liver as manifested by hepatic necrosis, bile duct proliferation, icterus and hemorrhage. [ncbi.nlm.nih.gov]

[…] to orange. ( J13 .41.w2) GIT: in the jejunum, traces of fresh blood in one individual. ( J13 .41.w2) Histopathology: Hepatic: focal necrosis, sinusoids dilated and engorged [wildpro.twycrosszoo.org]

Acute Liver Failure

NOS Acute and subacute hepatic failure Approximate Synonyms Acute and subacute hepatic failure Acute hepatic failure Acute hepatic necrosis Acute liver failure Acute necrosis [icd10data.com]

(or both), a lesion classified as subacute hepatic necrosis (SHN). [doi.org]

The condition is also referred to as a fulminant hepatic failure, acute hepatic necrosis, fulminant hepatic necrosis, and fulminant hepatitis. [verywell.com]

Drug-Induced Toxic Hepatitis

necrosis Toxic liver disease w hepatic necrosis, w coma Toxic liver disease with acute hepatitis Toxic liver disease with cholestasis Toxic liver disease with chronic active [icd9data.com]

necrosis, acute hepatitis and granulomatous hepatitis Cholestatic injury: bland cholestasis, acute cholestatic hepatitis and chronic cholestatic injury Steatosis and steatohepatitis [pathologyoutlines.com]

Paracetamol poisoning is treated with gastric lavage and N-acetyl cystine which reduces hepatic necrosis, if therapy is started within 8 hours of ingestion. [medicscientist.com]

Idiosyncratic Drug-Induced Liver Injury

necrosis Hepatic failure (acute)(chronic) due to drugs K71.2 Toxic liver disease with acute hepatitis K71.3 Toxic liver disease with chronic persistent hepatitis K71.4 Toxic [apps.who.int]

necrosis K71.10 …… without coma K71.11 …… with coma K71.2 Toxic liver disease with acute hepatitis K71.3 Toxic liver disease with chronic persistent hepatitis K71.4 Toxic [icd10data.com]

Toxic Liver Disease

necrosis Hepatic failure (acute)(chronic) due to drugs K71.2 Toxic liver disease with acute hepatitis K71.3 Toxic liver disease with chronic persistent hepatitis K71.4 Toxic [apps.who.int]

[…] disease with hepatic necrosis K71.2 Toxic liver disease with acute hepatitis K71.3 Toxic liver disease with chronic persistent hepatitis K71.4 Toxic liver disease with chronic [icd10data.com]

necrosis K71.10 …… without coma K71.11 …… with coma K71.2 Toxic liver disease with acute hepatitis K71.3 Toxic liver disease with chronic persistent hepatitis K71.4 Toxic [icd10data.com]

Drug-Induced Cholestatic Hepatitis

necrosis Toxic liver disease w hepatic necrosis, w coma Toxic liver disease with acute hepatitis Toxic liver disease with cholestasis Toxic liver disease with chronic active [icd9data.com]

necrosis, not a cholestasis. [gpnotebook.co.uk]

Isoniazid Hepatitis

Page 218 - Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J. Pharmacol. Exp. Ther. ‎ [books.google.com]

This damage is caused by hepatic necrosis or death of liver cells, as Isoniazid is metabolized in the liver. [livertoxicity.weebly.com]

Toxic Hepatitis

This compound produces cholestasis and hepatic necrosis in many animals and caused the so-called Epping jaundice when 84 persons ate bread contaminated with it. [nejm.org]

Herbal hepatitis: subacute hepatic necrosis secondary to chaparral leaf. J Clin Gastroenterol 1990;12:203-6. Larrey D, Vial T, Pauwels A, et al. [cdc.gov]

Ergotism

Ergotism (pron. UR -gət-iz-əm ) is the effect of long-term ergot poisoning, traditionally due to the ingestion of the alkaloids produced by the Claviceps purpurea fungus that infects rye and other cereals, and more recently by the action of a number of ergoline -based drugs. It is also known as ergotoxicosis,[…] [en.wikipedia.org]

Passive Congestion of the Liver

Congestion Sinusoidal engorgement, degeneration, and variable hemorrhagic necrosis in zone 3 of the hepatic acinus Fatty change Variable degrees of cholestasis with occasional [mdnxs.com]

They reported an association between free hepatic venous pressure and the presence of centrilobular necrosis, inflammation, periportal necrosis, and stainable hepatic iron [nature.com]

Prominent necrosis involving centrilobular zones or entire lobules in most of liver; associated with hepatic failure May also be called confluent necrosis Bile ductular proliferation [pathologyoutlines.com]

Anicteric Viral Hepatitis

necrosis Toxic liver disease w hepatic necrosis, w coma Toxic liver disease with acute hepatitis Toxic liver disease with cholestasis Toxic liver disease with chronic active [icd9data.com]

Hepatic necrosis associated with halothane anesthesia. Am J Med. 1969 Nov; 47 (5):748–764. [ PubMed ] [ Google Scholar ] LARSEN RR, SAWYER RB, SAWYER KC, McCURDY RE. [ncbi.nlm.nih.gov]

CMV hepatitis rarely includes granulomatous hepatitis, cholestatic hepatitis, or acute hepatic failure with massive necrosis. [wjgnet.com]

Autoimmune Hepatitis

A second biopsy specimen revealed massive hepatic necrosis. She started oral prednisone therapy for presumed liraglutide-induced marker-negative autoimmune hepatitis. [ncbi.nlm.nih.gov]

Autoimmune chronic active hepatitis Autoimmune hepatitis (disorder) autoimmune hepatitis with centrilobular necrosis AIH Chronic autoimmune hepatitis autoimmune liver disease [wikidata.org]

ruling out hereditary, infectious, and toxicity-related causes of liver disease is an important component of diagnosis. 2 Interface hepatitis (piecemeal necrosis) in liver [questdiagnostics.com]

Hepatic Infarction

On diagnostic imaging, celiac axis and hepatic artery were thrombosed, resulting in ischemic necrosis of the left hepatic lobe. [ncbi.nlm.nih.gov]

In addition, the presence of a left hepatic artery completely replaced to the left gastric artery should alert one to the potential for hepatic necrosis. [ncbi.nlm.nih.gov]

can develop hepatic necrosis as a complication of the procedure. [explainmedicine.com]

Chronic Active Hepatitis

Interface hepatitis Piecemeal necrosis in hepatitis B Lobular inflammation Fibrosis and cirrhosis Advertisement [pathologyoutlines.com]

Abstract A 19-yr-old man had features of chronic hepatitis with piecemeal necrosis as the sole clinical feature of the idiopathic hypereosinophilic syndrome. [ncbi.nlm.nih.gov]

In chronic active hepatitis (CAH), which is also known as 'chronic aggressive hepatitis', inflammatory changes are associated with continued necrosis of liver cells. [somalidoc.com]

Chloroform Poisoning

الصفحة 218 - Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J. Pharmacol. Exp. Ther. ‏ [books.google.com]

Diagnosis is based on a history of exposure and the clinical presentation of mucous membrane irritation, CNS depression, arrhythmias, and hepatic necrosis. [mhmedical.com]

Transient jaundice has also been reported in one study (Whitaker and Jones 1965), while several earlier studies report acute hepatic necrosis in women exposed to chloroform [answers.google.com]

Macronodular Cirrhosis

[…] macronodular cirrhosis cirrhosis in which regenerative nodules are more than 3 mm in diameter, seen most often following subacute hepatic necrosis due to toxic or viral hepatitis [medicine.academic.ru]

necrosis due to toxic or viral hepatitis. metabolic cirrhosis a type associated with metabolic diseases, such as hemochromatosis, Wilson’s disease, glycogen storage disease [livingwiththediagnosis.wordpress.com]

necrosis in regenerative stage of acute hepatitis. [nature.com]

Iron Poisoning

In rare cases of iron intoxication, late sequelae such as hepatic necrosis and gastrointestinal scarring with obstruction may occur. [arizona.pure.elsevier.com]

الصفحة 218 - Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J. Pharmacol. Exp. Ther. ‏ [books.google.com]

Amanita Phalloides Poisoning

Am·a·ni·ta phal·loi·'des a species of fungus containing poisonous elements, including phalloidin and amanitin, which cause gastroenteritis, hepatic necrosis, and renal necrosis [medical-dictionary.thefreedictionary.com]

The typical liver and kidney alterations of Amanita phalloides poisoning, consisting of massive hepatic central lobular cell necrosis and acute tubular necrosis of the kidney [ncbi.nlm.nih.gov]

Ten recoveries were obtained, which denote, on the basis of the necrosis enzymes and the hepatic histo-pathological aspects from bioptic samplings, the use of the E.T. method [ncbi.nlm.nih.gov]

Chronic Persistent Hepatitis

necrosis Toxic liver disease w hepatic necrosis, w coma Toxic liver disease with acute hepatitis Toxic liver disease with cholestasis Toxic liver disease with chronic active [icd9data.com]

Piecemeal Necrosis 2. Portal fibrosis 3. Bridging Necrosis 4. Interface hepatitis 5. [gradestack.com]

necrosis, without coma K7111Toxic liver disease with hepatic necrosis, with coma K712Toxic liver disease with acute hepatitis K713Toxic liver disease with chronic persistent [cms.gov]

Subcapsular Liver Hematoma

To the Editor: Hepatocellular neoplasms, peliosis hepatis, and hepatic necrosis have been reported to be complications of long-term therapy with androgenic anabolic steroids [nejm.org]

Toxic liver disease with chronic persistent hepatitis Toxic liver disease with fibrosis and cirrhosis of liver Toxic liver disease with hepatic necrosis Vascular disorder [icd9data.com]

necrosis Focal nodular hyperplasia of liver Hemorrhage of liver Hepatic neuropathy Hepatic schistosomiasis Hepatocellular dysplasia Hepatocellular liver damage Hepatoptosis [icdlist.com]

Echovirus Infection

Necropsy revealed hepatic necrosis, renal hemorrhage, adrenal hemorrhagic necrosis, gastrointestinal hemorrhage, and severe encephalomalacia. [nature.com]

Fulminant Neonatal Hepatic Necrosis Associated with Echovirus Type 11 Infection. West J Med. 1983;138(2):260-3. Piraino FF, Sedmak G, Raab K. [ama.ba]

Echovirus 14 infection associated with fatal neonatal hepatic necrosis. Am J Dis Child. 1972 Jan;123(1):61–67. [PubMed] [Google Scholar] Philip AG, Larson EJ. [ncbi.nlm.nih.gov]

Acetaminophen Overdose

Algorithms for hepatotoxicity (including codes for hepatic necrosis, toxic hepatitis and encephalopathy) and ALF (hepatic necrosis and encephalopathy) were also highly predictive [ncbi.nlm.nih.gov]

Postmortem findings included massive centrilobular hepatic necrosis and renal tubular necrosis. [ncbi.nlm.nih.gov]

If untreated, the normal outcome of a large acetaminophen overdose would be massive hepatic necrosis with delayed death and low blood and tissue acetaminophen concentrations [ncbi.nlm.nih.gov]

Cardiac Cirrhosis

[…] lobular necrosis. [healthfrom.com]

Abstract The pathogenesis of congestive cirrhosis is generally thought to be a reaction of the hepatic stroma to hypoxia, pressure, or necrosis. [ncbi.nlm.nih.gov]

Long-term hepatic congestion with relative ischemia can induce centrilobular necrosis and pericentral fibrosis, triggering extensive hepatic fibrosis and the formation of [kjim.org]

Granulomatous Liver Disease

necrosis Hepatic failure (acute)(chronic) due to drugs K71.2 Toxic liver disease with acute hepatitis K71.3 Toxic liver disease with chronic persistent hepatitis K71.4 Toxic [apps.who.int]

[…] injury → extensive necrosis → fatal outcome Chronic hepatitis -sustained inflammatory process in liver > 6 months -often impossible to differentiate from acute hepatitis [quizlet.com]

The severity of necroinflammatory activity is quite variable, ranging from mildly active hepatitis ( Figure 4 ) to bridging necrosis to massive hepatic necrosis. [nature.com]

Acetanilide Poisoning

This results in formation of covalent adducts which produce hepatic necrosis and renal tubular necrosis. [pharmaxchange.info]

Hepatic necrosis v. Skin rash ii. Renal tubular necrosis vi. Pancytopenia iii. Hypoglycemic coma vii. Urticaria iv. Leucopenia Dose: Single dose: 500 mg or 1 gm daily. [slideshare.net]

Overdose of paracetamol can result in severe hepatic necrosis and renal failure to the extent of fatality. [pharmaxchange.info]

Chronic Active Hepatitis B

However, periportal necroinflammation, portal fibrosis, focal hepatic necrosis, regeneration and polyploid nuclear changes were more prominent in the CAH-B group than in the [ncbi.nlm.nih.gov]

Massive and submassive hepatic necrosis Fig 101 - Massive and submassive hepatic necrosis: Massive necrosis is fatal, involving the entire liver parenchyma. [meddean.luc.edu]

B with or without Hepatitis D and Hepatitis C as the causative agents], and hepatitis [indicating necrosis and inflammation of the liver]. [hepatitisbannual.org]

Gold Salt Poisoning

Seite 218 - Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J. Pharmacol. Exp. Ther. ‎ [books.google.de]

Fatal hepatic necrosis associated with parenteral gold therapy. Dig Dis Sci 1988; 33: 1025-9. [livertox.nih.gov]

Several cases of massive hepatic necrosis have also been reported in the literature. [drugs.com]

Liver Injury

KEYWORDS: Acute hepatitis; Autoimmune hepatitis; Cholestasis; Hepatic necrosis; Hepatotoxicity [ncbi.nlm.nih.gov]

We report a rare case of hydralazine-induced hepatotoxicity in the form of subacute hepatic necrosis. [ncbi.nlm.nih.gov]

Hepatic encephalopathy, hypoalbuminemia, and hepatic necrosis were significantly associated with mortality (p CONCLUSION: Adequate regulation and scrutiny regarding AHM use [ncbi.nlm.nih.gov]

Hepatic Nodular Hyperplasia

急性広範性肝壊死 acute massive hepatic necrosis 虚血-再灌流傷害 ischemia-reperfusion injury 巨細胞性肝炎 giant cell hepatitis 巨大ミトコンドリア megamitochondria (giant mitochondria) グリピカン-３ Glypican- [jsge.or.jp]

When there is loss of hepatic function due to either necrosis or fibrosis, the result is liver failure. [vet.uga.edu]

Hepatic adenoma: Inhomogeneous liver mass that proved to be a liver adenoma with hemorrhagic changes Hepatic adenoma: Hypoechoic liver lesions undergoing hemorrhage and necrosis [ultrasoundcases.info]