Hepatocellular Carcinoma: Causes & Reasons

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Possible Causes for Hepatocellular Carcinoma

Hemochromatosis

It is very rare to see hepatocellular carcinoma in the absence of evidence of liver injury. [ncbi.nlm.nih.gov]

carcinoma. [ncbi.nlm.nih.gov]

The current histological, computed tomography, and magnetic resonance imaging findings revealed hepatocellular carcinoma (HCC) and non-cirrhotic liver hemochromatosis. [ncbi.nlm.nih.gov]

Portal Cirrhosis

It also addressed the efficiency of splenectomy in reducing hepatocellular carcinoma risk. [clinicaltrials.gov]

One of the key roles of diagnostic radiology is detection of hepatocellular carcinoma. [radiopaedia.org]

Hepatocellular carcinoma Cirrhosis is a major risk factor for hepatocellular carcinoma. See the separate Hepatocellular Carcinoma article [ 3 ]. [patient.info]

Neoplasm of the Liver

We therefore developed a quantitative immunohistochemical assay and monitored epoxide hydrolase expression in hepatocellular carcinomas (HCC, n = 20), cholangio-cellular carcinomas [ncbi.nlm.nih.gov]

[…] nodules, hepatocellular carcinoma, Malignant liver tumors [scienceopen.com]

Radiofrequency ablation combined with percutaneous ethanol injection in patients with hepatocellular carcinoma. [hepatmon.com]

Macronodular Cirrhosis

Hepatocellular carcinoma is rare in infancy. [ncbi.nlm.nih.gov]

AASLD Guidelines for the treatment of hepatocellular carcinoma 2016. 71. Bruix J, Sherman M. Management of hepatocellular carcinoma: An update. [scriptiebank.be]

carcinoma, liver, gross [CT] Hepatocellular carcinoma with satellite nodules, liver, gross Hepatocellular carcinoma, liver, gross [CT] Hepatocellular carcinoma, liver, microscopic [ar.utmb.edu]

Cryptogenic Cirrhosis

The lower occurrence of hepatocellular carcinoma and higher survival rate may indicate an indolent clinical course in CC as compared with viral cirrhosis. [ncbi.nlm.nih.gov]

Obesity and hepatocellular carcinoma. Gastroenterology. 2004 Nov;127(5 Suppl 1):S97-103. [PubMed: 15508109] 8. [ncbi.nlm.nih.gov]

Kaplan-Meier analysis demonstrated lower occurrence of hepatocellular carcinoma and higher survival rate in the CC than in the controls in contrast to the similar cumulative [ncbi.nlm.nih.gov]

Viral Hepatitis

carcinoma, HCC). [ncbi.nlm.nih.gov]

KEYWORDS: chronic viral hepatitis; hepatitis B; hepatitis C; hepatocarcinogenesis; hepatocellular carcinoma; virus-induced cancer [ncbi.nlm.nih.gov]

Keywords Hepatocellular carcinoma Hepatitis B Hepatitis C Viral hepatitis Background Hepatocellular Carcinoma (HCC) is the third leading cause of cancer related mortality [bmcgastroenterol.biomedcentral.com]

Chronic Hepatitis C

A 55 year old gentleman was diagnosed with hepatocellular carcinoma and concomitant chronic hepatitis C viral infection. [ncbi.nlm.nih.gov]

Long-term consequences of chronic hepatitis C are hepatic failure due to cirrhosis and hepatocellular carcinoma. [symptoma.com]

Abstract Background: Hepatitis C virus (HCV) is a leading cause of hepatocellular carcinoma (HCC). [doi.org]

Acute Hepatic Porphyria

Acute hepatic porphyria and hepatocellular carcinoma. [nature.com]

(Source: Clinical Lab International) The long-term complications involve chronic kidney disease, chronic hypertension, hepatocellular carcinoma, polyneuropathy and depression [clinlabint.com]

carcinoma (HCC). [ajmc.com]

Hepatopathy

We present a patient who developed Hepatocellular carcinoma (HCC) from nonalcoholic steatohepatitis (NASH) cirrhosis. [ncbi.nlm.nih.gov]

Hepatocellular carcinoma. Lancet 379, 1245–1255 (2012). 3. El-Serag, H. B. Epidemiology of viral hepatitis and hepatocellular carcinoma. [doi.org]

Today is a certainty that fatty liver can complicate with cirrhosis and hepatocellular carcinoma; moreover, nonalcoholic fatty liver disease is the main cause of cryptogenic [ncbi.nlm.nih.gov]

Hepatitis B

Key words: antiviral drugs, cirrhosis, hepatocellular carcinoma, liver. [web.archive.org]

carcinoma. [ncbi.nlm.nih.gov]

Potential long-term sequelae include cirrhosis, hepatic decompensation, and hepatocellular carcinoma. [doi.org]

Primary Biliary Cirrhosis

carcinoma-cholangiocellular carcinoma and hepatocellular carcinoma, World Journal of Hepatology, 9, 36, (1378), (2017). [doi.org]

About 10% of patients presented with complications such as ascites (10.3%), variceal bleeding (5.8%) and/or hepatocellular carcinoma (HCC) (1.3%). [ncbi.nlm.nih.gov]

The incidence of hepatocellular carcinoma (HCC) complicating primary biliary cirrhosis (PBC) is between 0.7% and 16%. [ncbi.nlm.nih.gov]

Chronic Active Hepatitis B

Transforming growth factor alpha was expressed in 26 (68.4%) of 38 chronic active hepatitis B, 18 (56.3%) of 32 cirrhosis and 16 (51.6%) of 31 hepatocellular carcinoma tissue [ncbi.nlm.nih.gov]

We assumed that only patients with active viral replication would be treated and that alpha-interferon would prevent cirrhosis and hepatocellular carcinoma in a portion of [ncbi.nlm.nih.gov]

carcinoma. [library.med.utah.edu]

Hepatitis C

The presentation of primary hepatocellular carcinoma with spinal cord compression is very rare. [ncbi.nlm.nih.gov]

Abstract Background: Hepatitis C virus (HCV) is a leading cause of hepatocellular carcinoma (HCC). [doi.org]

Chronic infection is associated with serious morbidity and mortality (e.g., cirrhosis, hepatocellular carcinoma). [ncbi.nlm.nih.gov]

Congenital Liver Cirrhosis

Screening for Hepatocellular Carcinoma Also important to consider is screening for hepatocellular carcinoma. [acc.org]

One of the key roles of diagnostic radiology is detection of hepatocellular carcinoma. [radiopaedia.org]

Evaluate all patients periodically for gastroesophageal varices and hepatocellular carcinoma. [merckmanuals.com]

Hepatocellular Adenoma

[…] adenoma and hepatocellular carcinoma. [ncbi.nlm.nih.gov]

KEYWORDS: Differential diagnosis; Focal nodular hyperplasia; Hepatocellular adenoma; Hepatocellular carcinoma; Liver biopsy [ncbi.nlm.nih.gov]

The clinical significance of HA is chiefly due to the possibility of malignant transformation into hepatocellular carcinoma (HCC). [ncbi.nlm.nih.gov]

Chronic Persistent Hepatitis

Furthermore, HB AG is detected in a high rate among cases with hepatocellular carcinoma suggesting the intimate causal relationship between hepatitis b virus and hepatocellular [ncbi.nlm.nih.gov]

Cost-effectiveness of sorafenib treatment in field practice for patients with hepatocellular carcinoma. Hepatology. 2013;57(3):1046–54. [doi.org]

carcinoma caused by Hepatitis C Hepatocellular carcinoma caused by Hepatitis C- higher magnification Hepatocellular carcinoma caused by Hepatitis C: gross anatomy Hepatitis-E [commons.wikimedia.org]

Chronic Alcoholism

Mutations, decreased promoter activity, and decreased expression in PTEN are frequently identified in patients with hepatocellular carcinoma. [ncbi.nlm.nih.gov]

Hepatocellular carcinoma was present at the time of diagnosis in 15.4% of cases. [ncbi.nlm.nih.gov]

ONCOLOGY – alcohol predisposes to multiple cancers, most notably Hepatocellular carcinoma (secondary to cirrhosis), also ENT and esophageal cancers (synergistic with smoking [errolozdalga.com]

Chronic Active Hepatitis

Nine of 63 (14.2%) and 6/63 (9.5%) developed cirrhosis and hepatocellular carcinoma, respectively. [ncbi.nlm.nih.gov]

We report data on decompensation, detection of hepatocellular carcinoma, and mortality rates. [ncbi.nlm.nih.gov]

A 57 year old man with auto-immune chronic active hepatitis, regularly treated with immunosuppressive therapy, had hepatocellular carcinoma (HCC) 10 years after diagnosis [ncbi.nlm.nih.gov]

Alpha-1 Antitrypsin Deficiency

Cirrhosis and hepatocellular carcinoma then result in some patients. [ncbi.nlm.nih.gov]

With cirrhosis there is a risk of hepatocellular carcinoma. Investigations Serum levels of A1AT can be measured. [patient.info]

Due to increased risk of hepatocellular carcinoma, surveillance imaging and/or α-fetoprotein levels should be considered. [unboundmedicine.com]

Hereditary Coproporphyria

In these studies, etiological factors for hepatocellular carcinoma were not completely sought. [ncbi.nlm.nih.gov]

People with repeated attacks are at risk for developing chronic renal disease and liver cancer (hepatocellular carcinoma) How is Hereditary Coproporphyria diagnosed? [porphyriafoundation.blogspot.com]

The increased predisposition for hepatocellular carcinoma is seen in various types of porphyria. [clinicaladvisor.com]

Porphyria Cutanea Tarda

Patients with severe hepatic pathology or longstanding untreated PCT need to be monitored for the development of hepatocellular carcinoma in the long term. [ncbi.nlm.nih.gov]

In the literature, concomitant presentation of porphyria with hepatocellular carcinoma is common; however, no case of porphyria cutanea tarda associated with cholangiocarcinoma [ncbi.nlm.nih.gov]

Liver damage might present in a wide range of ways from liver function test abnormalities to hepatocellular carcinoma. [ncbi.nlm.nih.gov]

Tyrosinemia

Hepatocellular carcinoma (HCC) was found either preoperatively or incidentally in five patients, all older than 2 years at the time of their transplant. [ncbi.nlm.nih.gov]

What is the risk of development of hepatocellular carcinoma? Hepatorenal tyrosinemia carries a significant long term risk of development of hepatocellular carcinoma. [childrenliverindia.org]

carcinoma. [ncbi.nlm.nih.gov]

Chronic Hepatic Schistosomiasis

carcinoma, particularly secondary to the S.Mansoni subtype Promoted articles (advertising) [radiopaedia.org]

Risk factors for hepatocellular carcinoma in Egypt: the role of hepatitis-B viral infection and schistosomiasis. Anticancer Res 1999;19:4565–4569. [link.springer.com]

Transforming growth factor-alpha and epidermal growth factor receptor in chronic liver disease and hepatocellular carcinoma. [pacificejournals.com]

Wilson Disease

Here, we describe a 45-year-old woman who presented with an incidental hepatocellular carcinoma at the time of transplant. [ncbi.nlm.nih.gov]

LT is also used to treat hepatocellular carcinoma when it develops in patients with WD when tumor resection is not feasible. [ncbi.nlm.nih.gov]

Our team works side by side with oncologists to care for patients with hepatocellular carcinoma (HCC) to increase treatment options and optimize survival. [northwell.edu]

Aflatoxicosis

Indeed, long-term aflatoxin exposure is linked to the development of hepatocellular carcinoma (HCC). [ncbi.nlm.nih.gov]

There is a positive association between dietary aflatoxins and hepatocellular carcinoma. [visualdx.com]

Gaucher Disease

Gaucher's disease has been correlated with cases of myeloma, leukemia, glioblastoma, lung cancer, and hepatocellular carcinoma, although the reasons for the correlation are [ncbi.nlm.nih.gov]

Arthur Zimmermann, Etiology and Pathogenesis of Hepatocellular Carcinoma: Hepatocellular Carcinoma Associated with Inborn Errors of Metabolism and Hepatobiliary Malformations [doi.org]

In addition, an increased risk has been reported for hepatocellular carcinoma and renal cell carcinoma. [doi.org]

Thalassemia

KEYWORDS: Hepatitis B virus (HBV); hepatitis C virus (HCV); hepatocellular carcinoma (HCC); iron overload; liver iron concentration (LIC); thalassemia [ncbi.nlm.nih.gov]

More aggressive approaches to the treatment of hepatitis C may be particularly valuable because of the additive risks for cirrhosis and hepatocellular carcinoma that are posed [ncbi.nlm.nih.gov]

Hepatocellular carcinoma in the thalassaemia syndromes. [ncbi.nlm.nih.gov]

Beta Thalassaemia Major

Carcinoma in Thalassemia. [nyas.org]

carcinoma, 12 and pseudoxanthoma elasticum. 13 Hypogonadotropic hypogonadism is probably attributable to the free-radical oxidative damage caused by non-transferrin bound [haematologica.org]

25 PM Renal Aspects of Thalassemia Sunil Bhandari, MBChB, MRCP, FRCP, PhD, M Clin Ed, FHEA, Hull & East Yorkshire Hospitals NHS Trust & Hull York Medical School 3:50 PM Hepatocellular [nyas.org]

Anabolic Steroid

The histopathological findings were compatible with those of multiple hepatocellular carcinoma without liver cirrhosis. [ncbi.nlm.nih.gov]

A 35-year-old male bodybuilder was found to have a hepatocellular carcinoma (HCC) arising in a pre-existing hepatic adenoma following recreational anabolic steroid use. [ncbi.nlm.nih.gov]

For instance, relevant concern has been raised by the AAS hepatotoxicity including adenoma, hepatocellular carcinoma, cholestasis, and peliosis hepatis. [ncbi.nlm.nih.gov]

Androgen Therapy

Abbondanzo SL, Manz HJ, Klappenbach RS, Gootenberg JE (1986) Hepatocellular carcinoma in an 11-year-old girl with Fanconi's anemia. [link.springer.com]

The case of a young man with hypogonadism, who was treated for five years withmethyltestosterone and who developed hepatocellular carcinoma, is discussed. [ncbi.nlm.nih.gov]

carcinoma. [link.springer.com]