Hepatic Necrosis Causes & Reasons

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Hepatic Necrosis Symptom Checker: Possible causes include Massive Hepatic Necrosis. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Possible Causes

Massive Hepatic Necrosis

Abstract Serum concentrations of alpha-fetoprotein (AFP) were measured by radioimmunoassay in 12 patients with massive hepatic necrosis, 11 of whom died. [ncbi.nlm.nih.gov]

At autopsy massive hepatic necrosis was found, associated with enlargement of the liver. [ncbi.nlm.nih.gov]

necrosis. [ncbi.nlm.nih.gov]

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Acute Liver Failure

(or both), a lesion classified as subacute hepatic necrosis (SHN). [doi.org]

NOS Acute and subacute hepatic failure Approximate Synonyms Acute and subacute hepatic failure Acute hepatic failure Acute hepatic necrosis Acute liver failure Acute necrosis [icd10data.com]

The condition is also referred to as a fulminant hepatic failure, acute hepatic necrosis, fulminant hepatic necrosis, and fulminant hepatitis. [verywell.com]

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Drug-induced Toxic Hepatitis

Paracetamol poisoning is treated with gastric lavage and N-acetyl cystine which reduces hepatic necrosis, if therapy is started within 8 hours of ingestion. [medicscientist.com]

necrosis Toxic liver disease w hepatic necrosis, w coma Toxic liver disease with acute hepatitis Toxic liver disease with cholestasis Toxic liver disease with chronic active [icd9data.com]

[…] cells (so-called piecemeal necrosis or interface hepatitis ); the degree of confluent necrosis that links or forms bridges between vascular structures—between portal tract [clinicalgate.com]

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Aflatoxicosis

[…] will present with acute hepatic necrosis within a short period of time. [visualdx.com]

The toxic effects of AFB1 are mainly localized in liver as manifested by hepatic necrosis, bile duct proliferation, icterus and hemorrhage. [ncbi.nlm.nih.gov]

[…] to orange. ( J13 .41.w2) GIT: in the jejunum, traces of fresh blood in one individual. ( J13 .41.w2) Histopathology: Hepatic: focal necrosis, sinusoids dilated and engorged [wildpro.twycrosszoo.org]

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Toxic Liver Disease

[…] disease with hepatic necrosis K71.2 Toxic liver disease with acute hepatitis K71.3 Toxic liver disease with chronic persistent hepatitis K71.4 Toxic liver disease with chronic [icd10data.com]

necrosis K71.10 …… without coma K71.11 …… with coma K71.2 Toxic liver disease with acute hepatitis K71.3 Toxic liver disease with chronic persistent hepatitis K71.4 Toxic [icd10data.com]

necrosis Hepatic failure (acute)(chronic) due to drugs K71.2 Toxic liver disease with acute hepatitis K71.3 Toxic liver disease with chronic persistent hepatitis K71.4 Toxic [apps.who.int]

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Drug-induced Cholestatic Hepatitis

necrosis Toxic liver disease w hepatic necrosis, w coma Toxic liver disease with acute hepatitis Toxic liver disease with cholestasis Toxic liver disease with chronic active [icd9data.com]

necrosis, not a cholestasis. [gpnotebook.co.uk]

necrosis, acute hepatitis and granulomatous hepatitis Cholestatic injury: bland cholestasis, acute cholestatic hepatitis and chronic cholestatic injury Steatosis and steatohepatitis [pathologyoutlines.com]

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Adenovirus Infection

Herein we report three patients with AIDS and fatally disseminated adenovirus infection with hepatic necrosis. [ncbi.nlm.nih.gov]

This is an unusual case of fatal hepatic necrosis caused by disseminated type 5 adenovirus in a renal transplant recipient. [ncbi.nlm.nih.gov]

Abstract Disseminated adenovirus infection with fatal hepatic necrosis has been reported in 16 patients, 15 of whom had immunocompromising conditions. [ncbi.nlm.nih.gov]

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Drug-induced Idiosyncratic Hepatitis

necrosis Hepatic failure (acute)(chronic) due to drugs K71.2 Toxic liver disease with acute hepatitis K71.3 Toxic liver disease with chronic persistent hepatitis K71.4 Toxic [apps.who.int]

necrosis K71.10 …… without coma K71.11 …… with coma K71.2 Toxic liver disease with acute hepatitis K71.3 Toxic liver disease with chronic persistent hepatitis K71.4 Toxic [icd10data.com]

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Toxic Hepatitis

This compound produces cholestasis and hepatic necrosis in many animals and caused the so-called Epping jaundice when 84 persons ate bread contaminated with it. [nejm.org]

Herbal hepatitis: subacute hepatic necrosis secondary to chaparral leaf. J Clin Gastroenterol 1990;12:203-6. Larrey D, Vial T, Pauwels A, et al. [cdc.gov]

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Isoniazid Hepatitis

Page 218 - Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J. Pharmacol. Exp. Ther. ‎ [books.google.com]

Three of these patients died with fulminant hepatic failure, and 8 of the 11 surviving patients had bridging or multilobular necrosis, or both, on liver biopsy. [annals.org]

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Acetaminophen Overdose

Postmortem findings included massive centrilobular hepatic necrosis and renal tubular necrosis. [ncbi.nlm.nih.gov]

Algorithms for hepatotoxicity (including codes for hepatic necrosis, toxic hepatitis and encephalopathy) and ALF (hepatic necrosis and encephalopathy) were also highly predictive [ncbi.nlm.nih.gov]

If untreated, the normal outcome of a large acetaminophen overdose would be massive hepatic necrosis with delayed death and low blood and tissue acetaminophen concentrations [ncbi.nlm.nih.gov]

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Hepatic Infarction

In addition, the presence of a left hepatic artery completely replaced to the left gastric artery should alert one to the potential for hepatic necrosis. [ncbi.nlm.nih.gov]

On diagnostic imaging, celiac axis and hepatic artery were thrombosed, resulting in ischemic necrosis of the left hepatic lobe. [ncbi.nlm.nih.gov]

can develop hepatic necrosis as a complication of the procedure. [explainmedicine.com]

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Autoimmune Hepatitis

A second biopsy specimen revealed massive hepatic necrosis. She started oral prednisone therapy for presumed liraglutide-induced marker-negative autoimmune hepatitis. [ncbi.nlm.nih.gov]

Autoimmune chronic active hepatitis Autoimmune hepatitis (disorder) autoimmune hepatitis with centrilobular necrosis AIH Chronic autoimmune hepatitis autoimmune liver disease [wikidata.org]

Aminotransferase values correlate poorly with the degree of hepatic necrosis but very high levels may indicate acute hepatitis or a severe flare of pre-existing disease. [patient.info]

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Viral Upper Respiratory Tract Infection

Oral Adults 500mg to 1000mg 4-6 hourly – Max. 60mg/kg/day Precautions- Renal or hepatic dysfunction. [slideshare.net]

Overdose can result in severe liver damage, renal tubular necrosis. NSAID Ibuprofen Indication Temporary relief of pain. [slideshare.net]

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Cholestatic Jaundice

It is not caused by hepatitis, hepatic necrosis, or excessive hemolysis, but the biochemical FULL TEXT [annals.org]

Pathology showed cholestasis and mild ductal proliferation with focal pericholangitis but no hepatic steatosis, fibrosis, hepatocellular injury, or necrosis. [onlinelibrary.wiley.com]

necrosis. [en.wikipedia.org]

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Acute Cystitis

With more prolonged use, TMP-SMZ can cause agranulocytosis, aplastic anemia, or hepatic necrosis. [journals.lww.com]

- Effects on hepatic Hepatitis, very rarely : liver disorders including hepatic necrosis. - Effects on cardiovascular system Rarely : tachycardia, palpitation, atrial flutter [caprifarmindo.com]

Patients taking TMP-SMZ with a sulfonylurea, an oral agent for hyperglycemia, are at risk for developing hypoglycemia, especially if they are malnourished or have renal or hepatic [journals.lww.com]

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Acute Alcohol Intoxication

In the type II, due to necrosis of wall of common hepatic duct, there is a fistula with various degrees of defect of hepatic duct wall and presence of stone in hepatic duct [intechopen.com]

fatty infiltration and alcoholic hepatitis, cirrhosis, jaundice, hypoglycaemia, ascities, hepatic encephalopathy CVS: dilated cardiomyopathy, hypertension NEURO: Wernicke-Korsakoff [lifeinthefastlane.com]

I, a large stone blocked in the cystic duct and in the Hartmann’s pouch of gallbladder compresses the common bile duct but without fistula between gallbladder and common hepatic [intechopen.com]

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Hypersensitivity

[…] and rarely hepatic necrosis with liver failure. [dermnetnz.org]

[…] less often, reduced white count), eosinophilia (in 30% this is 2.0 x 109/L), atypical lymphocytes, thrombocytopenia, anaemia, haemophagocytic syndrome Liver enlargement, hepatitis [dermnetnz.org]

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Macronodular Cirrhosis

[…] macronodular cirrhosis cirrhosis in which regenerative nodules are more than 3 mm in diameter, seen most often following subacute hepatic necrosis due to toxic or viral hepatitis [medicine.academic.ru]

necrosis due to toxic or viral hepatitis. metabolic cirrhosis a type associated with metabolic diseases, such as hemochromatosis, Wilson’s disease, glycogen storage disease [livingwiththediagnosis.wordpress.com]

necrosis in regenerative stage of acute hepatitis. [nature.com]

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Acetanilide Poisoning

This results in formation of covalent adducts which produce hepatic necrosis and renal tubular necrosis. [pharmaxchange.info]

Hepatic necrosis v. Skin rash ii. Renal tubular necrosis vi. Pancytopenia iii. Hypoglycemic coma vii. Urticaria iv. Leucopenia Dose: Single dose: 500 mg or 1 gm daily. [slideshare.net]

Overdose of paracetamol can result in severe hepatic necrosis and renal failure to the extent of fatality. [pharmaxchange.info]

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Drug-induced Fever

[…] and rarely hepatic necrosis with liver failure. [dermnetnz.org]

The impact of eosinophilia and hepatic necrosis on prognosis in patients with drug-induced liver injury. Aliment Pharmacol Ther 2007;25:1411–1421. 36. [gi.org]

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Chloroform Poisoning

الصفحة 218 - Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J. Pharmacol. Exp. Ther. ‏ [books.google.com]

Diagnosis is based on a history of exposure and the clinical presentation of mucous membrane irritation, CNS depression, arrhythmias, and hepatic necrosis. [mhmedical.com]

Transient jaundice has also been reported in one study (Whitaker and Jones 1965), while several earlier studies report acute hepatic necrosis in women exposed to chloroform [answers.google.com]

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Hypertension

100/µL]), hepatic swelling with or without liver dysfunction, hepatic infarction/rupture and subcapsular hematoma (which may lead to massive internal hemorrhage and shock) [emedicine.medscape.com]

[ATN], or renal cortical necrosis), proteinuria greater than 4-5 g/d, HELLP syndrome (microangiopathic hemolysis, elevated liver enzymes, and thrombocytopenia [platelets [emedicine.medscape.com]

[…] intracerebral hemorrhage, pulmonary edema (due to capillary leak, myocardial dysfunction, excess IV fluid administration), acute renal failure (due to vasospasm, acute tubular necrosis [emedicine.medscape.com]

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Essential Hypertension

The hepatic lesion associated with HELLP syndrome is periportal or focal parenchymal necrosis, in which large hyaline deposits of fibrin-like material can be seen in the sinusoids [glowm.com]

Rarely, profound renal insufficiency may lead to acute tubular necrosis. [glowm.com]

HEPATIC Hepatic damage in association with preeclampsia can range from mildly elevated liver enzyme levels to subcapsular liver hematomas and hepatic ruptures. [glowm.com]

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Iron Poisoning

In rare cases of iron intoxication, late sequelae such as hepatic necrosis and gastrointestinal scarring with obstruction may occur. [ncbi.nlm.nih.gov]

الصفحة 218 - Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J. Pharmacol. Exp. Ther. ‏ [books.google.com]

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Amanita Phalloides Poisoning

Am·a·ni·ta phal·loi·'des a species of fungus containing poisonous elements, including phalloidin and amanitin, which cause gastroenteritis, hepatic necrosis, and renal necrosis [medical-dictionary.thefreedictionary.com]

The typical liver and kidney alterations of Amanita phalloides poisoning, consisting of massive hepatic central lobular cell necrosis and acute tubular necrosis of the kidney [ncbi.nlm.nih.gov]

Ten recoveries were obtained, which denote, on the basis of the necrosis enzymes and the hepatic histo-pathological aspects from bioptic samplings, the use of the E.T. method [ncbi.nlm.nih.gov]

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Echovirus Infection

Necropsy revealed hepatic necrosis, renal hemorrhage, adrenal hemorrhagic necrosis, gastrointestinal hemorrhage, and severe encephalomalacia. [nature.com]

Fulminant Neonatal Hepatic Necrosis Associated with Echovirus Type 11 Infection. West J Med. 1983;138(2):260-3. Piraino FF, Sedmak G, Raab K. [ama.ba]

Echovirus 14 infection associated with fatal neonatal hepatic necrosis. Am J Dis Child. 1972 Jan;123(1):61–67. [PubMed] [Google Scholar] Philip AG, Larson EJ. [ncbi.nlm.nih.gov]

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Acute Respiratory Infection

The increase of serum level of hepatic enzymes, transaminases (AST and ALT), and alkaline phosphatase is the markers of liver damage [19]. [hindawi.com]

The mechanisms proposed for acute renal disturbance in Plasmodium vivax infection are heavy parasitaemia, acute tubular necrosis, volume depletion, intravascular haemolysis [hindawi.com]

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Metabolic Syndrome

Anderson and Khosrow Adeli, Tumor necrosis factor-α directly stimulates the overproduction of hepatic apolipoprotein B100-containing VLDL via impairment of hepatic insulin [doi.org]

Hilla Knobler, Taiba Zhornicky, Alex Sandler, Nurit Haran, Yafa Ashur and Ami Schattner, Tumor necrosis factor-alpha-induced insulin resistance may mediate the hepatitis C [doi.org]

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Insulin Resistance

Insulin resistance (HOMA-IR), serum adiponectin, and tumor necrosis factor (TNF) were determined. [ncbi.nlm.nih.gov]

Lang CH, Dobrescu C, Bagby GJ: Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. [doi.org]

Tumor necrosis factor-alpha TNF-α is an adipose tissue-derived pro-inflammatory cytokine. [dx.doi.org]

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