Hepatic Necrosis: Causes & Reasons

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Possible Causes for Hepatic Necrosis

Massive Hepatic Necrosis

[…] an alert for: MASSIVE HEPATIC NECROSIS You will receive an email whenever this article is corrected, updated, or cited in the literature. [anesthesiology.pubs.asahq.org]

Numerology Chaldean Numerology The numerical value of massive hepatic necrosis in Chaldean Numerology is: 7 Pythagorean Numerology The numerical value of massive hepatic necrosis [definitions.net]

Abstract Serum concentrations of alpha-fetoprotein (AFP) were measured by radioimmunoassay in 12 patients with massive hepatic necrosis, 11 of whom died. [ncbi.nlm.nih.gov]

Aflatoxicosis

[…] will present with acute hepatic necrosis within a short period of time. [visualdx.com]

The toxic effects of AFB1 are mainly localized in liver as manifested by hepatic necrosis, bile duct proliferation, icterus and hemorrhage. [ncbi.nlm.nih.gov]

[…] to orange. ( J13 .41.w2) GIT: in the jejunum, traces of fresh blood in one individual. ( J13 .41.w2) Histopathology: Hepatic: focal necrosis, sinusoids dilated and engorged [wildpro.twycrosszoo.org]

Acute Liver Failure

(or both), a lesion classified as subacute hepatic necrosis (SHN). [doi.org]

NOS Acute and subacute hepatic failure Approximate Synonyms Acute and subacute hepatic failure Acute hepatic failure Acute hepatic necrosis Acute liver failure Acute necrosis [icd10data.com]

The condition is also referred to as a fulminant hepatic failure, acute hepatic necrosis, fulminant hepatic necrosis, and fulminant hepatitis. [verywell.com]

Drug-Induced Toxic Hepatitis

necrosis Toxic liver disease w hepatic necrosis, w coma Toxic liver disease with acute hepatitis Toxic liver disease with cholestasis Toxic liver disease with chronic active [icd9data.com]

necrosis, acute hepatitis and granulomatous hepatitis Cholestatic injury: bland cholestasis, acute cholestatic hepatitis and chronic cholestatic injury Steatosis and steatohepatitis [pathologyoutlines.com]

Paracetamol poisoning is treated with gastric lavage and N-acetyl cystine which reduces hepatic necrosis, if therapy is started within 8 hours of ingestion. [medicscientist.com]

Drug-Induced Cholestatic Hepatitis

necrosis Toxic liver disease w hepatic necrosis, w coma Toxic liver disease with acute hepatitis Toxic liver disease with cholestasis Toxic liver disease with chronic active [icd9data.com]

necrosis, not a cholestasis. [gpnotebook.co.uk]

Idiosyncratic Drug-Induced Liver Injury

necrosis Hepatic failure (acute)(chronic) due to drugs K71.2 Toxic liver disease with acute hepatitis K71.3 Toxic liver disease with chronic persistent hepatitis K71.4 Toxic [apps.who.int]

necrosis K71.10 …… without coma K71.11 …… with coma K71.2 Toxic liver disease with acute hepatitis K71.3 Toxic liver disease with chronic persistent hepatitis K71.4 Toxic [icd10data.com]

Toxic Liver Disease

necrosis Hepatic failure (acute)(chronic) due to drugs K71.2 Toxic liver disease with acute hepatitis K71.3 Toxic liver disease with chronic persistent hepatitis K71.4 Toxic [apps.who.int]

[…] disease with hepatic necrosis K71.2 Toxic liver disease with acute hepatitis K71.3 Toxic liver disease with chronic persistent hepatitis K71.4 Toxic liver disease with chronic [icd10data.com]

necrosis K71.10 …… without coma K71.11 …… with coma K71.2 Toxic liver disease with acute hepatitis K71.3 Toxic liver disease with chronic persistent hepatitis K71.4 Toxic [icd10data.com]

Ergotism

Ergotism (pron. UR -gət-iz-əm ) is the effect of long-term ergot poisoning, traditionally due to the ingestion of the alkaloids produced by the Claviceps purpurea fungus that infects rye and other cereals, and more recently by the action of a number of ergoline -based drugs. It is also known as ergotoxicosis,[…] [en.wikipedia.org]

Toxic Hepatitis

This compound produces cholestasis and hepatic necrosis in many animals and caused the so-called Epping jaundice when 84 persons ate bread contaminated with it. [nejm.org]

Herbal hepatitis: subacute hepatic necrosis secondary to chaparral leaf. J Clin Gastroenterol 1990;12:203-6. Larrey D, Vial T, Pauwels A, et al. [cdc.gov]

Isoniazid Hepatitis

Page 218 - Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J. Pharmacol. Exp. Ther. ‎ [books.google.com]

This damage is caused by hepatic necrosis or death of liver cells, as Isoniazid is metabolized in the liver. [livertoxicity.weebly.com]

Hepatic Infarction

On diagnostic imaging, celiac axis and hepatic artery were thrombosed, resulting in ischemic necrosis of the left hepatic lobe. [ncbi.nlm.nih.gov]

In addition, the presence of a left hepatic artery completely replaced to the left gastric artery should alert one to the potential for hepatic necrosis. [ncbi.nlm.nih.gov]

[…] infarction and gallbladder necrosis. [ncbi.nlm.nih.gov]

Anicteric Viral Hepatitis

necrosis Toxic liver disease w hepatic necrosis, w coma Toxic liver disease with acute hepatitis Toxic liver disease with cholestasis Toxic liver disease with chronic active [icd9data.com]

Hepatic necrosis associated with halothane anesthesia. Am J Med. 1969 Nov; 47 (5):748–764. [ PubMed ] [ Google Scholar ] LARSEN RR, SAWYER RB, SAWYER KC, McCURDY RE. [ncbi.nlm.nih.gov]

CMV hepatitis rarely includes granulomatous hepatitis, cholestatic hepatitis, or acute hepatic failure with massive necrosis. [wjgnet.com]

Passive Congestion of the Liver

Congestion Sinusoidal engorgement, degeneration, and variable hemorrhagic necrosis in zone 3 of the hepatic acinus Fatty change Variable degrees of cholestasis with occasional [mdnxs.com]

They reported an association between free hepatic venous pressure and the presence of centrilobular necrosis, inflammation, periportal necrosis, and stainable hepatic iron [nature.com]

Prominent necrosis involving centrilobular zones or entire lobules in most of liver; associated with hepatic failure May also be called confluent necrosis Bile ductular proliferation [pathologyoutlines.com]

Autoimmune Hepatitis

A second biopsy specimen revealed massive hepatic necrosis. She started oral prednisone therapy for presumed liraglutide-induced marker-negative autoimmune hepatitis. [ncbi.nlm.nih.gov]

Autoimmune chronic active hepatitis Autoimmune hepatitis (disorder) autoimmune hepatitis with centrilobular necrosis AIH Chronic autoimmune hepatitis autoimmune liver disease [wikidata.org]

ruling out hereditary, infectious, and toxicity-related causes of liver disease is an important component of diagnosis. 2 Interface hepatitis (piecemeal necrosis) in liver [questdiagnostics.com]

Chronic Active Hepatitis

Interface hepatitis Piecemeal necrosis in hepatitis B Lobular inflammation Fibrosis and cirrhosis Advertisement [pathologyoutlines.com]

Abstract A 19-yr-old man had features of chronic hepatitis with piecemeal necrosis as the sole clinical feature of the idiopathic hypereosinophilic syndrome. [ncbi.nlm.nih.gov]

In chronic active hepatitis (CAH), which is also known as 'chronic aggressive hepatitis', inflammatory changes are associated with continued necrosis of liver cells. [somalidoc.com]

Chloroform Poisoning

الصفحة 218 - Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J. Pharmacol. Exp. Ther. ‏ [books.google.com]

Diagnosis is based on a history of exposure and the clinical presentation of mucous membrane irritation, CNS depression, arrhythmias, and hepatic necrosis. [mhmedical.com]

Transient jaundice has also been reported in one study (Whitaker and Jones 1965), while several earlier studies report acute hepatic necrosis in women exposed to chloroform [answers.google.com]

Iron Poisoning

In rare cases of iron intoxication, late sequelae such as hepatic necrosis and gastrointestinal scarring with obstruction may occur. [arizona.pure.elsevier.com]

الصفحة 218 - Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J. Pharmacol. Exp. Ther. ‏ [books.google.com]

Macronodular Cirrhosis

[…] macronodular cirrhosis cirrhosis in which regenerative nodules are more than 3 mm in diameter, seen most often following subacute hepatic necrosis due to toxic or viral hepatitis [medicine.academic.ru]

necrosis due to toxic or viral hepatitis. metabolic cirrhosis a type associated with metabolic diseases, such as hemochromatosis, Wilson’s disease, glycogen storage disease [livingwiththediagnosis.wordpress.com]

necrosis in regenerative stage of acute hepatitis. [nature.com]

Amanita Phalloides Poisoning

Am·a·ni·ta phal·loi·'des a species of fungus containing poisonous elements, including phalloidin and amanitin, which cause gastroenteritis, hepatic necrosis, and renal necrosis [medical-dictionary.thefreedictionary.com]

The typical liver and kidney alterations of Amanita phalloides poisoning, consisting of massive hepatic central lobular cell necrosis and acute tubular necrosis of the kidney [ncbi.nlm.nih.gov]

Ten recoveries were obtained, which denote, on the basis of the necrosis enzymes and the hepatic histo-pathological aspects from bioptic samplings, the use of the E.T. method [ncbi.nlm.nih.gov]

Acetaminophen Overdose

Postmortem findings included massive centrilobular hepatic necrosis and renal tubular necrosis. [ncbi.nlm.nih.gov]

Algorithms for hepatotoxicity (including codes for hepatic necrosis, toxic hepatitis and encephalopathy) and ALF (hepatic necrosis and encephalopathy) were also highly predictive [ncbi.nlm.nih.gov]

If untreated, the normal outcome of a large acetaminophen overdose would be massive hepatic necrosis with delayed death and low blood and tissue acetaminophen concentrations [ncbi.nlm.nih.gov]

Chemical and Drug-Induced Liver Injury

Fatal Acute Hepatic Necrosis Due to Fluconazole. Am J Med. 1994;96:188–90. https://doi.org/10.1016/0002-9343(94)90141-4 Chien R, Yang L, Lin P, Liaw Y. [revistagastrocol.com]

Flucloxacillin-associated hepatic iniurv. [revistagastrocol.com]

Hepatic Injury During Ketoconazole Therapy in Patients With Onychomycosis: A Controlled Cohort Study. [revistagastrocol.com]

Left-Sided Heart Failure

Liver biopsies performed on all patients revealed central hepatic necrosis without evidence of acute or chronic hepatitis. [ncbi.nlm.nih.gov]

We now report 4 patients whose initial diagnosis was hepatitis but who were later shown to have central hepatic necrosis associated with left ventricular failure. [ncbi.nlm.nih.gov]

Hepatitis was initially suspected in 3 patients because of striking transaminase elevations and in 1 patient because of jaundice and symptoms compatible with hepatitis. [ncbi.nlm.nih.gov]

Acetaminophen Poisoning

Ultimately this may lead to hepatic necrosis, renal tubular necrosis, hypoglycemic coma, and death. [openanesthesia.org]

fulminant hepatic necrosis may occur, resulting in Jaundice Hepatic encephalopathy Acute kidney injury Death Rarely, massive ingestion (eg, serum levels over 500–1000 mg [accessmedicine.mhmedical.com]

The most important complication of a major overdose of acetaminophen is acute centrilobular hepatic necrosis, but only a small minority of patients is at risk. [ispub.com]

Traumatic Liver Injury

In the post–embolization period, the patient experienced an important hepatic necrosis: AST = 1720 UI/L, ALT = 1927 UI/L, Total Bilirubin = 6.20 mg/d ( Figure 15 ). [ncbi.nlm.nih.gov]

Angiography with contrast in the right hepatic artery, after all bleeding sources embolization. [ncbi.nlm.nih.gov]

Angiography with contrast in the right hepatic artery, after arteriovenous fistula embolization. [ncbi.nlm.nih.gov]

Umbilical Vein Catheterization

[…] fluid with hepatic necrosis. [mjdrdypu.org]

Abstract We report 22 cases of hepatic necrosis following catheterization of the umbilical vein. [ncbi.nlm.nih.gov]

[…] consequent hepatic necrosis. [ijri.org]

Biliary Duct Obstruction

Note the following: Hepatitis is inflammation of the liver characterized by diffuse or patchy necrosis. Causes of hepatitis include viruses, drugs, and alcohol. [emedicine.medscape.com]

Intrahepatic causes Mechanical or intrahepatic causes are most commonly hepatitis and cirrhosis. [emedicine.medscape.com]

Chronic Persistent Hepatitis

necrosis Toxic liver disease w hepatic necrosis, w coma Toxic liver disease with acute hepatitis Toxic liver disease with cholestasis Toxic liver disease with chronic active [icd9data.com]

Piecemeal Necrosis 2. Portal fibrosis 3. Bridging Necrosis 4. Interface hepatitis 5. [gradestack.com]

necrosis, without coma K7111Toxic liver disease with hepatic necrosis, with coma K712Toxic liver disease with acute hepatitis K713Toxic liver disease with chronic persistent [cms.gov]

Echovirus Infection

Necropsy revealed hepatic necrosis, renal hemorrhage, adrenal hemorrhagic necrosis, gastrointestinal hemorrhage, and severe encephalomalacia. [nature.com]

Fulminant Neonatal Hepatic Necrosis Associated with Echovirus Type 11 Infection. West J Med. 1983;138(2):260-3. Piraino FF, Sedmak G, Raab K. [ama.ba]

Echovirus 14 infection associated with fatal neonatal hepatic necrosis. Am J Dis Child. 1972 Jan;123(1):61–67. [PubMed] [Google Scholar] Philip AG, Larson EJ. [ncbi.nlm.nih.gov]

Subcapsular Liver Hematoma

To the Editor: Hepatocellular neoplasms, peliosis hepatis, and hepatic necrosis have been reported to be complications of long-term therapy with androgenic anabolic steroids [nejm.org]

Toxic liver disease with chronic persistent hepatitis Toxic liver disease with fibrosis and cirrhosis of liver Toxic liver disease with hepatic necrosis Vascular disorder [icd9data.com]

necrosis Focal nodular hyperplasia of liver Hemorrhage of liver Hepatic neuropathy Hepatic schistosomiasis Hepatocellular dysplasia Hepatocellular liver damage Hepatoptosis [icdlist.com]

Cardiac Cirrhosis

[…] lobular necrosis. [healthfrom.com]

Abstract The pathogenesis of congestive cirrhosis is generally thought to be a reaction of the hepatic stroma to hypoxia, pressure, or necrosis. [ncbi.nlm.nih.gov]

Long-term hepatic congestion with relative ischemia can induce centrilobular necrosis and pericentral fibrosis, triggering extensive hepatic fibrosis and the formation of [kjim.org]