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77 Possible Causes for Hepatocyte Ballooning

  • Citrullinemia Type 2

    Citrullinemia type 2 (CTLN2) is caused by mutations in the SLC25A13 gene. The disease is inherited in an autosomal recessive manner. It may manifest in form of early-onset cholestasis or as adult-onset recurrent encephalopathy. Spontaneous resolution is the most likely outcome in case of neonatal-onset disease, but[…][symptoma.com]

  • Insulin Resistance

    NASH refers to the presence of hepatic steatosis and inflammation with hepatocyte injury (ballooning) in the presence or absence of fibrosis.[dx.doi.org]

  • Chronic Alcoholism

    Hepatocytes are classically ballooned, which causes compression of the sinusoid and reversible portal hypertension.[clevelandclinicmeded.com] The inflammatory cell infiltrate, located primarily in the sinusoids and close to necrotic hepatocytes, consists of polymorphonuclear cells and mononuclear cells.[clevelandclinicmeded.com]

  • Liver Cirrhosis

    The perisinusoidal or chicken-wire fibrosis may no longer be apparent, and other features (eg, inflammatory cells, ballooned hepatocytes, and steatosis) may subside.[pubs.rsna.org] […] of this, in particular with enlarged hepatocytes showing prominent cytoplasmic clumping, were considered borderline.[atsjournals.org] The presence of clear-cut zone 3 pericellular fibrosis, ballooning degeneration, or Mallory body formation was considered definite for steatohepatitis; changes falling short[atsjournals.org]

  • Alcoholic Liver Disease

    […] cytoplasm and clumped strands of intermediate filaments Satellitosis is featured by ballooned hepatocyte surrounded by neutrophils Mallory-Denk body, also known as Mallory[pathologyoutlines.com] Within this spectrum, varying degrees of inflammation, hepatocellular ballooning degeneration, hepatocyte necrosis, cholestasis, and fibrosis may be encountered.[ncbi.nlm.nih.gov] ETHANOL 14Mallory body with the characteristic twisted-rope appearance (centre of image - withina ballooning hepatocyte). H&E stain 15. ETHANOL 15 16. ETHANOL 16 17.[slideshare.net]

  • Hepatitis

    In the NAFLD activity score (NAS)[ 34 ], cases with a high grade of inflammation activity and hepatocyte ballooning without evidence of steatosis can be diagnosed as borderline[doi.org] Microscopically, changes that can be seen include steatosis with large and swollen hepatocytes (ballooning), evidence of cellular injury and cell death (apoptosis, necrosis[en.wikipedia.org] In uncomplicated cases, histology of AH is characterized by neutrophilic infiltration (a marker of alcohol-induced hepatitis), ballooning degeneration of hepatocytes, spotty[doi.org]

  • Alcoholic Hepatitis

    The principal cause of AH is alcoholic steatohepatitis (ASH) defined histologically by the coexistence of steatosis, hepatocyte ballooning and satellitosis.[ncbi.nlm.nih.gov] Ballooning degeneration – hepatocytes in the setting of alcoholic change often swell up with excess fat, water and protein; normally these proteins are exported into the bloodstream[en.wikipedia.org] The MDB is the result of aggregation and accumulation of proteins in the cytoplasm of balloon degenerated liver cells.[ncbi.nlm.nih.gov]

  • Macronodular Cirrhosis

    Hepatocyte s changes like ballooning (Figure 2), steatosis, necrosis and cholestasis in 0.8%, 67% and 9.3% respectively.[omicsgroup.org] Endoscopic retrograde cholangiopancreatography *magnetic retrograde cholangiopancreatography Describe ballooning degeneration of hepatocytes.[quizlet.com] […] are surrounded by bands of fibrosis, accompanied by thickened hepatic vessels and diffuse ballooning degeneration.[medical-dictionary.thefreedictionary.com]

  • Liver Metastasis

    Large droplet steatosis (% of hepatocytes): mild (20%). Ballooning of hepatocytes: not identified. Mallory-Denk bodies: not identified.[librepathology.org]

  • Liver Transplant Rejection

    ballooning and dropout Due to chronic injury Acute bile duct loss after acute rejection may be reversible Obliterative arteriopathy Requires hepatectomy for diagnosis Occluded[surgpathcriteria.stanford.edu] ballooning Viral inclusions may be small and/or rare We perform immunoperoxidase stain for CMV when there are microabcesses or prominent hepatocyte necrosis or possible inclusions[surgpathcriteria.stanford.edu] […] damage Also loss of bile ducts, arteritis, central ischemic damage with ballooning degeneration and hepatocyte dropout Microscopic (histologic) images Images hosted on other[pathologyoutlines.com]

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