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77 Possible Causes for Hepatocyte Ballooning

  • Citrullinemia Type 2

    Citrullinemia type 2 (CTLN2) is caused by mutations in the SLC25A13 gene. The disease is inherited in an autosomal recessive manner. It may manifest in form of early-onset cholestasis or as adult-onset recurrent encephalopathy. Spontaneous resolution is the most likely outcome in case of neonatal-onset disease, but[…][]

  • Insulin Resistance

    NASH refers to the presence of hepatic steatosis and inflammation with hepatocyte injury (ballooning) in the presence or absence of fibrosis.[]

  • Chronic Alcoholism

    Hepatocytes are classically ballooned, which causes compression of the sinusoid and reversible portal hypertension.[] The inflammatory cell infiltrate, located primarily in the sinusoids and close to necrotic hepatocytes, consists of polymorphonuclear cells and mononuclear cells.[]

  • Liver Cirrhosis

    The perisinusoidal or chicken-wire fibrosis may no longer be apparent, and other features (eg, inflammatory cells, ballooned hepatocytes, and steatosis) may subside.[] […] of this, in particular with enlarged hepatocytes showing prominent cytoplasmic clumping, were considered borderline.[] The presence of clear-cut zone 3 pericellular fibrosis, ballooning degeneration, or Mallory body formation was considered definite for steatohepatitis; changes falling short[]

  • Alcoholic Liver Disease

    […] cytoplasm and clumped strands of intermediate filaments Satellitosis is featured by ballooned hepatocyte surrounded by neutrophils Mallory-Denk body, also known as Mallory[] Within this spectrum, varying degrees of inflammation, hepatocellular ballooning degeneration, hepatocyte necrosis, cholestasis, and fibrosis may be encountered.[] ETHANOL 14Mallory body with the characteristic twisted-rope appearance (centre of image - withina ballooning hepatocyte). H&E stain 15. ETHANOL 15 16. ETHANOL 16 17.[]

  • Hepatitis

    In the NAFLD activity score (NAS)[ 34 ], cases with a high grade of inflammation activity and hepatocyte ballooning without evidence of steatosis can be diagnosed as borderline[] Microscopically, changes that can be seen include steatosis with large and swollen hepatocytes (ballooning), evidence of cellular injury and cell death (apoptosis, necrosis[] In uncomplicated cases, histology of AH is characterized by neutrophilic infiltration (a marker of alcohol-induced hepatitis), ballooning degeneration of hepatocytes, spotty[]

  • Alcoholic Hepatitis

    The principal cause of AH is alcoholic steatohepatitis (ASH) defined histologically by the coexistence of steatosis, hepatocyte ballooning and satellitosis.[] Ballooning degeneration – hepatocytes in the setting of alcoholic change often swell up with excess fat, water and protein; normally these proteins are exported into the bloodstream[] The MDB is the result of aggregation and accumulation of proteins in the cytoplasm of balloon degenerated liver cells.[]

  • Macronodular Cirrhosis

    Hepatocyte s changes like ballooning (Figure 2), steatosis, necrosis and cholestasis in 0.8%, 67% and 9.3% respectively.[] Endoscopic retrograde cholangiopancreatography *magnetic retrograde cholangiopancreatography Describe ballooning degeneration of hepatocytes.[] […] are surrounded by bands of fibrosis, accompanied by thickened hepatic vessels and diffuse ballooning degeneration.[]

  • Liver Metastasis

    Large droplet steatosis (% of hepatocytes): mild (20%). Ballooning of hepatocytes: not identified. Mallory-Denk bodies: not identified.[]

  • Liver Transplant Rejection

    ballooning and dropout Due to chronic injury Acute bile duct loss after acute rejection may be reversible Obliterative arteriopathy Requires hepatectomy for diagnosis Occluded[] ballooning Viral inclusions may be small and/or rare We perform immunoperoxidase stain for CMV when there are microabcesses or prominent hepatocyte necrosis or possible inclusions[] […] damage Also loss of bile ducts, arteritis, central ischemic damage with ballooning degeneration and hepatocyte dropout Microscopic (histologic) images Images hosted on other[]

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