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10 Possible Causes for Hepatitis, Non-Hemolytic Unconjugated Hyperbilirubinemia

  • Gilbert Syndrome

    It can be mistaken for chronic hepatitis or other liver disorders. Gilbert syndrome may affect as many as 5% of people.[] Constitutional liver dysfunction Familial non-hemolytic non-obstructive jaundice Icterus intermittens juvenilis Low-grade chronic hyperbilirubinemia Unconjugated benign bilirubinemia[] The protease inhibitor atazanavir (ATV) is an inhibitor of hepatic UGT activity leading to hyperbilirubinemia in individual patients.[]

  • Crigler-Najjar Syndrome Type 1

    […] through the hepatic artery.[] Mutations in the UGT1A1 gene cause Crigler-Najjar syndrome (CN), which causes non-hemolytic unconjugated hyperbilirubinemia, and is categorized as CN1 and CN2 according to[] Crigler-Najjar (CN) syndrome is a rare autosomal recessive inherited disorder characterized by non-hemolytic, unconjugated hyperbilirubinemia.[]

  • Massive Hepatic Necrosis

    An unusual case of varicella-zoster hepatitis is reported which resulted in fatal massive hepatic necrosis in a 64-year old white female.[] Gilbert’s Disease Chronic, benign, intermittent, familial (AD), non-hemolytic unconjugated hyperbilirubinemia with evanescent increases of B1 Due to defective transport and[] A chronic hepatitis B virus (HBV) carrier with diffuse nodular transformation of the liver and malignant lymphoma in the lymph nodes and spleen developed massive hepatic necrosis[]

  • Dubin-Johnson Syndrome

    Laparoscopically, a patient with a chronic aggressive hepatitis showed a dark gray decololization of the liver surface and another patient with a chronic aggressive hepatitis[] Dubin-Johnson syndrome (DJS, OMIM 237500) is a rare, autosomal recessive disorder characterized by non-hemolytic hyperbilirubinemia with no progression to end-stage liver[] Hunter FM, Sparks RD, Flinner RL: Hepatitis with resulting mobilization of hepatic pigment in a patient with Dubin-Johnson syndrome.[]

  • Crigler-Najjar Syndrome Type 2

    The study of inheritable disorders of bilirubin metabolism has been essential for understanding normal hepatic physiology.[] In severe CNS-I, the absence of UGT1A1 enzyme activity lead to non-hemolytic unconjugated hyperbilirubinemia, marked jaundice and may cause bilirubin encephalopathy (kernicterus[] Kreek MJ, Sleisinger MH: Reduction of serum-unconjugated bilirubin with phenobarbitone in adult congenital non-hemolytic unconjugated hyperbilirubinemia.[]

  • Pyruvate Kinase Deficiency

    To the best of our knowledge, only a few similar cases of severe neonatal presentation of PKD complicated with severe hepatic failure and cholestasis have been reported.[] It constitutes one of the common causes of hereditary non-spherocytic hemolytic anemia.[] MRI of the liver was negative for iron accumulation (alloimmune hepatitis of the newborn) and steatosis.[]

  • Brandt Syndrome

    Hepatic infarction with portal thrombosis. J Gastroenterol 32:684–6881997. 2. Saegusa M, Takano Y, Okudaira M.[] Icterus intermittens juvenilis; Low-grade chronic hyperbilirubinemia; Familial non-hemolytic-non-obstructive jaundice; Constitutional liver dysfunction; Unconjugated benign[] Intermittent or mild cases of the disease and those presenting with uncommon features such as ophthalmic, cerebral or hepatic involvement, are easily overlooked.[]

  • Early Infantile Epileptic Encephalopathy Type 6

    […] change in hepatic aminotransferase levels.[] , resulting from exacerbated hemolysis) Chronic, non-immune hemolytic anemia High mean corpuscular hemoglobin concentration (MCHC) Presence of spherocytes in the peripheral[] […] epilepsies Folinic acid-responsive seizures Inborn errors of metabolism, including mitochondrial dysfunction Biotinidase deficiency Glucose transporter type 1 deficiency Hepatic[]

  • Dicarboxylic Aminoaciduria

    In liver disease (such as hepatitis), the intrahepatic urobilinogen cycle is inhibited urobilinogen levels.[] […] in an autosomal recessive pattern, but some may be acquired secondary to several diseases such as hyperparathyroidism, multiple myeloma, osteomalacia, rickets, and viral hepatitis[] \'antithrombin\' Pittsburgh; 613490; SERPINA1 Hemosiderosis, systemic, due to aceruloplasminemia; 604290; CP Hennekam lymphangiectasia-lymphedema syndrome; 235510; CCBE1 Hepatic[]

  • Hereditary Elliptocytosis 2

    Randomized trial of surgery versus surgery followed by adjuvant hepatic arterial infusion with 5-fluorouracil and folinic acid for liver metastases of colorectal cancer. ‎[] , resulting from exacerbated hemolysis) Chronic, non-immune hemolytic anemia High mean corpuscular hemoglobin concentration (MCHC) Presence of spherocytes in the peripheral[] The diagnosis of anemia of chronic disease is not usually applied to the anemias associated with renal, hepatic or endocrine disorders.[]

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