Possible Causes for hepatic necrosis Massive Hepatic Necrosis Abstract Serum concentrations of alpha-fetoprotein (AFP) were measured by radioimmunoassay in 12 patients with massive hepatic necrosis, 11 of whom died. [ncbi.nlm.nih.gov] At autopsy massive hepatic necrosis was found, associated with enlargement of the liver. [ncbi.nlm.nih.gov] necrosis. [ncbi.nlm.nih.gov] Acute Liver Failure (or both), a lesion classified as subacute hepatic necrosis (SHN). [doi.org] NOS Acute and subacute hepatic failure Approximate Synonyms Acute and subacute hepatic failure Acute hepatic failure Acute hepatic necrosis Acute liver failure Acute necrosis [icd10data.com] The condition is also referred to as a fulminant hepatic failure, acute hepatic necrosis, fulminant hepatic necrosis, and fulminant hepatitis. [verywell.com] Drug-induced Toxic Hepatitis Paracetamol poisoning is treated with gastric lavage and N-acetyl cystine which reduces hepatic necrosis, if therapy is started within 8 hours of ingestion. [medicscientist.com] necrosis Toxic liver disease w hepatic necrosis, w coma Toxic liver disease with acute hepatitis Toxic liver disease with cholestasis Toxic liver disease with chronic active [icd9data.com] […] cells (so-called piecemeal necrosis or interface hepatitis ); the degree of confluent necrosis that links or forms bridges between vascular structures—between portal tract [clinicalgate.com] Aflatoxicosis […] will present with acute hepatic necrosis within a short period of time. [visualdx.com] The toxic effects of AFB1 are mainly localized in liver as manifested by hepatic necrosis, bile duct proliferation, icterus and hemorrhage. [ncbi.nlm.nih.gov] […] to orange. ( J13 .41.w2) GIT: in the jejunum, traces of fresh blood in one individual. ( J13 .41.w2) Histopathology: Hepatic: focal necrosis, sinusoids dilated and engorged [wildpro.twycrosszoo.org] Toxic Liver Disease […] disease with hepatic necrosis K71.2 Toxic liver disease with acute hepatitis K71.3 Toxic liver disease with chronic persistent hepatitis K71.4 Toxic liver disease with chronic [icd10data.com] necrosis K71.10 …… without coma K71.11 …… with coma K71.2 Toxic liver disease with acute hepatitis K71.3 Toxic liver disease with chronic persistent hepatitis K71.4 Toxic [icd10data.com] necrosis Hepatic failure (acute)(chronic) due to drugs K71.2 Toxic liver disease with acute hepatitis K71.3 Toxic liver disease with chronic persistent hepatitis K71.4 Toxic [apps.who.int] Ergotism Abstract Vasospasm related to ergot intoxication is unusual. The authors report the case of 15-year-old boy who developed vasospasm necessitating amputation, due to an ergot derivative prescribed for thromboembolic prophylaxis. The importance of prompt angiographic recognition and therapy is stressed. [ncbi.nlm.nih.gov] Drug-induced Cholestatic Hepatitis necrosis Toxic liver disease w hepatic necrosis, w coma Toxic liver disease with acute hepatitis Toxic liver disease with cholestasis Toxic liver disease with chronic active [icd9data.com] necrosis, acute hepatitis and granulomatous hepatitis Cholestatic injury: bland cholestasis, acute cholestatic hepatitis and chronic cholestatic injury Steatosis and steatohepatitis [pathologyoutlines.com] necrosis, not a cholestasis. [gpnotebook.co.uk] Adenovirus Infection Herein we report three patients with AIDS and fatally disseminated adenovirus infection with hepatic necrosis. [ncbi.nlm.nih.gov] This is an unusual case of fatal hepatic necrosis caused by disseminated type 5 adenovirus in a renal transplant recipient. [ncbi.nlm.nih.gov] Abstract Disseminated adenovirus infection with fatal hepatic necrosis has been reported in 16 patients, 15 of whom had immunocompromising conditions. [ncbi.nlm.nih.gov] Drug-induced Idiosyncratic Hepatitis necrosis, acute hepatitis and granulomatous hepatitis Cholestatic injury: bland cholestasis, acute cholestatic hepatitis and chronic cholestatic injury Steatosis and steatohepatitis [pathologyoutlines.com] necrosis Hepatic failure (acute)(chronic) due to drugs K71.2 Toxic liver disease with acute hepatitis K71.3 Toxic liver disease with chronic persistent hepatitis K71.4 Toxic [apps.who.int] necrosis K71.10 …… without coma K71.11 …… with coma K71.2 Toxic liver disease with acute hepatitis K71.3 Toxic liver disease with chronic persistent hepatitis K71.4 Toxic [icd10data.com] Isoniazid Hepatitis Page 218 - Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J. Pharmacol. Exp. Ther. [books.google.com] necrosis, acute hepatitis and granulomatous hepatitis Cholestatic injury: bland cholestasis, acute cholestatic hepatitis and chronic cholestatic injury Steatosis and steatohepatitis [pathologyoutlines.com] Three of these patients died with fulminant hepatic failure, and 8 of the 11 surviving patients had bridging or multilobular necrosis, or both, on liver biopsy. [annals.org] Toxic Hepatitis This compound produces cholestasis and hepatic necrosis in many animals and caused the so-called Epping jaundice when 84 persons ate bread contaminated with it. [nejm.org] Herbal hepatitis: subacute hepatic necrosis secondary to chaparral leaf. J Clin Gastroenterol 1990;12:203-6. Larrey D, Vial T, Pauwels A, et al. [cdc.gov] necrosis, acute hepatitis and granulomatous hepatitis Cholestatic injury: bland cholestasis, acute cholestatic hepatitis and chronic cholestatic injury Steatosis and steatohepatitis [pathologyoutlines.com] Acetaminophen Overdose Postmortem findings included massive centrilobular hepatic necrosis and renal tubular necrosis. [ncbi.nlm.nih.gov] Algorithms for hepatotoxicity (including codes for hepatic necrosis, toxic hepatitis and encephalopathy) and ALF (hepatic necrosis and encephalopathy) were also highly predictive [ncbi.nlm.nih.gov] If untreated, the normal outcome of a large acetaminophen overdose would be massive hepatic necrosis with delayed death and low blood and tissue acetaminophen concentrations [ncbi.nlm.nih.gov] Hepatic Infarction In addition, the presence of a left hepatic artery completely replaced to the left gastric artery should alert one to the potential for hepatic necrosis. [ncbi.nlm.nih.gov] On diagnostic imaging, celiac axis and hepatic artery were thrombosed, resulting in ischemic necrosis of the left hepatic lobe. [ncbi.nlm.nih.gov] can develop hepatic necrosis as a complication of the procedure. [explainmedicine.com] Autoimmune Hepatitis A second biopsy specimen revealed massive hepatic necrosis. She started oral prednisone therapy for presumed liraglutide-induced marker-negative autoimmune hepatitis. [ncbi.nlm.nih.gov] Autoimmune chronic active hepatitis Autoimmune hepatitis (disorder) autoimmune hepatitis with centrilobular necrosis AIH Chronic autoimmune hepatitis autoimmune liver disease [wikidata.org] Aminotransferase values correlate poorly with the degree of hepatic necrosis but very high levels may indicate acute hepatitis or a severe flare of pre-existing disease. [patient.info] Viral Upper Respiratory Tract Infection Oral Adults 500mg to 1000mg 4-6 hourly – Max. 60mg/kg/day Precautions- Renal or hepatic dysfunction. [slideshare.net] Overdose can result in severe liver damage, renal tubular necrosis. NSAID Ibuprofen Indication Temporary relief of pain. [slideshare.net] Macronodular Cirrhosis […] macronodular cirrhosis cirrhosis in which regenerative nodules are more than 3 mm in diameter, seen most often following subacute hepatic necrosis due to toxic or viral hepatitis [medicine.academic.ru] necrosis due to toxic or viral hepatitis. metabolic cirrhosis a type associated with metabolic diseases, such as hemochromatosis, Wilson’s disease, glycogen storage disease [livingwiththediagnosis.wordpress.com] necrosis in regenerative stage of acute hepatitis. [nature.com] Cholestatic Jaundice It is not caused by hepatitis, hepatic necrosis, or excessive hemolysis, but the biochemical FULL TEXT [annals.org] Pathology showed cholestasis and mild ductal proliferation with focal pericholangitis but no hepatic steatosis, fibrosis, hepatocellular injury, or necrosis. [onlinelibrary.wiley.com] necrosis. [en.wikipedia.org] Acute Cystitis With more prolonged use, TMP-SMZ can cause agranulocytosis, aplastic anemia, or hepatic necrosis. [journals.lww.com] - Effects on hepatic Hepatitis, very rarely : liver disorders including hepatic necrosis. - Effects on cardiovascular system Rarely : tachycardia, palpitation, atrial flutter [caprifarmindo.com] Patients taking TMP-SMZ with a sulfonylurea, an oral agent for hyperglycemia, are at risk for developing hypoglycemia, especially if they are malnourished or have renal or hepatic [journals.lww.com] Acute Alcohol Intoxication In the type II, due to necrosis of wall of common hepatic duct, there is a fistula with various degrees of defect of hepatic duct wall and presence of stone in hepatic duct [intechopen.com] fatty infiltration and alcoholic hepatitis, cirrhosis, jaundice, hypoglycaemia, ascities, hepatic encephalopathy CVS: dilated cardiomyopathy, hypertension NEURO: Wernicke-Korsakoff [lifeinthefastlane.com] I, a large stone blocked in the cystic duct and in the Hartmann’s pouch of gallbladder compresses the common bile duct but without fistula between gallbladder and common hepatic [intechopen.com] Hypersensitivity […] and rarely hepatic necrosis with liver failure. [dermnetnz.org] […] less often, reduced white count), eosinophilia (in 30% this is 2.0 x 109/L), atypical lymphocytes, thrombocytopenia, anaemia, haemophagocytic syndrome Liver enlargement, hepatitis [dermnetnz.org] Acetanilide Poisoning This results in formation of covalent adducts which produce hepatic necrosis and renal tubular necrosis. [pharmaxchange.info] Hepatic necrosis v. Skin rash ii. Renal tubular necrosis vi. Pancytopenia iii. Hypoglycemic coma vii. Urticaria iv. Leucopenia Dose: Single dose: 500 mg or 1 gm daily. [slideshare.net] Overdose of paracetamol can result in severe hepatic necrosis and renal failure to the extent of fatality. [pharmaxchange.info] Drug-induced Fever […] and rarely hepatic necrosis with liver failure. [dermnetnz.org] The impact of eosinophilia and hepatic necrosis on prognosis in patients with drug-induced liver injury. Aliment Pharmacol Ther 2007;25:1411–1421. 36. [gi.org] […] less often, reduced white count), eosinophilia (in 30% this is 2.0 x 109/L), atypical lymphocytes, thrombocytopenia, anaemia, haemophagocytic syndrome Liver enlargement, hepatitis [dermnetnz.org] Viral Disease […] factor-Î in treatment naà ve patients with chronic hepatitis C genotype 1 and 4: A case-control study PPT Version PDF Version Mauricio Laerte Silva Cardiac Diastolic Function [omicsonline.org] […] tumor with viral peptides PPT Version PDF Version Ahmed Mohammed Ashshi The correlations of activins and follistatin with viral load, liver damage, Interleukin-6 and tumour necrosis [omicsonline.org] Anicteric Viral Hepatitis necrosis Toxic liver disease w hepatic necrosis, w coma Toxic liver disease with acute hepatitis Toxic liver disease with cholestasis Toxic liver disease with chronic active [icd9data.com] Hepatic necrosis associated with halothane anesthesia. Am J Med. 1969 Nov; 47 (5):748–764. [ PubMed ] [ Google Scholar ] LARSEN RR, SAWYER RB, SAWYER KC, McCURDY RE. [ncbi.nlm.nih.gov] CMV hepatitis rarely includes granulomatous hepatitis, cholestatic hepatitis, or acute hepatic failure with massive necrosis. [wjgnet.com] Hypertension 100/µL]), hepatic swelling with or without liver dysfunction, hepatic infarction/rupture and subcapsular hematoma (which may lead to massive internal hemorrhage and shock) [emedicine.medscape.com] [ATN], or renal cortical necrosis), proteinuria greater than 4-5 g/d, HELLP syndrome (microangiopathic hemolysis, elevated liver enzymes, and thrombocytopenia [platelets [emedicine.medscape.com] […] intracerebral hemorrhage, pulmonary edema (due to capillary leak, myocardial dysfunction, excess IV fluid administration), acute renal failure (due to vasospasm, acute tubular necrosis [emedicine.medscape.com] Chloroform Poisoning الصفحة 218 - Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J. Pharmacol. Exp. Ther. [books.google.com] Diagnosis is based on a history of exposure and the clinical presentation of mucous membrane irritation, CNS depression, arrhythmias, and hepatic necrosis. [mhmedical.com] Transient jaundice has also been reported in one study (Whitaker and Jones 1965), while several earlier studies report acute hepatic necrosis in women exposed to chloroform [answers.google.com] Essential Hypertension The hepatic lesion associated with HELLP syndrome is periportal or focal parenchymal necrosis, in which large hyaline deposits of fibrin-like material can be seen in the sinusoids [glowm.com] Rarely, profound renal insufficiency may lead to acute tubular necrosis. [glowm.com] HEPATIC Hepatic damage in association with preeclampsia can range from mildly elevated liver enzyme levels to subcapsular liver hematomas and hepatic ruptures. [glowm.com] Iron Poisoning In rare cases of iron intoxication, late sequelae such as hepatic necrosis and gastrointestinal scarring with obstruction may occur. [ncbi.nlm.nih.gov] الصفحة 218 - Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J. Pharmacol. Exp. Ther. [books.google.com] Amanita Phalloides Poisoning Am·a·ni·ta phal·loi·'des a species of fungus containing poisonous elements, including phalloidin and amanitin, which cause gastroenteritis, hepatic necrosis, and renal necrosis [medical-dictionary.thefreedictionary.com] The typical liver and kidney alterations of Amanita phalloides poisoning, consisting of massive hepatic central lobular cell necrosis and acute tubular necrosis of the kidney [ncbi.nlm.nih.gov] Ten recoveries were obtained, which denote, on the basis of the necrosis enzymes and the hepatic histo-pathological aspects from bioptic samplings, the use of the E.T. method [ncbi.nlm.nih.gov] Acute Respiratory Infection The increase of serum level of hepatic enzymes, transaminases (AST and ALT), and alkaline phosphatase is the markers of liver damage [19]. [hindawi.com] The mechanisms proposed for acute renal disturbance in Plasmodium vivax infection are heavy parasitaemia, acute tubular necrosis, volume depletion, intravascular haemolysis [hindawi.com]
