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10 Possible Causes for Hepatitis, Non-Hemolytic Unconjugated Hyperbilirubinemia

  • Gilbert Syndrome

    It can be mistaken for chronic hepatitis or other liver disorders. Gilbert syndrome may affect as many as 5% of people.[merckmanuals.com] Constitutional liver dysfunction Familial non-hemolytic non-obstructive jaundice Icterus intermittens juvenilis Low-grade chronic hyperbilirubinemia Unconjugated benign bilirubinemia[en.wikipedia.org] The protease inhibitor atazanavir (ATV) is an inhibitor of hepatic UGT activity leading to hyperbilirubinemia in individual patients.[ncbi.nlm.nih.gov]

  • Crigler-Najjar Syndrome Type 1

    […] through the hepatic artery.[ncbi.nlm.nih.gov] Mutations in the UGT1A1 gene cause Crigler-Najjar syndrome (CN), which causes non-hemolytic unconjugated hyperbilirubinemia, and is categorized as CN1 and CN2 according to[ncbi.nlm.nih.gov] Crigler-Najjar (CN) syndrome is a rare autosomal recessive inherited disorder characterized by non-hemolytic, unconjugated hyperbilirubinemia.[ncbi.nlm.nih.gov]

  • Massive Hepatic Necrosis

    An unusual case of varicella-zoster hepatitis is reported which resulted in fatal massive hepatic necrosis in a 64-year old white female.[ncbi.nlm.nih.gov] Gilbert’s Disease Chronic, benign, intermittent, familial (AD), non-hemolytic unconjugated hyperbilirubinemia with evanescent increases of B1 Due to defective transport and[slideshare.net] A chronic hepatitis B virus (HBV) carrier with diffuse nodular transformation of the liver and malignant lymphoma in the lymph nodes and spleen developed massive hepatic necrosis[ncbi.nlm.nih.gov]

  • Dubin-Johnson Syndrome

    Laparoscopically, a patient with a chronic aggressive hepatitis showed a dark gray decololization of the liver surface and another patient with a chronic aggressive hepatitis[ncbi.nlm.nih.gov] Dubin-Johnson syndrome (DJS, OMIM 237500) is a rare, autosomal recessive disorder characterized by non-hemolytic hyperbilirubinemia with no progression to end-stage liver[wjgnet.com] Hunter FM, Sparks RD, Flinner RL: Hepatitis with resulting mobilization of hepatic pigment in a patient with Dubin-Johnson syndrome.[link.springer.com]

  • Crigler-Najjar Syndrome Type 2

    The study of inheritable disorders of bilirubin metabolism has been essential for understanding normal hepatic physiology.[einstein.pure.elsevier.com] In severe CNS-I, the absence of UGT1A1 enzyme activity lead to non-hemolytic unconjugated hyperbilirubinemia, marked jaundice and may cause bilirubin encephalopathy (kernicterus[bmcpediatr.biomedcentral.com] Kreek MJ, Sleisinger MH: Reduction of serum-unconjugated bilirubin with phenobarbitone in adult congenital non-hemolytic unconjugated hyperbilirubinemia.[link.springer.com]

  • Pyruvate Kinase Deficiency

    To the best of our knowledge, only a few similar cases of severe neonatal presentation of PKD complicated with severe hepatic failure and cholestasis have been reported.[ncbi.nlm.nih.gov] It constitutes one of the common causes of hereditary non-spherocytic hemolytic anemia.[ncbi.nlm.nih.gov] MRI of the liver was negative for iron accumulation (alloimmune hepatitis of the newborn) and steatosis.[pediatrics.aappublications.org]

  • Brandt Syndrome

    Hepatic infarction with portal thrombosis. J Gastroenterol 32:684–6881997. 2. Saegusa M, Takano Y, Okudaira M.[kjim.org] Icterus intermittens juvenilis; Low-grade chronic hyperbilirubinemia; Familial non-hemolytic-non-obstructive jaundice; Constitutional liver dysfunction; Unconjugated benign[medlineplus.gov] Intermittent or mild cases of the disease and those presenting with uncommon features such as ophthalmic, cerebral or hepatic involvement, are easily overlooked.[ncbi.nlm.nih.gov]

  • Early Infantile Epileptic Encephalopathy Type 6

    […] change in hepatic aminotransferase levels.[doi.org] , resulting from exacerbated hemolysis) Chronic, non-immune hemolytic anemia High mean corpuscular hemoglobin concentration (MCHC) Presence of spherocytes in the peripheral[centogene.com] […] epilepsies Folinic acid-responsive seizures Inborn errors of metabolism, including mitochondrial dysfunction Biotinidase deficiency Glucose transporter type 1 deficiency Hepatic[centogene.com]

  • Dicarboxylic Aminoaciduria

    In liver disease (such as hepatitis), the intrahepatic urobilinogen cycle is inhibited urobilinogen levels.[flashcardmachine.com] […] in an autosomal recessive pattern, but some may be acquired secondary to several diseases such as hyperparathyroidism, multiple myeloma, osteomalacia, rickets, and viral hepatitis[medigoo.com] \'antithrombin\' Pittsburgh; 613490; SERPINA1 Hemosiderosis, systemic, due to aceruloplasminemia; 604290; CP Hennekam lymphangiectasia-lymphedema syndrome; 235510; CCBE1 Hepatic[howlingpixel.com]

  • Hereditary Elliptocytosis 2

    Randomized trial of surgery versus surgery followed by adjuvant hepatic arterial infusion with 5-fluorouracil and folinic acid for liver metastases of colorectal cancer. ‎[books.google.de] , resulting from exacerbated hemolysis) Chronic, non-immune hemolytic anemia High mean corpuscular hemoglobin concentration (MCHC) Presence of spherocytes in the peripheral[centogene.com] The diagnosis of anemia of chronic disease is not usually applied to the anemias associated with renal, hepatic or endocrine disorders.[aafp.org]

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